Click here to switch to the map view.

The map label for this gene is gyaR [H]

Identifier: 182677506

GI number: 182677506

Start: 565360

End: 566355

Strand: Direct

Name: gyaR [H]

Synonym: Bind_0511

Alternate gene names: 182677506

Gene position: 565360-566355 (Clockwise)

Preceding gene: 182677504

Following gene: 182677507

Centisome position: 13.56

GC content: 59.94

Gene sequence:

>996_bases
ATGGTGAGAAAGAAGCCTCTCGTCGTCTTGACCCGGAAATTGCCGGACGTCATCGAGACACGGATGTGTGAGCTGTTCAA
CACGCAGCTCAACCTCGACGATACGCCGATGGATAAGGAGGCCTTGGCCAAGGCGCTCGCGACAGCGGACGTCCTGGTGC
CGACCGTGACTGACCGGATCGATGCGGAATTACTCGCTGTGGCCGGGCCGCAATTGCAATTGATCGCCAATTTCGGCAAT
GGCGTCGATAATATCGATGTGAATGCCGCGCTCGAACGCGGTCTGACTGTGACCAATACGCCGGGCGTGTTGACCGAAGA
CACGGCCGATATGACGATGGCATTGATCCTCGCGGTGGCGCGCCGGCTTGTCGAGGGCTCGCGGATCATTCCCGAAAGTG
AATGGGATGGCTGGTCGCCAACCTGGATGCTGGGGCGGCGCATTACCGGCAAGAGACTAGGCATTATCGGCATGGGGCGT
ATCGGCCAGGCCCTTGCTCGCCGCGCCAAGGCTTTCGGTTTGCAGATTCATTACCACAATCGTCGCAAGGTCGCGGCGCA
GGTGGAAGAGACGCTTGAGGCGACTTATTGGGACTCGCTGGACCAGATGCTGGCGCGCATGGATATCGTTTCGATCAATT
GCCCCCATACACCGGCGACTTACCATCTTCTCTCGGCGCGGCGTCTCAGCCATTTGCAGCCGCATTCGATCCTCGTCAAT
ACGGCACGCGGCGAGCTGATCGACGAAGCCGCGCTGACTCGTATGCTGGAGGCAGGTCAGATCGCTGGAGCGGGGCTCGA
TGTCTTCGAGCACGAGCCGGCCGTCTCGACCAAATTGATCCGGCTTGCCAAGGCGGGCAAGGTCACGCTCCTGCCGCATA
TGGGTTCGGCGACGACCGAGGGGCGCATCGACATGGGCGAGAAAGTGTTGATCAATATCAAGACCTTCATGGACGGTCAC
CGGCCGCCGGACAGGGTTTTGCCGGGGATGCTTTAA

Upstream 100 bases:

>100_bases
CGACGTCGATGGTTAAAGTGGTGTGAAAGCCTGCGGCGGAACGGGACCGGCGCGGGTCGTTCCTGATCAAACCCGGAAAG
ATCGCGGCGCGGGAAAAACA

Downstream 100 bases:

>100_bases
TCCCTGTCGCGATTGAGGTTCGGACTGGCTCTTGAAGCACTGATTGCAAGCGCCATATATGCCCAAGGGCGATGCCGGAA
GGGTCGCCCAACGAAGGCCA

Product: glyoxylate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MVRKKPLVVLTRKLPDVIETRMCELFNTQLNLDDTPMDKEALAKALATADVLVPTVTDRIDAELLAVAGPQLQLIANFGN
GVDNIDVNAALERGLTVTNTPGVLTEDTADMTMALILAVARRLVEGSRIIPESEWDGWSPTWMLGRRITGKRLGIIGMGR
IGQALARRAKAFGLQIHYHNRRKVAAQVEETLEATYWDSLDQMLARMDIVSINCPHTPATYHLLSARRLSHLQPHSILVN
TARGELIDEAALTRMLEAGQIAGAGLDVFEHEPAVSTKLIRLAKAGKVTLLPHMGSATTEGRIDMGEKVLINIKTFMDGH
RPPDRVLPGML

Sequences:

>Translated_331_residues
MVRKKPLVVLTRKLPDVIETRMCELFNTQLNLDDTPMDKEALAKALATADVLVPTVTDRIDAELLAVAGPQLQLIANFGN
GVDNIDVNAALERGLTVTNTPGVLTEDTADMTMALILAVARRLVEGSRIIPESEWDGWSPTWMLGRRITGKRLGIIGMGR
IGQALARRAKAFGLQIHYHNRRKVAAQVEETLEATYWDSLDQMLARMDIVSINCPHTPATYHLLSARRLSHLQPHSILVN
TARGELIDEAALTRMLEAGQIAGAGLDVFEHEPAVSTKLIRLAKAGKVTLLPHMGSATTEGRIDMGEKVLINIKTFMDGH
RPPDRVLPGML
>Mature_331_residues
MVRKKPLVVLTRKLPDVIETRMCELFNTQLNLDDTPMDKEALAKALATADVLVPTVTDRIDAELLAVAGPQLQLIANFGN
GVDNIDVNAALERGLTVTNTPGVLTEDTADMTMALILAVARRLVEGSRIIPESEWDGWSPTWMLGRRITGKRLGIIGMGR
IGQALARRAKAFGLQIHYHNRRKVAAQVEETLEATYWDSLDQMLARMDIVSINCPHTPATYHLLSARRLSHLQPHSILVN
TARGELIDEAALTRMLEAGQIAGAGLDVFEHEPAVSTKLIRLAKAGKVTLLPHMGSATTEGRIDMGEKVLINIKTFMDGH
RPPDRVLPGML

