Click here to switch to the map view.

The map label for this gene is pyrC [H]

Identifier: 182680839

GI number: 182680839

Start: 358473

End: 359822

Strand: Reverse

Name: pyrC [H]

Synonym: XfasM23_0274

Alternate gene names: 182680839

Gene position: 359822-358473 (Counterclockwise)

Preceding gene: 182680840

Following gene: 182680838

Centisome position: 14.19

GC content: 56.15

Gene sequence:

>1350_bases
ATGAATCCAACCTTGATCGTGAACGCCCGCTTGGTCAATGAAGGCCGCGAATTCGACAGCGATTTGAGAATCGAGAACGG
ACGCATCGCCCGTATCGACACCGGACTGTCTGCACAAAGTAAGGACATCGTCATTGATGCAGCGGGCCGCCGTTTACTGC
CTGGCATGATCGACGACCAAGTCCATTTTCGCGAACCTGGACTCACCCACAAGGGCGATATTGCCAGCGAGTCCGCTGCT
GCAGTGGCCGGCGGACTGACGAGCTTTATGGATATGCCCAACACCAATCCACCGACATTAGGCGCTGCTGCATTGCAGGC
CAAGTATGACGCTGCAAGGGGGCGTGCCTGGGGCAACTATGGTTTCTACCTCGGCGCCAGCAACGATAATCTTGCGGCAA
TCCAAGCACTAGACCCCAAAACCAGTCCAGGCATCAAAGTGTTCATGGGGGCCTCCACAGGCAACATGCTGGTGGACAAT
GAAACCACGCTGGAAGGGATTTTCCGCTATGCACCCACCCCGATCATCACCCACTGCGAGGACACACCGACCATCAACGC
AACACTGGCCAAGTACCACTCTCGCTACGGCAATACACTGAGTGCCGAGCAACACCCAGATATCCGCTCGCGCCAAGCCT
GCTTGAAATCCTCGCAGCTAGCCGTATCGCTGGCAAAGAAAAACGGCACCCGGCTGCACGTACTCCATATTTCTACCGCT
GATGAGCTGAGACTGTTTGAAGCTGGCCCACTGGTCGATGCCGCCGGCAAACGATGCAAGCAAATCACCGCCGAAACCTG
TATCCATTTCCTACATTTTGATCGCATGGACTATGCACGCCTTGGCAACCTCATCAAGTGCAACCCAGCCATCAAGGAAG
CCAGCGACCGCGAAGCACTGATCGCCGCTTTGGCAAAGGACGTGATCGACGTCCTCGCCACCGATCATGCACCGCACACC
TGGGAAGAGAAACAGCAACCATATGCACAGGCTCCCTCCGGCCTGCCATTGGTCCAGTACGCGCTGGTCGCAGCACTGGA
ACTGGTGCATGCCGGTCGGTTATCGGTAACTGAGATCGTGCGCAAGTTTGCCCATGCACCGGCACAACTGTTTGACGTGA
TTGAACGTGGTTTCCTGCGCGAGGGCTACTGGGCGGACTTGGTACTGGTCGAAGACACACCATTCACTGTCAAACGTCAG
GAGATACTTTCTAAATGTGGCTGGTCGCCATTCGAAGGCACCACATTTCGTTCTCGTATCGCTTCCACGTGGGTCAACGG
CAACCATGTGTGGGACGGCAACCGCCTTGTTGGCGTACCGAACGGCCAACGTCTGGAATTTGACCGCTGA

Upstream 100 bases:

>100_bases
CACGCTGCCATCCGTTGCAACTGGGTGGCCACGACCCGGTACCCGACAACACCAGCACACAGGTCAATCCCCGTTCTCAT
CGCTGTACAGGACACCACCA

Downstream 100 bases:

>100_bases
TGCTTGCACTCACTGTGAATAGGTTACTCGCGCTCGGTATGTTGGTCACAATGACTTTACCGCCCATTACATATGCCCAG
AACAAGATAAACACACAAGA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MNPTLIVNARLVNEGREFDSDLRIENGRIARIDTGLSAQSKDIVIDAAGRRLLPGMIDDQVHFREPGLTHKGDIASESAA
AVAGGLTSFMDMPNTNPPTLGAAALQAKYDAARGRAWGNYGFYLGASNDNLAAIQALDPKTSPGIKVFMGASTGNMLVDN
ETTLEGIFRYAPTPIITHCEDTPTINATLAKYHSRYGNTLSAEQHPDIRSRQACLKSSQLAVSLAKKNGTRLHVLHISTA
DELRLFEAGPLVDAAGKRCKQITAETCIHFLHFDRMDYARLGNLIKCNPAIKEASDREALIAALAKDVIDVLATDHAPHT
WEEKQQPYAQAPSGLPLVQYALVAALELVHAGRLSVTEIVRKFAHAPAQLFDVIERGFLREGYWADLVLVEDTPFTVKRQ
EILSKCGWSPFEGTTFRSRIASTWVNGNHVWDGNRLVGVPNGQRLEFDR

Sequences:

>Translated_449_residues
MNPTLIVNARLVNEGREFDSDLRIENGRIARIDTGLSAQSKDIVIDAAGRRLLPGMIDDQVHFREPGLTHKGDIASESAA
AVAGGLTSFMDMPNTNPPTLGAAALQAKYDAARGRAWGNYGFYLGASNDNLAAIQALDPKTSPGIKVFMGASTGNMLVDN
ETTLEGIFRYAPTPIITHCEDTPTINATLAKYHSRYGNTLSAEQHPDIRSRQACLKSSQLAVSLAKKNGTRLHVLHISTA
DELRLFEAGPLVDAAGKRCKQITAETCIHFLHFDRMDYARLGNLIKCNPAIKEASDREALIAALAKDVIDVLATDHAPHT
WEEKQQPYAQAPSGLPLVQYALVAALELVHAGRLSVTEIVRKFAHAPAQLFDVIERGFLREGYWADLVLVEDTPFTVKRQ
EILSKCGWSPFEGTTFRSRIASTWVNGNHVWDGNRLVGVPNGQRLEFDR
>Mature_449_residues
MNPTLIVNARLVNEGREFDSDLRIENGRIARIDTGLSAQSKDIVIDAAGRRLLPGMIDDQVHFREPGLTHKGDIASESAA
AVAGGLTSFMDMPNTNPPTLGAAALQAKYDAARGRAWGNYGFYLGASNDNLAAIQALDPKTSPGIKVFMGASTGNMLVDN
ETTLEGIFRYAPTPIITHCEDTPTINATLAKYHSRYGNTLSAEQHPDIRSRQACLKSSQLAVSLAKKNGTRLHVLHISTA
DELRLFEAGPLVDAAGKRCKQITAETCIHFLHFDRMDYARLGNLIKCNPAIKEASDREALIAALAKDVIDVLATDHAPHT
WEEKQQPYAQAPSGLPLVQYALVAALELVHAGRLSVTEIVRKFAHAPAQLFDVIERGFLREGYWADLVLVEDTPFTVKRQ
EILSKCGWSPFEGTTFRSRIASTWVNGNHVWDGNRLVGVPNGQRLEFDR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=395, Percent_Identity=29.620253164557, Blast_Score=149, Evalue=4e-36,
Organism=Escherichia coli, GI1786722, Length=452, Percent_Identity=26.7699115044248, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI87082175, Length=455, Percent_Identity=23.0769230769231, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI193204318, Length=401, Percent_Identity=28.927680798005, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71989490, Length=470, Percent_Identity=22.9787234042553, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17539558, Length=467, Percent_Identity=23.3404710920771, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322218, Length=459, Percent_Identity=24.6187363834423, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24642586, Length=402, Percent_Identity=32.089552238806, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI18859883, Length=446, Percent_Identity=26.6816143497758, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 49188; Mature: 49188

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPTLIVNARLVNEGREFDSDLRIENGRIARIDTGLSAQSKDIVIDAAGRRLLPGMIDDQ
CCCEEEEEEEEECCCCCCCCCEEECCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCC
VHFREPGLTHKGDIASESAAAVAGGLTSFMDMPNTNPPTLGAAALQAKYDAARGRAWGNY
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
GFYLGASNDNLAAIQALDPKTSPGIKVFMGASTGNMLVDNETTLEGIFRYAPTPIITHCE
EEEEECCCCCEEEEEEECCCCCCCEEEEEECCCCCEEECCCHHHHHHHHHCCCCEEECCC
DTPTINATLAKYHSRYGNTLSAEQHPDIRSRQACLKSSQLAVSLAKKNGTRLHVLHISTA
CCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCEEEEEEECCC
DELRLFEAGPLVDAAGKRCKQITAETCIHFLHFDRMDYARLGNLIKCNPAIKEASDREAL
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEECCHHHHCCCCHHHH
IAALAKDVIDVLATDHAPHTWEEKQQPYAQAPSGLPLVQYALVAALELVHAGRLSVTEIV
HHHHHHHHHHHHHCCCCCCCCHHHCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
RKFAHAPAQLFDVIERGFLREGYWADLVLVEDTPFTVKRQEILSKCGWSPFEGTTFRSRI
HHHHCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEHHHHHHHCCCCCCCCCHHHHHH
ASTWVNGNHVWDGNRLVGVPNGQRLEFDR
HHHCCCCCEEECCCEEEECCCCCEECCCC
>Mature Secondary Structure
MNPTLIVNARLVNEGREFDSDLRIENGRIARIDTGLSAQSKDIVIDAAGRRLLPGMIDDQ
CCCEEEEEEEEECCCCCCCCCEEECCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCC
VHFREPGLTHKGDIASESAAAVAGGLTSFMDMPNTNPPTLGAAALQAKYDAARGRAWGNY
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
GFYLGASNDNLAAIQALDPKTSPGIKVFMGASTGNMLVDNETTLEGIFRYAPTPIITHCE
EEEEECCCCCEEEEEEECCCCCCCEEEEEECCCCCEEECCCHHHHHHHHHCCCCEEECCC
DTPTINATLAKYHSRYGNTLSAEQHPDIRSRQACLKSSQLAVSLAKKNGTRLHVLHISTA
CCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCEEEEEEECCC
DELRLFEAGPLVDAAGKRCKQITAETCIHFLHFDRMDYARLGNLIKCNPAIKEASDREAL
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEECCHHHHCCCCHHHH
IAALAKDVIDVLATDHAPHTWEEKQQPYAQAPSGLPLVQYALVAALELVHAGRLSVTEIV
HHHHHHHHHHHHHCCCCCCCCHHHCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
RKFAHAPAQLFDVIERGFLREGYWADLVLVEDTPFTVKRQEILSKCGWSPFEGTTFRSRI
HHHHCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEHHHHHHHCCCCCCCCCHHHHHH
ASTWVNGNHVWDGNRLVGVPNGQRLEFDR
HHHCCCCCEEECCCEEEECCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]