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The map label for this gene is hisC

Identifier: 182677304

GI number: 182677304

Start: 351685

End: 352821

Strand: Direct

Name: hisC

Synonym: Bind_0307

Alternate gene names: 182677304

Gene position: 351685-352821 (Clockwise)

Preceding gene: 182677303

Following gene: 182677305

Centisome position: 8.43

GC content: 60.69

Gene sequence:

>1137_bases
ATGACCCAATCCGGCTCCTCGCCCCGTCCCTCGTCCGTGCGTCCGATGCCGCATGCGGGCGTTCTTGGCATTGAGCCCTA
TGTTCCGGGCAAGAGCGCCGCGCCGGGTGTGGCGAAAATCCACAAGCTGTCCTCCAACGAAACGCCGCTTGGTCCTTCGC
CCGAGGCGCAAAAGGCCTTTGCCGCCAGTGCCGAAAAGCTTGCCCTTTATCCAGATGGCGCGGCCACGCTTTTGCGCACG
GCCATCGCTTCCCGCCATGGGCTCGATCCGGCGCGGATCGTCTGCGGCGCGGGTTCGGATGAATTGCTTTCGCTTCTTGC
CGCCGTCTATCTCGGCCCCGGCGAAGAGGGAATTTTCACCGAGCATGGTTTTCTCGTCTATAAAATCGCGATTCTGACCG
CTGGCGGCACGCCCATCGTCGTGCCCGAGAAGGATCTCACCACCGATGTGGACGCGATTCTCGCCGCCGTCACGCCGCGG
ACACGGATCGTCTATATCGCCAATCCGAACAATCCGACCGGCACCTATCTGCCCTTTGCCGAGGTCAAAAGACTGGCGAC
GAGCCTGCCGCCGAACGTGCTGCTCGTGCTCGATGCTGCCTATGGGGAATATGTGACGCGCAATGATTATTCCGCCGGGC
TCGAACTCGTTTCGACCCATGAGAATGTCGTGATGACCCGCACCTTCTCCAAAATCTATGGGCTCGCGGCTTTGCGGCTT
GGCTGGTGCTACGCGCCTCTTGCTGTGGCCGATGCGTTGAACCGGGTGCGCGGGCCCTTTAACACCAGTGGTCCGGCTAT
CGCGACGGGCGTCGCGGCTCTGGCCGATCAGGCGCATATCGACCGGGCGATTGCTCATAACGAGACCTGGCTGTCCTGGC
TCGGCGAGGAAATCGGGAAACTTGGATTTAAAGTCACGCCAAGCGTTGCCAATTTTCTCCTGCTGCATTTCGAGGATCAG
GCCGAGGCCCAGGCTGTTGACGCCTTTTTGTCGTCGCGCGGCCTTATTCTGCGGGCTGTGGCTTCCTATGGCCTGCCGAA
TTGTTTGCGCCTGACCGTTGGGACGGAGGAGGCTAATCGGCTTGTCGTAGACGGCTTGAAGGATTTTTGCCGCGAAAGGA
TGAAACAGCGTGGCTGA

Upstream 100 bases:

>100_bases
TTCAAAGCGAGAGCGAAAATTCAAGAGCGGTCCAACGGTCATCTATTGTGACCGTTGGTATTAAAGGCGGTTTCGCCAAA
ACCCTTTTTGGAGTCCTTTC

Downstream 100 bases:

>100_bases
TGGTTTGGGCGCCCGGCTCGAGACGCCCCTGTTCGAGCAATTGACGCTCATCGGCGTTGGTCTGATCGGTTCTTCACTGG
CGCGTGTCGCGAGCCGCAAG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MTQSGSSPRPSSVRPMPHAGVLGIEPYVPGKSAAPGVAKIHKLSSNETPLGPSPEAQKAFAASAEKLALYPDGAATLLRT
AIASRHGLDPARIVCGAGSDELLSLLAAVYLGPGEEGIFTEHGFLVYKIAILTAGGTPIVVPEKDLTTDVDAILAAVTPR
TRIVYIANPNNPTGTYLPFAEVKRLATSLPPNVLLVLDAAYGEYVTRNDYSAGLELVSTHENVVMTRTFSKIYGLAALRL
GWCYAPLAVADALNRVRGPFNTSGPAIATGVAALADQAHIDRAIAHNETWLSWLGEEIGKLGFKVTPSVANFLLLHFEDQ
AEAQAVDAFLSSRGLILRAVASYGLPNCLRLTVGTEEANRLVVDGLKDFCRERMKQRG

Sequences:

>Translated_378_residues
MTQSGSSPRPSSVRPMPHAGVLGIEPYVPGKSAAPGVAKIHKLSSNETPLGPSPEAQKAFAASAEKLALYPDGAATLLRT
AIASRHGLDPARIVCGAGSDELLSLLAAVYLGPGEEGIFTEHGFLVYKIAILTAGGTPIVVPEKDLTTDVDAILAAVTPR
TRIVYIANPNNPTGTYLPFAEVKRLATSLPPNVLLVLDAAYGEYVTRNDYSAGLELVSTHENVVMTRTFSKIYGLAALRL
GWCYAPLAVADALNRVRGPFNTSGPAIATGVAALADQAHIDRAIAHNETWLSWLGEEIGKLGFKVTPSVANFLLLHFEDQ
AEAQAVDAFLSSRGLILRAVASYGLPNCLRLTVGTEEANRLVVDGLKDFCRERMKQRG
>Mature_377_residues
TQSGSSPRPSSVRPMPHAGVLGIEPYVPGKSAAPGVAKIHKLSSNETPLGPSPEAQKAFAASAEKLALYPDGAATLLRTA
IASRHGLDPARIVCGAGSDELLSLLAAVYLGPGEEGIFTEHGFLVYKIAILTAGGTPIVVPEKDLTTDVDAILAAVTPRT
RIVYIANPNNPTGTYLPFAEVKRLATSLPPNVLLVLDAAYGEYVTRNDYSAGLELVSTHENVVMTRTFSKIYGLAALRLG
WCYAPLAVADALNRVRGPFNTSGPAIATGVAALADQAHIDRAIAHNETWLSWLGEEIGKLGFKVTPSVANFLLLHFEDQA
EAQAVDAFLSSRGLILRAVASYGLPNCLRLTVGTEEANRLVVDGLKDFCRERMKQRG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=334, Percent_Identity=27.2455089820359, Blast_Score=98, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6322075, Length=388, Percent_Identity=26.5463917525773, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_BEII9 (B2IDA4)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001831450.1
- ProteinModelPortal:   B2IDA4
- GeneID:   6198408
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_0307
- HOGENOM:   HBG646350
- OMA:   NPANILC
- ProtClustDB:   PRK02731
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40120; Mature: 39989

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSGSSPRPSSVRPMPHAGVLGIEPYVPGKSAAPGVAKIHKLSSNETPLGPSPEAQKAF
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHH
AASAEKLALYPDGAATLLRTAIASRHGLDPARIVCGAGSDELLSLLAAVYLGPGEEGIFT
HCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHEEECCCHHHHHHHHHHHHCCCCCCCCEE
EHGFLVYKIAILTAGGTPIVVPEKDLTTDVDAILAAVTPRTRIVYIANPNNPTGTYLPFA
CCCEEEEEEEEEECCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHH
EVKRLATSLPPNVLLVLDAAYGEYVTRNDYSAGLELVSTHENVVMTRTFSKIYGLAALRL
HHHHHHHCCCCCEEEEEECCCCCCEECCCHHHCCEEEECCCCEEEEEHHHHHHHHHHHHH
GWCYAPLAVADALNRVRGPFNTSGPAIATGVAALADQAHIDRAIAHNETWLSWLGEEIGK
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LGFKVTPSVANFLLLHFEDQAEAQAVDAFLSSRGLILRAVASYGLPNCLRLTVGTEEANR
CCCEECHHHHCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCHHH
LVVDGLKDFCRERMKQRG
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQSGSSPRPSSVRPMPHAGVLGIEPYVPGKSAAPGVAKIHKLSSNETPLGPSPEAQKAF
CCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHH
AASAEKLALYPDGAATLLRTAIASRHGLDPARIVCGAGSDELLSLLAAVYLGPGEEGIFT
HCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHEEECCCHHHHHHHHHHHHCCCCCCCCEE
EHGFLVYKIAILTAGGTPIVVPEKDLTTDVDAILAAVTPRTRIVYIANPNNPTGTYLPFA
CCCEEEEEEEEEECCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHH
EVKRLATSLPPNVLLVLDAAYGEYVTRNDYSAGLELVSTHENVVMTRTFSKIYGLAALRL
HHHHHHHCCCCCEEEEEECCCCCCEECCCHHHCCEEEECCCCEEEEEHHHHHHHHHHHHH
GWCYAPLAVADALNRVRGPFNTSGPAIATGVAALADQAHIDRAIAHNETWLSWLGEEIGK
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LGFKVTPSVANFLLLHFEDQAEAQAVDAFLSSRGLILRAVASYGLPNCLRLTVGTEEANR
CCCEECHHHHCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCHHH
LVVDGLKDFCRERMKQRG
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA