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The map label for this gene is hppA [H]

Identifier: 182677208

GI number: 182677208

Start: 246019

End: 248157

Strand: Direct

Name: hppA [H]

Synonym: Bind_0209

Alternate gene names: 182677208

Gene position: 246019-248157 (Clockwise)

Preceding gene: 182677207

Following gene: 182677209

Centisome position: 5.9

GC content: 60.36

Gene sequence:

>2139_bases
ATGAATCCTTTGTGGTGGATCATTTTTGGCGGATTATTATCCGTAGCCTATGGCATCGTGACATCGAAACAGTTGCTGGA
ACAGCCAGCCGGTTCCTTGCGGATGCAGGAGATTGCCGGAGCGATAGCGGAAGGCGCCAACGCTTATCTCAAGCGCCAAT
ATACAACCATCGCTCTTGTCGGAACCGTGATCTTCGTGGTGCTTGGCCTTCTGCTCTCATGGACGGTCGCCTGGGCCTAC
CTCTTTGGCGCGGTGCTGTCGGGCGCGGCGGGGTTCATCGGCATGAATGTGTCGGTGCGCGCTAATGTCCGCACCGCACA
GGCGGCGTCACAATCGCTCGGCGAGGGACTTGACCTCTCCTTCAAGGCGGGGGCTGTCACCGGCCTGTTGGTCGCGGGCC
TGGCGCTGCTCGGCGTGACCTTGACCTTTTACCTGCTGACGGGTCCCTTGGGCCACGCGCAAGATAGCCGCGAAGTCGTC
AATGCTTTGGTTGGGCTTGGCTTTGGGGCCTCGCTGATCTCGATCTTCGCGCGGCTCGGAGGCGGGATATTCACCAAGGG
CGCTGACGTCGGGGCCGATCTTGTGGGCAAGGTTGAGGCCGGCATTCCTGAGGATGATCCGCGCAATCCAGCCACCATCG
CTGATAATGTCGGCGACAATGTCGGTGATTGCGCCGGCATGGCGGCCGATCTGTTTGAAACCTATGTGGTGACGGTCGTT
GCCACCATGGTGCTCGGCGCGATCTTTTTCGGGGGCGACGCGGTGCTCGCGAGCGCCATGCTTTATCCTTTGGCGATTTG
CGCGACCTGCATCGTCACATCGCTCATCGGCACCGCTTTCGTGAAACTCGGTCTCGATGAGGCGATCATGAGCGCCCTCT
ACAAGGGCTTGATCGCGACCGGACTCCTGACCATTCCGGGGCTCGCTCTCGCCACTTACGCCACGGTCGGTTTCGGCACG
ATCGGCACGGTGCATGGCGTGCCGCTCACAGGGCTCCATCTGTTCTTCTGCGGGCTCATCGGGCTTGCCGTCACCGGTGC
CCTTGTCGTTATTACCGAATATTATACAGGCAGCGGCAAACGGCCGGTGGTTTCGATCGCTCAGGCCTCCGTGACCGGCC
ATGGCACCAATGTCATTCAGGGGCTTGCCGTATCGCTCGAATCGACCGCCTTGCCGGCCCTTGTCATTGCCGCCGGCATT
ATCGCGACCTCGCAACTCGGCGGCCTTTACGGCACGGCGATCGCGGTCACGACCATGCTCGGCCTTGCCGGCATGATTGT
CGCGCTTGATGCTTTTGGCCCTGTCACTGACAATGCCGGCGGCATTGCGGAAATGGCGGGCCTGCCCAAGGAGGTGCGGC
GCGCCACTGATGCGCTCGATGCCGTGGGCAATACCACTAAGGCGGTAACGAAGGGCTATGCGATTGGCTCCGCCGGCCTC
GGGGCACTCGTGTTGTTTGCCGCCTATAGCTACGACCTCGATTATTTCACCAAACATGGCGATGTCTTTTCCTATTTTCG
CAATGTCGGCGTGGTCTCCTTCGATCTCTCCAACCCATATGTGGTTGCCGGCCTGATTTTCGGCGGCCTGATACCTTACC
TCTTCGGCGGCATCGCCATGACGGCCGTCGGTCGGGCGGCGGGCTCTGTTGTCGAGGAAGTGCGGCGGCAATTCCGGGAA
AAGCCCGGCATTATGGAAGGCACTGAAAGGCCGGACTATGGCCGCGCGGTCGATATGCTGACGAAAGCCGCGATCCGCGA
AATGATCATTCCTTCGCTGCTGCCGGTGCTCGCGCCGCCGTTCGTCTATTTCGTGGTTCTCGCTGTGTCGGGCTCCAAGG
CCTCGGCCTTTGCGGCGCTTGGCGCCTCGCTGCTGGGCGTCATCGTCAACGGCCTGTTCGTGGCGATTTCCATGACTTCA
GGCGGCGGTGCCTGGGACAATGCGAAGAAAAGTTTCGAGGAAGGGTTTCTCGATAAGAATGGTGTCACCCATTACAAGGG
GAGTGAGGCGCATAAGGCCTCGGTAACGGGTGACACGGTCGGCGATCCCTATAAGGATACGGCCGGGCCAGCGATCAATC
CGGCGATCAAGATCACCAATATTGTCGCTCTCCTGCTTCTGGCGATTCTCGCTCATTGA

Upstream 100 bases:

>100_bases
GCGGCGATCTGTGGATTCTGTAAGCTGACCCGAAACATATCGATCCATGCCTGATTCTTTCACAGGAAATCGGGCCAGGT
GGGCGGCGAGGGAGGAATCC

Downstream 100 bases:

>100_bases
TGGAGCGCCCCAAGGATGCCGTCTTGGGGCGATTCTTCCTCTATTTGAAATGATAGGGCGCGACGTTCCATCCGGTTCGC
CGTGTCCTATCGACGCCTTT

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 712; Mature: 712

Protein sequence:

>712_residues
MNPLWWIIFGGLLSVAYGIVTSKQLLEQPAGSLRMQEIAGAIAEGANAYLKRQYTTIALVGTVIFVVLGLLLSWTVAWAY
LFGAVLSGAAGFIGMNVSVRANVRTAQAASQSLGEGLDLSFKAGAVTGLLVAGLALLGVTLTFYLLTGPLGHAQDSREVV
NALVGLGFGASLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYVVTVV
ATMVLGAIFFGGDAVLASAMLYPLAICATCIVTSLIGTAFVKLGLDEAIMSALYKGLIATGLLTIPGLALATYATVGFGT
IGTVHGVPLTGLHLFFCGLIGLAVTGALVVITEYYTGSGKRPVVSIAQASVTGHGTNVIQGLAVSLESTALPALVIAAGI
IATSQLGGLYGTAIAVTTMLGLAGMIVALDAFGPVTDNAGGIAEMAGLPKEVRRATDALDAVGNTTKAVTKGYAIGSAGL
GALVLFAAYSYDLDYFTKHGDVFSYFRNVGVVSFDLSNPYVVAGLIFGGLIPYLFGGIAMTAVGRAAGSVVEEVRRQFRE
KPGIMEGTERPDYGRAVDMLTKAAIREMIIPSLLPVLAPPFVYFVVLAVSGSKASAFAALGASLLGVIVNGLFVAISMTS
GGGAWDNAKKSFEEGFLDKNGVTHYKGSEAHKASVTGDTVGDPYKDTAGPAINPAIKITNIVALLLLAILAH

Sequences:

>Translated_712_residues
MNPLWWIIFGGLLSVAYGIVTSKQLLEQPAGSLRMQEIAGAIAEGANAYLKRQYTTIALVGTVIFVVLGLLLSWTVAWAY
LFGAVLSGAAGFIGMNVSVRANVRTAQAASQSLGEGLDLSFKAGAVTGLLVAGLALLGVTLTFYLLTGPLGHAQDSREVV
NALVGLGFGASLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYVVTVV
ATMVLGAIFFGGDAVLASAMLYPLAICATCIVTSLIGTAFVKLGLDEAIMSALYKGLIATGLLTIPGLALATYATVGFGT
IGTVHGVPLTGLHLFFCGLIGLAVTGALVVITEYYTGSGKRPVVSIAQASVTGHGTNVIQGLAVSLESTALPALVIAAGI
IATSQLGGLYGTAIAVTTMLGLAGMIVALDAFGPVTDNAGGIAEMAGLPKEVRRATDALDAVGNTTKAVTKGYAIGSAGL
GALVLFAAYSYDLDYFTKHGDVFSYFRNVGVVSFDLSNPYVVAGLIFGGLIPYLFGGIAMTAVGRAAGSVVEEVRRQFRE
KPGIMEGTERPDYGRAVDMLTKAAIREMIIPSLLPVLAPPFVYFVVLAVSGSKASAFAALGASLLGVIVNGLFVAISMTS
GGGAWDNAKKSFEEGFLDKNGVTHYKGSEAHKASVTGDTVGDPYKDTAGPAINPAIKITNIVALLLLAILAH
>Mature_712_residues
MNPLWWIIFGGLLSVAYGIVTSKQLLEQPAGSLRMQEIAGAIAEGANAYLKRQYTTIALVGTVIFVVLGLLLSWTVAWAY
LFGAVLSGAAGFIGMNVSVRANVRTAQAASQSLGEGLDLSFKAGAVTGLLVAGLALLGVTLTFYLLTGPLGHAQDSREVV
NALVGLGFGASLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYVVTVV
ATMVLGAIFFGGDAVLASAMLYPLAICATCIVTSLIGTAFVKLGLDEAIMSALYKGLIATGLLTIPGLALATYATVGFGT
IGTVHGVPLTGLHLFFCGLIGLAVTGALVVITEYYTGSGKRPVVSIAQASVTGHGTNVIQGLAVSLESTALPALVIAAGI
IATSQLGGLYGTAIAVTTMLGLAGMIVALDAFGPVTDNAGGIAEMAGLPKEVRRATDALDAVGNTTKAVTKGYAIGSAGL
GALVLFAAYSYDLDYFTKHGDVFSYFRNVGVVSFDLSNPYVVAGLIFGGLIPYLFGGIAMTAVGRAAGSVVEEVRRQFRE
KPGIMEGTERPDYGRAVDMLTKAAIREMIIPSLLPVLAPPFVYFVVLAVSGSKASAFAALGASLLGVIVNGLFVAISMTS
GGGAWDNAKKSFEEGFLDKNGVTHYKGSEAHKASVTGDTVGDPYKDTAGPAINPAIKITNIVALLLLAILAH

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 72826; Mature: 72826

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPLWWIIFGGLLSVAYGIVTSKQLLEQPAGSLRMQEIAGAIAEGANAYLKRQYTTIALV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTVIFVVLGLLLSWTVAWAYLFGAVLSGAAGFIGMNVSVRANVRTAQAASQSLGEGLDLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCEEEEECCHHHHHHHHHHCCCCCCE
FKAGAVTGLLVAGLALLGVTLTFYLLTGPLGHAQDSREVVNALVGLGFGASLISIFARLG
ECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHC
GGIFTKGADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYVVTVV
CCEEECCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLGAIFFGGDAVLASAMLYPLAICATCIVTSLIGTAFVKLGLDEAIMSALYKGLIAT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
GLLTIPGLALATYATVGFGTIGTVHGVPLTGLHLFFCGLIGLAVTGALVVITEYYTGSGK
HHHHHCHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEHHCCCCC
RPVVSIAQASVTGHGTNVIQGLAVSLESTALPALVIAAGIIATSQLGGLYGTAIAVTTML
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
GLAGMIVALDAFGPVTDNAGGIAEMAGLPKEVRRATDALDAVGNTTKAVTKGYAIGSAGL
HHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHH
GALVLFAAYSYDLDYFTKHGDVFSYFRNVGVVSFDLSNPYVVAGLIFGGLIPYLFGGIAM
HHHHHHHHHHCCHHHHHCCCHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
TAVGRAAGSVVEEVRRQFREKPGIMEGTERPDYGRAVDMLTKAAIREMIIPSLLPVLAPP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
FVYFVVLAVSGSKASAFAALGASLLGVIVNGLFVAISMTSGGGAWDNAKKSFEEGFLDKN
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHCCCCCC
GVTHYKGSEAHKASVTGDTVGDPYKDTAGPAINPAIKITNIVALLLLAILAH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPLWWIIFGGLLSVAYGIVTSKQLLEQPAGSLRMQEIAGAIAEGANAYLKRQYTTIALV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTVIFVVLGLLLSWTVAWAYLFGAVLSGAAGFIGMNVSVRANVRTAQAASQSLGEGLDLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCEEEEECCHHHHHHHHHHCCCCCCE
FKAGAVTGLLVAGLALLGVTLTFYLLTGPLGHAQDSREVVNALVGLGFGASLISIFARLG
ECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHC
GGIFTKGADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYVVTVV
CCEEECCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLGAIFFGGDAVLASAMLYPLAICATCIVTSLIGTAFVKLGLDEAIMSALYKGLIAT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
GLLTIPGLALATYATVGFGTIGTVHGVPLTGLHLFFCGLIGLAVTGALVVITEYYTGSGK
HHHHHCHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEHHCCCCC
RPVVSIAQASVTGHGTNVIQGLAVSLESTALPALVIAAGIIATSQLGGLYGTAIAVTTML
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
GLAGMIVALDAFGPVTDNAGGIAEMAGLPKEVRRATDALDAVGNTTKAVTKGYAIGSAGL
HHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHH
GALVLFAAYSYDLDYFTKHGDVFSYFRNVGVVSFDLSNPYVVAGLIFGGLIPYLFGGIAM
HHHHHHHHHHCCHHHHHCCCHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
TAVGRAAGSVVEEVRRQFREKPGIMEGTERPDYGRAVDMLTKAAIREMIIPSLLPVLAPP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
FVYFVVLAVSGSKASAFAALGASLLGVIVNGLFVAISMTSGGGAWDNAKKSFEEGFLDKN
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHCCCCCC
GVTHYKGSEAHKASVTGDTVGDPYKDTAGPAINPAIKITNIVALLLLAILAH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]