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=300, Percent_Identity=31.3333333333333, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI23308577, Length=283, Percent_Identity=29.3286219081272, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI61743967, Length=260, Percent_Identity=35.3846153846154, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI4557497, Length=260, Percent_Identity=35.3846153846154, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI145580578, Length=258, Percent_Identity=34.1085271317829, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4557499, Length=258, Percent_Identity=34.1085271317829, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI145580575, Length=258, Percent_Identity=34.1085271317829, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI87082289, Length=327, Percent_Identity=37.6146788990826, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1789279, Length=256, Percent_Identity=30.078125, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1787645, Length=258, Percent_Identity=29.0697674418605, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1788660, Length=292, Percent_Identity=25.3424657534247, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87081824, Length=279, Percent_Identity=25.089605734767, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=286, Percent_Identity=29.7202797202797, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25147481, Length=257, Percent_Identity=29.9610894941634, Blast_Score=111, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=264, Percent_Identity=36.3636363636364, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320925, Length=258, Percent_Identity=30.2325581395349, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6322116, Length=258, Percent_Identity=29.4573643410853, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=276, Percent_Identity=28.9855072463768, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321253, Length=163, Percent_Identity=32.5153374233129, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=175, Percent_Identity=30.8571428571429, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=149, Percent_Identity=28.8590604026846, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28571528, Length=319, Percent_Identity=35.423197492163, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI28574286, Length=310, Percent_Identity=32.9032258064516, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI45551003, Length=285, Percent_Identity=34.0350877192982, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI28574284, Length=285, Percent_Identity=34.0350877192982, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45552429, Length=285, Percent_Identity=34.0350877192982, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24585514, Length=285, Percent_Identity=34.0350877192982, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28574282, Length=285, Percent_Identity=34.0350877192982, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI19921140, Length=270, Percent_Identity=32.2222222222222, Blast_Score=141, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24646446, Length=210, Percent_Identity=38.0952380952381, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24646448, Length=210, Percent_Identity=38.0952380952381, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24646452, Length=210, Percent_Identity=38.0952380952381, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24646450, Length=210, Percent_Identity=38.0952380952381, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI62472511, Length=210, Percent_Identity=38.0952380952381, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24585516, Length=302, Percent_Identity=27.8145695364238, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36320; Mature: 36320

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRKKPLVVLTRKLPDVIETRMCELFNTQLNLDDTPMDKEALAKALATADVLVPTVTDRI
CCCCCCCEEEEHHCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DAELLAVAGPQLQLIANFGNGVDNIDVNAALERGLTVTNTPGVLTEDTADMTMALILAVA
CHHHHEECCCCEEEEEECCCCCCCCCHHHHHHCCCEEECCCCCEECCHHHHHHHHHHHHH
RRLVEGSRIIPESEWDGWSPTWMLGRRITGKRLGIIGMGRIGQALARRAKAFGLQIHYHN
HHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCEECEEECCHHHHHHHHHHHHHEEEEEECC
RRKVAAQVEETLEATYWDSLDQMLARMDIVSINCPHTPATYHLLSARRLSHLQPHSILVN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEE
TARGELIDEAALTRMLEAGQIAGAGLDVFEHEPAVSTKLIRLAKAGKVTLLPHMGSATTE
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCC
GRIDMGEKVLINIKTFMDGHRPPDRVLPGML
CCCCCCCEEEEEEHHHHCCCCCHHHCCCCCC
>Mature Secondary Structure
MVRKKPLVVLTRKLPDVIETRMCELFNTQLNLDDTPMDKEALAKALATADVLVPTVTDRI
CCCCCCCEEEEHHCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DAELLAVAGPQLQLIANFGNGVDNIDVNAALERGLTVTNTPGVLTEDTADMTMALILAVA
CHHHHEECCCCEEEEEECCCCCCCCCHHHHHHCCCEEECCCCCEECCHHHHHHHHHHHHH
RRLVEGSRIIPESEWDGWSPTWMLGRRITGKRLGIIGMGRIGQALARRAKAFGLQIHYHN
HHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCEECEEECCHHHHHHHHHHHHHEEEEEECC
RRKVAAQVEETLEATYWDSLDQMLARMDIVSINCPHTPATYHLLSARRLSHLQPHSILVN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEE
TARGELIDEAALTRMLEAGQIAGAGLDVFEHEPAVSTKLIRLAKAGKVTLLPHMGSATTE
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCC
GRIDMGEKVLINIKTFMDGHRPPDRVLPGML
CCCCCCCEEEEEEHHHHCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA