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The map label for this gene is clcB [H]

Identifier: 182677190

GI number: 182677190

Start: 224578

End: 226485

Strand: Direct

Name: clcB [H]

Synonym: Bind_0191

Alternate gene names: 182677190

Gene position: 224578-226485 (Clockwise)

Preceding gene: 182677185

Following gene: 182677191

Centisome position: 5.39

GC content: 62.0

Gene sequence:

>1908_bases
ATGTGGTTTGCCCTTGTTTTGCCGCCAGAGGTGTTGCCTCCCCTTATGCCCGCCCCAGCCCCGATTTTTTCTGAAAAAGT
GCTTCGGATCGATGTGCCCGCGATTCTGCGCGGTATCGTGCGCCGTCATGAATTGGGCCTCATCCTGCTTGGTCTCATCA
CAGGCCAGATCGCCGGCATTTTCGTCGCGGGCATTTTTTTCCTCGCTGGCCAAATGCACAAGCTGCTCTTCGGCATTGCT
TTGGAATCCCATCTGAGCAGCCTAAGTGTCCTCAGCCATCCGCTCCAGGCTTTGGTGCCGGTCGTGGGCGGCCTGGTAGT
CGGCGTCACCGGTCATTTTATCCAGACCTGGCGCAACGACCGGCCGATCGATCCGATCGAGGCCAATGCGTTGCGTGGCG
GCACCATGTCCTTGCTCGACAGTCTGCTCATCACCGGCCAGACGATTCTCTCCAATGGCAGCGGCGCCTCGGTCGGGCTG
GAGGCCTCCTATACACAGCTCGGCTCCGGTTTTGCGTCCTGGCTCGGGCAGGCTTTCCGGCTGCGGCGCGCTGATCTGCG
CACGCTTGTTGCCTGCGGCTCGGCGGGCGCCATTGCCGCGGCCTTCGAGGCGCCGCTGACCGGTTCCTTCTATGCTTTCG
AGCTGATTCTCGGCTCCTACACCCCTTTCGGTCTCGCGCCGATCGGAGCCGCGGCGGTGGGAGGTGCGCTGACCGCCCGG
GCACTTGGCACAGGCGGCGATTTCATCGGCCATATTCCCGCCGTCGCTCTCTCGAACAGCGATATGGCGCTGCTCCTCCT
GCTTGGGATGATCTGCGGCCTGTTTGGCATTGGTGTCATGCGCGCGGTGACCACCGCCGAGGCTTTGTTCCGCAACAGCC
GCATACCGATCATCCTGCGGCCGGCCGTCGGGGGCGTCGTTCTCGGCGCTTTCGCCCTGATCACACCGCATGTGCTGGCT
TCCGGCCATGGTGCGCTCTCAGACCTTTTCGACGAGGAGGCGCCCGCTATCGGGTTCCTCTTCGGCGTGCTGTTGCTCAA
GGCCACGGCCTCGGCCATTTCCATCGGCTCGGGTTTTCGCGGCGGCCTTTTCTTCGCCTCGCTCTATCTCGGCGGTATTC
TCGGGCGAATATTCGTCGGGGTCACGGCCTGGGCCAATCCGACGCTGGCGCCCGATGCCTGGCTGGCGACCATTGTCGGA
ATGGCGGCCATGGCTGTGGCGATTATCGGTGGCCCGATGACCATGACCTTTCTGGCGCTGGAGACGACCGGCGATCTGCC
GCTCTCAATCGAAATGCTGGCGGTCGCGGCGATCGTTTCGGTCATGGTGCGGCGCATGTTCGGCTATTCCTTCGCTACAT
GGCGCCTGCATTTGCGCGGGGAATCGATCCGCAGCGCGCAAGACATCGGCTGGATGCGTGATTTGACGGTTGGCAAGCTG
ATGCGCAGCGATACGGCCATCGTCCGGTCCGATCTGCCGCTCGCCCGTTTCAAGCGAGAATTTCCCTTAGGTTCCGCCCA
ATGGGTCATCGCCGCCGACACGCAGGGCCATTATGCCGGCATGGTGGCGGTGACCGATGCCTGGCTCACCGAATTTCAAA
ACAATCCGGTTCAGGAGGATTTTGGCCGCGAAAAGGGTGGTAAAAGCGATACGGGTGCGCCGAAAGATGCAACCATAACC
CCTTTGCTGCGCCAAAAAATGTGCGTCCTTCTACCGGAGATGAACGTCAAAATGGCGGCGCAGATGTTCGAGCGCAGCGA
AAGCGAGGCCCTGGCCGTCGTCGCCGATGTCAAGGATTGGCGGATCATCGGCCTGCTCACGGAATCCCAAGTCCTGCGCC
GCTATACGCAGGAACTCGACAAAGCGCGCCGGGATTTGTCGGGCGAGACCTGGTCAGGTGAGGGATAA

Upstream 100 bases:

>100_bases
ATAGATCATTGGTTCGATAAAGATATTTTCACGAGGGCCTGTATTGTTGCCGGGGTTCGGTTCAAAAAATCTTGTTTCTT
CCTCATCGAGGCCAAGCCAA

Downstream 100 bases:

>100_bases
AGAAGGAAAGGCCGTCATGGGCTCTTTGGGTTCGCTTCTTGTCATTGGCATCGTGATCTCGCTCTCCATCTGTGTCACTT
TGCTTGTCCATCATCACATC

Product: chloride channel core protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MWFALVLPPEVLPPLMPAPAPIFSEKVLRIDVPAILRGIVRRHELGLILLGLITGQIAGIFVAGIFFLAGQMHKLLFGIA
LESHLSSLSVLSHPLQALVPVVGGLVVGVTGHFIQTWRNDRPIDPIEANALRGGTMSLLDSLLITGQTILSNGSGASVGL
EASYTQLGSGFASWLGQAFRLRRADLRTLVACGSAGAIAAAFEAPLTGSFYAFELILGSYTPFGLAPIGAAAVGGALTAR
ALGTGGDFIGHIPAVALSNSDMALLLLLGMICGLFGIGVMRAVTTAEALFRNSRIPIILRPAVGGVVLGAFALITPHVLA
SGHGALSDLFDEEAPAIGFLFGVLLLKATASAISIGSGFRGGLFFASLYLGGILGRIFVGVTAWANPTLAPDAWLATIVG
MAAMAVAIIGGPMTMTFLALETTGDLPLSIEMLAVAAIVSVMVRRMFGYSFATWRLHLRGESIRSAQDIGWMRDLTVGKL
MRSDTAIVRSDLPLARFKREFPLGSAQWVIAADTQGHYAGMVAVTDAWLTEFQNNPVQEDFGREKGGKSDTGAPKDATIT
PLLRQKMCVLLPEMNVKMAAQMFERSESEALAVVADVKDWRIIGLLTESQVLRRYTQELDKARRDLSGETWSGEG

Sequences:

>Translated_635_residues
MWFALVLPPEVLPPLMPAPAPIFSEKVLRIDVPAILRGIVRRHELGLILLGLITGQIAGIFVAGIFFLAGQMHKLLFGIA
LESHLSSLSVLSHPLQALVPVVGGLVVGVTGHFIQTWRNDRPIDPIEANALRGGTMSLLDSLLITGQTILSNGSGASVGL
EASYTQLGSGFASWLGQAFRLRRADLRTLVACGSAGAIAAAFEAPLTGSFYAFELILGSYTPFGLAPIGAAAVGGALTAR
ALGTGGDFIGHIPAVALSNSDMALLLLLGMICGLFGIGVMRAVTTAEALFRNSRIPIILRPAVGGVVLGAFALITPHVLA
SGHGALSDLFDEEAPAIGFLFGVLLLKATASAISIGSGFRGGLFFASLYLGGILGRIFVGVTAWANPTLAPDAWLATIVG
MAAMAVAIIGGPMTMTFLALETTGDLPLSIEMLAVAAIVSVMVRRMFGYSFATWRLHLRGESIRSAQDIGWMRDLTVGKL
MRSDTAIVRSDLPLARFKREFPLGSAQWVIAADTQGHYAGMVAVTDAWLTEFQNNPVQEDFGREKGGKSDTGAPKDATIT
PLLRQKMCVLLPEMNVKMAAQMFERSESEALAVVADVKDWRIIGLLTESQVLRRYTQELDKARRDLSGETWSGEG
>Mature_635_residues
MWFALVLPPEVLPPLMPAPAPIFSEKVLRIDVPAILRGIVRRHELGLILLGLITGQIAGIFVAGIFFLAGQMHKLLFGIA
LESHLSSLSVLSHPLQALVPVVGGLVVGVTGHFIQTWRNDRPIDPIEANALRGGTMSLLDSLLITGQTILSNGSGASVGL
EASYTQLGSGFASWLGQAFRLRRADLRTLVACGSAGAIAAAFEAPLTGSFYAFELILGSYTPFGLAPIGAAAVGGALTAR
ALGTGGDFIGHIPAVALSNSDMALLLLLGMICGLFGIGVMRAVTTAEALFRNSRIPIILRPAVGGVVLGAFALITPHVLA
SGHGALSDLFDEEAPAIGFLFGVLLLKATASAISIGSGFRGGLFFASLYLGGILGRIFVGVTAWANPTLAPDAWLATIVG
MAAMAVAIIGGPMTMTFLALETTGDLPLSIEMLAVAAIVSVMVRRMFGYSFATWRLHLRGESIRSAQDIGWMRDLTVGKL
MRSDTAIVRSDLPLARFKREFPLGSAQWVIAADTQGHYAGMVAVTDAWLTEFQNNPVQEDFGREKGGKSDTGAPKDATIT
PLLRQKMCVLLPEMNVKMAAQMFERSESEALAVVADVKDWRIIGLLTESQVLRRYTQELDKARRDLSGETWSGEG

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081943, Length=335, Percent_Identity=26.865671641791, Blast_Score=75, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 67273; Mature: 67273

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWFALVLPPEVLPPLMPAPAPIFSEKVLRIDVPAILRGIVRRHELGLILLGLITGQIAGI
CEEEEECCHHHCCCCCCCCCCHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVAGIFFLAGQMHKLLFGIALESHLSSLSVLSHPLQALVPVVGGLVVGVTGHFIQTWRND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RPIDPIEANALRGGTMSLLDSLLITGQTILSNGSGASVGLEASYTQLGSGFASWLGQAFR
CCCCCCCCCCCCCCHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LRRADLRTLVACGSAGAIAAAFEAPLTGSFYAFELILGSYTPFGLAPIGAAAVGGALTAR
HHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
ALGTGGDFIGHIPAVALSNSDMALLLLLGMICGLFGIGVMRAVTTAEALFRNSRIPIILR
HCCCCCCHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
PAVGGVVLGAFALITPHVLASGHGALSDLFDEEAPAIGFLFGVLLLKATASAISIGSGFR
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
GGLFFASLYLGGILGRIFVGVTAWANPTLAPDAWLATIVGMAAMAVAIIGGPMTMTFLAL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
ETTGDLPLSIEMLAVAAIVSVMVRRMFGYSFATWRLHLRGESIRSAQDIGWMRDLTVGKL
ECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHCCHHHHHHHHHH
MRSDTAIVRSDLPLARFKREFPLGSAQWVIAADTQGHYAGMVAVTDAWLTEFQNNPVQED
HHCCHHHHHCCCCHHHHHHHCCCCCCCEEEEECCCCCEEEEEEHHHHHHHHHCCCCCHHH
FGREKGGKSDTGAPKDATITPLLRQKMCVLLPEMNVKMAAQMFERSESEALAVVADVKDW
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEECCCE
RIIGLLTESQVLRRYTQELDKARRDLSGETWSGEG
EEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MWFALVLPPEVLPPLMPAPAPIFSEKVLRIDVPAILRGIVRRHELGLILLGLITGQIAGI
CEEEEECCHHHCCCCCCCCCCHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVAGIFFLAGQMHKLLFGIALESHLSSLSVLSHPLQALVPVVGGLVVGVTGHFIQTWRND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RPIDPIEANALRGGTMSLLDSLLITGQTILSNGSGASVGLEASYTQLGSGFASWLGQAFR
CCCCCCCCCCCCCCHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LRRADLRTLVACGSAGAIAAAFEAPLTGSFYAFELILGSYTPFGLAPIGAAAVGGALTAR
HHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
ALGTGGDFIGHIPAVALSNSDMALLLLLGMICGLFGIGVMRAVTTAEALFRNSRIPIILR
HCCCCCCHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
PAVGGVVLGAFALITPHVLASGHGALSDLFDEEAPAIGFLFGVLLLKATASAISIGSGFR
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
GGLFFASLYLGGILGRIFVGVTAWANPTLAPDAWLATIVGMAAMAVAIIGGPMTMTFLAL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
ETTGDLPLSIEMLAVAAIVSVMVRRMFGYSFATWRLHLRGESIRSAQDIGWMRDLTVGKL
ECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHCCHHHHHHHHHH
MRSDTAIVRSDLPLARFKREFPLGSAQWVIAADTQGHYAGMVAVTDAWLTEFQNNPVQED
HHCCHHHHHCCCCHHHHHHHCCCCCCCEEEEECCCCCEEEEEEHHHHHHHHHCCCCCHHH
FGREKGGKSDTGAPKDATITPLLRQKMCVLLPEMNVKMAAQMFERSESEALAVVADVKDW
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEECCCE
RIIGLLTESQVLRRYTQELDKARRDLSGETWSGEG
EEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA