Click here to switch to the map view.

The map label for this gene is ahcY

Identifier: 182680876

GI number: 182680876

Start: 408460

End: 409902

Strand: Reverse

Name: ahcY

Synonym: XfasM23_0314

Alternate gene names: 182680876

Gene position: 409902-408460 (Counterclockwise)

Preceding gene: 182680879

Following gene: 182680873

Centisome position: 16.17

GC content: 51.21

Gene sequence:

>1443_bases
ATGAACACCCACCCCCAAACATCACCAAATACTCACTACAAAATCGCAGACATTTCCTTGGCCGACTGGGGCCGCAAAGA
AATCGACATTGCCGAGCACGAAATGCCGGGACTCATGTCCATTCGCCGCAAATATGCCAGCAAACAACCACTCAAAGGCG
TACGCGTGACCGGCTCGCTTCATATGACCATCCAGACAGCCGTACTGATCGAGACACTAAAAGATATCGGTGCCGATGTA
CGCTGGGCCTCGTGCAACATTTTTTCCACTCAAGATCATGCCGCTGCTGCGATCGCCACCAGCGGCACACCCGTGTTCGC
CTGGAAGGGAGAGACATTAGAGGAATACTGGGATTGCACCCTGCAAGCACTCACCTTCACCCTGGCGGATGGCACACTGA
CCGGCCCAGAATTGATTGTGGATGATGGCGGCGACGCTACCCTCCTCATCCACAAAGGCTATGAATTAGAGAACGGATCA
ACCTGGGTCGATGAACCCAGCGACTCACTTGAAGAACAGGTGATTAAACGCCTGCTCAAACGCATCGCCATTGAGCGCCC
CGGCTACTGGACCCGAGTCGTCAACGACTGGAAGGGCGTGTCTGAAGAAACCACCACAGGTGTACACCGTCTGTACCAAA
TCGCTGCAACCGGCAGGCTGCTCGTACCTGCAATCAACGTCAATGATTCGGTCACTAAAAGTAAATTCGACAACCTATAT
GGTTGCCGCGAATCGCTGGCTGATGGTTTGAAGCGTGCAATGGACGTGATGTTGGCCGGTAAATTAGCGGTGGTATGCGG
CTATGGCGATGTTGGCAAAGGGTCGGCACATAGTTTGCGCGCCTACGGTGCCCGCGTGATTGTGACCGAAATCGATCCAA
TCTGTGCGTTACAAGCCGCGATGGAGGGTTTTGAAGTCACAACGGTTGAGGACACACTCGGTCAGGCTGACATCTATGTC
ACCACCACAGGTAACAAAGATGTCATCCGGATCGAACACATGACCGCAATGAAAGACCAAGTGATCGTCTGCAACATCGG
CCACTTTGACAATGAAATTCAAGTCGATGCACTCAATGCCCTGACTGGGGTACAAAAAATCAATATCAAACCGCAGGTGG
ATAAATTCATATTACCCAACGGCAATACACTCTTTCTTCTTGCAGAAGGACGCCTCGTCAACCTGGGCTGCGCAACGGGT
CATCCCAGCTTCGTCATGTCTAACAGCTTCGCCAATCAAACTCTGGCGCAGATTGATCTGTGGCAAAACAAAGACGTTTA
CGAAAAAAATGTTTACCGCTTGCCAAAAAAATTGGATGAAGAAGTCGCACGCCTTCATCTGGAGAAAATCGGCGTGAAAC
TCACCACACTCACGGCTAACCAAGCCGCCTATTTAGGCATATCAGTAGAAGGACCATTCAAACCTGAGCACTATCGGTAT
TGA

Upstream 100 bases:

>100_bases
ACGTCTTACCGATAGCCAGGCCCGAGCGGAATTTTACCGTTCTACAGCGCCAGGAAACGTGCAGACCTTCCGCCTATCTG
CCCATAACTGATATCCCGCC

Downstream 100 bases:

>100_bases
ACACACCCCGAAAACACCAGAAGTATTTAGCACACACCGACAATAGCAATTGCTATAGAAAACATGCCCGTCGGCTAACA
CAAGCAGACGACGGGCATGC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MNTHPQTSPNTHYKIADISLADWGRKEIDIAEHEMPGLMSIRRKYASKQPLKGVRVTGSLHMTIQTAVLIETLKDIGADV
RWASCNIFSTQDHAAAAIATSGTPVFAWKGETLEEYWDCTLQALTFTLADGTLTGPELIVDDGGDATLLIHKGYELENGS
TWVDEPSDSLEEQVIKRLLKRIAIERPGYWTRVVNDWKGVSEETTTGVHRLYQIAATGRLLVPAINVNDSVTKSKFDNLY
GCRESLADGLKRAMDVMLAGKLAVVCGYGDVGKGSAHSLRAYGARVIVTEIDPICALQAAMEGFEVTTVEDTLGQADIYV
TTTGNKDVIRIEHMTAMKDQVIVCNIGHFDNEIQVDALNALTGVQKINIKPQVDKFILPNGNTLFLLAEGRLVNLGCATG
HPSFVMSNSFANQTLAQIDLWQNKDVYEKNVYRLPKKLDEEVARLHLEKIGVKLTTLTANQAAYLGISVEGPFKPEHYRY

Sequences:

>Translated_480_residues
MNTHPQTSPNTHYKIADISLADWGRKEIDIAEHEMPGLMSIRRKYASKQPLKGVRVTGSLHMTIQTAVLIETLKDIGADV
RWASCNIFSTQDHAAAAIATSGTPVFAWKGETLEEYWDCTLQALTFTLADGTLTGPELIVDDGGDATLLIHKGYELENGS
TWVDEPSDSLEEQVIKRLLKRIAIERPGYWTRVVNDWKGVSEETTTGVHRLYQIAATGRLLVPAINVNDSVTKSKFDNLY
GCRESLADGLKRAMDVMLAGKLAVVCGYGDVGKGSAHSLRAYGARVIVTEIDPICALQAAMEGFEVTTVEDTLGQADIYV
TTTGNKDVIRIEHMTAMKDQVIVCNIGHFDNEIQVDALNALTGVQKINIKPQVDKFILPNGNTLFLLAEGRLVNLGCATG
HPSFVMSNSFANQTLAQIDLWQNKDVYEKNVYRLPKKLDEEVARLHLEKIGVKLTTLTANQAAYLGISVEGPFKPEHYRY
>Mature_480_residues
MNTHPQTSPNTHYKIADISLADWGRKEIDIAEHEMPGLMSIRRKYASKQPLKGVRVTGSLHMTIQTAVLIETLKDIGADV
RWASCNIFSTQDHAAAAIATSGTPVFAWKGETLEEYWDCTLQALTFTLADGTLTGPELIVDDGGDATLLIHKGYELENGS
TWVDEPSDSLEEQVIKRLLKRIAIERPGYWTRVVNDWKGVSEETTTGVHRLYQIAATGRLLVPAINVNDSVTKSKFDNLY
GCRESLADGLKRAMDVMLAGKLAVVCGYGDVGKGSAHSLRAYGARVIVTEIDPICALQAAMEGFEVTTVEDTLGQADIYV
TTTGNKDVIRIEHMTAMKDQVIVCNIGHFDNEIQVDALNALTGVQKINIKPQVDKFILPNGNTLFLLAEGRLVNLGCATG
HPSFVMSNSFANQTLAQIDLWQNKDVYEKNVYRLPKKLDEEVARLHLEKIGVKLTTLTANQAAYLGISVEGPFKPEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=468, Percent_Identity=61.5384615384615, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI239937451, Length=446, Percent_Identity=60.9865470852018, Blast_Score=514, Evalue=1e-146,
Organism=Homo sapiens, GI195539349, Length=472, Percent_Identity=47.0338983050847, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI24308043, Length=472, Percent_Identity=46.8220338983051, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI298286489, Length=472, Percent_Identity=47.0338983050847, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI195539337, Length=472, Percent_Identity=46.8220338983051, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI21361647, Length=472, Percent_Identity=45.9745762711864, Blast_Score=410, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17506425, Length=478, Percent_Identity=59.6234309623431, Blast_Score=545, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6320882, Length=488, Percent_Identity=57.3770491803279, Blast_Score=520, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24642172, Length=468, Percent_Identity=61.1111111111111, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24656245, Length=459, Percent_Identity=48.1481481481481, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI45553387, Length=479, Percent_Identity=46.3465553235908, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI45553385, Length=478, Percent_Identity=46.234309623431, Blast_Score=406, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_XYLF2 (B2I7N4)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001829036.1
- ProteinModelPortal:   B2I7N4
- GeneID:   6204133
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_0314
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- ProtClustDB:   PRK05476
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 52921; Mature: 52921

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 63-63 BINDING 142-142 BINDING 203-203 BINDING 233-233 BINDING 237-237 BINDING 238-238 BINDING 290-290 BINDING 325-325 BINDING 394-394

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTHPQTSPNTHYKIADISLADWGRKEIDIAEHEMPGLMSIRRKYASKQPLKGVRVTGSL
CCCCCCCCCCCEEEEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHCCCCCCCCEEEECEE
HMTIQTAVLIETLKDIGADVRWASCNIFSTQDHAAAAIATSGTPVFAWKGETLEEYWDCT
EEEEHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEECCCEEEEECCCCHHHHHHHE
LQALTFTLADGTLTGPELIVDDGGDATLLIHKGYELENGSTWVDEPSDSLEEQVIKRLLK
EEEEEEEEECCCCCCCEEEEECCCCEEEEEECCEEECCCCCCCCCCCHHHHHHHHHHHHH
RIAIERPGYWTRVVNDWKGVSEETTTGVHRLYQIAATGRLLVPAINVNDSVTKSKFDNLY
HHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHH
GCRESLADGLKRAMDVMLAGKLAVVCGYGDVGKGSAHSLRAYGARVIVTEIDPICALQAA
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCEEEEEECCHHHHHHHH
MEGFEVTTVEDTLGQADIYVTTTGNKDVIRIEHMTAMKDQVIVCNIGHFDNEIQVDALNA
HCCCEEEEEHHCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCCCCCEEEEEHHHH
LTGVQKINIKPQVDKFILPNGNTLFLLAEGRLVNLGCATGHPSFVMSNSFANQTLAQIDL
HCCCEEECCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHCHHHEEEE
WQNKDVYEKNVYRLPKKLDEEVARLHLEKIGVKLTTLTANQAAYLGISVEGPFKPEHYRY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MNTHPQTSPNTHYKIADISLADWGRKEIDIAEHEMPGLMSIRRKYASKQPLKGVRVTGSL
CCCCCCCCCCCEEEEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHCCCCCCCCEEEECEE
HMTIQTAVLIETLKDIGADVRWASCNIFSTQDHAAAAIATSGTPVFAWKGETLEEYWDCT
EEEEHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEECCCEEEEECCCCHHHHHHHE
LQALTFTLADGTLTGPELIVDDGGDATLLIHKGYELENGSTWVDEPSDSLEEQVIKRLLK
EEEEEEEEECCCCCCCEEEEECCCCEEEEEECCEEECCCCCCCCCCCHHHHHHHHHHHHH
RIAIERPGYWTRVVNDWKGVSEETTTGVHRLYQIAATGRLLVPAINVNDSVTKSKFDNLY
HHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHH
GCRESLADGLKRAMDVMLAGKLAVVCGYGDVGKGSAHSLRAYGARVIVTEIDPICALQAA
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCEEEEEECCHHHHHHHH
MEGFEVTTVEDTLGQADIYVTTTGNKDVIRIEHMTAMKDQVIVCNIGHFDNEIQVDALNA
HCCCEEEEEHHCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCCCCCEEEEEHHHH
LTGVQKINIKPQVDKFILPNGNTLFLLAEGRLVNLGCATGHPSFVMSNSFANQTLAQIDL
HCCCEEECCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHCHHHEEEE
WQNKDVYEKNVYRLPKKLDEEVARLHLEKIGVKLTTLTANQAAYLGISVEGPFKPEHYRY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA