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The map label for this gene is lon [H]

Identifier: 182681030

GI number: 182681030

Start: 566745

End: 569216

Strand: Direct

Name: lon [H]

Synonym: XfasM23_0469

Alternate gene names: 182681030

Gene position: 566745-569216 (Clockwise)

Preceding gene: 182681029

Following gene: 182681031

Centisome position: 22.35

GC content: 48.62

Gene sequence:

>2472_bases
ATGACTCAGTCCTCTCAAAAAGCCCTTGATCTGCAGGTATTGCCGCTGCGTGACGTGGTTGTATTCCCGTACATGGTGAT
TCCATTGTTCGTAGGTCGTGAAAAGTCAATGCGGGCGCTTGAAAAGGCAATGGACGCTGATAAGCGCATCTTGTTGGTTG
CACAAAAAACGGCTGACATTGACGATCCTGGTGTGGTTGATTTGCATGCCATCGGTACTTATGCTCAGGTGCTGCAGTTG
TTAAAGCTTCCTGACGGCACGATTAAGGTGTTGGTCGAAGGCCTAACCCGTGTGAGTGTGGATCAAGTAGTCGAGCATGA
TGGTGCGTTACGAGGTTGTGGTATCGAAATTGCCTCTACTCAGGGGCGCGAAGAACGTGAAATTGAGGCAATTGTTCGAT
CTCTGTTGTCGCTCTTCGAGCAGTACGTTAAGACCAATCGCAAGCTCCCTCCAGAATTGTTACAAACTTTGAGTGGTATT
GATGATCCAGGTCGTTTAGCCGATACCATTGCTGCGCACCTGAGTGTGCGTTTGGCGCATAAGCAGCGTCTGTTGGAAAC
TATCGAAATTGGTGACCGACTTGAAATACTCATTGGACTAGTCGATGGTGAAATCGACGTTCAGCAGATGGAAAAGCGTA
TCCGTGGTCGAGTTAAGTCGCAGATGGAGAAGAGTCAGCGTGAGTACTATCTCAATGAGCAGATGAAGGCGATCCAGAAG
GAGTTGGGTGACTTCGACGATCTTCCGAGTGAATTGGAGGAGTTGGCTCGTAAAATTGCCGAAATCGGGATGCCAAAATC
AGTCCAGAGTAAGGCTAAGAGCGAACTCAACAAGCTTAAACAGATGTCTCCAATGTCAGCTGAGGCAGCAGTAGTGCGTA
ATTACCTTGACTGGTTGTTGGGGGTCCCTTGGAGGAAGTGCACTAAGGTACGAAAGGACTTGAAAGTCGCTCAATCTACA
CTGGATGATGACCACTATGGTCTTGATAAGGTGAAAGAACGCATCCTTGAGTATCTTGCGGTCCAGTCACGAGTCAAACA
GATGCGAGGTCCGATTTTGTGTTTAGTTGGCCCTCCTGGTGTAGGTAAAACTTCCCTCGGTCAGTCTATTGCTAAGGCGA
CCAATCGCAAGTTCGTACGGATGTCTTTGGGGGGTGTGCGTGACGAAGCTGAGGTTCGGGGGCATCGACGTACTTATGTT
GGCTCAATGCCGGGCCGGGTCGTACAGAATCTCAACAAGGTTGGCAGTAAAAACCCTCTGTTTGTGCTTGATGAGATCGA
TAAGATGGCTATGGACTTCCGGGGTGATCCTTCTGCAGCGCTCTTGGAGGTGCTTGATCCTGAGCAGAATAATGCGTTCA
ATGATCATTACCTTGATGTTGACCTGGATTTGTCCGAGGTTATGTTCGTGGCAACCTCTAATTCGCTGAACATTCCTGGT
CCATTGCTTGATCGCATGGAAGTGATTCGTATACCAGGCTATACTGAGGACGAAAAACTCAACATTGCTACCCGTTACTT
GGTACCTAAACAGATTAGAGCCAATGGTTTGGTTGTTGGGGAATTGGCGATTGGAGAGGACGCGATTCGCGACATTGTGC
GCTACTACACGCGTGAGTCTGGAGTGCGTAACCTTGAGCGCGAGATCTCTAAAATTTGCCGTAAAATTGTCAAGGAGATT
GCCTTAGTTGGTGTGAAGCCTTTTGCTAAGAAGTCAACCAAGTCTAAGGTATTATTTGCGGTGACTTCGAAAAATCTTGA
AAAGTATCTTGGGGTGCGCCGCTTTGATTTTGGCCGTGCTGAGGAAGCTAACGAGATTGGCCTAGTCACTGGTTTGGCTT
GGACAGAAGTAGGTGGAGATTTGTTGCAAATCGAATCTACTCTTGTCCCGGGTAAGGGTAACCTGATTTTGACTGGTCAG
CTTGGTAGCGTGATGAAGGAGTCGGCGTCTGCGGCGTTGACGGTGGTCCGTTCGCGCGCTGATCGCTTCTGTATTGACGT
GGACTTTTTGCATAATCAAGATGTTCACCTTCATGTGCCTGACGGTGCCACGCCGAAGGATGGTCCAAGTGCAGGTATTG
CCATGGTCACATCCTTGGTGTCAATGCTTACCAAGGTGCCAGTGCGTGCTGATGTAGCGATGACTGGTGAGATTACTTTG
CGTGGCCGAGTTTCTGTGATTGGTGGTTTGAAGGAGAAATTGTTGGCTGCATTACGTGGCGGTATCCGAACAGTATTGAT
CCCTGAAGGAAATCGTAGAGATTTGGCTGATATCCCGGCTAATGTGACACGTGCTTTGACGATTGTTCCAGTAAAGTGGA
TTGATGAAGTGTTGGATTTAGCTCTTGAAAGTCCACTTGAACCTAAAGTTGCGGCCCAATTAGGTAAGAGCAAACCGCGT
AAGGCCCATTCGCGTGTGTCTACTGTGCGTGGCAAGTCCAAGGGATCAAGCAATGCTCGTGTCAGACACTGA

