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The map label for this gene is edd [H]

Identifier: 182680897

GI number: 182680897

Start: 432489

End: 434381

Strand: Reverse

Name: edd [H]

Synonym: XfasM23_0335

Alternate gene names: 182680897

Gene position: 434381-432489 (Counterclockwise)

Preceding gene: 182680898

Following gene: 182680896

Centisome position: 17.13

GC content: 60.27

Gene sequence:

>1893_bases
ATGCGCCCACATCCCAACATTCAAGCCGTCACCGACCATATCCGCCAACGCAGTGCCACCACGCGCACCGACTACCTCGC
CGGGATTGATGCAGCACTGCGCGACGGACCATCCCGCAGCCGCCTAAGCTGCGGCAACCTCGCCCACGGCTTCGCCGCCT
GCGGCACGACTGATAAAGAACGTCTACGGGAAGCAATCACCCCGAACCTAGGCATCATTACCGCCTACAACGACATGCTT
TCGGCACACCAACCGTTTGAACATTACCCAGACATCATCCGTAACACGGCGCGCGCACTGGGTGCCACCGCACAAGTCGC
CGGCAGTGTCCCGGCCATGTGCGATGGTGTCACCCAAGGCCGTGCAGGCATGGAACTGTCGCTATTTTCACGCGACAACA
TTGCTCAAAGCACTGCTATCGGACTGAGCCACGACATGTTCGACGCAGCAATCTACTTGGGCGTATGCGACAAAATCGTC
CCCGGCCTGCTGATCGGCGCATTGGCATTTGGCCACCTACCCGCCGCCTTCGTCCCTGCAGGACCCATGCCCTCCGGCAT
CCCAAACAAACAAAAAGCAGAAATACGCGAACGCTACGCGGCTGGTCAGGCAACACGTGCTGAACTGCTCGCAGTCGAGG
CCGCCTCCTACCACGCCCCCGGAACCTGCACCTTCTATGGCACCGCCAATTCCAACCAAGTATTGCTGGAAGCAATGGGC
GTGCAATTACCCGGCGCCTCGTTTGTCTCTCCAGGCACCCCACTGCGTGAGGCACTGACCCAAGCCGCCACAGAACGCGT
CCTACACATCACCGCACTGGGGCAGGATTTCCGCCCGATTGGGCGATTAATCGACGAACGCGCCATCGTGAATGCCATCG
TCGCCCTCATGGCTACAGGCGGCTCAACCAACCATACCATCCACTGGATCGCCGTCGCACGTGCAGCCGGCATCTTGCTA
ACCTGGGACGATATGGATCGCATCTCCCAAACCGTACCACTCCTGGCACGCGTCTATCCCAACGGTGAAGCCGATGTCAA
TCGATTCCATGCCGCCGGTGGCACTGCCTTTGTGTTCCGTGAACTGATGGATGCCGGACTGATGTACGACGACTTGCCAA
CCATCGTCGCAGGCGGCATGCGCGCCTACACCCAAGAACCTCACCTACATCACGGCACACTCGGCTACAGCCCCTCACCG
ACCACAAGCACCGACGCATCCGTAGTCCGCCCGGTGACCCATCCATTCGAACCCCAAGGAGGCCTGCGCCTCCTACATGG
CAACCTAGGCCGTGCGCTCATCAAACTGTCAGCGGTTAAACCAGAATACAGGGCCATCGAAGCGCCAGCCGTGGTGATCG
ACACGCCACAGACACTGCATAAACTGCATGCCGCAGGTGCACTCCCCAAAGATTTCATCCTGGTCGTTCGCTATCAAGGA
CCACGCGCCAACGGAATGCCAGAACTTCACTCGCTGGCACCATTGCTAGGATTGCTGCAAAACCAAGGTCGGCGGGTCGC
CCTAGTCACCGACGGACGTCTCTCCGGTGCCTCAGGAAAATTCCCGGCGGCGATCCACTTGACCCCAGAAGCAGCACGGG
GCGGCCCGATTGGACGCATCCGCGAAGGCGACCTCTTACGCCTTGATGGTGAAGCCGGCATCTTGGAAGCCCTGGTACCG
ACAACCGAATGGGAGACGCGCACCCCAGCCCCAAACACAGCAACCACAAGCAACGACCTGGGGCGCAACCTGTTTGCGAT
CAACCGCCAAGTGGTTGGCCCTGCCGACCAAGGCGGACTATCGATCTCCTGTGGTCCGAAACCTCCGGACAACCACGTGT
GGAGCAACACTGCCAACGACACGCCAGACGATCACGCCACCTTGGCCCCCTGA

Upstream 100 bases:

>100_bases
TACAAACCCTCGCAACAGATCCCACACCCTATCACTGGCCTGCAATGAGAGAGCAAAGTCAACTAAAACACCCTCTGCTC
CATTCATAAACCCACCGCCC

Downstream 100 bases:

>100_bases
CAGACGAGTCCAAAGCCCCCTGAGACATCACCCAATACACAGCCCCAAATAGCACACACCGCTTGCCCTGAATCCCCTGT
CCTATTCGACATCGCCCTAT

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 630; Mature: 630

Protein sequence:

>630_residues
MRPHPNIQAVTDHIRQRSATTRTDYLAGIDAALRDGPSRSRLSCGNLAHGFAACGTTDKERLREAITPNLGIITAYNDML
SAHQPFEHYPDIIRNTARALGATAQVAGSVPAMCDGVTQGRAGMELSLFSRDNIAQSTAIGLSHDMFDAAIYLGVCDKIV
PGLLIGALAFGHLPAAFVPAGPMPSGIPNKQKAEIRERYAAGQATRAELLAVEAASYHAPGTCTFYGTANSNQVLLEAMG
VQLPGASFVSPGTPLREALTQAATERVLHITALGQDFRPIGRLIDERAIVNAIVALMATGGSTNHTIHWIAVARAAGILL
TWDDMDRISQTVPLLARVYPNGEADVNRFHAAGGTAFVFRELMDAGLMYDDLPTIVAGGMRAYTQEPHLHHGTLGYSPSP
TTSTDASVVRPVTHPFEPQGGLRLLHGNLGRALIKLSAVKPEYRAIEAPAVVIDTPQTLHKLHAAGALPKDFILVVRYQG
PRANGMPELHSLAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHLTPEAARGGPIGRIREGDLLRLDGEAGILEALVP
TTEWETRTPAPNTATTSNDLGRNLFAINRQVVGPADQGGLSISCGPKPPDNHVWSNTANDTPDDHATLAP

Sequences:

>Translated_630_residues
MRPHPNIQAVTDHIRQRSATTRTDYLAGIDAALRDGPSRSRLSCGNLAHGFAACGTTDKERLREAITPNLGIITAYNDML
SAHQPFEHYPDIIRNTARALGATAQVAGSVPAMCDGVTQGRAGMELSLFSRDNIAQSTAIGLSHDMFDAAIYLGVCDKIV
PGLLIGALAFGHLPAAFVPAGPMPSGIPNKQKAEIRERYAAGQATRAELLAVEAASYHAPGTCTFYGTANSNQVLLEAMG
VQLPGASFVSPGTPLREALTQAATERVLHITALGQDFRPIGRLIDERAIVNAIVALMATGGSTNHTIHWIAVARAAGILL
TWDDMDRISQTVPLLARVYPNGEADVNRFHAAGGTAFVFRELMDAGLMYDDLPTIVAGGMRAYTQEPHLHHGTLGYSPSP
TTSTDASVVRPVTHPFEPQGGLRLLHGNLGRALIKLSAVKPEYRAIEAPAVVIDTPQTLHKLHAAGALPKDFILVVRYQG
PRANGMPELHSLAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHLTPEAARGGPIGRIREGDLLRLDGEAGILEALVP
TTEWETRTPAPNTATTSNDLGRNLFAINRQVVGPADQGGLSISCGPKPPDNHVWSNTANDTPDDHATLAP
>Mature_630_residues
MRPHPNIQAVTDHIRQRSATTRTDYLAGIDAALRDGPSRSRLSCGNLAHGFAACGTTDKERLREAITPNLGIITAYNDML
SAHQPFEHYPDIIRNTARALGATAQVAGSVPAMCDGVTQGRAGMELSLFSRDNIAQSTAIGLSHDMFDAAIYLGVCDKIV
PGLLIGALAFGHLPAAFVPAGPMPSGIPNKQKAEIRERYAAGQATRAELLAVEAASYHAPGTCTFYGTANSNQVLLEAMG
VQLPGASFVSPGTPLREALTQAATERVLHITALGQDFRPIGRLIDERAIVNAIVALMATGGSTNHTIHWIAVARAAGILL
TWDDMDRISQTVPLLARVYPNGEADVNRFHAAGGTAFVFRELMDAGLMYDDLPTIVAGGMRAYTQEPHLHHGTLGYSPSP
TTSTDASVVRPVTHPFEPQGGLRLLHGNLGRALIKLSAVKPEYRAIEAPAVVIDTPQTLHKLHAAGALPKDFILVVRYQG
PRANGMPELHSLAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHLTPEAARGGPIGRIREGDLLRLDGEAGILEALVP
TTEWETRTPAPNTATTSNDLGRNLFAINRQVVGPADQGGLSISCGPKPPDNHVWSNTANDTPDDHATLAP

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=601, Percent_Identity=54.7420965058236, Blast_Score=673, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=523, Percent_Identity=28.1070745697897, Blast_Score=178, Evalue=1e-45,
Organism=Escherichia coli, GI2367371, Length=475, Percent_Identity=30.1052631578947, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1786464, Length=471, Percent_Identity=28.8747346072187, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6322476, Length=471, Percent_Identity=30.3609341825902, Blast_Score=184, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 66840; Mature: 66840

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPHPNIQAVTDHIRQRSATTRTDYLAGIDAALRDGPSRSRLSCGNLAHGFAACGTTDKE
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHH
RLREAITPNLGIITAYNDMLSAHQPFEHYPDIIRNTARALGATAQVAGSVPAMCDGVTQG
HHHHHHCCCCEEEEEEHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHCCCCHHHCCCCCC
RAGMELSLFSRDNIAQSTAIGLSHDMFDAAIYLGVCDKIVPGLLIGALAFGHLPAAFVPA
CCCCEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
GPMPSGIPNKQKAEIRERYAAGQATRAELLAVEAASYHAPGTCTFYGTANSNQVLLEAMG
CCCCCCCCCHHHHHHHHHHHCCCCCHHHEEEEEHHCCCCCCEEEEEECCCCCEEEEEECC
VQLPGASFVSPGTPLREALTQAATERVLHITALGQDFRPIGRLIDERAIVNAIVALMATG
CCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCC
GSTNHTIHWIAVARAAGILLTWDDMDRISQTVPLLARVYPNGEADVNRFHAAGGTAFVFR
CCCCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHH
ELMDAGLMYDDLPTIVAGGMRAYTQEPHLHHGTLGYSPSPTTSTDASVVRPVTHPFEPQG
HHHHCCCCHHCCHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCC
GLRLLHGNLGRALIKLSAVKPEYRAIEAPAVVIDTPQTLHKLHAAGALPKDFILVVRYQG
CEEEEECCCCHHHHHHHCCCCHHHEECCCEEEECCHHHHHHHHHHCCCCCCEEEEEEECC
PRANGMPELHSLAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHLTPEAARGGPIGRI
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCC
REGDLLRLDGEAGILEALVPTTEWETRTPAPNTATTSNDLGRNLFAINRQVVGPADQGGL
CCCCEEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCEEEECCEEECCCCCCCE
SISCGPKPPDNHVWSNTANDTPDDHATLAP
EEECCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRPHPNIQAVTDHIRQRSATTRTDYLAGIDAALRDGPSRSRLSCGNLAHGFAACGTTDKE
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHH
RLREAITPNLGIITAYNDMLSAHQPFEHYPDIIRNTARALGATAQVAGSVPAMCDGVTQG
HHHHHHCCCCEEEEEEHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHCCCCHHHCCCCCC
RAGMELSLFSRDNIAQSTAIGLSHDMFDAAIYLGVCDKIVPGLLIGALAFGHLPAAFVPA
CCCCEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
GPMPSGIPNKQKAEIRERYAAGQATRAELLAVEAASYHAPGTCTFYGTANSNQVLLEAMG
CCCCCCCCCHHHHHHHHHHHCCCCCHHHEEEEEHHCCCCCCEEEEEECCCCCEEEEEECC
VQLPGASFVSPGTPLREALTQAATERVLHITALGQDFRPIGRLIDERAIVNAIVALMATG
CCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCC
GSTNHTIHWIAVARAAGILLTWDDMDRISQTVPLLARVYPNGEADVNRFHAAGGTAFVFR
CCCCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHH
ELMDAGLMYDDLPTIVAGGMRAYTQEPHLHHGTLGYSPSPTTSTDASVVRPVTHPFEPQG
HHHHCCCCHHCCHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCC
GLRLLHGNLGRALIKLSAVKPEYRAIEAPAVVIDTPQTLHKLHAAGALPKDFILVVRYQG
CEEEEECCCCHHHHHHHCCCCHHHEECCCEEEECCHHHHHHHHHHCCCCCCEEEEEEECC
PRANGMPELHSLAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHLTPEAARGGPIGRI
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCC
REGDLLRLDGEAGILEALVPTTEWETRTPAPNTATTSNDLGRNLFAINRQVVGPADQGGL
CCCCEEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCEEEECCEEECCCCCCCE
SISCGPKPPDNHVWSNTANDTPDDHATLAP
EEECCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]