Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 17547403

GI number: 17547403

Start: 2892833

End: 2893657

Strand: Direct

Name: proC [H]

Synonym: RSc2684

Alternate gene names: 17547403

Gene position: 2892833-2893657 (Clockwise)

Preceding gene: 17547402

Following gene: 17547404

Centisome position: 77.84

GC content: 71.64

Gene sequence:

>825_bases
ATGCTCGACACTCTGAAATTCGGCTTCATCGGCGGCGGCAACATGGCTTCGGCGCTGATCGGCGGCCTGGTCTCCCGCGG
CGCCCCGGGCGCCAACATCGTGGTGGTGGACCCGACCGAGCCGGCCCGCGCGCACGCCGCGCAGACCTGGGGCGCAACCA
CCATCGCCGCCCCCGGCGCCGAGCTGGCCGACCGCGACGTGATCGTGCTGGCCGTCAAGCCGCAGCAGATGCGAGAAGTC
TGCGCGCAACTGGCCCCGCACCTGCGTGACAGCCTGGTGCTGTCGGTGGCGGCCGGCATCCGTATCCAGGACCTGTCGCG
CTGGCTCGGCGGCCATGCCCGCGTCGTGCGTGCCATGCCGAACACGCCGGCGCTGTCGGGCATGGGCATGACCGGCTTGG
CTGCCCGCGCCGGCCTGGGCGGAACCGATCGCGACATCGCCAGCGCCATCGCCAACGCCGTCGGCAAGAGCGTGTGGGTG
CCCGACGAAGCGCAGATCGACGCCGTCACCGCCATTTCCGGCAGCGGTCCGGCCTACGTGTTCTACTTCATCGAAGCGAT
GCAGCAGGTTGCACTGGAACTGGGCCTGTCGCCCGAGGCAGGCCGCCTGCTGGCGGCGGAAACCTTCATCGGCGCGGCCA
CGCTGGCGGAGCAGTCGAGCGAGCCGGTCGAGGTGCTGCGCGAGCGCGTGACCTCCAAGGGCGGCACGACCTACGCCGCG
CTCACCGCCATGGATGCGGCCGGCATCAAGCCCGCCTTCGTGCGCGCCATGCACGCGGCGGCCGCGCGCGGCAAGGCGAT
GGGTGAGGAATTCGGCCGCGACTGA

Upstream 100 bases:

>100_bases
GCCACCATCGTGCGCGTCGGCAGCGCCATCTTCGGCGCGCGGCAGTATGCGCATGCGCCCGCCTGATTCCCGCTTGACCC
TTTCTCTATCGACCCTTCCC

Downstream 100 bases:

>100_bases
CCCGGCCCGTGCGTTCGCCCCATGGATTTCGCCGCCCTCTTCGCGATCGAGCGGCCGGGGCTGTTCAAGGCCGCGCTCGT
GCTGGCGCTGCCGCTGGATA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MLDTLKFGFIGGGNMASALIGGLVSRGAPGANIVVVDPTEPARAHAAQTWGATTIAAPGAELADRDVIVLAVKPQQMREV
CAQLAPHLRDSLVLSVAAGIRIQDLSRWLGGHARVVRAMPNTPALSGMGMTGLAARAGLGGTDRDIASAIANAVGKSVWV
PDEAQIDAVTAISGSGPAYVFYFIEAMQQVALELGLSPEAGRLLAAETFIGAATLAEQSSEPVEVLRERVTSKGGTTYAA
LTAMDAAGIKPAFVRAMHAAAARGKAMGEEFGRD

Sequences:

>Translated_274_residues
MLDTLKFGFIGGGNMASALIGGLVSRGAPGANIVVVDPTEPARAHAAQTWGATTIAAPGAELADRDVIVLAVKPQQMREV
CAQLAPHLRDSLVLSVAAGIRIQDLSRWLGGHARVVRAMPNTPALSGMGMTGLAARAGLGGTDRDIASAIANAVGKSVWV
PDEAQIDAVTAISGSGPAYVFYFIEAMQQVALELGLSPEAGRLLAAETFIGAATLAEQSSEPVEVLRERVTSKGGTTYAA
LTAMDAAGIKPAFVRAMHAAAARGKAMGEEFGRD
>Mature_274_residues
MLDTLKFGFIGGGNMASALIGGLVSRGAPGANIVVVDPTEPARAHAAQTWGATTIAAPGAELADRDVIVLAVKPQQMREV
CAQLAPHLRDSLVLSVAAGIRIQDLSRWLGGHARVVRAMPNTPALSGMGMTGLAARAGLGGTDRDIASAIANAVGKSVWV
PDEAQIDAVTAISGSGPAYVFYFIEAMQQVALELGLSPEAGRLLAAETFIGAATLAEQSSEPVEVLRERVTSKGGTTYAA
LTAMDAAGIKPAFVRAMHAAAARGKAMGEEFGRD

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=267, Percent_Identity=30.7116104868914, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=29.7397769516729, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI24797097, Length=269, Percent_Identity=29.7397769516729, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI21361454, Length=269, Percent_Identity=28.2527881040892, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1786585, Length=268, Percent_Identity=35.8208955223881, Blast_Score=136, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17569021, Length=269, Percent_Identity=33.457249070632, Blast_Score=136, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17540664, Length=292, Percent_Identity=28.7671232876712, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320861, Length=207, Percent_Identity=30.4347826086957, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=35.2272727272727, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=31.6363636363636, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=35.5029585798817, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28114; Mature: 28114

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDTLKFGFIGGGNMASALIGGLVSRGAPGANIVVVDPTEPARAHAAQTWGATTIAAPGA
CCCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCEEECCCC
ELADRDVIVLAVKPQQMREVCAQLAPHLRDSLVLSVAAGIRIQDLSRWLGGHARVVRAMP
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHEEEEECC
NTPALSGMGMTGLAARAGLGGTDRDIASAIANAVGKSVWVPDEAQIDAVTAISGSGPAYV
CCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCHH
FYFIEAMQQVALELGLSPEAGRLLAAETFIGAATLAEQSSEPVEVLRERVTSKGGTTYAA
HHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEHH
LTAMDAAGIKPAFVRAMHAAAARGKAMGEEFGRD
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDTLKFGFIGGGNMASALIGGLVSRGAPGANIVVVDPTEPARAHAAQTWGATTIAAPGA
CCCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCEEECCCC
ELADRDVIVLAVKPQQMREVCAQLAPHLRDSLVLSVAAGIRIQDLSRWLGGHARVVRAMP
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHEEEEECC
NTPALSGMGMTGLAARAGLGGTDRDIASAIANAVGKSVWVPDEAQIDAVTAISGSGPAYV
CCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCHH
FYFIEAMQQVALELGLSPEAGRLLAAETFIGAATLAEQSSEPVEVLRERVTSKGGTTYAA
HHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEHH
LTAMDAAGIKPAFVRAMHAAAARGKAMGEEFGRD
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]