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The map label for this gene is rmlA1 [H]

Identifier: 182677209

GI number: 182677209

Start: 248333

End: 249238

Strand: Direct

Name: rmlA1 [H]

Synonym: Bind_0210

Alternate gene names: 182677209

Gene position: 248333-249238 (Clockwise)

Preceding gene: 182677208

Following gene: 182677210

Centisome position: 5.96

GC content: 55.96

Gene sequence:

>906_bases
ATGAAAGGGATTATCCTCGCGGGTGGGTCAGGCACGCGCCTTTATCCGATTACCCGCGTCGTCTCGAAGCAATTGCTGCC
GGTTTTCGACAAGCCGATGATCTATTATCCGCTGGCCACTTTGATGCTGGCGGGGATCAAGGATTTCTTGATCATTTCGA
CCCCGCGCGACACGCCGCTGTTCGAGCGCCTGCTCGGGGATGGCAAGGACCTCGGCATGTCCTTGACCTATGCCGTGCAG
GATGAACCGCGCGGACTGGCGGAATCCTTCATCATCGGCCGTGACTTTATCGGATCTGATCGTGTGGCCTTGATCCTTGG
TGATAATATTTTTCATGGCCACGGACTGCCGCAAATGCTCCAACAGGCCGTGGCTCGGACCACGGATGCGACGATTTTCG
GCTATCAGGTCACCACCCCGGAGCAATATGGCGTCGTGACGCTCGATCGGACCGGAAAGGCGCTCGATATTGTCGAGAAA
CCCAAAACCTTCCACTCCAATGTCGCCGTCACGGGCCTTTATTTCTATCCCAATGATGTTGTCGATATTGCCGCCAAGAT
CACCCCCTCGGCCCGAGGCGAGCTCGAAATCACCGATGTCAACCGGGCCTATCTCCAACGCGGACAATTATTCGTCGAAA
TGCTCGGACGCGGCTTTGCCTGGCTCGACACGGGCACCCATGCCTCGCTCGTGGAAGCGAGCCATTACATCCAGATCCTT
GAACAAAGGCAGGGAATCCGGGTCGCCTGTATCGAGGAAATCGCGCTGCGGATGGGTTATATCCCCCTGGACCAATTCCA
TGAACTTGCCAAACGCTCGATGAAGAGCAGTTATGGCGAATATCTTCTGGCGATTTACGAAGCCGCGAAAAAAGACCCCA
CATCCTTTGCTCCCTCGATCGCCTGA

Upstream 100 bases:

>100_bases
TTCGCCGTGTCCTATCGACGCCTTTCCATGCATCAAGTAGAAAACAATCATTAATCAGCCCCATAGGGTCGAATCTGCGG
TGCAATGGAAGGACATGGAG

Downstream 100 bases:

>100_bases
GACGGTCTTAAAGCGCGGTCTTGCATGGGACCGGGTAGGGACGGATTCGCGCGGGAAGGCCAGCAAAAGGCTTTTATCTA
GTATTTTTATGGACTACTAT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKGIILAGGSGTRLYPITRVVSKQLLPVFDKPMIYYPLATLMLAGIKDFLIISTPRDTPLFERLLGDGKDLGMSLTYAVQ
DEPRGLAESFIIGRDFIGSDRVALILGDNIFHGHGLPQMLQQAVARTTDATIFGYQVTTPEQYGVVTLDRTGKALDIVEK
PKTFHSNVAVTGLYFYPNDVVDIAAKITPSARGELEITDVNRAYLQRGQLFVEMLGRGFAWLDTGTHASLVEASHYIQIL
EQRQGIRVACIEEIALRMGYIPLDQFHELAKRSMKSSYGEYLLAIYEAAKKDPTSFAPSIA

Sequences:

>Translated_301_residues
MKGIILAGGSGTRLYPITRVVSKQLLPVFDKPMIYYPLATLMLAGIKDFLIISTPRDTPLFERLLGDGKDLGMSLTYAVQ
DEPRGLAESFIIGRDFIGSDRVALILGDNIFHGHGLPQMLQQAVARTTDATIFGYQVTTPEQYGVVTLDRTGKALDIVEK
PKTFHSNVAVTGLYFYPNDVVDIAAKITPSARGELEITDVNRAYLQRGQLFVEMLGRGFAWLDTGTHASLVEASHYIQIL
EQRQGIRVACIEEIALRMGYIPLDQFHELAKRSMKSSYGEYLLAIYEAAKKDPTSFAPSIA
>Mature_301_residues
MKGIILAGGSGTRLYPITRVVSKQLLPVFDKPMIYYPLATLMLAGIKDFLIISTPRDTPLFERLLGDGKDLGMSLTYAVQ
DEPRGLAESFIIGRDFIGSDRVALILGDNIFHGHGLPQMLQQAVARTTDATIFGYQVTTPEQYGVVTLDRTGKALDIVEK
PKTFHSNVAVTGLYFYPNDVVDIAAKITPSARGELEITDVNRAYLQRGQLFVEMLGRGFAWLDTGTHASLVEASHYIQIL
EQRQGIRVACIEEIALRMGYIPLDQFHELAKRSMKSSYGEYLLAIYEAAKKDPTSFAPSIA

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=256, Percent_Identity=26.5625, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI11761621, Length=256, Percent_Identity=26.5625, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI1788351, Length=281, Percent_Identity=62.2775800711744, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1790224, Length=288, Percent_Identity=57.6388888888889, Blast_Score=345, Evalue=2e-96,
Organism=Escherichia coli, GI1788355, Length=275, Percent_Identity=26.1818181818182, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI133931050, Length=230, Percent_Identity=28.2608695652174, Blast_Score=91, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6320148, Length=257, Percent_Identity=29.1828793774319, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21355443, Length=249, Percent_Identity=27.3092369477912, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24644084, Length=249, Percent_Identity=27.3092369477912, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 33294; Mature: 33294

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPITRVVSKQLLPVFDKPMIYYPLATLMLAGIKDFLIISTPRDTPL
CCCEEEECCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCHH
FERLLGDGKDLGMSLTYAVQDEPRGLAESFIIGRDFIGSDRVALILGDNIFHGHGLPQML
HHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCEEEEEECCEECCCCHHHHH
QQAVARTTDATIFGYQVTTPEQYGVVTLDRTGKALDIVEKPKTFHSNVAVTGLYFYPNDV
HHHHHHCCCCEEEEEEECCCCCCCEEEECCCCCEEEHHHCCCHHCCCEEEEEEEECCCHH
VDIAAKITPSARGELEITDVNRAYLQRGQLFVEMLGRGFAWLDTGTHASLVEASHYIQIL
HHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
EQRQGIRVACIEEIALRMGYIPLDQFHELAKRSMKSSYGEYLLAIYEAAKKDPTSFAPSI
HHCCCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
A
C
>Mature Secondary Structure
MKGIILAGGSGTRLYPITRVVSKQLLPVFDKPMIYYPLATLMLAGIKDFLIISTPRDTPL
CCCEEEECCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCHH
FERLLGDGKDLGMSLTYAVQDEPRGLAESFIIGRDFIGSDRVALILGDNIFHGHGLPQML
HHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCEEEEEECCEECCCCHHHHH
QQAVARTTDATIFGYQVTTPEQYGVVTLDRTGKALDIVEKPKTFHSNVAVTGLYFYPNDV
HHHHHHCCCCEEEEEEECCCCCCCEEEECCCCCEEEHHHCCCHHCCCEEEEEEEECCCHH
VDIAAKITPSARGELEITDVNRAYLQRGQLFVEMLGRGFAWLDTGTHASLVEASHYIQIL
HHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
EQRQGIRVACIEEIALRMGYIPLDQFHELAKRSMKSSYGEYLLAIYEAAKKDPTSFAPSI
HHCCCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]