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The map label for this gene is dxs [H]

Identifier: 17546940

GI number: 17546940

Start: 2408516

End: 2410426

Strand: Reverse

Name: dxs [H]

Synonym: RSc2221

Alternate gene names: 17546940

Gene position: 2410426-2408516 (Counterclockwise)

Preceding gene: 17546941

Following gene: 17546939

Centisome position: 64.86

GC content: 68.81

Gene sequence:

>1911_bases
ATGACGTACGAACTTCTGAACACCATCGACGCTCCGGCCGAGCTACGCCGCCTGGACCGTCGCCAGCTCGGCACCCTGGC
CGATGAGCTGCGCGCCTTCGTGCTCGAATCCGTCGCGCAGACGGGGGGCCACCTGTCGTCGAATCTGGGCACGGTCGAGC
TGACCATCGCGCTGCACTACGTCTTCAACACGCCGGACGATCGCATCGTGTGGGACGTCGGTCACCAGAGCTATCCGCAC
AAGATCCTGACCGGCCGCCGCGAGCAGATGGCGACACTGCGCCAACTGGACGGCATCTCCGGTTTCCCGCGCCGCAGCGA
GAGCCCGTACGACACCTTCGGCACCGCGCATTCCTCCACCTCGATCTCCGCCGCGCTGGGCATGGCGCTGGGCGCCAAGA
CGCAGGGCGAGAACCGCGTCGCCATCGCCGTGATCGGCGACGGGGCGATGAGCGCGGGCATGGCCTTCGAGGCGATGAAC
AACGCCGGTGTCTATCGAAACCTGCCGCTGGTGGTGGTGCTCAACGACAACGACATGTCGATCTCGCCGCCGGTGGGCGC
GCTCAACCGCTACCTGGCGCGGTTGATGAGCGGCCAGTTCTACGCCGCCACCAAGAAGGGCGTGGAGAAGCTGCTGTCGG
TGGCGCCGCCGGTGCTGGAGTTCGCCAAGCGCTTCGAGGAGCACGCCAAGGGCATGCTGGTGCCGGCGACGATGTTCGAG
GAATTCGGCTTCAACTACATCGGGCCGATCGATGGGCACGATCTCGAATCCCTGGTGCCGACGCTGCAGAACATCCGCCA
GCGCGCGCTGGAGGGCGGCCGGCCGCAGTTCCTGCACGTGGTGACCAAGAAGGGGCAGGGCTACAAGCTGGCCGAGGCCG
ATCCGATCCTTTATCACGGCCCGGGCAAGTTCAATCCGCAGGAAGGCATCAAGCCCGCCGCGCGCCCGGCCAAGGTGTCC
TACACGCAGGTGTTCGGCCAGTGGCTGTGCGACATGGCCGCCGCCGACAAGCGTCTGGTCGGTATCACGCCCGCCATGCG
CGAGGGCTCGGGCATGGTGGAGTTCGAGCAGCGCTTCCCCGACCGCTATTACGACGTCGGCATCGCTGAGCAGCACGCTG
TCACCTTCGCCGGTGGCCTGGCGTGCGAGGGCCTCAAGCCGGTGGTCGCCATCTATTCGACCTTCCTGCAGCGCGGCTAC
GACCAGCTGATCCACGACGTGGCGCTGCAGAACCTGCCGGTGGTGTTCGCGCTGGACCGCGCGGGCCTGGTCGGCGCGGA
CGGCGCGACGCATGCCGGCGCCTACGACATGGCCTACCTGCGCTGCATCCCCAACATGATGGTGATGGCGCCGGCCGACG
AGAACGAGTGCCGCCAGCTGCTCAGCACGGCGTTCGCCCAGGACTGCCCGACGGCGGTGCGCTATCCACGCGGTGCCGGC
ACGGGCGTGGTGGTGCAGCCGACGCTGGAGCCGCTGCCGGTGGGCAAGGCCGAGGTGCGCCGCGCGTCCACCGCACCGGC
GGGCCAGCGCGTGGTGATCCTGGCTTTCGGTTCGATGGTCGCGCCGGCCGCCGCCGCCGCCGAGCGCCTGGATGCCACCG
TGGTCAACATGCGCTTCGTCAAGCCGCTGGACGCGGCCTGCGTGCTGGAGATGGCACGCACCCACGATTATGTGGTCACA
GTGGAAGAGGGTTGCGTGATGGGCGGCGCCGGCAGCGCCTGCCTGGAGGCGCTTGCCGCCGCCGGGGTGGCCACGCCGGT
GCTGCAGTTGGGCTTGCCCGACCGCTTCGTCGATCACGGCGATCATGCGGCGCTGCTGGCGCTGTGCGGACTGGACGCCA
ACGGCATCCTGGCGTCGATCCGCGAGCGCTTTGCGGTGCAGCCGCGCGCGGTGCAACCGCGCGTGGCGTAA

Upstream 100 bases:

>100_bases
CTGGCCGGGATGGCCGACCTGATCGTGTGGCGTGGCCACTGAACAACATTGCACTGACACATTAGAAGTCTTTGCCTAGA
CGCCGGAGCGGCGGTCTCAC

Downstream 100 bases:

>100_bases
GGGGCACTTTGCGATAGGCCGTTTCAATCACCCGCATTGTCACTGCGGGTTTGAGCAGCCGACAGCAGAGGTGGCAAATT
TCCCTTACACTGCGTCCGTT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 636; Mature: 635

Protein sequence:

>636_residues
MTYELLNTIDAPAELRRLDRRQLGTLADELRAFVLESVAQTGGHLSSNLGTVELTIALHYVFNTPDDRIVWDVGHQSYPH
KILTGRREQMATLRQLDGISGFPRRSESPYDTFGTAHSSTSISAALGMALGAKTQGENRVAIAVIGDGAMSAGMAFEAMN
NAGVYRNLPLVVVLNDNDMSISPPVGALNRYLARLMSGQFYAATKKGVEKLLSVAPPVLEFAKRFEEHAKGMLVPATMFE
EFGFNYIGPIDGHDLESLVPTLQNIRQRALEGGRPQFLHVVTKKGQGYKLAEADPILYHGPGKFNPQEGIKPAARPAKVS
YTQVFGQWLCDMAAADKRLVGITPAMREGSGMVEFEQRFPDRYYDVGIAEQHAVTFAGGLACEGLKPVVAIYSTFLQRGY
DQLIHDVALQNLPVVFALDRAGLVGADGATHAGAYDMAYLRCIPNMMVMAPADENECRQLLSTAFAQDCPTAVRYPRGAG
TGVVVQPTLEPLPVGKAEVRRASTAPAGQRVVILAFGSMVAPAAAAAERLDATVVNMRFVKPLDAACVLEMARTHDYVVT
VEEGCVMGGAGSACLEALAAAGVATPVLQLGLPDRFVDHGDHAALLALCGLDANGILASIRERFAVQPRAVQPRVA

Sequences:

>Translated_636_residues
MTYELLNTIDAPAELRRLDRRQLGTLADELRAFVLESVAQTGGHLSSNLGTVELTIALHYVFNTPDDRIVWDVGHQSYPH
KILTGRREQMATLRQLDGISGFPRRSESPYDTFGTAHSSTSISAALGMALGAKTQGENRVAIAVIGDGAMSAGMAFEAMN
NAGVYRNLPLVVVLNDNDMSISPPVGALNRYLARLMSGQFYAATKKGVEKLLSVAPPVLEFAKRFEEHAKGMLVPATMFE
EFGFNYIGPIDGHDLESLVPTLQNIRQRALEGGRPQFLHVVTKKGQGYKLAEADPILYHGPGKFNPQEGIKPAARPAKVS
YTQVFGQWLCDMAAADKRLVGITPAMREGSGMVEFEQRFPDRYYDVGIAEQHAVTFAGGLACEGLKPVVAIYSTFLQRGY
DQLIHDVALQNLPVVFALDRAGLVGADGATHAGAYDMAYLRCIPNMMVMAPADENECRQLLSTAFAQDCPTAVRYPRGAG
TGVVVQPTLEPLPVGKAEVRRASTAPAGQRVVILAFGSMVAPAAAAAERLDATVVNMRFVKPLDAACVLEMARTHDYVVT
VEEGCVMGGAGSACLEALAAAGVATPVLQLGLPDRFVDHGDHAALLALCGLDANGILASIRERFAVQPRAVQPRVA
>Mature_635_residues
TYELLNTIDAPAELRRLDRRQLGTLADELRAFVLESVAQTGGHLSSNLGTVELTIALHYVFNTPDDRIVWDVGHQSYPHK
ILTGRREQMATLRQLDGISGFPRRSESPYDTFGTAHSSTSISAALGMALGAKTQGENRVAIAVIGDGAMSAGMAFEAMNN
AGVYRNLPLVVVLNDNDMSISPPVGALNRYLARLMSGQFYAATKKGVEKLLSVAPPVLEFAKRFEEHAKGMLVPATMFEE
FGFNYIGPIDGHDLESLVPTLQNIRQRALEGGRPQFLHVVTKKGQGYKLAEADPILYHGPGKFNPQEGIKPAARPAKVSY
TQVFGQWLCDMAAADKRLVGITPAMREGSGMVEFEQRFPDRYYDVGIAEQHAVTFAGGLACEGLKPVVAIYSTFLQRGYD
QLIHDVALQNLPVVFALDRAGLVGADGATHAGAYDMAYLRCIPNMMVMAPADENECRQLLSTAFAQDCPTAVRYPRGAGT
GVVVQPTLEPLPVGKAEVRRASTAPAGQRVVILAFGSMVAPAAAAAERLDATVVNMRFVKPLDAACVLEMARTHDYVVTV
EEGCVMGGAGSACLEALAAAGVATPVLQLGLPDRFVDHGDHAALLALCGLDANGILASIRERFAVQPRAVQPRVA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=650, Percent_Identity=24.6153846153846, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI4507521, Length=650, Percent_Identity=24.6153846153846, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI225637461, Length=531, Percent_Identity=25.2354048964218, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI225637459, Length=531, Percent_Identity=25.2354048964218, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI225637463, Length=531, Percent_Identity=25.2354048964218, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI133778974, Length=665, Percent_Identity=24.3609022556391, Blast_Score=83, Evalue=1e-15,
Organism=Escherichia coli, GI1786622, Length=624, Percent_Identity=57.0512820512821, Blast_Score=735, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=674, Percent_Identity=23.7388724035608, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24666278, Length=601, Percent_Identity=24.459234608985, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45551847, Length=599, Percent_Identity=24.7078464106845, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45550715, Length=599, Percent_Identity=24.7078464106845, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24645119, Length=513, Percent_Identity=25.3411306042885, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21358145, Length=230, Percent_Identity=27.8260869565217, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24650940, Length=230, Percent_Identity=27.8260869565217, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68301; Mature: 68170

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYELLNTIDAPAELRRLDRRQLGTLADELRAFVLESVAQTGGHLSSNLGTVELTIALHY
CCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEE
VFNTPDDRIVWDVGHQSYPHKILTGRREQMATLRQLDGISGFPRRSESPYDTFGTAHSST
EECCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCC
SISAALGMALGAKTQGENRVAIAVIGDGAMSAGMAFEAMNNAGVYRNLPLVVVLNDNDMS
HHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHCHHHHHHCCCCCEECCCEEEEECCCCCC
ISPPVGALNRYLARLMSGQFYAATKKGVEKLLSVAPPVLEFAKRFEEHAKGMLVPATMFE
CCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEHHHHHH
EFGFNYIGPIDGHDLESLVPTLQNIRQRALEGGRPQFLHVVTKKGQGYKLAEADPILYHG
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCEEEEC
PGKFNPQEGIKPAARPAKVSYTQVFGQWLCDMAAADKRLVGITPAMREGSGMVEFEQRFP
CCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHCCCCCCHHHHHCC
DRYYDVGIAEQHAVTFAGGLACEGLKPVVAIYSTFLQRGYDQLIHDVALQNLPVVFALDR
HHHEECCCCCHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
AGLVGADGATHAGAYDMAYLRCIPNMMVMAPADENECRQLLSTAFAQDCPTAVRYPRGAG
CCEECCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHCCCCCCC
TGVVVQPTLEPLPVGKAEVRRASTAPAGQRVVILAFGSMVAPAAAAAERLDATVVNMRFV
CCEEEECCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHEEEEEC
KPLDAACVLEMARTHDYVVTVEEGCVMGGAGSACLEALAAAGVATPVLQLGLPDRFVDHG
CCCHHHHHHHHHHCCCEEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
DHAALLALCGLDANGILASIRERFAVQPRAVQPRVA
CCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TYELLNTIDAPAELRRLDRRQLGTLADELRAFVLESVAQTGGHLSSNLGTVELTIALHY
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEE
VFNTPDDRIVWDVGHQSYPHKILTGRREQMATLRQLDGISGFPRRSESPYDTFGTAHSST
EECCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCC
SISAALGMALGAKTQGENRVAIAVIGDGAMSAGMAFEAMNNAGVYRNLPLVVVLNDNDMS
HHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHCHHHHHHCCCCCEECCCEEEEECCCCCC
ISPPVGALNRYLARLMSGQFYAATKKGVEKLLSVAPPVLEFAKRFEEHAKGMLVPATMFE
CCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEHHHHHH
EFGFNYIGPIDGHDLESLVPTLQNIRQRALEGGRPQFLHVVTKKGQGYKLAEADPILYHG
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCEEEEC
PGKFNPQEGIKPAARPAKVSYTQVFGQWLCDMAAADKRLVGITPAMREGSGMVEFEQRFP
CCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHCCCCCCHHHHHCC
DRYYDVGIAEQHAVTFAGGLACEGLKPVVAIYSTFLQRGYDQLIHDVALQNLPVVFALDR
HHHEECCCCCHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
AGLVGADGATHAGAYDMAYLRCIPNMMVMAPADENECRQLLSTAFAQDCPTAVRYPRGAG
CCEECCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHCCCCCCC
TGVVVQPTLEPLPVGKAEVRRASTAPAGQRVVILAFGSMVAPAAAAAERLDATVVNMRFV
CCEEEECCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHEEEEEC
KPLDAACVLEMARTHDYVVTVEEGCVMGGAGSACLEALAAAGVATPVLQLGLPDRFVDHG
CCCHHHHHHHHHHCCCEEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
DHAALLALCGLDANGILASIRERFAVQPRAVQPRVA
CCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA