| Definition | Xylella fastidiosa M23 chromosome, complete genome. |
|---|---|
| Accession | NC_010577 |
| Length | 2,535,690 |
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The map label for this gene is nrdA [H]
Identifier: 182681035
GI number: 182681035
Start: 575749
End: 578241
Strand: Direct
Name: nrdA [H]
Synonym: XfasM23_0474
Alternate gene names: 182681035
Gene position: 575749-578241 (Clockwise)
Preceding gene: 182681034
Following gene: 182681036
Centisome position: 22.71
GC content: 51.3
Gene sequence:
>2493_bases ATGATTCCCAAAGAGCAATTTGTTGCGGCTATCGCTGATTCTTTACCCAATCCTGGCCATGTCGCTGGGTCTGTTCCGCC TGTTGCGTTATCTGTCTTCCATCCTGATGAACCGGAGGACGAGGTGCCTATCCCACGCCAAACTGCCATGATGCATACTC GGGCTGTGGAAGAAGCCAATGTGTCTACCTGGATTACCAAAGAAGCGGGTAACCGCCGTATGCCGTTCGACTGTGCGCGT TTGGAGTGCGCTATCGATACGATTCACCAAGAATTCCCACAATTGGACGTGGCTGAATATAAGCGCGCGGTGTTCGGGTT CGTCGAACGTAAGGATAGCGTTAATGCTGATGACTTGGTTGATCTGTTGATCCGTGAGGCTGAGTCACGTGTTGACCTGA CTGCGCCGGAGTGGGAGTACTTCGCTGCACGTTTGTATCTGCGTCGCTTATACAAGCGTGCCAGCCGCAATCGCTTCTAC GATGCCAGCCAGAAATACGGCTCGTTTGTCGGTTTACAGGAGAGTTTGGCTGACCGCAATATCTATTCCAACGATATTTT GCGCAGCTACTCCAAGGAGGAGTTGATCGAGGCTGGTCAGATGATCGATCCTGAGCGCGATAAGCTGTTTACTTATAACG GCTTGTACTTATTGGCCACACGTTACTTGGCGACCGATACTTCTCGCGGCGTGTTTGAATTGCCACAAGAACGTTGGCTT ACCATCGCCTTGTATTTGATGCAAGACGAGTATGGCCCCGGTAAAGGTGGACGTGAGCGCCGCATGCAACTAGTTGGCGA AGCGTACTGGGCACTGTCTAACTTGTACATGACGGTGGCGACTCCCACCCTGGGCAATGCCGGAAAAATCAATGGCCAGT TGTCTTCGTGCTTCATTGATACCGTTGACGACAGTTTGCAGGGTATTTACGACTCCAACACCGATATTGCGCGTGTGTCC AAGCATGGCGGAGGCGTTGGTGCTTATTTGGGTTACGTACGCTCCTCTGGGTCAATGATTCGTGGTGTAGCTAACTCTTC TGGTGGTGTTGTGCCGTGGATCAAACAGCTCAATAACACCGCTGTCTCTGTGGATCAGCTTGGTCAGCGCAAGGGTGCGA TTGCGGTTTATTTGGATATTTGGCACCGCGATATTGAAGCGTTCTTGGATTTGCGTCTGAATAACGGAGATCAGCGTTTA CGTGCCCATGATGTGTTTACCTCGGTCTGCATTCCCGACTTGTTTATGGAAGCGGTCGAACGTCGCGGCGATTGGTATTT GTTCGACCCATATGAGGTGAAGCGGGTTAAAGGTTGGTACCTGCAGGATTTCTATGACGAGAAGAGGGGTGACCCCAATG GCAGCTTCCGCCGTAAATACGAGGACGTTGTTGCTGACGAGCGTATCAGCCGTAAGACGGTCAAGGCCATTGACATCTTT AAACGCATCATGGTCAGCCAATTAGAGACGGGCAATCCATTCATGTTCTACCGGGATGAAGTGAACCGGAAGAATCCCAA CAAGCATGTTGGCATGGTGTATTCGTCTAATCTCTGTACTGAGATCCTGCAGAACATGACGCCAACCCGGCTCATACAGG AGATGATCAGTGGCAATCAGATCGTTACGACCAAGCATGCTGGTGATTTCGTCGTGTGCAATCTGTCTTCGATCAATCTT GGTCGTGCAATCACGGTACAGGCTGATTTGCTTGGCGCCGATGTATTGGAGCGTCTGATCCCGATTCAGGTGCGTATGCT TGATAATGTCATTGATCTGAATCTGTTGCCCGTCCCACAAGCCACGATTACTAATCAGAAATACCGTGCGATTGGTTTAG GTACTTTCGGTTGGCATCACTTGCTGGCGCAGAAGGCGATTCACTGGAATTCGCAGGAAGCTGAGCAATACAGCGACGCG TTGTATGAACGCATTAATTACCTGACGATTCGAGCAAGCATGGAGTTGGCTAAGGAGAAGGGCACCTATGCAGTGTTTCC CGGCAGTGACTGGCAGACCGGTGAGTATTTCCGCGCGCGTGACTACAACAGCCCACAATGGCTTGAATTAGCTGCCCAAG TTGCTGTCAATGGCGTGCGTAATGCCTATATGGTGGCGGTAGCGCCGAACATGAGTACTGCGCAGATTGCCGGTTCCACT GCGTCAATCGACCCCATCTATAGCGCGTTTTACTACGAAGAGAAGAAGGATTACCGCCGCCCGGTTGTGGCACCCGGATT GTCGCTGGATACGTGGCCGTATTATGAAAAGGGTGCTTATAAGCTCGACCAGTTCGCGAGCATACGCCAGAATGCCCGCC GCCAGCGTCACGTTGATCAATCGCTCAGTTTCAATTTCTATGTGCCAAGTACCATCCGTGCTAGCACGTTGTTGGATCTT CACATGACCGCTTGGCGTGAGGGCTTGAAGACGACTTACTACGTGCGCTCTAACGACATTGACATCAGCGAATGCGAGTG GTGTTCAAGCTGA
Upstream 100 bases:
>100_bases TGCGAGCTGTATGGCTACCTGCTGTTGTTTCCAGGTCCACTAAAGCTGGTTTCTACCTCACTGCTTGAGGTAGATCCGTG TATCACATGATGGAGGACGC
Downstream 100 bases:
>100_bases TGCTGTTTGCTCTGCCTGAATTTGTAGTCTATCGGTCCTGTGCCGGTGTCCTGCATCGTTTGACTTAAATGACCAACATG GCTATCTCACTAGATCGCAT
Product: ribonucleotide-diphosphate reductase subunit alpha
Products: NA
Alternate protein names: Ribonucleotide reductase [H]
Number of amino acids: Translated: 830; Mature: 830
Protein sequence:
>830_residues MIPKEQFVAAIADSLPNPGHVAGSVPPVALSVFHPDEPEDEVPIPRQTAMMHTRAVEEANVSTWITKEAGNRRMPFDCAR LECAIDTIHQEFPQLDVAEYKRAVFGFVERKDSVNADDLVDLLIREAESRVDLTAPEWEYFAARLYLRRLYKRASRNRFY DASQKYGSFVGLQESLADRNIYSNDILRSYSKEELIEAGQMIDPERDKLFTYNGLYLLATRYLATDTSRGVFELPQERWL TIALYLMQDEYGPGKGGRERRMQLVGEAYWALSNLYMTVATPTLGNAGKINGQLSSCFIDTVDDSLQGIYDSNTDIARVS KHGGGVGAYLGYVRSSGSMIRGVANSSGGVVPWIKQLNNTAVSVDQLGQRKGAIAVYLDIWHRDIEAFLDLRLNNGDQRL RAHDVFTSVCIPDLFMEAVERRGDWYLFDPYEVKRVKGWYLQDFYDEKRGDPNGSFRRKYEDVVADERISRKTVKAIDIF KRIMVSQLETGNPFMFYRDEVNRKNPNKHVGMVYSSNLCTEILQNMTPTRLIQEMISGNQIVTTKHAGDFVVCNLSSINL GRAITVQADLLGADVLERLIPIQVRMLDNVIDLNLLPVPQATITNQKYRAIGLGTFGWHHLLAQKAIHWNSQEAEQYSDA LYERINYLTIRASMELAKEKGTYAVFPGSDWQTGEYFRARDYNSPQWLELAAQVAVNGVRNAYMVAVAPNMSTAQIAGST ASIDPIYSAFYYEEKKDYRRPVVAPGLSLDTWPYYEKGAYKLDQFASIRQNARRQRHVDQSLSFNFYVPSTIRASTLLDL HMTAWREGLKTTYYVRSNDIDISECEWCSS
Sequences:
>Translated_830_residues MIPKEQFVAAIADSLPNPGHVAGSVPPVALSVFHPDEPEDEVPIPRQTAMMHTRAVEEANVSTWITKEAGNRRMPFDCAR LECAIDTIHQEFPQLDVAEYKRAVFGFVERKDSVNADDLVDLLIREAESRVDLTAPEWEYFAARLYLRRLYKRASRNRFY DASQKYGSFVGLQESLADRNIYSNDILRSYSKEELIEAGQMIDPERDKLFTYNGLYLLATRYLATDTSRGVFELPQERWL TIALYLMQDEYGPGKGGRERRMQLVGEAYWALSNLYMTVATPTLGNAGKINGQLSSCFIDTVDDSLQGIYDSNTDIARVS KHGGGVGAYLGYVRSSGSMIRGVANSSGGVVPWIKQLNNTAVSVDQLGQRKGAIAVYLDIWHRDIEAFLDLRLNNGDQRL RAHDVFTSVCIPDLFMEAVERRGDWYLFDPYEVKRVKGWYLQDFYDEKRGDPNGSFRRKYEDVVADERISRKTVKAIDIF KRIMVSQLETGNPFMFYRDEVNRKNPNKHVGMVYSSNLCTEILQNMTPTRLIQEMISGNQIVTTKHAGDFVVCNLSSINL GRAITVQADLLGADVLERLIPIQVRMLDNVIDLNLLPVPQATITNQKYRAIGLGTFGWHHLLAQKAIHWNSQEAEQYSDA LYERINYLTIRASMELAKEKGTYAVFPGSDWQTGEYFRARDYNSPQWLELAAQVAVNGVRNAYMVAVAPNMSTAQIAGST ASIDPIYSAFYYEEKKDYRRPVVAPGLSLDTWPYYEKGAYKLDQFASIRQNARRQRHVDQSLSFNFYVPSTIRASTLLDL HMTAWREGLKTTYYVRSNDIDISECEWCSS >Mature_830_residues MIPKEQFVAAIADSLPNPGHVAGSVPPVALSVFHPDEPEDEVPIPRQTAMMHTRAVEEANVSTWITKEAGNRRMPFDCAR LECAIDTIHQEFPQLDVAEYKRAVFGFVERKDSVNADDLVDLLIREAESRVDLTAPEWEYFAARLYLRRLYKRASRNRFY DASQKYGSFVGLQESLADRNIYSNDILRSYSKEELIEAGQMIDPERDKLFTYNGLYLLATRYLATDTSRGVFELPQERWL TIALYLMQDEYGPGKGGRERRMQLVGEAYWALSNLYMTVATPTLGNAGKINGQLSSCFIDTVDDSLQGIYDSNTDIARVS KHGGGVGAYLGYVRSSGSMIRGVANSSGGVVPWIKQLNNTAVSVDQLGQRKGAIAVYLDIWHRDIEAFLDLRLNNGDQRL RAHDVFTSVCIPDLFMEAVERRGDWYLFDPYEVKRVKGWYLQDFYDEKRGDPNGSFRRKYEDVVADERISRKTVKAIDIF KRIMVSQLETGNPFMFYRDEVNRKNPNKHVGMVYSSNLCTEILQNMTPTRLIQEMISGNQIVTTKHAGDFVVCNLSSINL GRAITVQADLLGADVLERLIPIQVRMLDNVIDLNLLPVPQATITNQKYRAIGLGTFGWHHLLAQKAIHWNSQEAEQYSDA LYERINYLTIRASMELAKEKGTYAVFPGSDWQTGEYFRARDYNSPQWLELAAQVAVNGVRNAYMVAVAPNMSTAQIAGST ASIDPIYSAFYYEEKKDYRRPVVAPGLSLDTWPYYEKGAYKLDQFASIRQNARRQRHVDQSLSFNFYVPSTIRASTLLDL HMTAWREGLKTTYYVRSNDIDISECEWCSS
Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]
COG id: COG0209
COG function: function code F; Ribonucleotide reductase, alpha subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ATP-cone domain [H]
Homologues:
Organism=Homo sapiens, GI4506749, Length=722, Percent_Identity=30.6094182825485, Blast_Score=304, Evalue=2e-82, Organism=Escherichia coli, GI1789030, Length=684, Percent_Identity=30.8479532163743, Blast_Score=274, Evalue=2e-74, Organism=Escherichia coli, GI2367133, Length=733, Percent_Identity=27.6944065484311, Blast_Score=240, Evalue=3e-64, Organism=Caenorhabditis elegans, GI17555242, Length=802, Percent_Identity=29.5511221945137, Blast_Score=301, Evalue=1e-81, Organism=Saccharomyces cerevisiae, GI6322123, Length=746, Percent_Identity=31.5013404825737, Blast_Score=303, Evalue=1e-82, Organism=Saccharomyces cerevisiae, GI6320914, Length=765, Percent_Identity=30.9803921568627, Blast_Score=302, Evalue=2e-82, Organism=Drosophila melanogaster, GI17352481, Length=735, Percent_Identity=30.3401360544218, Blast_Score=293, Evalue=4e-79,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005144 - InterPro: IPR013346 - InterPro: IPR013509 - InterPro: IPR000788 - InterPro: IPR008926 [H]
Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]
EC number: =1.17.4.1 [H]
Molecular weight: Translated: 94398; Mature: 94398
Theoretical pI: Translated: 6.08; Mature: 6.08
Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIPKEQFVAAIADSLPNPGHVAGSVPPVALSVFHPDEPEDEVPIPRQTAMMHTRAVEEAN CCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCC VSTWITKEAGNRRMPFDCARLECAIDTIHQEFPQLDVAEYKRAVFGFVERKDSVNADDLV CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHH DLLIREAESRVDLTAPEWEYFAARLYLRRLYKRASRNRFYDASQKYGSFVGLQESLADRN HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHCCC IYSNDILRSYSKEELIEAGQMIDPERDKLFTYNGLYLLATRYLATDTSRGVFELPQERWL CHHHHHHHHCCHHHHHHHCCCCCCCCCCEEEECCCEEEHHHHHHCCCCCCHHHCCCHHHE TIALYLMQDEYGPGKGGRERRMQLVGEAYWALSNLYMTVATPTLGNAGKINGQLSSCFID EEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHHH TVDDSLQGIYDSNTDIARVSKHGGGVGAYLGYVRSSGSMIRGVANSSGGVVPWIKQLNNT HHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCC AVSVDQLGQRKGAIAVYLDIWHRDIEAFLDLRLNNGDQRLRAHDVFTSVCIPDLFMEAVE EEEHHHHCCCCCCEEEEEHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH RRGDWYLFDPYEVKRVKGWYLQDFYDEKRGDPNGSFRRKYEDVVADERISRKTVKAIDIF HCCCEEEECCHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH KRIMVSQLETGNPFMFYRDEVNRKNPNKHVGMVYSSNLCTEILQNMTPTRLIQEMISGNQ HHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEEECHHHHHHHHCCCHHHHHHHHHCCCE IVTTKHAGDFVVCNLSSINLGRAITVQADLLGADVLERLIPIQVRMLDNVIDLNLLPVPQ EEEEECCCCEEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCC ATITNQKYRAIGLGTFGWHHLLAQKAIHWNSQEAEQYSDALYERINYLTIRASMELAKEK HHHCCCCEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEEHHHHHHCC GTYAVFPGSDWQTGEYFRARDYNSPQWLELAAQVAVNGVRNAYMVAVAPNMSTAQIAGST CCEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCC ASIDPIYSAFYYEEKKDYRRPVVAPGLSLDTWPYYEKGAYKLDQFASIRQNARRQRHVDQ CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH SLSFNFYVPSTIRASTLLDLHMTAWREGLKTTYYVRSNDIDISECEWCSS CCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHCCCCCCC >Mature Secondary Structure MIPKEQFVAAIADSLPNPGHVAGSVPPVALSVFHPDEPEDEVPIPRQTAMMHTRAVEEAN CCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCC VSTWITKEAGNRRMPFDCARLECAIDTIHQEFPQLDVAEYKRAVFGFVERKDSVNADDLV CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHH DLLIREAESRVDLTAPEWEYFAARLYLRRLYKRASRNRFYDASQKYGSFVGLQESLADRN HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHCCC IYSNDILRSYSKEELIEAGQMIDPERDKLFTYNGLYLLATRYLATDTSRGVFELPQERWL CHHHHHHHHCCHHHHHHHCCCCCCCCCCEEEECCCEEEHHHHHHCCCCCCHHHCCCHHHE TIALYLMQDEYGPGKGGRERRMQLVGEAYWALSNLYMTVATPTLGNAGKINGQLSSCFID EEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHHH TVDDSLQGIYDSNTDIARVSKHGGGVGAYLGYVRSSGSMIRGVANSSGGVVPWIKQLNNT HHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCC AVSVDQLGQRKGAIAVYLDIWHRDIEAFLDLRLNNGDQRLRAHDVFTSVCIPDLFMEAVE EEEHHHHCCCCCCEEEEEHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH RRGDWYLFDPYEVKRVKGWYLQDFYDEKRGDPNGSFRRKYEDVVADERISRKTVKAIDIF HCCCEEEECCHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH KRIMVSQLETGNPFMFYRDEVNRKNPNKHVGMVYSSNLCTEILQNMTPTRLIQEMISGNQ HHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEEECHHHHHHHHCCCHHHHHHHHHCCCE IVTTKHAGDFVVCNLSSINLGRAITVQADLLGADVLERLIPIQVRMLDNVIDLNLLPVPQ EEEEECCCCEEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCC ATITNQKYRAIGLGTFGWHHLLAQKAIHWNSQEAEQYSDALYERINYLTIRASMELAKEK HHHCCCCEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEEHHHHHHCC GTYAVFPGSDWQTGEYFRARDYNSPQWLELAAQVAVNGVRNAYMVAVAPNMSTAQIAGST CCEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCC ASIDPIYSAFYYEEKKDYRRPVVAPGLSLDTWPYYEKGAYKLDQFASIRQNARRQRHVDQ CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH SLSFNFYVPSTIRASTLLDLHMTAWREGLKTTYYVRSNDIDISECEWCSS CCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9665876 [H]