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The map label for this gene is proA

Identifier: 182680854

GI number: 182680854

Start: 375503

End: 376780

Strand: Direct

Name: proA

Synonym: XfasM23_0291

Alternate gene names: 182680854

Gene position: 375503-376780 (Clockwise)

Preceding gene: 182680853

Following gene: 182680855

Centisome position: 14.81

GC content: 60.72

Gene sequence:

>1278_bases
ATGTCCCACATCCGACACCTTGCCCAACAATGCCGCGACGCCGCCCGCATCTTGGCGACCTTATCCACCGACGCCAAACG
CCGCCTCCTTGAAACAATGGCGACCGCCTTGAACACCGATGCCGCAACCATCCTCGCCGCCAATGCTGCCGACCTCGACG
CCGCCCGCACCCAACAGGTTGGCACCGCCATGCTCGACAGACTCGCCCTAGACCCCCAACGCCTTGCCGCCATGGCCGAT
GCCTTACGTGACATTGCCGCATTGCCGGACCCCGTCGGCCAAGTGACCCGCGACGACCGGCGCCCTAACGGCATCCATAT
CCAAAAAATCCGCGTCCCACTGGGCGTCATTGCCATGATCTATGAAGCAAGACCCAATGTGACCGCCGATGCTGCCGCAC
TCTGCATCAAAGCCGGCAACGGCATCATCTTGCGTGGCGGCTCCGAAGCCATCCGCTCCAACATCGCCATTGCCACCGCA
CTACAGCGCGCCTTGCGCCTCGCCTCACTGCCTGAAACCGCCCTGATCCTCGTCCAAGACATGGCGCGCCACACCATGCT
GGAACTCCTACAACTCAGCGACCTCATTGACCTGGTGATCCCCCGTGGCGGCGAAGGCCTTATCCGCTTCGTTGCCGAAC
ATGCACGCATCCCCGTCATTAAACATTACAAAGGCGTCTGCCATCAGTTTGTCGATGCCTCAGCCGACATCGAGATGGCA
ATACGTCTGCTGATTGACGGAAAAACCACCCGTCCCGCCGCCTGCAACGCCCTGGAAACCTTACTCGTCCATACCGACAT
CGCCCCACGCTTCCTCCCTGCCGCCGCCGCTGCCTTACGTCCCTATGGCGTCCAACTGCGTGGTGACCACGCCACCTGCA
CCTTGCTTCCTGATGTGCTCCTGGCCACGGACGCCGACTACGCCGCCGAATATCTCGACTTAATCCTCGCAATACGTATT
GTTCCCAACTTAGATGCCGCACTTGAACATATTCGCCGCTACGGCTCCGATCACACCGAAGTCATCGTCACCGCCGACCC
CGCACATGCCGACACCTTCGTACAACAACTGCCTTCCGCCGTCGTCATGGTCAACGCCTCCTCGCGTTTTTCTGATGGTG
GCGCCCTCGGACTGGGCGCAGAGATTGGCATTTCCACTACACGACTCCATGCCTATGGCCCCATGGGATTAGACGCACTC
ACAGTAGAACGCTTTGTCGTCCGTGGCCAAGGCCAAGTCCGCCACTGCCCCCCTTATCCACCTGCACCGCGACGTTAG

Upstream 100 bases:

>100_bases
CAGCACCATCTCCCCACATCTCAGCGCCTGCGCCACCCGTGCCACACTGCGAACACACCCCCCGCCAACACCCATCCCCT
TGCACCCACGGCCCTACCTG

Downstream 100 bases:

>100_bases
CGTAGCGAACATACCGCCCATCACCTCCTAGCGCCTGCTCCCCCCTTGCATCGCCAAAAAAAAGTGATATAAATCGCAAA
AAATAAGGCAAAGGAAGCCG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSHIRHLAQQCRDAARILATLSTDAKRRLLETMATALNTDAATILAANAADLDAARTQQVGTAMLDRLALDPQRLAAMAD
ALRDIAALPDPVGQVTRDDRRPNGIHIQKIRVPLGVIAMIYEARPNVTADAAALCIKAGNGIILRGGSEAIRSNIAIATA
LQRALRLASLPETALILVQDMARHTMLELLQLSDLIDLVIPRGGEGLIRFVAEHARIPVIKHYKGVCHQFVDASADIEMA
IRLLIDGKTTRPAACNALETLLVHTDIAPRFLPAAAAALRPYGVQLRGDHATCTLLPDVLLATDADYAAEYLDLILAIRI
VPNLDAALEHIRRYGSDHTEVIVTADPAHADTFVQQLPSAVVMVNASSRFSDGGALGLGAEIGISTTRLHAYGPMGLDAL
TVERFVVRGQGQVRHCPPYPPAPRR

Sequences:

>Translated_425_residues
MSHIRHLAQQCRDAARILATLSTDAKRRLLETMATALNTDAATILAANAADLDAARTQQVGTAMLDRLALDPQRLAAMAD
ALRDIAALPDPVGQVTRDDRRPNGIHIQKIRVPLGVIAMIYEARPNVTADAAALCIKAGNGIILRGGSEAIRSNIAIATA
LQRALRLASLPETALILVQDMARHTMLELLQLSDLIDLVIPRGGEGLIRFVAEHARIPVIKHYKGVCHQFVDASADIEMA
IRLLIDGKTTRPAACNALETLLVHTDIAPRFLPAAAAALRPYGVQLRGDHATCTLLPDVLLATDADYAAEYLDLILAIRI
VPNLDAALEHIRRYGSDHTEVIVTADPAHADTFVQQLPSAVVMVNASSRFSDGGALGLGAEIGISTTRLHAYGPMGLDAL
TVERFVVRGQGQVRHCPPYPPAPRR
>Mature_424_residues
SHIRHLAQQCRDAARILATLSTDAKRRLLETMATALNTDAATILAANAADLDAARTQQVGTAMLDRLALDPQRLAAMADA
LRDIAALPDPVGQVTRDDRRPNGIHIQKIRVPLGVIAMIYEARPNVTADAAALCIKAGNGIILRGGSEAIRSNIAIATAL
QRALRLASLPETALILVQDMARHTMLELLQLSDLIDLVIPRGGEGLIRFVAEHARIPVIKHYKGVCHQFVDASADIEMAI
RLLIDGKTTRPAACNALETLLVHTDIAPRFLPAAAAALRPYGVQLRGDHATCTLLPDVLLATDADYAAEYLDLILAIRIV
PNLDAALEHIRRYGSDHTEVIVTADPAHADTFVQQLPSAVVMVNASSRFSDGGALGLGAEIGISTTRLHAYGPMGLDALT
VERFVVRGQGQVRHCPPYPPAPRR

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=416, Percent_Identity=39.1826923076923, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI21361368, Length=416, Percent_Identity=39.1826923076923, Blast_Score=272, Evalue=4e-73,
Organism=Escherichia coli, GI1786438, Length=407, Percent_Identity=44.963144963145, Blast_Score=338, Evalue=6e-94,
Organism=Caenorhabditis elegans, GI17569967, Length=414, Percent_Identity=35.9903381642512, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17569969, Length=414, Percent_Identity=35.9903381642512, Blast_Score=263, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6324899, Length=437, Percent_Identity=34.324942791762, Blast_Score=257, Evalue=2e-69,
Organism=Drosophila melanogaster, GI21357643, Length=410, Percent_Identity=37.3170731707317, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45650; Mature: 45519

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHIRHLAQQCRDAARILATLSTDAKRRLLETMATALNTDAATILAANAADLDAARTQQV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHH
GTAMLDRLALDPQRLAAMADALRDIAALPDPVGQVTRDDRRPNGIHIQKIRVPLGVIAMI
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEEECHHHHHHHH
YEARPNVTADAAALCIKAGNGIILRGGSEAIRSNIAIATALQRALRLASLPETALILVQD
HHCCCCCCHHHHHHEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
MARHTMLELLQLSDLIDLVIPRGGEGLIRFVAEHARIPVIKHYKGVCHQFVDASADIEMA
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHE
IRLLIDGKTTRPAACNALETLLVHTDIAPRFLPAAAAALRPYGVQLRGDHATCTLLPDVL
EEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEHHHHH
LATDADYAAEYLDLILAIRIVPNLDAALEHIRRYGSDHTEVIVTADPAHADTFVQQLPSA
HHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCE
VVMVNASSRFSDGGALGLGAEIGISTTRLHAYGPMGLDALTVERFVVRGQGQVRHCPPYP
EEEEECCCCCCCCCCEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCC
PAPRR
CCCCC
>Mature Secondary Structure 
SHIRHLAQQCRDAARILATLSTDAKRRLLETMATALNTDAATILAANAADLDAARTQQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHH
GTAMLDRLALDPQRLAAMADALRDIAALPDPVGQVTRDDRRPNGIHIQKIRVPLGVIAMI
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEEECHHHHHHHH
YEARPNVTADAAALCIKAGNGIILRGGSEAIRSNIAIATALQRALRLASLPETALILVQD
HHCCCCCCHHHHHHEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
MARHTMLELLQLSDLIDLVIPRGGEGLIRFVAEHARIPVIKHYKGVCHQFVDASADIEMA
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHE
IRLLIDGKTTRPAACNALETLLVHTDIAPRFLPAAAAALRPYGVQLRGDHATCTLLPDVL
EEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEHHHHH
LATDADYAAEYLDLILAIRIVPNLDAALEHIRRYGSDHTEVIVTADPAHADTFVQQLPSA
HHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCE
VVMVNASSRFSDGGALGLGAEIGISTTRLHAYGPMGLDALTVERFVVRGQGQVRHCPPYP
EEEEECCCCCCCCCCEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCC
PAPRR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA