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The map label for this gene is cobC [H]

Identifier: 182677385

GI number: 182677385

Start: 448356

End: 449366

Strand: Direct

Name: cobC [H]

Synonym: Bind_0389

Alternate gene names: 182677385

Gene position: 448356-449366 (Clockwise)

Preceding gene: 182677383

Following gene: 182677386

Centisome position: 10.75

GC content: 60.63

Gene sequence:

>1011_bases
TTGGCTGTTTGCGGCCATGGTGGCAATCTGGCGCTGGCGGCAGAATTGTTCCCTGGCGCACCGCAGCCCTGGCTCGATCT
TTCGACTGGTCTCAATCCCTTCGCCTATCCGTTCCAAATGCCCGATGAGCATTCGTTCACGCGCTTGCCCGACTTACCCG
AAGCTCTGGAGGCTTGTGCCGCACGGGCCTATGAGGCTCCTCCCCCTATTCAGATCGTTGCCGCTCCTGGATCGCAGGCG
CTGATCCAGGCTTTGCCCAGGCTCCATCGCTTGGATGGCAAGCCGAGCCCCCGGATCGGTATTCTCGGGATGACCTATGC
CGAGCATGCCTTGAACTGGCGGGCGGTTGGAGCGCGGGTGCAGGAGGATATGGACTTGGATGCCCTCGCGACAATGGATG
TCGCGATCGTCGTCAATCCGAATAATCCTGACGGTCGTCTCCTGCCTCCAGCCGCTCTGCTCGACTTGGCCGCGCGTCTT
TCCAAGCATGGCGGTTTGCTGATTGTCGACGAGGCGTTCATGGATTTCGAGGCGCCAGAGACGCATTTTGTGCCTGTCAT
GCCAGAAAATGGTGTTCTCGTTCTGCGCTCTTTCGGCAAGGCCTATGGACTGGGCGGTCTGCGGCTTGGTTTCGCGTTGA
CCGGCCCCAAATTGGCGGCGGATTTACGGGCCTGGTTTGGACCTTGGGCTGTCTCGGGGCCTGCGATTGCCATCGGGCGA
CAGGCCTTGGGGGATTCTCTTTGGCTCGTCGAGGCGCGCAAACGGCTTGAGACGATGGGGACGGCCTTGGATCGTCTGCT
ATGTGAGGCCGGTTTTGCGGTTTTGGGGGGAACGAGACTTTATCGTCTCGTCACGCATGAAAAGGCTGCGGCCTGGTTCG
CCCGGCTCGGCGAGGCTGGCATATTCGTCCGGCGTTTCGCCGAGCGCCCGCTATGGCTGCGTTTCGGTATTCCAGGCGAT
GCACCGGCTTTGTCGCGTCTTGCCGAGGCTTTGAAAGTGGGGATAAGATGA

Upstream 100 bases:

>100_bases
CGCGAGGGCGAGTGGGGCGAGCAGCCAAGGATGAGAGAGAGAAGGGAACAGGGACATCGAAACCGGGATACAACAGAACG
GGCCAGCGGGCGCAAAAGTT

Downstream 100 bases:

>100_bases
CGACCATGCCTGCCTAAGTAATAAAGCGCAGGAGGTAGCTTTTTTATAATAATTCTAATTAAAAAGATTGATCTCATGCA
GAAAAGTGCAGCAAGGATGA

Product: L-threonine-O-3-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAVCGHGGNLALAAELFPGAPQPWLDLSTGLNPFAYPFQMPDEHSFTRLPDLPEALEACAARAYEAPPPIQIVAAPGSQA
LIQALPRLHRLDGKPSPRIGILGMTYAEHALNWRAVGARVQEDMDLDALATMDVAIVVNPNNPDGRLLPPAALLDLAARL
SKHGGLLIVDEAFMDFEAPETHFVPVMPENGVLVLRSFGKAYGLGGLRLGFALTGPKLAADLRAWFGPWAVSGPAIAIGR
QALGDSLWLVEARKRLETMGTALDRLLCEAGFAVLGGTRLYRLVTHEKAAAWFARLGEAGIFVRRFAERPLWLRFGIPGD
APALSRLAEALKVGIR

Sequences:

>Translated_336_residues
MAVCGHGGNLALAAELFPGAPQPWLDLSTGLNPFAYPFQMPDEHSFTRLPDLPEALEACAARAYEAPPPIQIVAAPGSQA
LIQALPRLHRLDGKPSPRIGILGMTYAEHALNWRAVGARVQEDMDLDALATMDVAIVVNPNNPDGRLLPPAALLDLAARL
SKHGGLLIVDEAFMDFEAPETHFVPVMPENGVLVLRSFGKAYGLGGLRLGFALTGPKLAADLRAWFGPWAVSGPAIAIGR
QALGDSLWLVEARKRLETMGTALDRLLCEAGFAVLGGTRLYRLVTHEKAAAWFARLGEAGIFVRRFAERPLWLRFGIPGD
APALSRLAEALKVGIR
>Mature_335_residues
AVCGHGGNLALAAELFPGAPQPWLDLSTGLNPFAYPFQMPDEHSFTRLPDLPEALEACAARAYEAPPPIQIVAAPGSQAL
IQALPRLHRLDGKPSPRIGILGMTYAEHALNWRAVGARVQEDMDLDALATMDVAIVVNPNNPDGRLLPPAALLDLAARLS
KHGGLLIVDEAFMDFEAPETHFVPVMPENGVLVLRSFGKAYGLGGLRLGFALTGPKLAADLRAWFGPWAVSGPAIAIGRQ
ALGDSLWLVEARKRLETMGTALDRLLCEAGFAVLGGTRLYRLVTHEKAAAWFARLGEAGIFVRRFAERPLWLRFGIPGDA
PALSRLAEALKVGIR

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=302, Percent_Identity=26.8211920529801, Blast_Score=78, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 36107; Mature: 35976

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVCGHGGNLALAAELFPGAPQPWLDLSTGLNPFAYPFQMPDEHSFTRLPDLPEALEACA
CEEECCCCCEEEEEEECCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
ARAYEAPPPIQIVAAPGSQALIQALPRLHRLDGKPSPRIGILGMTYAEHALNWRAVGARV
HHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHCCHHHHCCHH
QEDMDLDALATMDVAIVVNPNNPDGRLLPPAALLDLAARLSKHGGLLIVDEAFMDFEAPE
HCCCCCHHEEEEEEEEEECCCCCCCCEECHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCC
THFVPVMPENGVLVLRSFGKAYGLGGLRLGFALTGPKLAADLRAWFGPWAVSGPAIAIGR
CCEEEECCCCCEEEEEEHHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHH
QALGDSLWLVEARKRLETMGTALDRLLCEAGFAVLGGTRLYRLVTHEKAAAWFARLGEAG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHCCCH
IFVRRFAERPLWLRFGIPGDAPALSRLAEALKVGIR
HHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVCGHGGNLALAAELFPGAPQPWLDLSTGLNPFAYPFQMPDEHSFTRLPDLPEALEACA
EEECCCCCEEEEEEECCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
ARAYEAPPPIQIVAAPGSQALIQALPRLHRLDGKPSPRIGILGMTYAEHALNWRAVGARV
HHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHCCHHHHCCHH
QEDMDLDALATMDVAIVVNPNNPDGRLLPPAALLDLAARLSKHGGLLIVDEAFMDFEAPE
HCCCCCHHEEEEEEEEEECCCCCCCCEECHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCC
THFVPVMPENGVLVLRSFGKAYGLGGLRLGFALTGPKLAADLRAWFGPWAVSGPAIAIGR
CCEEEECCCCCEEEEEEHHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHH
QALGDSLWLVEARKRLETMGTALDRLLCEAGFAVLGGTRLYRLVTHEKAAAWFARLGEAG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHCCCH
IFVRRFAERPLWLRFGIPGDAPALSRLAEALKVGIR
HHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211520 [H]