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The map label for this gene is dxr [H]

Identifier: 182680886

GI number: 182680886

Start: 421558

End: 422742

Strand: Reverse

Name: dxr [H]

Synonym: XfasM23_0324

Alternate gene names: 182680886

Gene position: 422742-421558 (Counterclockwise)

Preceding gene: 182680887

Following gene: 182680885

Centisome position: 16.67

GC content: 56.54

Gene sequence:

>1185_bases
ATGACTAAACCGATCCGCAACGTCGCCGTACTCGGTGCCACTGGCTCAATTGGGGCAGCAGCACTGGATGTGCTCGCACG
CCACCCCAGACAGTTCCACGTAAGCCTGCTAGCCGCTGGCCAGCGCGTCGATGCACTGTTGGCATTGTGCCGCACGTATC
GTCCGGACCATGCGGTGATCGGCGATGCAACGCTCTACACCACTCTTCGCGACGGCCTGAATGCCGCTGGTTTAGCCACC
AAAGCGTACGCTGGAGAAGCAGCATTAGCAGAACTAGTCGCCAGCACCACATGCGATACCGTAGTGGCAGCAATCGTCGG
AGCAGCGGGCCTCCATTCGACACTGGCGGCAGCACGCGCCGGAAAACGTCTGTTGCTGGCGAACAAAGAATCGCTGGTCC
TGGCCGGAATGCTGCTGATGCGTGAGGCCAGCATCAGTGGCGCGGAGATCATACCGATCGATAGCGAACACAACGCAATT
TTTCAGTGCCTGCGTTCGCGTACTACAGATGGCGTGCATCGGGTCACTTTGACTGCTTCTGGCGGTCCATTTCGTGGCCA
CAACCGCACGATGCTAGCCAAGATCACTCCCACTCAAGCAATGGCCCACCCAACGTGGTCGATGGGACCAAAGATATCGG
TAGATTCGGCTACACTGATGAACAAGGGCTTGGAAGTCATTGAGGCCCACCATTTGTTCGGGCTACCTAGCGAACAGATT
GATGTACTAGTGCATCCACAAAGTTTGGTGCACTCTCTGGTGGAGTTTATTGATGGTTCGACGCTCGCTCAGTTAAGCCT
GCCAGACATGCGTACCACCCTGGCAGTTGGCCTCGCCTGGCCAGAGCGAATCGGTTCCGGGGTGCAGGGTTTGGACTTGA
TGAAGCACAACAGGTTGGACTTTGAGCATCCGGATACCGAAACGTTTTCCTGTCTGCGTCTGGCACGAGACGCCATGCAG
ACTGGCGGCACGGCGCCTGCGGTGCTAAATGCTGCCAATGAAATCGCTGTTTCAGCGTTTCTTCAGGGGCGCATCGGTTT
CCTAACAATTCCAGCACTGATAGAACACGCACTGACTACACTTCCTCGTTACGAGGCAGACACTTTGGAGACTCTACTGA
CCGTGGACACAGAAACCCGCCGCATCACACACGCAGCACTCACCCATTTCCCACTCCCTCTCTAA

Upstream 100 bases:

>100_bases
GTATGATTCCAGGCCACGGTGGCGTTCTCGATCGTATCGATAGCACGCTCGCCGCACTCCCCGTGTTCGCACTGGGAAAA
GACATCTTCGGTTTCTGAGC

Downstream 100 bases:

>100_bases
TATCACAAACATCAATACAAAATCTTATGGGTGATTTCTTAGCATCTATCTGGTGGATGATCGTCAGCTTCAGTGTCCTG
GTTACGTTCCACGAATTCGG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTKPIRNVAVLGATGSIGAAALDVLARHPRQFHVSLLAAGQRVDALLALCRTYRPDHAVIGDATLYTTLRDGLNAAGLAT
KAYAGEAALAELVASTTCDTVVAAIVGAAGLHSTLAAARAGKRLLLANKESLVLAGMLLMREASISGAEIIPIDSEHNAI
FQCLRSRTTDGVHRVTLTASGGPFRGHNRTMLAKITPTQAMAHPTWSMGPKISVDSATLMNKGLEVIEAHHLFGLPSEQI
DVLVHPQSLVHSLVEFIDGSTLAQLSLPDMRTTLAVGLAWPERIGSGVQGLDLMKHNRLDFEHPDTETFSCLRLARDAMQ
TGGTAPAVLNAANEIAVSAFLQGRIGFLTIPALIEHALTTLPRYEADTLETLLTVDTETRRITHAALTHFPLPL

Sequences:

>Translated_394_residues
MTKPIRNVAVLGATGSIGAAALDVLARHPRQFHVSLLAAGQRVDALLALCRTYRPDHAVIGDATLYTTLRDGLNAAGLAT
KAYAGEAALAELVASTTCDTVVAAIVGAAGLHSTLAAARAGKRLLLANKESLVLAGMLLMREASISGAEIIPIDSEHNAI
FQCLRSRTTDGVHRVTLTASGGPFRGHNRTMLAKITPTQAMAHPTWSMGPKISVDSATLMNKGLEVIEAHHLFGLPSEQI
DVLVHPQSLVHSLVEFIDGSTLAQLSLPDMRTTLAVGLAWPERIGSGVQGLDLMKHNRLDFEHPDTETFSCLRLARDAMQ
TGGTAPAVLNAANEIAVSAFLQGRIGFLTIPALIEHALTTLPRYEADTLETLLTVDTETRRITHAALTHFPLPL
>Mature_393_residues
TKPIRNVAVLGATGSIGAAALDVLARHPRQFHVSLLAAGQRVDALLALCRTYRPDHAVIGDATLYTTLRDGLNAAGLATK
AYAGEAALAELVASTTCDTVVAAIVGAAGLHSTLAAARAGKRLLLANKESLVLAGMLLMREASISGAEIIPIDSEHNAIF
QCLRSRTTDGVHRVTLTASGGPFRGHNRTMLAKITPTQAMAHPTWSMGPKISVDSATLMNKGLEVIEAHHLFGLPSEQID
VLVHPQSLVHSLVEFIDGSTLAQLSLPDMRTTLAVGLAWPERIGSGVQGLDLMKHNRLDFEHPDTETFSCLRLARDAMQT
GGTAPAVLNAANEIAVSAFLQGRIGFLTIPALIEHALTTLPRYEADTLETLLTVDTETRRITHAALTHFPLPL

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=388, Percent_Identity=46.3917525773196, Blast_Score=321, Evalue=5e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 41868; Mature: 41737

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPIRNVAVLGATGSIGAAALDVLARHPRQFHVSLLAAGQRVDALLALCRTYRPDHAVI
CCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEE
GDATLYTTLRDGLNAAGLATKAYAGEAALAELVASTTCDTVVAAIVGAAGLHSTLAAARA
CCHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKRLLLANKESLVLAGMLLMREASISGAEIIPIDSEHNAIFQCLRSRTTDGVHRVTLTAS
CCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEEEEC
GGPFRGHNRTMLAKITPTQAMAHPTWSMGPKISVDSATLMNKGLEVIEAHHLFGLPSEQI
CCCCCCCCCEEEEEECCHHHHCCCCCCCCCEEECCHHHHHHHCHHHHHHHHHCCCCCHHE
DVLVHPQSLVHSLVEFIDGSTLAQLSLPDMRTTLAVGLAWPERIGSGVQGLDLMKHNRLD
EEEECCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCHHHHCCCCCHHHHHHCCCCC
FEHPDTETFSCLRLARDAMQTGGTAPAVLNAANEIAVSAFLQGRIGFLTIPALIEHALTT
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHH
LPRYEADTLETLLTVDTETRRITHAALTHFPLPL
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TKPIRNVAVLGATGSIGAAALDVLARHPRQFHVSLLAAGQRVDALLALCRTYRPDHAVI
CCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEE
GDATLYTTLRDGLNAAGLATKAYAGEAALAELVASTTCDTVVAAIVGAAGLHSTLAAARA
CCHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKRLLLANKESLVLAGMLLMREASISGAEIIPIDSEHNAIFQCLRSRTTDGVHRVTLTAS
CCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEEEEC
GGPFRGHNRTMLAKITPTQAMAHPTWSMGPKISVDSATLMNKGLEVIEAHHLFGLPSEQI
CCCCCCCCCEEEEEECCHHHHCCCCCCCCCEEECCHHHHHHHCHHHHHHHHHCCCCCHHE
DVLVHPQSLVHSLVEFIDGSTLAQLSLPDMRTTLAVGLAWPERIGSGVQGLDLMKHNRLD
EEEECCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCHHHHCCCCCHHHHHHCCCCC
FEHPDTETFSCLRLARDAMQTGGTAPAVLNAANEIAVSAFLQGRIGFLTIPALIEHALTT
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHH
LPRYEADTLETLLTVDTETRRITHAALTHFPLPL
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]