Upstream 100 bases:

>100_bases
GGTTTTAAAGAAAGCTCTTGTAAGCTTGCCCGAATGGCCTCATAACGGGGCCATTGTCTTTTCTGTTGCCGTAAATTCAA
TGCATTACACTGGAGTGCTA

Downstream 100 bases:

>100_bases
TATACGCTATTTAAATGTGTGCAAAAGCGGTTGCCTTAATCGTTATTGTTCATGTTCAGCTTGCGCGTGTTGGATAGGCG
CTGGTATAAAAGCATGCGAC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 823; Mature: 822

Protein sequence:

>823_residues
MTQSSQKALDLQVLPLRDVVVFPYMVIPLFVGREKSMRALEKAMDADKRILLVAQKTADIDDPGVVDLHAIGTYAQVLQL
LKLPDGTIKVLVEGLTRVSVDQVVEHDGALRGCGIEIASTQGREEREIEAIVRSLLSLFEQYVKTNRKLPPELLQTLSGI
DDPGRLADTIAAHLSVRLAHKQRLLETIEIGDRLEILIGLVDGEIDVQQMEKRIRGRVKSQMEKSQREYYLNEQMKAIQK
ELGDFDDLPSELEELARKIAEIGMPKSVQSKAKSELNKLKQMSPMSAEAAVVRNYLDWLLGVPWRKCTKVRKDLKVAQST
LDDDHYGLDKVKERILEYLAVQSRVKQMRGPILCLVGPPGVGKTSLGQSIAKATNRKFVRMSLGGVRDEAEVRGHRRTYV
GSMPGRVVQNLNKVGSKNPLFVLDEIDKMAMDFRGDPSAALLEVLDPEQNNAFNDHYLDVDLDLSEVMFVATSNSLNIPG
PLLDRMEVIRIPGYTEDEKLNIATRYLVPKQIRANGLVVGELAIGEDAIRDIVRYYTRESGVRNLEREISKICRKIVKEI
ALVGVKPFAKKSTKSKVLFAVTSKNLEKYLGVRRFDFGRAEEANEIGLVTGLAWTEVGGDLLQIESTLVPGKGNLILTGQ
LGSVMKESASAALTVVRSRADRFCIDVDFLHNQDVHLHVPDGATPKDGPSAGIAMVTSLVSMLTKVPVRADVAMTGEITL
RGRVSVIGGLKEKLLAALRGGIRTVLIPEGNRRDLADIPANVTRALTIVPVKWIDEVLDLALESPLEPKVAAQLGKSKPR
KAHSRVSTVRGKSKGSSNARVRH

Sequences:

>Translated_823_residues
MTQSSQKALDLQVLPLRDVVVFPYMVIPLFVGREKSMRALEKAMDADKRILLVAQKTADIDDPGVVDLHAIGTYAQVLQL
LKLPDGTIKVLVEGLTRVSVDQVVEHDGALRGCGIEIASTQGREEREIEAIVRSLLSLFEQYVKTNRKLPPELLQTLSGI
DDPGRLADTIAAHLSVRLAHKQRLLETIEIGDRLEILIGLVDGEIDVQQMEKRIRGRVKSQMEKSQREYYLNEQMKAIQK
ELGDFDDLPSELEELARKIAEIGMPKSVQSKAKSELNKLKQMSPMSAEAAVVRNYLDWLLGVPWRKCTKVRKDLKVAQST
LDDDHYGLDKVKERILEYLAVQSRVKQMRGPILCLVGPPGVGKTSLGQSIAKATNRKFVRMSLGGVRDEAEVRGHRRTYV
GSMPGRVVQNLNKVGSKNPLFVLDEIDKMAMDFRGDPSAALLEVLDPEQNNAFNDHYLDVDLDLSEVMFVATSNSLNIPG
PLLDRMEVIRIPGYTEDEKLNIATRYLVPKQIRANGLVVGELAIGEDAIRDIVRYYTRESGVRNLEREISKICRKIVKEI
ALVGVKPFAKKSTKSKVLFAVTSKNLEKYLGVRRFDFGRAEEANEIGLVTGLAWTEVGGDLLQIESTLVPGKGNLILTGQ
LGSVMKESASAALTVVRSRADRFCIDVDFLHNQDVHLHVPDGATPKDGPSAGIAMVTSLVSMLTKVPVRADVAMTGEITL
RGRVSVIGGLKEKLLAALRGGIRTVLIPEGNRRDLADIPANVTRALTIVPVKWIDEVLDLALESPLEPKVAAQLGKSKPR
KAHSRVSTVRGKSKGSSNARVRH
>Mature_822_residues
TQSSQKALDLQVLPLRDVVVFPYMVIPLFVGREKSMRALEKAMDADKRILLVAQKTADIDDPGVVDLHAIGTYAQVLQLL
KLPDGTIKVLVEGLTRVSVDQVVEHDGALRGCGIEIASTQGREEREIEAIVRSLLSLFEQYVKTNRKLPPELLQTLSGID
DPGRLADTIAAHLSVRLAHKQRLLETIEIGDRLEILIGLVDGEIDVQQMEKRIRGRVKSQMEKSQREYYLNEQMKAIQKE
LGDFDDLPSELEELARKIAEIGMPKSVQSKAKSELNKLKQMSPMSAEAAVVRNYLDWLLGVPWRKCTKVRKDLKVAQSTL
DDDHYGLDKVKERILEYLAVQSRVKQMRGPILCLVGPPGVGKTSLGQSIAKATNRKFVRMSLGGVRDEAEVRGHRRTYVG
SMPGRVVQNLNKVGSKNPLFVLDEIDKMAMDFRGDPSAALLEVLDPEQNNAFNDHYLDVDLDLSEVMFVATSNSLNIPGP
LLDRMEVIRIPGYTEDEKLNIATRYLVPKQIRANGLVVGELAIGEDAIRDIVRYYTRESGVRNLEREISKICRKIVKEIA
LVGVKPFAKKSTKSKVLFAVTSKNLEKYLGVRRFDFGRAEEANEIGLVTGLAWTEVGGDLLQIESTLVPGKGNLILTGQL
GSVMKESASAALTVVRSRADRFCIDVDFLHNQDVHLHVPDGATPKDGPSAGIAMVTSLVSMLTKVPVRADVAMTGEITLR
GRVSVIGGLKEKLLAALRGGIRTVLIPEGNRRDLADIPANVTRALTIVPVKWIDEVLDLALESPLEPKVAAQLGKSKPRK
AHSRVSTVRGKSKGSSNARVRH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=783, Percent_Identity=38.4418901660281, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI21396489, Length=671, Percent_Identity=40.6855439642325, Blast_Score=508, Evalue=1e-144,
Organism=Escherichia coli, GI1786643, Length=784, Percent_Identity=65.0510204081633, Blast_Score=1016, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=655, Percent_Identity=41.3740458015267, Blast_Score=491, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17556486, Length=550, Percent_Identity=37.8181818181818, Blast_Score=402, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6319449, Length=710, Percent_Identity=40.8450704225352, Blast_Score=516, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24666867, Length=677, Percent_Identity=40.768094534712, Blast_Score=513, Evalue=1e-145,
Organism=Drosophila melanogaster, GI221513036, Length=677, Percent_Identity=40.768094534712, Blast_Score=512, Evalue=1e-145,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 90938; Mature: 90807

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSSQKALDLQVLPLRDVVVFPYMVIPLFVGREKSMRALEKAMDADKRILLVAQKTADI
CCCCCCCCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCC
DDPGVVDLHAIGTYAQVLQLLKLPDGTIKVLVEGLTRVSVDQVVEHDGALRGCGIEIAST
CCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEEECC
QGREEREIEAIVRSLLSLFEQYVKTNRKLPPELLQTLSGIDDPGRLADTIAAHLSVRLAH
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
KQRLLETIEIGDRLEILIGLVDGEIDVQQMEKRIRGRVKSQMEKSQREYYLNEQMKAIQK
HHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELGDFDDLPSELEELARKIAEIGMPKSVQSKAKSELNKLKQMSPMSAEAAVVRNYLDWLL
HHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GVPWRKCTKVRKDLKVAQSTLDDDHYGLDKVKERILEYLAVQSRVKQMRGPILCLVGPPG
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
VGKTSLGQSIAKATNRKFVRMSLGGVRDEAEVRGHRRTYVGSMPGRVVQNLNKVGSKNPL
CCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCCHHHCCCCCCHHHHHHHHHHCCCCCE
FVLDEIDKMAMDFRGDPSAALLEVLDPEQNNAFNDHYLDVDLDLSEVMFVATSNSLNIPG
EEEEHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCHHHEEEEEECCCCCCCC
PLLDRMEVIRIPGYTEDEKLNIATRYLVPKQIRANGLVVGELAIGEDAIRDIVRYYTRES
HHHCCHHEEECCCCCCCCCEEHHHHHHCCHHHCCCCEEEEEECCCHHHHHHHHHHHHHHH
GVRNLEREISKICRKIVKEIALVGVKPFAKKSTKSKVLFAVTSKNLEKYLGVRRFDFGRA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEEEHHHHHHHHCCHHCCCCCC
EEANEIGLVTGLAWTEVGGDLLQIESTLVPGKGNLILTGQLGSVMKESASAALTVVRSRA
CCCCCCEEEECCHHHHCCCCCEEEHHEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHCC
DRFCIDVDFLHNQDVHLHVPDGATPKDGPSAGIAMVTSLVSMLTKVPVRADVAMTGEITL
CCEEEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECEEEE
RGRVSVIGGLKEKLLAALRGGIRTVLIPEGNRRDLADIPANVTRALTIVPVKWIDEVLDL
EEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHCCCHHHHHEEEEEHHHHHHHHHH
ALESPLEPKVAAQLGKSKPRKAHSRVSTVRGKSKGSSNARVRH
HHCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQSSQKALDLQVLPLRDVVVFPYMVIPLFVGREKSMRALEKAMDADKRILLVAQKTADI
CCCCCCCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCC
DDPGVVDLHAIGTYAQVLQLLKLPDGTIKVLVEGLTRVSVDQVVEHDGALRGCGIEIAST
CCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEEECC
QGREEREIEAIVRSLLSLFEQYVKTNRKLPPELLQTLSGIDDPGRLADTIAAHLSVRLAH
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
KQRLLETIEIGDRLEILIGLVDGEIDVQQMEKRIRGRVKSQMEKSQREYYLNEQMKAIQK
HHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELGDFDDLPSELEELARKIAEIGMPKSVQSKAKSELNKLKQMSPMSAEAAVVRNYLDWLL
HHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GVPWRKCTKVRKDLKVAQSTLDDDHYGLDKVKERILEYLAVQSRVKQMRGPILCLVGPPG
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
VGKTSLGQSIAKATNRKFVRMSLGGVRDEAEVRGHRRTYVGSMPGRVVQNLNKVGSKNPL
CCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCCHHHCCCCCCHHHHHHHHHHCCCCCE
FVLDEIDKMAMDFRGDPSAALLEVLDPEQNNAFNDHYLDVDLDLSEVMFVATSNSLNIPG
EEEEHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCHHHEEEEEECCCCCCCC
PLLDRMEVIRIPGYTEDEKLNIATRYLVPKQIRANGLVVGELAIGEDAIRDIVRYYTRES
HHHCCHHEEECCCCCCCCCEEHHHHHHCCHHHCCCCEEEEEECCCHHHHHHHHHHHHHHH
GVRNLEREISKICRKIVKEIALVGVKPFAKKSTKSKVLFAVTSKNLEKYLGVRRFDFGRA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEEEHHHHHHHHCCHHCCCCCC
EEANEIGLVTGLAWTEVGGDLLQIESTLVPGKGNLILTGQLGSVMKESASAALTVVRSRA
CCCCCCEEEECCHHHHCCCCCEEEHHEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHCC
DRFCIDVDFLHNQDVHLHVPDGATPKDGPSAGIAMVTSLVSMLTKVPVRADVAMTGEITL
CCEEEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECEEEE
RGRVSVIGGLKEKLLAALRGGIRTVLIPEGNRRDLADIPANVTRALTIVPVKWIDEVLDL
EEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHCCCHHHHHEEEEEHHHHHHHHHH
ALESPLEPKVAAQLGKSKPRKAHSRVSTVRGKSKGSSNARVRH
HHCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA