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The map label for this gene is pepA

Identifier: 182680669

GI number: 182680669

Start: 134692

End: 136167

Strand: Reverse

Name: pepA

Synonym: XfasM23_0098

Alternate gene names: 182680669

Gene position: 136167-134692 (Counterclockwise)

Preceding gene: 182680672

Following gene: 182680668

Centisome position: 5.37

GC content: 61.72

Gene sequence:

>1476_bases
ATGGCCCTCCAATTCCAGCTCAACCAAACCACACCACAGACTGTCACCACCGATTGCGTGATCGTCGGCATCTATGCTGA
CAAGACACTCTCACCCACCGCAAAAACTCTGGACGCCGCCAGCGGCGGCCGCATCACCGCATTGACAGCACGCGGCGACC
TCACCGGAAAATCTGGCACCTCCGCATTACTCCACGACCTGAACGGTGTCACCGCACCCCGTGTCCTGGTGGTGGGCTTA
GGTGAAGCGGATAAATTCGGCGCCGGACAGTACATCAAAGCCGTTGGCAACGCCGTCCGCGCCCTGAAAGATGCCCCAGT
GACGCACGCCCTACTCACCTTATCTGAACTCCCCGTCAAAGACCGCAACGCCGCCTGGAACATCCACCAAGCCGTGATCG
CCGCTGACCACGCCGCCTACCGCTACACCGCCACCCTAGGGACCAGCCGCAAAAAAGCCGAAGAATCCGGCCTCATCACC
CTGGCGATCCACGGTCAAGAGACCAGCGGACTGACACTAGGTCAAGCCATCGCTGAAGGCGTGGAGTACGCACGTGCCCT
AGGTAACTTGCCGCCGAACATCTGCACCCCTGCCTATCTGGCAGAAACCACAGCCCACTTTGCCGCCACACACCCTGGTG
CAACATGCGAAATCCTGGACGAATCCAACATGGAGGCATTGGGCATGGGCGCACTGCTTGCCGTGGCCCGTGGCTCAGCC
AACCGCCCCCGCCTGATTGTGCTGAAGTGGAACGGCGGCGGTGACGCCCGCCCCTATGTCCTCGTTGGTAAAGGCATCAC
CTTCGATACCGGCGGCGTCAACTTGAAGACCCAGGGCGGCATTGAAGAGATGAAGTACGACATGTGCGGCGGCGCGGCGG
TCATTGGCACCTTCGTCGCCGCAGTCAAAGTACGGCTACCGCTCAACCTGATTGTGATCGTACCGGCGGTAGAAAACGCC
ATTGATGGCAACGCCTACCGCCCCTCGGACGTCATTACCAGCATGTCCGGCAAAACCATCGAAGTCGGCAACACCGACGC
AGAAGGCCGCCTCATCCTCTGCGATGCCCTGACCTACGCCGAACGCTTCAAACCGGAAGCACTGATCGACGTCGCCACCC
TCACCGGCGCCTGCATGATCGCCCTCGGGCGCGCCGCCACTGGCCTGATGACTCATCATGACGATCTTGCCAACGAACTG
CTGACCGCCGGTGAGCACGTCCACGACCGCGCCTGGCGTCTGCCCCTGTGGGACGAATACCAAGGCTTGCTGGACTCCAC
GTTTGCCGACGTCTACAACATCGGCGGCCGCTGGGGAGGCGCCATCACCGCCGGCTGCTTCTTATCGCGCTTCACCGAAG
GCCAACGCTGGGCACACCTGGATATTGCCGGCTCAGCCAGCAACGAAGGCAAACGCGGCATGGCCACCGGGCGTCCTGTC
GGCCTACTGACACAGTGGCTCGTGGATCGATGCTAA

Upstream 100 bases:

>100_bases
TTGCTTTAGACTTGTAAGCTCGTTCGCGGCAGCCGCCAAGATAACCCAAGCGGCGACAAACTCCGCGATTGTAAGGACTC
GCAACAGGAATCTGAATCTA

Downstream 100 bases:

>100_bases
GCGACCACGCATGGATGCATATTTACGGTATGGGAAGTCCCTTATTGGGACTTCTCCTAACTTTTATCGTGAAACGTATT
TCGGCTTGGCTAAAGATCAG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MALQFQLNQTTPQTVTTDCVIVGIYADKTLSPTAKTLDAASGGRITALTARGDLTGKSGTSALLHDLNGVTAPRVLVVGL
GEADKFGAGQYIKAVGNAVRALKDAPVTHALLTLSELPVKDRNAAWNIHQAVIAADHAAYRYTATLGTSRKKAEESGLIT
LAIHGQETSGLTLGQAIAEGVEYARALGNLPPNICTPAYLAETTAHFAATHPGATCEILDESNMEALGMGALLAVARGSA
NRPRLIVLKWNGGGDARPYVLVGKGITFDTGGVNLKTQGGIEEMKYDMCGGAAVIGTFVAAVKVRLPLNLIVIVPAVENA
IDGNAYRPSDVITSMSGKTIEVGNTDAEGRLILCDALTYAERFKPEALIDVATLTGACMIALGRAATGLMTHHDDLANEL
LTAGEHVHDRAWRLPLWDEYQGLLDSTFADVYNIGGRWGGAITAGCFLSRFTEGQRWAHLDIAGSASNEGKRGMATGRPV
GLLTQWLVDRC

Sequences:

>Translated_491_residues
MALQFQLNQTTPQTVTTDCVIVGIYADKTLSPTAKTLDAASGGRITALTARGDLTGKSGTSALLHDLNGVTAPRVLVVGL
GEADKFGAGQYIKAVGNAVRALKDAPVTHALLTLSELPVKDRNAAWNIHQAVIAADHAAYRYTATLGTSRKKAEESGLIT
LAIHGQETSGLTLGQAIAEGVEYARALGNLPPNICTPAYLAETTAHFAATHPGATCEILDESNMEALGMGALLAVARGSA
NRPRLIVLKWNGGGDARPYVLVGKGITFDTGGVNLKTQGGIEEMKYDMCGGAAVIGTFVAAVKVRLPLNLIVIVPAVENA
IDGNAYRPSDVITSMSGKTIEVGNTDAEGRLILCDALTYAERFKPEALIDVATLTGACMIALGRAATGLMTHHDDLANEL
LTAGEHVHDRAWRLPLWDEYQGLLDSTFADVYNIGGRWGGAITAGCFLSRFTEGQRWAHLDIAGSASNEGKRGMATGRPV
GLLTQWLVDRC
>Mature_490_residues
ALQFQLNQTTPQTVTTDCVIVGIYADKTLSPTAKTLDAASGGRITALTARGDLTGKSGTSALLHDLNGVTAPRVLVVGLG
EADKFGAGQYIKAVGNAVRALKDAPVTHALLTLSELPVKDRNAAWNIHQAVIAADHAAYRYTATLGTSRKKAEESGLITL
AIHGQETSGLTLGQAIAEGVEYARALGNLPPNICTPAYLAETTAHFAATHPGATCEILDESNMEALGMGALLAVARGSAN
RPRLIVLKWNGGGDARPYVLVGKGITFDTGGVNLKTQGGIEEMKYDMCGGAAVIGTFVAAVKVRLPLNLIVIVPAVENAI
DGNAYRPSDVITSMSGKTIEVGNTDAEGRLILCDALTYAERFKPEALIDVATLTGACMIALGRAATGLMTHHDDLANELL
TAGEHVHDRAWRLPLWDEYQGLLDSTFADVYNIGGRWGGAITAGCFLSRFTEGQRWAHLDIAGSASNEGKRGMATGRPVG
LLTQWLVDRC

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=325, Percent_Identity=41.8461538461538, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI47155554, Length=355, Percent_Identity=32.112676056338, Blast_Score=132, Evalue=8e-31,
Organism=Escherichia coli, GI1790710, Length=498, Percent_Identity=47.1887550200803, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI87082123, Length=294, Percent_Identity=38.0952380952381, Blast_Score=172, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17556903, Length=309, Percent_Identity=35.9223300970874, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=252, Percent_Identity=34.9206349206349, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24661038, Length=492, Percent_Identity=32.1138211382114, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI21355725, Length=494, Percent_Identity=32.3886639676113, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI20129969, Length=492, Percent_Identity=28.2520325203252, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI21355645, Length=493, Percent_Identity=27.5862068965517, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24662223, Length=493, Percent_Identity=27.5862068965517, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI19922386, Length=486, Percent_Identity=29.8353909465021, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24662227, Length=492, Percent_Identity=28.0487804878049, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI161077148, Length=494, Percent_Identity=28.3400809716599, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI20130057, Length=494, Percent_Identity=28.3400809716599, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI20129963, Length=494, Percent_Identity=26.3157894736842, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI21357381, Length=263, Percent_Identity=36.5019011406844, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI221379063, Length=263, Percent_Identity=36.5019011406844, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI221379062, Length=263, Percent_Identity=36.5019011406844, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646701, Length=178, Percent_Identity=35.9550561797753, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24646703, Length=178, Percent_Identity=35.9550561797753, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21358201, Length=178, Percent_Identity=35.9550561797753, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_XYLF2 (B2I6L3)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001828829.1
- ProteinModelPortal:   B2I6L3
- SMR:   B2I6L3
- GeneID:   6203128
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_0098
- HOGENOM:   HBG742580
- OMA:   LGHHISG
- ProtClustDB:   PRK00913
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 51670; Mature: 51538

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 276-276 ACT_SITE 350-350

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALQFQLNQTTPQTVTTDCVIVGIYADKTLSPTAKTLDAASGGRITALTARGDLTGKSGT
CEEEEEECCCCCCEEECCEEEEEEEECCCCCCCHHHHHCCCCCEEEEEEECCCCCCCCCC
SALLHDLNGVTAPRVLVVGLGEADKFGAGQYIKAVGNAVRALKDAPVTHALLTLSELPVK
HHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DRNAAWNIHQAVIAADHAAYRYTATLGTSRKKAEESGLITLAIHGQETSGLTLGQAIAEG
CCCCCCHHHHHHHEECCCCEEEEEECCCCHHHHHHCCEEEEEEECCCCCCCCHHHHHHHH
VEYARALGNLPPNICTPAYLAETTAHFAATHPGATCEILDESNMEALGMGALLAVARGSA
HHHHHHHCCCCCCCCCCHHHHHHHHHHEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCC
NRPRLIVLKWNGGGDARPYVLVGKGITFDTGGVNLKTQGGIEEMKYDMCGGAAVIGTFVA
CCCEEEEEEECCCCCCCCEEEEECCEEECCCCEEEEECCCHHHHHHHHCCCHHHHHHHHH
AVKVRLPLNLIVIVPAVENAIDGNAYRPSDVITSMSGKTIEVGNTDAEGRLILCDALTYA
HHHEECCEEEEEEEECHHCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCCEEEEEHHHHH
ERFKPEALIDVATLTGACMIALGRAATGLMTHHDDLANELLTAGEHVHDRAWRLPLWDEY
HHCCCHHHEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHEECCCCHHHH
QGLLDSTFADVYNIGGRWGGAITAGCFLSRFTEGQRWAHLDIAGSASNEGKRGMATGRPV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCH
GLLTQWLVDRC
HHHHHHHHHCC
>Mature Secondary Structure 
ALQFQLNQTTPQTVTTDCVIVGIYADKTLSPTAKTLDAASGGRITALTARGDLTGKSGT
EEEEEECCCCCCEEECCEEEEEEEECCCCCCCHHHHHCCCCCEEEEEEECCCCCCCCCC
SALLHDLNGVTAPRVLVVGLGEADKFGAGQYIKAVGNAVRALKDAPVTHALLTLSELPVK
HHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DRNAAWNIHQAVIAADHAAYRYTATLGTSRKKAEESGLITLAIHGQETSGLTLGQAIAEG
CCCCCCHHHHHHHEECCCCEEEEEECCCCHHHHHHCCEEEEEEECCCCCCCCHHHHHHHH
VEYARALGNLPPNICTPAYLAETTAHFAATHPGATCEILDESNMEALGMGALLAVARGSA
HHHHHHHCCCCCCCCCCHHHHHHHHHHEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCC
NRPRLIVLKWNGGGDARPYVLVGKGITFDTGGVNLKTQGGIEEMKYDMCGGAAVIGTFVA
CCCEEEEEEECCCCCCCCEEEEECCEEECCCCEEEEECCCHHHHHHHHCCCHHHHHHHHH
AVKVRLPLNLIVIVPAVENAIDGNAYRPSDVITSMSGKTIEVGNTDAEGRLILCDALTYA
HHHEECCEEEEEEEECHHCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCCEEEEEHHHHH
ERFKPEALIDVATLTGACMIALGRAATGLMTHHDDLANELLTAGEHVHDRAWRLPLWDEY
HHCCCHHHEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHEECCCCHHHH
QGLLDSTFADVYNIGGRWGGAITAGCFLSRFTEGQRWAHLDIAGSASNEGKRGMATGRPV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCH
GLLTQWLVDRC
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA