Click here to switch to the map view.

The map label for this gene is pyrH

Identifier: 182680894

GI number: 182680894

Start: 429584

End: 430315

Strand: Reverse

Name: pyrH

Synonym: XfasM23_0332

Alternate gene names: 182680894

Gene position: 430315-429584 (Counterclockwise)

Preceding gene: 182680896

Following gene: 182680890

Centisome position: 16.97

GC content: 52.05

Gene sequence:

>732_bases
ATGTCAAAACTTGCCTATCACCGCGTTCTCCTCAAACTTTCAGGAGAGGCGTTGATGGGAAGTGCGGATTACGGCATTGA
TCCAAAAGTGATCAATCGACTGGCGGGTGAAGTCATTGAGGCACAAAACGCAGGTGCCGAGTTAGCCTTGGTGATCGGCG
GCGGTAACATCTTCCGAGGTGCAGGTCTGGCTGCCAAGGGTATGGACCGCGTCACCGGTGACCAGATGGGGATGCTGGCA
ACAATCATCAACGCATTGGCAATGCAAGATGCACTGGAAAAGCTCGGCACCAAAGTACGAGTGATGAGTGCAATCAAAAT
CAACAACGTATGCGAAGACTTCATCCGCCGCCGCGCAATCCGTCACCTGGAAAAAAGCCGTATCACCATCTTCGCAGCGG
GCACTGGCAATCCCTTTTTCACCACCGATTCTGGCGCGGCGCTACGCGCCATTGAAATTGGCGCAGATTTGCTATTGAAG
GCGACCAAAGTCGATGGCATTTACAACAAAGATCCGCAAAAGCACTGCGACGCAGTCAAGTACAGCACGCTGAGTTACGA
CGAAGTCATTTCGCAGAACCTTGAAGTCATGGATACCGCCGCCTTCGCACTGGCACGTGACAGCAACCTACCATTACGCA
TTTTCGACATTGAGCAACCTGGCGTACTACTACGCATCTTGCACGGCGAAGAGATTGGCACTTTGGTCAAGGAACGCAAC
TCAAAAAGCTAA

Upstream 100 bases:

>100_bases
TCCACCAACATGACTTTGCTTTTGCTTTGCCAACAGCACAGCTTGTGCGCCTCCGCTAGAATGACACTGTTTGCTCCCCC
CTCACTCATTGAGATATCCC

Downstream 100 bases:

>100_bases
AAATGATGGCCTGCCCATGTAAAAACGCTCGATCATCTCTGCATATCCACGGCTGTTGAGGCTGAAGGTCAAATAGAAGG
TAAGCAGGGCTCTGACCCGA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSKLAYHRVLLKLSGEALMGSADYGIDPKVINRLAGEVIEAQNAGAELALVIGGGNIFRGAGLAAKGMDRVTGDQMGMLA
TIINALAMQDALEKLGTKVRVMSAIKINNVCEDFIRRRAIRHLEKSRITIFAAGTGNPFFTTDSGAALRAIEIGADLLLK
ATKVDGIYNKDPQKHCDAVKYSTLSYDEVISQNLEVMDTAAFALARDSNLPLRIFDIEQPGVLLRILHGEEIGTLVKERN
SKS

Sequences:

>Translated_243_residues
MSKLAYHRVLLKLSGEALMGSADYGIDPKVINRLAGEVIEAQNAGAELALVIGGGNIFRGAGLAAKGMDRVTGDQMGMLA
TIINALAMQDALEKLGTKVRVMSAIKINNVCEDFIRRRAIRHLEKSRITIFAAGTGNPFFTTDSGAALRAIEIGADLLLK
ATKVDGIYNKDPQKHCDAVKYSTLSYDEVISQNLEVMDTAAFALARDSNLPLRIFDIEQPGVLLRILHGEEIGTLVKERN
SKS
>Mature_242_residues
SKLAYHRVLLKLSGEALMGSADYGIDPKVINRLAGEVIEAQNAGAELALVIGGGNIFRGAGLAAKGMDRVTGDQMGMLAT
IINALAMQDALEKLGTKVRVMSAIKINNVCEDFIRRRAIRHLEKSRITIFAAGTGNPFFTTDSGAALRAIEIGADLLLKA
TKVDGIYNKDPQKHCDAVKYSTLSYDEVISQNLEVMDTAAFALARDSNLPLRIFDIEQPGVLLRILHGEEIGTLVKERNS
KS

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=237, Percent_Identity=54.0084388185654, Blast_Score=268, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 26271; Mature: 26140

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLAYHRVLLKLSGEALMGSADYGIDPKVINRLAGEVIEAQNAGAELALVIGGGNIFRG
CCCHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCEECC
AGLAAKGMDRVTGDQMGMLATIINALAMQDALEKLGTKVRVMSAIKINNVCEDFIRRRAI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHH
RHLEKSRITIFAAGTGNPFFTTDSGAALRAIEIGADLLLKATKVDGIYNKDPQKHCDAVK
HHHHHCCEEEEEECCCCCCEECCCCCEEEEEECCHHHHEEHHHCCCCCCCCHHHHHHHHH
YSTLSYDEVISQNLEVMDTAAFALARDSNLPLRIFDIEQPGVLLRILHGEEIGTLVKERN
HCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHCC
SKS
CCC
>Mature Secondary Structure 
SKLAYHRVLLKLSGEALMGSADYGIDPKVINRLAGEVIEAQNAGAELALVIGGGNIFRG
CCHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCEECC
AGLAAKGMDRVTGDQMGMLATIINALAMQDALEKLGTKVRVMSAIKINNVCEDFIRRRAI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHH
RHLEKSRITIFAAGTGNPFFTTDSGAALRAIEIGADLLLKATKVDGIYNKDPQKHCDAVK
HHHHHCCEEEEEECCCCCCEECCCCCEEEEEECCHHHHEEHHHCCCCCCCCHHHHHHHHH
YSTLSYDEVISQNLEVMDTAAFALARDSNLPLRIFDIEQPGVLLRILHGEEIGTLVKERN
HCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHCC
SKS
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]