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The map label for this gene is rmlA [H]

Identifier: 182680767

GI number: 182680767

Start: 266408

End: 267295

Strand: Direct

Name: rmlA [H]

Synonym: XfasM23_0196

Alternate gene names: 182680767

Gene position: 266408-267295 (Clockwise)

Preceding gene: 182680766

Following gene: 182680768

Centisome position: 10.51

GC content: 54.62

Gene sequence:

>888_bases
ATGACACAGCGCAAGGGCATCATCTTGGCGGGTGGGGCCGGGACACGGTTGTATCCGATCACTCAAGGGATCGGTAAGCA
GTTACTGCCGGTGTATGACAAGCCGATGATTTATTACCCGCTCAGTGTGTTGATGTTGGCAGGGATTCGCCAGGTGCTGG
TGATCACGATGTTGCATGAGCAGGCGTTGTTTCAGCGCCTGTTGGGTGATGGTACGCAGTGGGGGATGGAGATTTGCTAC
GCGGTACAGGCCAGTCCCGATGGTGTGGCGCAGTCTTATTTGATTGGCCGTGCATTTATCGATGACAAGCCAAGTTGTCT
GATTTTGGGAGACAACATTTTTTATGGTCATGGTCTGACGGACACGCTGTGTCATGCCGATGCGCGCACCGTGGGCGCGA
CCGTGTTTGGTTATTGGGTCAGTGATCCGGAGCGCTATGGGGTGGCGGAGTTCGATGGGGACGGACGAGTGATTAATATT
GAGGAGAAGCCGGCGCAGCCACGTTCTAACTATGCGGTGACGGGGTTGTATTTCTACGATGGGCGTGCGCCTGCATTTGC
TGCGGAACTGACGCCTTCGGCGCGTGGTGAGTTGGAGATTACTGATCTTAATCGCCGTTATTTGGCAGAAGGTGCGTTGC
ACTTGGAGGCGCTTGGACGCGGTTATGCCTGGTTGGATACAGGGACCCATCAGTCGTTGCACGATGCGTCCAACTTTATT
GGAACGATCCAGACGAGGCAGGGTTTACAGGTGTGTTGTCCTGAGGAGGTCGCGTTCTGGAAAGGATGGATTGATGCGAC
GCATTTAGAGCGCTTGGCGGCACCGTTGGCAAAGAATGCTTACGGGCAGTATTTGTTGAATTTAGCGCAGCGGGGACGGT
CTCTGTGA

Upstream 100 bases:

>100_bases
GGCGTGACCGCGTTGAGGGCCTACTGACTGCGGTGTAAGGCCTTAGGTTCGGTAAAGAGTGCGTATCCATATGCAGACTT
TCATATCAGGAAATCGTTCC

Downstream 100 bases:

>100_bases
AGGTGATTGATACGGCGCTGCCAGGCTGTTTGGTGATTGAGCCGAGGGTGTTTGATGATGCGCGCGGTGAATTTTTTGAG
GTATGGAATGCGGAGTGTTT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MTQRKGIILAGGAGTRLYPITQGIGKQLLPVYDKPMIYYPLSVLMLAGIRQVLVITMLHEQALFQRLLGDGTQWGMEICY
AVQASPDGVAQSYLIGRAFIDDKPSCLILGDNIFYGHGLTDTLCHADARTVGATVFGYWVSDPERYGVAEFDGDGRVINI
EEKPAQPRSNYAVTGLYFYDGRAPAFAAELTPSARGELEITDLNRRYLAEGALHLEALGRGYAWLDTGTHQSLHDASNFI
GTIQTRQGLQVCCPEEVAFWKGWIDATHLERLAAPLAKNAYGQYLLNLAQRGRSL

Sequences:

>Translated_295_residues
MTQRKGIILAGGAGTRLYPITQGIGKQLLPVYDKPMIYYPLSVLMLAGIRQVLVITMLHEQALFQRLLGDGTQWGMEICY
AVQASPDGVAQSYLIGRAFIDDKPSCLILGDNIFYGHGLTDTLCHADARTVGATVFGYWVSDPERYGVAEFDGDGRVINI
EEKPAQPRSNYAVTGLYFYDGRAPAFAAELTPSARGELEITDLNRRYLAEGALHLEALGRGYAWLDTGTHQSLHDASNFI
GTIQTRQGLQVCCPEEVAFWKGWIDATHLERLAAPLAKNAYGQYLLNLAQRGRSL
>Mature_294_residues
TQRKGIILAGGAGTRLYPITQGIGKQLLPVYDKPMIYYPLSVLMLAGIRQVLVITMLHEQALFQRLLGDGTQWGMEICYA
VQASPDGVAQSYLIGRAFIDDKPSCLILGDNIFYGHGLTDTLCHADARTVGATVFGYWVSDPERYGVAEFDGDGRVINIE
EKPAQPRSNYAVTGLYFYDGRAPAFAAELTPSARGELEITDLNRRYLAEGALHLEALGRGYAWLDTGTHQSLHDASNFIG
TIQTRQGLQVCCPEEVAFWKGWIDATHLERLAAPLAKNAYGQYLLNLAQRGRSL

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=290, Percent_Identity=62.0689655172414, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1790224, Length=284, Percent_Identity=60.9154929577465, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1788355, Length=240, Percent_Identity=25.4166666666667, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787488, Length=235, Percent_Identity=25.9574468085106, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=227, Percent_Identity=23.7885462555066, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=179, Percent_Identity=24.5810055865922, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355443, Length=233, Percent_Identity=26.6094420600858, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644084, Length=233, Percent_Identity=26.6094420600858, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32489; Mature: 32358

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRKGIILAGGAGTRLYPITQGIGKQLLPVYDKPMIYYPLSVLMLAGIRQVLVITMLHE
CCCCCCEEEECCCCCEEEEEHHHCCHHHCHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
QALFQRLLGDGTQWGMEICYAVQASPDGVAQSYLIGRAFIDDKPSCLILGDNIFYGHGLT
HHHHHHHHCCCHHHHEEEEEEEECCCCHHHHHHHHHHHEECCCCCEEEEECCEEECCCCH
DTLCHADARTVGATVFGYWVSDPERYGVAEFDGDGRVINIEEKPAQPRSNYAVTGLYFYD
HHHHHCCHHHHCEEEEEEECCCCCCCCCEEECCCCCEEEECCCCCCCCCCEEEEEEEEEC
GRAPAFAAELTPSARGELEITDLNRRYLAEGALHLEALGRGYAWLDTGTHQSLHDASNFI
CCCCEEEEECCCCCCCCEEEEECCHHHHHHCCCEEEHHCCCEEEEECCCCHHHHHHHHHE
GTIQTRQGLQVCCPEEVAFWKGWIDATHLERLAAPLAKNAYGQYLLNLAQRGRSL
EEEECCCCCEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQRKGIILAGGAGTRLYPITQGIGKQLLPVYDKPMIYYPLSVLMLAGIRQVLVITMLHE
CCCCCEEEECCCCCEEEEEHHHCCHHHCHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
QALFQRLLGDGTQWGMEICYAVQASPDGVAQSYLIGRAFIDDKPSCLILGDNIFYGHGLT
HHHHHHHHCCCHHHHEEEEEEEECCCCHHHHHHHHHHHEECCCCCEEEEECCEEECCCCH
DTLCHADARTVGATVFGYWVSDPERYGVAEFDGDGRVINIEEKPAQPRSNYAVTGLYFYD
HHHHHCCHHHHCEEEEEEECCCCCCCCCEEECCCCCEEEECCCCCCCCCCEEEEEEEEEC
GRAPAFAAELTPSARGELEITDLNRRYLAEGALHLEALGRGYAWLDTGTHQSLHDASNFI
CCCCEEEEECCCCCCCCEEEEECCHHHHHHCCCEEEHHCCCEEEEECCCCHHHHHHHHHE
GTIQTRQGLQVCCPEEVAFWKGWIDATHLERLAAPLAKNAYGQYLLNLAQRGRSL
EEEECCCCCEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8253667 [H]