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The map label for this gene is fucA [C]

Identifier: 17546486

GI number: 17546486

Start: 1894334

End: 1895140

Strand: Direct

Name: fucA [C]

Synonym: RSc1767

Alternate gene names: 17546486

Gene position: 1894334-1895140 (Clockwise)

Preceding gene: 17546485

Following gene: 17546487

Centisome position: 50.97

GC content: 68.4

Gene sequence:

>807_bases
ATGGCGGCCAACCTCAGCCCCGAGGTCCGCGAGAAATACCGCAACCTGCCGCGTCCGCCCCGGTTCGACACCGTGGCGCA
GGAGCGCCTGCACCGCAAGCAGCGGCTGGCGGCGGCGTTCCGGCTGTTCTCGAAGTTCGGTTTCGACGAGGGCGTGGCCG
GGCACATCACCGCGCGCGATCCGGAGGTCCTGGACAGTTTCTGGGTGAACCCGTTCGGCGTGCATTTCAGCCAGGTGAAG
GTGTCCAACCTGATCCGCTGCGATCATCATGGCAACGTGGTGGAGGGCGATTACCCGGTCAACGCGGCGGCCTTCGCCAT
CCACTCGCGCGTGCACCAGGCGCGGCCCGACGCGGTGGCGGCGGCGCATTCGCACAGCATCTACGGGCGCGCCTGGTCGA
CGCTCGGCCGCAAGCTCGATCCGCTCACGCAGGACGTCTGCGCCTTCTACGAAGACCACGCGCTATACGACGATTTCGGC
GGCGTGGTGGTCGAGCTCGACGAGGGCCAGCGCATTGCCCAGGCGCTCGGCGGCAACAAGGCCGCGATCCTGCAGAACCA
CGGCCTGCTGACGGTGGGCAAGACGGTGGACGAGGCGGCCTGGTGGTTCATCACCATGGAACGCTCGTGCCAGGTGCAGT
TGCTGGCCGAGGCCGCCGCCGCGCGCACCAGCGAGCCGCTGCGCCTGATTTCCGAGGCGGCGGCGCGGCAGGCGTATTCC
ATCGTCGGCACGGCGCAGGCGGGGTGGTTCCAGTTCCAGCCGCTGTATGCGCGCATCGTCAAGGAACAACCCGACCTGCT
GGACTGA

Upstream 100 bases:

>100_bases
GCCGGGCACGGGCCGCAACGGAATGACCCAGCCACGACGACAGCGCGAAGGAGGCACCATGAACGCACCCGACACCGCAC
AGGCCAAGCGGCCCGACGAG

Downstream 100 bases:

>100_bases
ACAGCGACCCTCGGAGCCCCCATGACGGACCTGATCCTGCATCACTACGCCACCTCGCCGTTCTCGGAGAAAGTGCGCCT
GATCCTCGGCTACAAGGACC

Product: hypothetical protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MAANLSPEVREKYRNLPRPPRFDTVAQERLHRKQRLAAAFRLFSKFGFDEGVAGHITARDPEVLDSFWVNPFGVHFSQVK
VSNLIRCDHHGNVVEGDYPVNAAAFAIHSRVHQARPDAVAAAHSHSIYGRAWSTLGRKLDPLTQDVCAFYEDHALYDDFG
GVVVELDEGQRIAQALGGNKAAILQNHGLLTVGKTVDEAAWWFITMERSCQVQLLAEAAAARTSEPLRLISEAAARQAYS
IVGTAQAGWFQFQPLYARIVKEQPDLLD

Sequences:

>Translated_268_residues
MAANLSPEVREKYRNLPRPPRFDTVAQERLHRKQRLAAAFRLFSKFGFDEGVAGHITARDPEVLDSFWVNPFGVHFSQVK
VSNLIRCDHHGNVVEGDYPVNAAAFAIHSRVHQARPDAVAAAHSHSIYGRAWSTLGRKLDPLTQDVCAFYEDHALYDDFG
GVVVELDEGQRIAQALGGNKAAILQNHGLLTVGKTVDEAAWWFITMERSCQVQLLAEAAAARTSEPLRLISEAAARQAYS
IVGTAQAGWFQFQPLYARIVKEQPDLLD
>Mature_267_residues
AANLSPEVREKYRNLPRPPRFDTVAQERLHRKQRLAAAFRLFSKFGFDEGVAGHITARDPEVLDSFWVNPFGVHFSQVKV
SNLIRCDHHGNVVEGDYPVNAAAFAIHSRVHQARPDAVAAAHSHSIYGRAWSTLGRKLDPLTQDVCAFYEDHALYDDFGG
VVVELDEGQRIAQALGGNKAAILQNHGLLTVGKTVDEAAWWFITMERSCQVQLLAEAAAARTSEPLRLISEAAARQAYSI
VGTAQAGWFQFQPLYARIVKEQPDLLD

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI29826325, Length=240, Percent_Identity=30.4166666666667, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI29826323, Length=240, Percent_Identity=30.4166666666667, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI29826321, Length=240, Percent_Identity=30.4166666666667, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI29826319, Length=240, Percent_Identity=30.4166666666667, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI297307160, Length=232, Percent_Identity=29.3103448275862, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI89276787, Length=232, Percent_Identity=29.3103448275862, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI9257190, Length=232, Percent_Identity=29.7413793103448, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI297307158, Length=232, Percent_Identity=29.7413793103448, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI9257192, Length=232, Percent_Identity=29.7413793103448, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI9951927, Length=201, Percent_Identity=28.3582089552239, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI62912453, Length=201, Percent_Identity=28.3582089552239, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI9943848, Length=201, Percent_Identity=28.3582089552239, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1789164, Length=193, Percent_Identity=27.4611398963731, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115533216, Length=224, Percent_Identity=25.8928571428571, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI115533218, Length=224, Percent_Identity=25.8928571428571, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71989560, Length=200, Percent_Identity=27.5, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71989541, Length=200, Percent_Identity=27.5, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71989555, Length=200, Percent_Identity=27.5, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71989550, Length=200, Percent_Identity=27.5, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71989544, Length=200, Percent_Identity=27.5, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI281363763, Length=186, Percent_Identity=35.4838709677419, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281363757, Length=186, Percent_Identity=35.4838709677419, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17136738, Length=186, Percent_Identity=35.4838709677419, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281363755, Length=189, Percent_Identity=34.9206349206349, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281363751, Length=189, Percent_Identity=34.9206349206349, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24655690, Length=189, Percent_Identity=34.9206349206349, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24655685, Length=186, Percent_Identity=35.4838709677419, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281363761, Length=186, Percent_Identity=35.4838709677419, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI281363759, Length=186, Percent_Identity=35.4838709677419, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI281363753, Length=186, Percent_Identity=35.4838709677419, Blast_Score=101, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 29788; Mature: 29657

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAANLSPEVREKYRNLPRPPRFDTVAQERLHRKQRLAAAFRLFSKFGFDEGVAGHITARD
CCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCC
PEVLDSFWVNPFGVHFSQVKVSNLIRCDHHGNVVEGDYPVNAAAFAIHSRVHQARPDAVA
HHHHHHHCCCHHCCHHHHHHHHHHEEECCCCCEECCCCCCCHHHHHHHHHHHHCCCCHHH
AAHSHSIYGRAWSTLGRKLDPLTQDVCAFYEDHALYDDFGGVVVELDEGQRIAQALGGNK
HHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHCCCCEEEEECCCHHHHHHHCCCC
AAILQNHGLLTVGKTVDEAAWWFITMERSCQVQLLAEAAAARTSEPLRLISEAAARQAYS
EEEEECCCEEEECCCHHCCEEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IVGTAQAGWFQFQPLYARIVKEQPDLLD
HEECCCCCCEEHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AANLSPEVREKYRNLPRPPRFDTVAQERLHRKQRLAAAFRLFSKFGFDEGVAGHITARD
CCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCC
PEVLDSFWVNPFGVHFSQVKVSNLIRCDHHGNVVEGDYPVNAAAFAIHSRVHQARPDAVA
HHHHHHHCCCHHCCHHHHHHHHHHEEECCCCCEECCCCCCCHHHHHHHHHHHHCCCCHHH
AAHSHSIYGRAWSTLGRKLDPLTQDVCAFYEDHALYDDFGGVVVELDEGQRIAQALGGNK
HHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHCCCCEEEEECCCHHHHHHHCCCC
AAILQNHGLLTVGKTVDEAAWWFITMERSCQVQLLAEAAAARTSEPLRLISEAAARQAYS
EEEEECCCEEEECCCHHCCEEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IVGTAQAGWFQFQPLYARIVKEQPDLLD
HEECCCCCCEEHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]