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The map label for this gene is cobQ

Identifier: 182677383

GI number: 182677383

Start: 445849

End: 447315

Strand: Direct

Name: cobQ

Synonym: Bind_0387

Alternate gene names: 182677383

Gene position: 445849-447315 (Clockwise)

Preceding gene: 182677382

Following gene: 182677385

Centisome position: 10.69

GC content: 58.76

Gene sequence:

>1467_bases
ATGGCCAAAGCTTTGATGCTGCAGGGGACGGGCTCCGATGTCGGCAAGACGCTGATCGTCGCCGGGCTCTGTCGGGCCTA
TATGCGGCGCGGTCTCCGTGTGCGTCCTTTCAAGCCACAGAATATGTCGAACAATGCCGCCGTGACACTCGATGGAGGAG
AGATCGGCCGGGCTCAGGCGCTGCAGGCGCAAGCGTGTGGCGTACCGCCCTCGGTCCATATGAATCCGGTGCTTTTGAAG
CCGCAGAGCGGCACCGGCTCGCAGATCATTCTGCAAGGCCGCCTCAGCGGTCAGGCCGAGGCGCGCACCTATCAGGCGAT
GAAAAAGCACTGGCTCGCAATCGTGCTGGAGAGTTTTCAGCATTTGAAGGATGAAGCCGATCTCGTTCTGGTGGAAGGCG
CCGGGAGCGCATCCGAAATCAATCTGCGGGCCAATGACATTGCCAATATGGGATTTGCCCGTGCTGCTGATGTGCCGGTG
ATTGTCATCGGTGACATTGATCGCGGGGGTGTCATTGCCCAGATCGCGGGAACGAAATTGGTGATTACGCCGCAGGATGC
GGAGATGGTCGTCGGGTTTCTCGTCAATCGGTTTCGGGGCGATCCGGATTTGTTCAAGGAAGGGATGCGCCAGATTGAGC
ATTTTTCCGGCTGGCGCGGGCTGGGCCTCATTCCCCATTGTCCCGCCGCGCGCGATCTGCCGGCCGAGGATGCCATGGCG
CTTGGCCGTCATCTGAATGGGGAAAGGTCGGCGCATACAAAGTTCAAGATCGTTGTCCCGGTTTTGCCGGGCATTGCCAA
TTTCGATGACCTCGATCCTTTACGCATGGAGCGGGGCGTCGAACTGATCATGATACGGCCGGGCACCTATCTGCCTGTCG
AGGCCGATCTTGTTCTGCTCATCGGTTCCAAGACGACGATTGCCGATCTCGTAGCTTTTCGGGAGGCTGGTTGGGATGTG
GATCTTGCCGCTTATGTGCGGCGCGGCGGCAAAGTTTTTGGTCTTTGCGGTGGCTATCAAATGCTGGGCGAAAATTTGCG
CGATCCCTTGGGCTTGGAGGGGCCTCCGAGCGAGGTGCGCGGCCTTGGCTTGTTGGCTCTTGAAACAGTCTTCACACAGG
AAAAAACATTGGTTGCTGTCGAGGGCGTGAGCCTGCCCGATGAAGTGCCCTTTACTGGCTTCGAAATGCATGTGGGCCAT
ACATCAGGGGATGATTGCGCCCGGCCCTTTCTGCGTTTGACCGATGGCCGGCAGGATGGCGCGGTTTCAAAGGATGGGCG
TATCGCCGGCTGTTATGTGCATGGCCTGTTTGGCATGGATACGCAGCGGCGCGCCTTCCTGGCGCGCTTTGGTGTCGCGG
CTGGGGATTTCTCTTATCTGGAAAAGGTCGAGGCGGCGCTCGATGCCGTCGCAGATCATTTGGCCCAGCATATCGATCTC
GACCATTTGCTTACGCTAGCGCGATGA

Upstream 100 bases:

>100_bases
TCTCGTGACCGAAATGGGGCTTGTCAAACATCCTTTTGCGGCGGGGGTTCGGGCTCAGGCCGGCATTGAGTTTTGATCAG
GATGAGGCACGAAGACGATC

Downstream 100 bases:

>100_bases
CCAGGCAAAGGAGGGTGAGACCAGCGCCATTGAGGAAACAGGCCAGACGATAAAGCGTGAGTGCCCGGCCGAGATCGGTC
TGTGTCATCGGTGCCATGCC

Product: cobyric acid synthase CobQ

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MAKALMLQGTGSDVGKTLIVAGLCRAYMRRGLRVRPFKPQNMSNNAAVTLDGGEIGRAQALQAQACGVPPSVHMNPVLLK
PQSGTGSQIILQGRLSGQAEARTYQAMKKHWLAIVLESFQHLKDEADLVLVEGAGSASEINLRANDIANMGFARAADVPV
IVIGDIDRGGVIAQIAGTKLVITPQDAEMVVGFLVNRFRGDPDLFKEGMRQIEHFSGWRGLGLIPHCPAARDLPAEDAMA
LGRHLNGERSAHTKFKIVVPVLPGIANFDDLDPLRMERGVELIMIRPGTYLPVEADLVLLIGSKTTIADLVAFREAGWDV
DLAAYVRRGGKVFGLCGGYQMLGENLRDPLGLEGPPSEVRGLGLLALETVFTQEKTLVAVEGVSLPDEVPFTGFEMHVGH
TSGDDCARPFLRLTDGRQDGAVSKDGRIAGCYVHGLFGMDTQRRAFLARFGVAAGDFSYLEKVEAALDAVADHLAQHIDL
DHLLTLAR

Sequences:

>Translated_488_residues
MAKALMLQGTGSDVGKTLIVAGLCRAYMRRGLRVRPFKPQNMSNNAAVTLDGGEIGRAQALQAQACGVPPSVHMNPVLLK
PQSGTGSQIILQGRLSGQAEARTYQAMKKHWLAIVLESFQHLKDEADLVLVEGAGSASEINLRANDIANMGFARAADVPV
IVIGDIDRGGVIAQIAGTKLVITPQDAEMVVGFLVNRFRGDPDLFKEGMRQIEHFSGWRGLGLIPHCPAARDLPAEDAMA
LGRHLNGERSAHTKFKIVVPVLPGIANFDDLDPLRMERGVELIMIRPGTYLPVEADLVLLIGSKTTIADLVAFREAGWDV
DLAAYVRRGGKVFGLCGGYQMLGENLRDPLGLEGPPSEVRGLGLLALETVFTQEKTLVAVEGVSLPDEVPFTGFEMHVGH
TSGDDCARPFLRLTDGRQDGAVSKDGRIAGCYVHGLFGMDTQRRAFLARFGVAAGDFSYLEKVEAALDAVADHLAQHIDL
DHLLTLAR
>Mature_487_residues
AKALMLQGTGSDVGKTLIVAGLCRAYMRRGLRVRPFKPQNMSNNAAVTLDGGEIGRAQALQAQACGVPPSVHMNPVLLKP
QSGTGSQIILQGRLSGQAEARTYQAMKKHWLAIVLESFQHLKDEADLVLVEGAGSASEINLRANDIANMGFARAADVPVI
VIGDIDRGGVIAQIAGTKLVITPQDAEMVVGFLVNRFRGDPDLFKEGMRQIEHFSGWRGLGLIPHCPAARDLPAEDAMAL
GRHLNGERSAHTKFKIVVPVLPGIANFDDLDPLRMERGVELIMIRPGTYLPVEADLVLLIGSKTTIADLVAFREAGWDVD
LAAYVRRGGKVFGLCGGYQMLGENLRDPLGLEGPPSEVRGLGLLALETVFTQEKTLVAVEGVSLPDEVPFTGFEMHVGHT
SGDDCARPFLRLTDGRQDGAVSKDGRIAGCYVHGLFGMDTQRRAFLARFGVAAGDFSYLEKVEAALDAVADHLAQHIDLD
HLLTLAR

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_BEII9 (B2IE16)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001831529.1
- ProteinModelPortal:   B2IE16
- GeneID:   6199098
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_0387
- HOGENOM:   HBG302271
- OMA:   RGDIANM
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 52520; Mature: 52389

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 336-336 ACT_SITE 434-434

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKALMLQGTGSDVGKTLIVAGLCRAYMRRGLRVRPFKPQNMSNNAAVTLDGGEIGRAQA
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEECCCCCCHHHH
LQAQACGVPPSVHMNPVLLKPQSGTGSQIILQGRLSGQAEARTYQAMKKHWLAIVLESFQ
HHHHHCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
HLKDEADLVLVEGAGSASEINLRANDIANMGFARAADVPVIVIGDIDRGGVIAQIAGTKL
HHCCCCCEEEEECCCCCCEEEEEHHHHHHCCCCHHCCCCEEEEECCCCCCEEEEECCCEE
VITPQDAEMVVGFLVNRFRGDPDLFKEGMRQIEHFSGWRGLGLIPHCPAARDLPAEDAMA
EECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
LGRHLNGERSAHTKFKIVVPVLPGIANFDDLDPLRMERGVELIMIRPGTYLPVEADLVLL
HHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCEEEE
IGSKTTIADLVAFREAGWDVDLAAYVRRGGKVFGLCGGYQMLGENLRDPLGLEGPPSEVR
ECCCHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCHHHHHHHCCCCCCCCCCHHHHH
GLGLLALETVFTQEKTLVAVEGVSLPDEVPFTGFEMHVGHTSGDDCARPFLRLTDGRQDG
CCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHEECCCCCCC
AVSKDGRIAGCYVHGLFGMDTQRRAFLARFGVAAGDFSYLEKVEAALDAVADHLAQHIDL
CCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCH
DHLLTLAR
HHHHHHCC
>Mature Secondary Structure 
AKALMLQGTGSDVGKTLIVAGLCRAYMRRGLRVRPFKPQNMSNNAAVTLDGGEIGRAQA
CCEEEEECCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEECCCCCCHHHH
LQAQACGVPPSVHMNPVLLKPQSGTGSQIILQGRLSGQAEARTYQAMKKHWLAIVLESFQ
HHHHHCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
HLKDEADLVLVEGAGSASEINLRANDIANMGFARAADVPVIVIGDIDRGGVIAQIAGTKL
HHCCCCCEEEEECCCCCCEEEEEHHHHHHCCCCHHCCCCEEEEECCCCCCEEEEECCCEE
VITPQDAEMVVGFLVNRFRGDPDLFKEGMRQIEHFSGWRGLGLIPHCPAARDLPAEDAMA
EECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
LGRHLNGERSAHTKFKIVVPVLPGIANFDDLDPLRMERGVELIMIRPGTYLPVEADLVLL
HHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCEEEE
IGSKTTIADLVAFREAGWDVDLAAYVRRGGKVFGLCGGYQMLGENLRDPLGLEGPPSEVR
ECCCHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCHHHHHHHCCCCCCCCCCHHHHH
GLGLLALETVFTQEKTLVAVEGVSLPDEVPFTGFEMHVGHTSGDDCARPFLRLTDGRQDG
CCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHEECCCCCCC
AVSKDGRIAGCYVHGLFGMDTQRRAFLARFGVAAGDFSYLEKVEAALDAVADHLAQHIDL
CCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCH
DHLLTLAR
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA