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The map label for this gene is mdtA [H]

Identifier: 182677124

GI number: 182677124

Start: 143272

End: 144525

Strand: Direct

Name: mdtA [H]

Synonym: Bind_0123

Alternate gene names: 182677124

Gene position: 143272-144525 (Clockwise)

Preceding gene: 182677123

Following gene: 182677125

Centisome position: 3.44

GC content: 56.3

Gene sequence:

>1254_bases
ATGCGCAAGAGTAAAGGCGCGGGACGCGCACTCATCGCCGTTCTCATTGTGGGCGGCATTGCCGGCTATCAAGTCTTCGA
TCGGACCAAGGCGGCGAAGGAAGTTGCCGACGAAACGCTCGAAGGCGCTGTGCCGAAGATCTCGGTCGTCAATCCGCAAG
CCGGACCGACGGAGGAATCCCTGACCTTGCCGGGAACGATCGAGGCCTGGTATCAGGCGCCGATCTACGCGCAGGTGTCC
GGCTATGTAAAAATGTGGCACAAGGATTATGGCGCGCATGTCAAGAGCGATGATCTCTTGGCGGAAATCAATACGCCCGG
CCTTGATGCCGAATATGCCCAGGCTCAGGCCAATCTGCGCTCGGCGCAGGCCAAATATAATCTCGCGGTCGTCACCGCCA
ATCGTTGGCGCGCCTTGCGCAAATCGCAGGCCGTCTCGGAACAATCGATCTCGGAACAGGAAGCCAACGAGAAATCGGAG
GCGGCTCTGGTCGATGCCGCGCAACATAATGTGGCGCGCTATGAGGCCTTGCAGAAATTCAAGAAGATCGTTGCGCCGTT
CGATGGCGTCATCACATCGCGCTCGATCAATGTCGGCGATTACGTCAATCAAGGCGGCGGCAGTGTGGGAGCCAGCGGCA
ATGCGACGGAACTTTTCTCCGTTGCCGATATTCACGCCATGCGTCTGTTTATTTCCGTGCCGGAAGTCTTCTCTTATATC
CTCAAGCCGGGCCTCACGGCGGATGTGGTCACGCCGCAATATCCAGATCGTCATTATACTGCAAAATTTCTCACGGTCGC
CAATGGCTATGACACGAATACCCGCACGGCAGTGACGGAATTCACCATTGATAATGACGATGCCAGCCTTTGGCCGGGTT
CCTATTCGACAGTCAAGTTGACGGCTTCCGCCGATCCTCATATCCTGACAATACCAACCAGTGCTCTTGTGTTTGAAGAA
GAAGGTTTGCAGGTCGCCACCGTGACGCCCGACAATCATATTCATTTCAAACCAGTCACTTCCGGCAAGATCCTCGGTGA
GCAGGTCCAGATCACCCTGGGCCTCACGAAAGCCGACCGCATTGCTGATAATCCGCCCGCCGCTTTGATGGAGGGACAGG
AGGTCAAAATCGTGCCAGCGACGCCCGGGTACAATAATGCGGTTCCAAACCATGAGGCGACGCAGGCCAATGGGTCCCGT
CAGCAGCTTGGTCTGGCGGATGAACAGACTTCGGCGCAAGAGACCAAAAAATGA

Upstream 100 bases:

>100_bases
TCGGCGGGTTGACGGTGGCGACCTTTGCGACATTGATGTTCGTTCCTTGTGTCTATGCCCTCGTTTACAATCGCACCAAT
CGCAAGAAGGAGAGCGCGTG

Downstream 100 bases:

>100_bases
AATGCCTCTTCCCAGCAGGAGCCCGTTCCAGTGGTCTTCTGTTTCTTTTGTCCCTCTCCGCCTGTGATCTCGCCCCCGCC
TACCAGCCGCCAGACCTCGA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MRKSKGAGRALIAVLIVGGIAGYQVFDRTKAAKEVADETLEGAVPKISVVNPQAGPTEESLTLPGTIEAWYQAPIYAQVS
GYVKMWHKDYGAHVKSDDLLAEINTPGLDAEYAQAQANLRSAQAKYNLAVVTANRWRALRKSQAVSEQSISEQEANEKSE
AALVDAAQHNVARYEALQKFKKIVAPFDGVITSRSINVGDYVNQGGGSVGASGNATELFSVADIHAMRLFISVPEVFSYI
LKPGLTADVVTPQYPDRHYTAKFLTVANGYDTNTRTAVTEFTIDNDDASLWPGSYSTVKLTASADPHILTIPTSALVFEE
EGLQVATVTPDNHIHFKPVTSGKILGEQVQITLGLTKADRIADNPPAALMEGQEVKIVPATPGYNNAVPNHEATQANGSR
QQLGLADEQTSAQETKK

Sequences:

>Translated_417_residues
MRKSKGAGRALIAVLIVGGIAGYQVFDRTKAAKEVADETLEGAVPKISVVNPQAGPTEESLTLPGTIEAWYQAPIYAQVS
GYVKMWHKDYGAHVKSDDLLAEINTPGLDAEYAQAQANLRSAQAKYNLAVVTANRWRALRKSQAVSEQSISEQEANEKSE
AALVDAAQHNVARYEALQKFKKIVAPFDGVITSRSINVGDYVNQGGGSVGASGNATELFSVADIHAMRLFISVPEVFSYI
LKPGLTADVVTPQYPDRHYTAKFLTVANGYDTNTRTAVTEFTIDNDDASLWPGSYSTVKLTASADPHILTIPTSALVFEE
EGLQVATVTPDNHIHFKPVTSGKILGEQVQITLGLTKADRIADNPPAALMEGQEVKIVPATPGYNNAVPNHEATQANGSR
QQLGLADEQTSAQETKK
>Mature_417_residues
MRKSKGAGRALIAVLIVGGIAGYQVFDRTKAAKEVADETLEGAVPKISVVNPQAGPTEESLTLPGTIEAWYQAPIYAQVS
GYVKMWHKDYGAHVKSDDLLAEINTPGLDAEYAQAQANLRSAQAKYNLAVVTANRWRALRKSQAVSEQSISEQEANEKSE
AALVDAAQHNVARYEALQKFKKIVAPFDGVITSRSINVGDYVNQGGGSVGASGNATELFSVADIHAMRLFISVPEVFSYI
LKPGLTADVVTPQYPDRHYTAKFLTVANGYDTNTRTAVTEFTIDNDDASLWPGSYSTVKLTASADPHILTIPTSALVFEE
EGLQVATVTPDNHIHFKPVTSGKILGEQVQITLGLTKADRIADNPPAALMEGQEVKIVPATPGYNNAVPNHEATQANGSR
QQLGLADEQTSAQETKK

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=326, Percent_Identity=26.0736196319018, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786668, Length=386, Percent_Identity=23.0569948186528, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI87081796, Length=334, Percent_Identity=26.3473053892216, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789929, Length=365, Percent_Identity=23.013698630137, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44807; Mature: 44807

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKSKGAGRALIAVLIVGGIAGYQVFDRTKAAKEVADETLEGAVPKISVVNPQAGPTEES
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
LTLPGTIEAWYQAPIYAQVSGYVKMWHKDYGAHVKSDDLLAEINTPGLDAEYAQAQANLR
EECCCCHHHHHCCCEEEEHHHHHHEEHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHH
SAQAKYNLAVVTANRWRALRKSQAVSEQSISEQEANEKSEAALVDAAQHNVARYEALQKF
HHCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
KKIVAPFDGVITSRSINVGDYVNQGGGSVGASGNATELFSVADIHAMRLFISVPEVFSYI
HHHHCCCCCEEECCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LKPGLTADVVTPQYPDRHYTAKFLTVANGYDTNTRTAVTEFTIDNDDASLWPGSYSTVKL
HCCCCEEECCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEE
TASADPHILTIPTSALVFEEEGLQVATVTPDNHIHFKPVTSGKILGEQVQITLGLTKADR
EECCCCEEEEECCCEEEEECCCCEEEEECCCCCEEEEECCCCCEECCEEEEEEECCHHHH
IADNPPAALMEGQEVKIVPATPGYNNAVPNHEATQANGSRQQLGLADEQTSAQETKK
CCCCCCHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHCCC
>Mature Secondary Structure
MRKSKGAGRALIAVLIVGGIAGYQVFDRTKAAKEVADETLEGAVPKISVVNPQAGPTEES
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
LTLPGTIEAWYQAPIYAQVSGYVKMWHKDYGAHVKSDDLLAEINTPGLDAEYAQAQANLR
EECCCCHHHHHCCCEEEEHHHHHHEEHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHH
SAQAKYNLAVVTANRWRALRKSQAVSEQSISEQEANEKSEAALVDAAQHNVARYEALQKF
HHCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
KKIVAPFDGVITSRSINVGDYVNQGGGSVGASGNATELFSVADIHAMRLFISVPEVFSYI
HHHHCCCCCEEECCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LKPGLTADVVTPQYPDRHYTAKFLTVANGYDTNTRTAVTEFTIDNDDASLWPGSYSTVKL
HCCCCEEECCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEE
TASADPHILTIPTSALVFEEEGLQVATVTPDNHIHFKPVTSGKILGEQVQITLGLTKADR
EECCCCEEEEECCCEEEEECCCCEEEEECCCCCEEEEECCCCCEECCEEEEEEECCHHHH
IADNPPAALMEGQEVKIVPATPGYNNAVPNHEATQANGSRQQLGLADEQTSAQETKK
CCCCCCHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA