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The map label for this gene is vipA [H]

Identifier: 182681025

GI number: 182681025

Start: 558321

End: 559613

Strand: Direct

Name: vipA [H]

Synonym: XfasM23_0464

Alternate gene names: 182681025

Gene position: 558321-559613 (Clockwise)

Preceding gene: 182681024

Following gene: 182681027

Centisome position: 22.02

GC content: 51.74

Gene sequence:

>1293_bases
ATGGTTGCTGATAAGCAAGGGGGGCCAACGTTGGCGCGCATCGCCGTGGTTGGACTAGGGTATGTGGGATTGCCGTTGGC
GGTTGCGTTTGGTCGACAGCGTCCGACACTTGGGTTCGACATTGATATATGTCGGGTACAGCAGTTGTGTGCCGGTCATG
ACATTACTTGTGAAATTGAGCTTGAGGAACTCCAAGCTGCGCGACATTTGCGTTATAGCAGTGATCCTCGGGAATTGAGT
GACTGTCAGATTTTCATCATTACGGTGCCTACCCCTATTGATGTGGTTGAGCAACCGGATTTGGGGCCGCTTCGTTCGGC
CAGCATGTTGGTTGCGTCGGTACTTAAGCCTGGGGATTTAGTGATCTATGAGTCCACAGTTTATCCGGGCACAACGGAGG
AAGTCTGTGTGCCATTGCTGGAGGCTGGGTCTGGGTTGCGCTTTAATGTCGATTTTCATTGTGGTTACAGTCCTGAGCGG
ATTAACCCTGGTGATCGTAAGCGTCGGCTACAGGACATCTGCAAGATTATTTCAGGTTCCACCCCTGATATTACAGCTGT
CGTGGACGCGTTATATTCGCAGATCATCGTTGCTGGTACTTGGTGTGCTCCGTCGATCAGAGTTGCCGAGGCAGCTAAGG
TGGTTGAGAACATTCAGCGTGACGTGAATATTGCGTTGGTCAATGAGTTGGCATTGATCTTTGATCGGCTCGGTATCGAC
ACCTTGGACGTTCTCGAAGCGGCAGAAACCAAGTGGAATTTTTTGCCTTTCCGCCCGGGTTTGGTGGGTGGTCATTGCAT
CGGTGTGGATCCTTACTATTTGTTGCACAAATCCGAGAGTGTGGGGTATTACCCGGATTTGATTCATACGGCACGTCGCG
TTAACAATCGTGTTAGTCGGCATGTTGTGGACCGTGTTGTGGCTTTACTTGGTGAGCTTAGTGTGCCGATGACACGTGCC
GTGGTGCTTGTGTTGGGTGTTACCTTCAAGGAAGATTGCCCCGATTTACGTAACAGCCGCGCTTTGGATTTGGTGCGCAT
GTTCAGGACTTTAGGTGCGCAAGTCGATGTTTGCGATCCTTGTGCTGATCCGCAGCAAGCGTTGGAGCATGAGGCTGTCA
CGTTGTGTACGGAGCCCAAGGCCGGTGCTTATGATGCAATTGTGCTCGCGGTGGCGCATGCCCAGTACCGAATGTACGAT
GTAGCGACTATTGCAGCTCTAGGTAAGTCGCAGGCGGTGGTTTATGATGTCAAATCAGTGTGGCCGCGTGCAGCGGTAAC
TGATCGTCTATAG

Upstream 100 bases:

>100_bases
AATGTGAACTGCCTAGTGGCGTCTATACGGTTCGTGGCCGGTACGTTATCTTAAGTAGTCTAGGTTTTATCGTGTAGGCG
GACAAGTATTTTTGAGTGGC

Downstream 100 bases:

>100_bases
AAATTATATTTTCGATGTTAGATTGCGCTTTTAGCTTGCGTGTATCCTTTCGTGCGTTTGTGATCTCGTATGTACTCTAG
AGTTTGTCTTGTAAAATGGT

Product: nucleotide sugar dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MVADKQGGPTLARIAVVGLGYVGLPLAVAFGRQRPTLGFDIDICRVQQLCAGHDITCEIELEELQAARHLRYSSDPRELS
DCQIFIITVPTPIDVVEQPDLGPLRSASMLVASVLKPGDLVIYESTVYPGTTEEVCVPLLEAGSGLRFNVDFHCGYSPER
INPGDRKRRLQDICKIISGSTPDITAVVDALYSQIIVAGTWCAPSIRVAEAAKVVENIQRDVNIALVNELALIFDRLGID
TLDVLEAAETKWNFLPFRPGLVGGHCIGVDPYYLLHKSESVGYYPDLIHTARRVNNRVSRHVVDRVVALLGELSVPMTRA
VVLVLGVTFKEDCPDLRNSRALDLVRMFRTLGAQVDVCDPCADPQQALEHEAVTLCTEPKAGAYDAIVLAVAHAQYRMYD
VATIAALGKSQAVVYDVKSVWPRAAVTDRL

Sequences:

>Translated_430_residues
MVADKQGGPTLARIAVVGLGYVGLPLAVAFGRQRPTLGFDIDICRVQQLCAGHDITCEIELEELQAARHLRYSSDPRELS
DCQIFIITVPTPIDVVEQPDLGPLRSASMLVASVLKPGDLVIYESTVYPGTTEEVCVPLLEAGSGLRFNVDFHCGYSPER
INPGDRKRRLQDICKIISGSTPDITAVVDALYSQIIVAGTWCAPSIRVAEAAKVVENIQRDVNIALVNELALIFDRLGID
TLDVLEAAETKWNFLPFRPGLVGGHCIGVDPYYLLHKSESVGYYPDLIHTARRVNNRVSRHVVDRVVALLGELSVPMTRA
VVLVLGVTFKEDCPDLRNSRALDLVRMFRTLGAQVDVCDPCADPQQALEHEAVTLCTEPKAGAYDAIVLAVAHAQYRMYD
VATIAALGKSQAVVYDVKSVWPRAAVTDRL
>Mature_430_residues
MVADKQGGPTLARIAVVGLGYVGLPLAVAFGRQRPTLGFDIDICRVQQLCAGHDITCEIELEELQAARHLRYSSDPRELS
DCQIFIITVPTPIDVVEQPDLGPLRSASMLVASVLKPGDLVIYESTVYPGTTEEVCVPLLEAGSGLRFNVDFHCGYSPER
INPGDRKRRLQDICKIISGSTPDITAVVDALYSQIIVAGTWCAPSIRVAEAAKVVENIQRDVNIALVNELALIFDRLGID
TLDVLEAAETKWNFLPFRPGLVGGHCIGVDPYYLLHKSESVGYYPDLIHTARRVNNRVSRHVVDRVVALLGELSVPMTRA
VVLVLGVTFKEDCPDLRNSRALDLVRMFRTLGAQVDVCDPCADPQQALEHEAVTLCTEPKAGAYDAIVLAVAHAQYRMYD
VATIAALGKSQAVVYDVKSVWPRAAVTDRL

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=434, Percent_Identity=33.1797235023041, Blast_Score=174, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17560350, Length=392, Percent_Identity=23.9795918367347, Blast_Score=85, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46983; Mature: 46983

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVADKQGGPTLARIAVVGLGYVGLPLAVAFGRQRPTLGFDIDICRVQQLCAGHDITCEIE
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEE
LEELQAARHLRYSSDPRELSDCQIFIITVPTPIDVVEQPDLGPLRSASMLVASVLKPGDL
HHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCE
VIYESTVYPGTTEEVCVPLLEAGSGLRFNVDFHCGYSPERINPGDRKRRLQDICKIISGS
EEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
TPDITAVVDALYSQIIVAGTWCAPSIRVAEAAKVVENIQRDVNIALVNELALIFDRLGID
CCHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
TLDVLEAAETKWNFLPFRPGLVGGHCIGVDPYYLLHKSESVGYYPDLIHTARRVNNRVSR
HHHHHHHHHCCCCEECCCCCCCCCEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
HVVDRVVALLGELSVPMTRAVVLVLGVTFKEDCPDLRNSRALDLVRMFRTLGAQVDVCDP
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHCCCHHCCCHHHHHHHHHHHHCCCEEECCC
CADPQQALEHEAVTLCTEPKAGAYDAIVLAVAHAQYRMYDVATIAALGKSQAVVYDVKSV
CCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHH
WPRAAVTDRL
CCCCHHCCCC
>Mature Secondary Structure
MVADKQGGPTLARIAVVGLGYVGLPLAVAFGRQRPTLGFDIDICRVQQLCAGHDITCEIE
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEE
LEELQAARHLRYSSDPRELSDCQIFIITVPTPIDVVEQPDLGPLRSASMLVASVLKPGDL
HHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCE
VIYESTVYPGTTEEVCVPLLEAGSGLRFNVDFHCGYSPERINPGDRKRRLQDICKIISGS
EEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
TPDITAVVDALYSQIIVAGTWCAPSIRVAEAAKVVENIQRDVNIALVNELALIFDRLGID
CCHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
TLDVLEAAETKWNFLPFRPGLVGGHCIGVDPYYLLHKSESVGYYPDLIHTARRVNNRVSR
HHHHHHHHHCCCCEECCCCCCCCCEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
HVVDRVVALLGELSVPMTRAVVLVLGVTFKEDCPDLRNSRALDLVRMFRTLGAQVDVCDP
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHCCCHHCCCHHHHHHHHHHHHCCCEEECCC
CADPQQALEHEAVTLCTEPKAGAYDAIVLAVAHAQYRMYDVATIAALGKSQAVVYDVKSV
CCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHH
WPRAAVTDRL
CCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]