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The map label for this gene is trpF

Identifier: 182681199

GI number: 182681199

Start: 759552

End: 760214

Strand: Direct

Name: trpF

Synonym: XfasM23_0643

Alternate gene names: 182681199

Gene position: 759552-760214 (Clockwise)

Preceding gene: 182681198

Following gene: 182681200

Centisome position: 29.95

GC content: 54.3

Gene sequence:

>663_bases
ATGAACATCCCCCCTTACCGTACCCGTATCAAGTTTTGTGGTATGACCCGCGTTGGAGATGTGAGGTTAGCCAGCGAGCT
TGGTGTCGATGCGGTGGGACTCATTTTTGCATCGGGCAGCTCGCGTCTGCTGACAGTTTCCGCGGCATGTGCGATACGCC
GAACCGTTGCGCCGATGGTCGATGTGGTTGCCCTCTTCCAAAATAACAGCGCAGATGAGATCCACACTGTGGTGCGCACG
GTACGTCCGACCTTGCTCCAGTTCCACGGTAAGGAGGAAGACGCATTCTGTCGTACCTTCAACGTGCCCTACCTAAAGGC
AATCCCAATGGCGGGTGCTGAAGCAAAGCGAATCTGTACGCGGACCTTATATTTGAAGTACCCGAATGCTGCTGGTTTCA
TTTTCGACAGTCATCTCAAGGGTGGTACCGGCCAGACGTTCGATTGGTCGCGTCTCCCTATCGATCTGCACCATCCCTTT
CTACTTGCCGGTGGTATTACTCCGGAAAACGTGTTTGATGCGATTGCTGCTACGGTCCCTTGGGGCGTTGATGTTTCTAG
TGGTATCGAATTGCAGCCGGGCATCAAGGATGGCGACAAAATGCGTCAATTTGTCGAAGAAGTACGGCGTGCCGACGGAC
GCAGGCTGCTTGGAGTGCCCTGA

Upstream 100 bases:

>100_bases
GTGACCGGACCATGGCTGGACCGACTGCCTCAGCGCGTGGGCTGGTCTTTGTCGGACCTTTGTATCCGGAAAAGTGGCAC
TTGCCTATGGAAGTGAGTGT

Downstream 100 bases:

>100_bases
TGGGGATACCGCAGTGCCATGTGTCACCATTGCCTTATCTTGCTTCATGGGATGACACTGTCTTGGTTGCCGGTTCGTTG
ACACGTCATGAAGCGGTTAA

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MNIPPYRTRIKFCGMTRVGDVRLASELGVDAVGLIFASGSSRLLTVSAACAIRRTVAPMVDVVALFQNNSADEIHTVVRT
VRPTLLQFHGKEEDAFCRTFNVPYLKAIPMAGAEAKRICTRTLYLKYPNAAGFIFDSHLKGGTGQTFDWSRLPIDLHHPF
LLAGGITPENVFDAIAATVPWGVDVSSGIELQPGIKDGDKMRQFVEEVRRADGRRLLGVP

Sequences:

>Translated_220_residues
MNIPPYRTRIKFCGMTRVGDVRLASELGVDAVGLIFASGSSRLLTVSAACAIRRTVAPMVDVVALFQNNSADEIHTVVRT
VRPTLLQFHGKEEDAFCRTFNVPYLKAIPMAGAEAKRICTRTLYLKYPNAAGFIFDSHLKGGTGQTFDWSRLPIDLHHPF
LLAGGITPENVFDAIAATVPWGVDVSSGIELQPGIKDGDKMRQFVEEVRRADGRRLLGVP
>Mature_220_residues
MNIPPYRTRIKFCGMTRVGDVRLASELGVDAVGLIFASGSSRLLTVSAACAIRRTVAPMVDVVALFQNNSADEIHTVVRT
VRPTLLQFHGKEEDAFCRTFNVPYLKAIPMAGAEAKRICTRTLYLKYPNAAGFIFDSHLKGGTGQTFDWSRLPIDLHHPF
LLAGGITPENVFDAIAATVPWGVDVSSGIELQPGIKDGDKMRQFVEEVRRADGRRLLGVP

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=201, Percent_Identity=30.8457711442786, Blast_Score=82, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320210, Length=220, Percent_Identity=28.1818181818182, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_XYLF2 (B2I9J1)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001829359.1
- ProteinModelPortal:   B2I9J1
- SMR:   B2I9J1
- GeneID:   6202880
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_0643
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- ProtClustDB:   PRK01222
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 24113; Mature: 24113

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIPPYRTRIKFCGMTRVGDVRLASELGVDAVGLIFASGSSRLLTVSAACAIRRTVAPMV
CCCCCCCCEEEEECCCCCCCEEEHHHCCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHH
DVVALFQNNSADEIHTVVRTVRPTLLQFHGKEEDAFCRTFNVPYLKAIPMAGAEAKRICT
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHEECCCCCCHHHHHHH
RTLYLKYPNAAGFIFDSHLKGGTGQTFDWSRLPIDLHHPFLLAGGITPENVFDAIAATVP
EEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCEECCCCEEEECCCCHHHHHHHHHHHCC
WGVDVSSGIELQPGIKDGDKMRQFVEEVRRADGRRLLGVP
CCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCEECCCC
>Mature Secondary Structure
MNIPPYRTRIKFCGMTRVGDVRLASELGVDAVGLIFASGSSRLLTVSAACAIRRTVAPMV
CCCCCCCCEEEEECCCCCCCEEEHHHCCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHH
DVVALFQNNSADEIHTVVRTVRPTLLQFHGKEEDAFCRTFNVPYLKAIPMAGAEAKRICT
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHEECCCCCCHHHHHHH
RTLYLKYPNAAGFIFDSHLKGGTGQTFDWSRLPIDLHHPFLLAGGITPENVFDAIAATVP
EEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCEECCCCEEEECCCCHHHHHHHHHHHCC
WGVDVSSGIELQPGIKDGDKMRQFVEEVRRADGRRLLGVP
CCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA