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The map label for this gene is ispA [H]

Identifier: 17546941

GI number: 17546941

Start: 2410485

End: 2411384

Strand: Reverse

Name: ispA [H]

Synonym: RSc2222

Alternate gene names: 17546941

Gene position: 2411384-2410485 (Counterclockwise)

Preceding gene: 17546942

Following gene: 17546940

Centisome position: 64.88

GC content: 71.78

Gene sequence:

>900_bases
ATGAGCGATTTCGCCCACTGGATGGCCTCCGTCGTTGCACGGACGGAAAGCGCGCTCGAACGCGCCCTGCCCGGCGAATC
GGTCGCGCCGCAGCGCCTGCATGCGGCGATGCGCTATGCCACGCTGGGGGCGGGCAAGCGGGTCCGCCCCCTGCTCGCGC
ATGCTGCCGGGGCGCTGGGCGAGGCATCGCCCGAGGCGCTGGACGGCGTGAGCTGCGCGGTGGAGATGATCCACGCCTAT
TCGCTGGTCCACGACGACATGCCCTGCATGGACGACGATGACCTGCGCCGAGGTCGCCCGACGGTGCATCGCGCCTATGA
TGAAGCGACGGCGCTGCTGGTCGGCGACGCTTTGCAGACCCAGGCCTTCATCGCGCTGGCCGAGCTGGGCGCGGTGAGCC
CGGCCACGCGCGCCGGACTGGTCGGCGAGTTGGCGCGCGCGTCGGGTTCGCTCGGCATGGCGGGCGGGCAGGCGATCGAT
CTGCAGAGCGTTGGCGTGGCCCTGTCGCAGGATGCGCTGGAGACCATGCACCGCATGAAGACCGGCGCGCTGCTGCGGGC
AAGCCTGCGCATGGGCGCCCTGTGCGCCGGCGTGAATGCCGCGGCGCTGGAACAGGTGGACGCCTACGCGGGCGCGGTCG
GACTGGCGTTCCAGGTGGTCGACGACATTCTCGACGTGACGGCCGACACCGCCACGCTGGGCAAGACCGCCGGCAAGGAC
GAGGCCAACGACAAGCCGACCTATGTGTCGATCCTCGGCCTGGAGCGCGCGCGGGCGCTGGCCGATGCGTTGCATGCCGC
GGCGGGCGCGGCGGTGGCGCAGCTGTCCCGCGAACTGGGTGAAGCGCGCACCGCCAGGCTGGCCGGGATGGCCGACCTGA
TCGTGTGGCGTGGCCACTGA

Upstream 100 bases:

>100_bases
GCCAGCAGGTGCTGGAGCGCGTCGAGCAGCAGGTGCGCGTGCTCGACGGCGATGCCCTGAAGCCCCTGGCGGGCGAAGGC
ACGAACGAACAGGGCGGAGC

Downstream 100 bases:

>100_bases
ACAACATTGCACTGACACATTAGAAGTCTTTGCCTAGACGCCGGAGCGGCGGTCTCACATGACGTACGAACTTCTGAACA
CCATCGACGCTCCGGCCGAG

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MSDFAHWMASVVARTESALERALPGESVAPQRLHAAMRYATLGAGKRVRPLLAHAAGALGEASPEALDGVSCAVEMIHAY
SLVHDDMPCMDDDDLRRGRPTVHRAYDEATALLVGDALQTQAFIALAELGAVSPATRAGLVGELARASGSLGMAGGQAID
LQSVGVALSQDALETMHRMKTGALLRASLRMGALCAGVNAAALEQVDAYAGAVGLAFQVVDDILDVTADTATLGKTAGKD
EANDKPTYVSILGLERARALADALHAAAGAAVAQLSRELGEARTARLAGMADLIVWRGH

Sequences:

>Translated_299_residues
MSDFAHWMASVVARTESALERALPGESVAPQRLHAAMRYATLGAGKRVRPLLAHAAGALGEASPEALDGVSCAVEMIHAY
SLVHDDMPCMDDDDLRRGRPTVHRAYDEATALLVGDALQTQAFIALAELGAVSPATRAGLVGELARASGSLGMAGGQAID
LQSVGVALSQDALETMHRMKTGALLRASLRMGALCAGVNAAALEQVDAYAGAVGLAFQVVDDILDVTADTATLGKTAGKD
EANDKPTYVSILGLERARALADALHAAAGAAVAQLSRELGEARTARLAGMADLIVWRGH
>Mature_298_residues
SDFAHWMASVVARTESALERALPGESVAPQRLHAAMRYATLGAGKRVRPLLAHAAGALGEASPEALDGVSCAVEMIHAYS
LVHDDMPCMDDDDLRRGRPTVHRAYDEATALLVGDALQTQAFIALAELGAVSPATRAGLVGELARASGSLGMAGGQAIDL
QSVGVALSQDALETMHRMKTGALLRASLRMGALCAGVNAAALEQVDAYAGAVGLAFQVVDDILDVTADTATLGKTAGKDE
ANDKPTYVSILGLERARALADALHAAAGAAVAQLSRELGEARTARLAGMADLIVWRGH

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=224, Percent_Identity=28.125, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786623, Length=299, Percent_Identity=47.4916387959866, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1789578, Length=214, Percent_Identity=31.3084112149533, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24651612, Length=211, Percent_Identity=28.436018957346, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 30912; Mature: 30780

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFAHWMASVVARTESALERALPGESVAPQRLHAAMRYATLGAGKRVRPLLAHAAGALG
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
EASPEALDGVSCAVEMIHAYSLVHDDMPCMDDDDLRRGRPTVHRAYDEATALLVGDALQT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHH
QAFIALAELGAVSPATRAGLVGELARASGSLGMAGGQAIDLQSVGVALSQDALETMHRMK
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
TGALLRASLRMGALCAGVNAAALEQVDAYAGAVGLAFQVVDDILDVTADTATLGKTAGKD
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCC
EANDKPTYVSILGLERARALADALHAAAGAAVAQLSRELGEARTARLAGMADLIVWRGH
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
>Mature Secondary Structure 
SDFAHWMASVVARTESALERALPGESVAPQRLHAAMRYATLGAGKRVRPLLAHAAGALG
CHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
EASPEALDGVSCAVEMIHAYSLVHDDMPCMDDDDLRRGRPTVHRAYDEATALLVGDALQT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHH
QAFIALAELGAVSPATRAGLVGELARASGSLGMAGGQAIDLQSVGVALSQDALETMHRMK
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
TGALLRASLRMGALCAGVNAAALEQVDAYAGAVGLAFQVVDDILDVTADTATLGKTAGKD
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCC
EANDKPTYVSILGLERARALADALHAAAGAAVAQLSRELGEARTARLAGMADLIVWRGH
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9655913; 12597275 [H]