Click here to switch to the map view.

The map label for this gene is pgi

Identifier: 182680747

GI number: 182680747

Start: 238795

End: 240303

Strand: Direct

Name: pgi

Synonym: XfasM23_0176

Alternate gene names: 182680747

Gene position: 238795-240303 (Clockwise)

Preceding gene: 182680746

Following gene: 182680748

Centisome position: 9.42

GC content: 51.42

Gene sequence:

>1509_bases
ATGCACAATGGGTTCGATGCTTTGCAGCTTCATGCCAATCGCTTGCGTGGGGTGACAATTCCAGATCTGTTGGCTGCTGA
GCTAAAAAGACCAGAGCAATATGCCAGACAAGTTGGTCCGTTGTATTTCAACTTTGCTCGGCAGAAGTATGACTGTGTGG
CGTTGGAAGCACTGTTTGCATTGGCGCGAAACCATAATGTGACTGGTGCGTTCCAGCGCATGTTTTGTGGGGAGCAGGTC
AATGTGACCGAGGGGCGTGCCGTGCTGCATACTGCGCTGCGCGGTGATCTTAGTGGTACTTCGGTGGCGGTTGCTGCTTA
CACGGCGGCTGCTAAAGTGCGCGAGCGAATGTATGCGTTGATTGCCGGGCTGGATGCCAGTGAGGTGACCGATATTGTTA
GTGTTGGCATTGGGGGCTCGGATCTTGGGCCACGTTTAGTAGTTGATGCGTTGCGTCCGATTTCCCAAGGACGTTTCCGA
GTCCATTTTGTCTCTAATGTTGATGGCGCTGCTATGCGGCGTACTCTGGATATGTTGGATCCATCACGTACGGCAGGCAT
TCTCATCTCCAAGACCTTTGGTACGCAGGAGACGTTGCTCAACGGTCGTATTTTGTACGATTGGTTAGGCGGCAGTGAGC
GCTTATATGCGGTCACTGCTAATCCGGAACGGGCCGCTAATGCGTTCGACATTGTACCCACGCAGGTTTTGCCAATCTGG
GATTGGGTGGGTGGACGCTATTCTTTATGGTCAGCAGTTGGTTTCCCGATTGCGTTGGCGATTGGTTCTCAACGTTTTGA
GGAGTTGCTGGCTGGTGCGGCTGAGTTTGATGCGTATGCCCTGAGGGTGCCGTTAGAAGAAAATGTTGCGGTGTTGCATG
GGTTAACTGCGGTGTGGAACCGTAACTTCCTTGGTTGCGCCACGTATGCGGTGATGGCTTATGACCAGCGCTTGGCATTG
CTCCCTACCTACTTGCAGCAACTGGTGATGGAAAGTTTGGGTAAGCGGGTTAAGTGCGACGGAACGCCAGTGGATAGGGA
TACTGTTCCAGTTTGGTGGGGTGGCGTGGGGACTGATGTGCAGCATAGTTTTTTCCAGGCGCTGCATCAGGGGACAAATA
TCGTACCTGCTGACTTTATCGGTACGATCCGCAATGATGATCTGTACACTGAGAATCATTTTGCTTTGAATGCCAACTTG
CTGGCTCAGATTGAAGTGTTAGCGAACGGCCAGCTTAGCGATAATCCGCATCGTGTTTATCCAGGAGGGAATCCGAGTAC
GTTGATTTTGCTTGATGCATTGACTCCACAGGCATTGGGGGGATTGATTGCGATGTATGAGCATAGTGTGTATGTGCAGT
CAGTGATTTGGGGTATTAATGCGTTTGATCAGTTTGGTGTGGAGTTGGGAAAGCATTTAGCCGTTCAATTACTACCTGCA
TTAAAGGGGGAGAGTGTTGAAGTGGCGGATCCAGTAACGCGTGCGGTGTTGCTGCGTTTGCGTGGTTGA

Upstream 100 bases:

>100_bases
GGACGAGGCAGCAGTTTTCAGACCGAATTTGGTATACGTCAATGCTGCCAATGCGATGACTCATACCAACCACAGTATTC
CTACACAGGTCGCATGACAC

Downstream 100 bases:

>100_bases
GTGTTGTAGCGACGTTATGATTAGGAATGAAGTCTAAGTTAAGCATCAGTTTGCCACTCTGGTTGCTTTTATTGATGCAG
TTCGTGAGTACGTGCAATGC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MHNGFDALQLHANRLRGVTIPDLLAAELKRPEQYARQVGPLYFNFARQKYDCVALEALFALARNHNVTGAFQRMFCGEQV
NVTEGRAVLHTALRGDLSGTSVAVAAYTAAAKVRERMYALIAGLDASEVTDIVSVGIGGSDLGPRLVVDALRPISQGRFR
VHFVSNVDGAAMRRTLDMLDPSRTAGILISKTFGTQETLLNGRILYDWLGGSERLYAVTANPERAANAFDIVPTQVLPIW
DWVGGRYSLWSAVGFPIALAIGSQRFEELLAGAAEFDAYALRVPLEENVAVLHGLTAVWNRNFLGCATYAVMAYDQRLAL
LPTYLQQLVMESLGKRVKCDGTPVDRDTVPVWWGGVGTDVQHSFFQALHQGTNIVPADFIGTIRNDDLYTENHFALNANL
LAQIEVLANGQLSDNPHRVYPGGNPSTLILLDALTPQALGGLIAMYEHSVYVQSVIWGINAFDQFGVELGKHLAVQLLPA
LKGESVEVADPVTRAVLLRLRG

Sequences:

>Translated_502_residues
MHNGFDALQLHANRLRGVTIPDLLAAELKRPEQYARQVGPLYFNFARQKYDCVALEALFALARNHNVTGAFQRMFCGEQV
NVTEGRAVLHTALRGDLSGTSVAVAAYTAAAKVRERMYALIAGLDASEVTDIVSVGIGGSDLGPRLVVDALRPISQGRFR
VHFVSNVDGAAMRRTLDMLDPSRTAGILISKTFGTQETLLNGRILYDWLGGSERLYAVTANPERAANAFDIVPTQVLPIW
DWVGGRYSLWSAVGFPIALAIGSQRFEELLAGAAEFDAYALRVPLEENVAVLHGLTAVWNRNFLGCATYAVMAYDQRLAL
LPTYLQQLVMESLGKRVKCDGTPVDRDTVPVWWGGVGTDVQHSFFQALHQGTNIVPADFIGTIRNDDLYTENHFALNANL
LAQIEVLANGQLSDNPHRVYPGGNPSTLILLDALTPQALGGLIAMYEHSVYVQSVIWGINAFDQFGVELGKHLAVQLLPA
LKGESVEVADPVTRAVLLRLRG
>Mature_502_residues
MHNGFDALQLHANRLRGVTIPDLLAAELKRPEQYARQVGPLYFNFARQKYDCVALEALFALARNHNVTGAFQRMFCGEQV
NVTEGRAVLHTALRGDLSGTSVAVAAYTAAAKVRERMYALIAGLDASEVTDIVSVGIGGSDLGPRLVVDALRPISQGRFR
VHFVSNVDGAAMRRTLDMLDPSRTAGILISKTFGTQETLLNGRILYDWLGGSERLYAVTANPERAANAFDIVPTQVLPIW
DWVGGRYSLWSAVGFPIALAIGSQRFEELLAGAAEFDAYALRVPLEENVAVLHGLTAVWNRNFLGCATYAVMAYDQRLAL
LPTYLQQLVMESLGKRVKCDGTPVDRDTVPVWWGGVGTDVQHSFFQALHQGTNIVPADFIGTIRNDDLYTENHFALNANL
LAQIEVLANGQLSDNPHRVYPGGNPSTLILLDALTPQALGGLIAMYEHSVYVQSVIWGINAFDQFGVELGKHLAVQLLPA
LKGESVEVADPVTRAVLLRLRG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=487, Percent_Identity=39.4250513347023, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI296080693, Length=460, Percent_Identity=39.1304347826087, Blast_Score=323, Evalue=2e-88,
Organism=Escherichia coli, GI1790457, Length=535, Percent_Identity=37.7570093457944, Blast_Score=351, Evalue=6e-98,
Organism=Caenorhabditis elegans, GI71996708, Length=524, Percent_Identity=36.4503816793893, Blast_Score=318, Evalue=5e-87,
Organism=Caenorhabditis elegans, GI71996703, Length=524, Percent_Identity=36.2595419847328, Blast_Score=317, Evalue=6e-87,
Organism=Saccharomyces cerevisiae, GI6319673, Length=531, Percent_Identity=35.4048964218456, Blast_Score=315, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24651916, Length=522, Percent_Identity=36.9731800766284, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24651914, Length=522, Percent_Identity=36.9731800766284, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI17737445, Length=522, Percent_Identity=36.9731800766284, Blast_Score=337, Evalue=1e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_XYLF2 (B2I723)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001828907.1
- ProteinModelPortal:   B2I723
- SMR:   B2I723
- GeneID:   6201920
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_0176
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- ProtClustDB:   PRK00179
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 54792; Mature: 54792

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 362-362 ACT_SITE 471-471

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNGFDALQLHANRLRGVTIPDLLAAELKRPEQYARQVGPLYFNFARQKYDCVALEALFA
CCCCHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHCCHHHHHHHHCHHHHHHHHHHH
LARNHNVTGAFQRMFCGEQVNVTEGRAVLHTALRGDLSGTSVAVAAYTAAAKVRERMYAL
HHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHH
IAGLDASEVTDIVSVGIGGSDLGPRLVVDALRPISQGRFRVHFVSNVDGAAMRRTLDMLD
HHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCC
PSRTAGILISKTFGTQETLLNGRILYDWLGGSERLYAVTANPERAANAFDIVPTQVLPIW
CCCCCCEEEEECCCCHHHHHCCEEEEEECCCCCEEEEEECCCHHHCCCEECCCCCEEEHH
DWVGGRYSLWSAVGFPIALAIGSQRFEELLAGAAEFDAYALRVPLEENVAVLHGLTAVWN
HCCCCCHHHHHHHCCHHEEHHHHHHHHHHHCCHHCCCEEEEEECCCCCHHHHHHHHHHHC
RNFLGCATYAVMAYDQRLALLPTYLQQLVMESLGKRVKCDGTPVDRDTVPVWWGGVGTDV
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCEEEECCCCCHH
QHSFFQALHQGTNIVPADFIGTIRNDDLYTENHFALNANLLAQIEVLANGQLSDNPHRVY
HHHHHHHHHCCCCCCCHHHHHCCCCCCCEECCEEEECCCCEEEEEEEECCCCCCCCCEEC
PGGNPSTLILLDALTPQALGGLIAMYEHSVYVQSVIWGINAFDQFGVELGKHLAVQLLPA
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LKGESVEVADPVTRAVLLRLRG
CCCCCEECCCHHHHHHHHHCCC
>Mature Secondary Structure
MHNGFDALQLHANRLRGVTIPDLLAAELKRPEQYARQVGPLYFNFARQKYDCVALEALFA
CCCCHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHCCHHHHHHHHCHHHHHHHHHHH
LARNHNVTGAFQRMFCGEQVNVTEGRAVLHTALRGDLSGTSVAVAAYTAAAKVRERMYAL
HHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHH
IAGLDASEVTDIVSVGIGGSDLGPRLVVDALRPISQGRFRVHFVSNVDGAAMRRTLDMLD
HHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCC
PSRTAGILISKTFGTQETLLNGRILYDWLGGSERLYAVTANPERAANAFDIVPTQVLPIW
CCCCCCEEEEECCCCHHHHHCCEEEEEECCCCCEEEEEECCCHHHCCCEECCCCCEEEHH
DWVGGRYSLWSAVGFPIALAIGSQRFEELLAGAAEFDAYALRVPLEENVAVLHGLTAVWN
HCCCCCHHHHHHHCCHHEEHHHHHHHHHHHCCHHCCCEEEEEECCCCCHHHHHHHHHHHC
RNFLGCATYAVMAYDQRLALLPTYLQQLVMESLGKRVKCDGTPVDRDTVPVWWGGVGTDV
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCEEEECCCCCHH
QHSFFQALHQGTNIVPADFIGTIRNDDLYTENHFALNANLLAQIEVLANGQLSDNPHRVY
HHHHHHHHHCCCCCCCHHHHHCCCCCCCEECCEEEECCCCEEEEEEEECCCCCCCCCEEC
PGGNPSTLILLDALTPQALGGLIAMYEHSVYVQSVIWGINAFDQFGVELGKHLAVQLLPA
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LKGESVEVADPVTRAVLLRLRG
CCCCCEECCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA