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The map label for this gene is trpC

Identifier: 182680731

GI number: 182680731

Start: 219611

End: 220405

Strand: Direct

Name: trpC

Synonym: XfasM23_0160

Alternate gene names: 182680731

Gene position: 219611-220405 (Clockwise)

Preceding gene: 182680730

Following gene: 182680732

Centisome position: 8.66

GC content: 50.69

Gene sequence:

>795_bases
ATGAGCAACATACTCACTAAGATTCTTGCGCGGAAGGTGGAGGAGATTGCCGAGCGCCTTTTGCATGTCTCACAGGCTGA
GTTGGTTGCGCGTTGTGCCGATTTGCCGACACCCCGTGGTTTTGCTGCTGCGTTGCAGGCGACGATTGCGCATGGTGACC
CAGCAGTGATTGCTGAGATTAAGAAGGCCAGTCCTTCAAAAGGGGTGCTTCGCGAGGATTTTCGTCCTGCAGAGATCGCT
ATCTCATATGAGCTTGGTGGTGCTAGCTGTCTATCAGTGCTGACGGACGTGCATTTCTTCAAGGGTCACGATGATTATTT
GAGTCAGGCGCGTGATGCTTGCACTCTTCCGGTGTTGCGCAAAGATTTCACGATAGACCCGTATCAGGTGTATGAGGCAC
GTGTGCTTGGTGCTGATTGTATTTTGCTGATTGTCGCTGCATTGGACGATGCTCAATTGGTTGATTTGTCCGGCTTGGCA
TTGCAATTGGGGATGGATGTGCTGGTTGAGGTTCACGATATTGACGAACTTGAGCGTGCAATACAGATTTCTGCGCCATT
GATTGGTATCAACAACCGTAATCTGAGTACCTTCAACGTGTCATTGGAGACAACGTTGACAATGAAAGGGTTAGTGCCGC
GTGATCGTTTGCTCGTAAGTGAGAGCGGTATCCTTACCTCTGCCGATGTGCAACGGTTGCGTGCTGCGGGTGTGAATGCG
TTTCTTGTTGGTGAGGCGTTTATGCGTGCGGCTGAACCTGGTGAGTCACTCAGAGAGATGTTCTTCATCACGTGA

Upstream 100 bases:

>100_bases
ACGTCGCCCACGCAATGTTTGAATACTGCCTGATTAAACACGCTGTAAACTGTTTTCCGAATCGTTTTCAGAGAATTCTT
TCTTGCGATGAGCAGACCCG

Downstream 100 bases:

>100_bases
GTGCATTATCTCCATCTTTGCGCGAGGATGCGCCATTAGTTGTCTTTGATTTCGATCATACGTTGTACGATGGCGATTCT
GGCAGTGATTTGTTCGCTTG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSNILTKILARKVEEIAERLLHVSQAELVARCADLPTPRGFAAALQATIAHGDPAVIAEIKKASPSKGVLREDFRPAEIA
ISYELGGASCLSVLTDVHFFKGHDDYLSQARDACTLPVLRKDFTIDPYQVYEARVLGADCILLIVAALDDAQLVDLSGLA
LQLGMDVLVEVHDIDELERAIQISAPLIGINNRNLSTFNVSLETTLTMKGLVPRDRLLVSESGILTSADVQRLRAAGVNA
FLVGEAFMRAAEPGESLREMFFIT

Sequences:

>Translated_264_residues
MSNILTKILARKVEEIAERLLHVSQAELVARCADLPTPRGFAAALQATIAHGDPAVIAEIKKASPSKGVLREDFRPAEIA
ISYELGGASCLSVLTDVHFFKGHDDYLSQARDACTLPVLRKDFTIDPYQVYEARVLGADCILLIVAALDDAQLVDLSGLA
LQLGMDVLVEVHDIDELERAIQISAPLIGINNRNLSTFNVSLETTLTMKGLVPRDRLLVSESGILTSADVQRLRAAGVNA
FLVGEAFMRAAEPGESLREMFFIT
>Mature_263_residues
SNILTKILARKVEEIAERLLHVSQAELVARCADLPTPRGFAAALQATIAHGDPAVIAEIKKASPSKGVLREDFRPAEIAI
SYELGGASCLSVLTDVHFFKGHDDYLSQARDACTLPVLRKDFTIDPYQVYEARVLGADCILLIVAALDDAQLVDLSGLAL
QLGMDVLVEVHDIDELERAIQISAPLIGINNRNLSTFNVSLETTLTMKGLVPRDRLLVSESGILTSADVQRLRAAGVNAF
LVGEAFMRAAEPGESLREMFFIT

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=250, Percent_Identity=41.2, Blast_Score=157, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6322638, Length=234, Percent_Identity=40.1709401709402, Blast_Score=159, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_XYLF2 (B2I6S5)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001828891.1
- ProteinModelPortal:   B2I6S5
- SMR:   B2I6S5
- GeneID:   6203521
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_0160
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28654; Mature: 28523

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNILTKILARKVEEIAERLLHVSQAELVARCADLPTPRGFAAALQATIAHGDPAVIAEI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHH
KKASPSKGVLREDFRPAEIAISYELGGASCLSVLTDVHFFKGHDDYLSQARDACTLPVLR
HHCCCCCCCHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHH
KDFTIDPYQVYEARVLGADCILLIVAALDDAQLVDLSGLALQLGMDVLVEVHDIDELERA
CCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCHHHHHHCHHHEEEHHCHHHHHHH
IQISAPLIGINNRNLSTFNVSLETTLTMKGLVPRDRLLVSESGILTSADVQRLRAAGVNA
HHHCCCEEECCCCCCEEEEEEEEEEEEECCCCCHHHEEEECCCCEEHHHHHHHHHCCCCE
FLVGEAFMRAAEPGESLREMFFIT
EEHHHHHHHHCCCCHHHHHHHCCC
>Mature Secondary Structure 
SNILTKILARKVEEIAERLLHVSQAELVARCADLPTPRGFAAALQATIAHGDPAVIAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHH
KKASPSKGVLREDFRPAEIAISYELGGASCLSVLTDVHFFKGHDDYLSQARDACTLPVLR
HHCCCCCCCHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHH
KDFTIDPYQVYEARVLGADCILLIVAALDDAQLVDLSGLALQLGMDVLVEVHDIDELERA
CCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCHHHHHHCHHHEEEHHCHHHHHHH
IQISAPLIGINNRNLSTFNVSLETTLTMKGLVPRDRLLVSESGILTSADVQRLRAAGVNA
HHHCCCEEECCCCCCEEEEEEEEEEEEECCCCCHHHEEEECCCCEEHHHHHHHHHCCCCE
FLVGEAFMRAAEPGESLREMFFIT
EEHHHHHHHHCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA