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The map label for this gene is alkK [H]

Identifier: 17546468

GI number: 17546468

Start: 1870828

End: 1872456

Strand: Direct

Name: alkK [H]

Synonym: RSc1749

Alternate gene names: 17546468

Gene position: 1870828-1872456 (Clockwise)

Preceding gene: 17546456

Following gene: 17546469

Centisome position: 50.34

GC content: 67.34

Gene sequence:

>1629_bases
ATGGGACACATGATGAGCGCGCCCTTGCTCATCTCGACCATCATCGAACATGCCGCGCGGAACTACGGTTCGACCGAAGT
CGTGTCGCGCCGCGTGGAGGGCGATGGGGGCGAGCTCCATCGCACCACGTACGCGGCCGTGCGCGATCGCGCCAAGCAAC
TGGCGAATGCGCTGGCCGCGCTCGGCGTGCAGCCCGGCGAGCGCATCGGCACGCTGGCCTGGAACGGCTACCGGCACCTG
GAGATCTACTACGGCGTGTCGGGCTCGGGCGCGGTGTGCCACACCATCAATCCGCGCCTGTTCCCCGACCAGGTCGCCTA
CATCGTCAACCACGCCGATGATCAGTACGTCTTCTTCGACCTGACCTTCGTGCCGCTGGTCGAGGGCCTCGCGCCGCATT
GCCCGAACGTCAAGGGCTGGGTGGCGATGACCGACCGCGCGCACATGCCGGCCTCCAGCGTGCCGATGCTGTGCTACGAA
GACCTGCTGGCCGCGCAGCGCGCCGAGTACACCTGGCCGCTGTTCGACGAGAACACCGCCTCCAGCCTGTGCTACACGTC
GGGCACGACCGGCAATCCGAAGGGGGCGCTGTATTCGCACCGCTCCACCGTGCTGCATTCGTATGGGTCGGCGCTGCCCG
ATGCGCTGGGCTGCTCGGCGCAGGACGTGATCCTGCCGGTGGTGCCGATGTTCCACGTCAATGCCTGGGGCCTGCCGTAT
TCGGTGCCGCTGGTGGGCGCCAAGCTGGTGTTTCCGGGGCCGAAGCTGGACGGCGCCTCGCTGTACGAACTGTTCGAGCA
GGAGCAGGTGAGCTTCTCCGCCGGCGTGCCGACGGTGTGGCTCGGCCTGCTGCAGCACGTGCAGGGCAAGGGCCTGAAGT
TTTCGTCGTTCCGCCGTACGGTGATCGGCGGCTCGGCGTGCCCGCCGGCCATGATCCGCACGCTCAATGCGCTCGGCGTG
GAGGTGATCCACGCCTGGGGCATGACCGAGATGTCGCCGCTGGGCACCACCTGCAAGCTGATGAGCAAGCACAATGGCCT
GCCGGACGAAACCCGGCAGCAGGTGCTCGAGCGCCAGGGCCGCGCCATCTACGGCGTGGAGATGAAGATCGTCGACGGCA
ACGGCCACGAGCTGCCGTGGGACGGCAAGGCCTTCGGCGACCTGCACGTGCGCGGGCCGTGGACCATCGCCAGCTACTAC
CGCAACGGCCAGTCGCCGCTGGTCGACGGCTGGTTCCCGACCGGCGACGTCGCCAACATCGACCCCGACGGCTACATGCA
GATCACCGATCGCAGCAAGGACGTGATCAAGTCGGGCGGGGAGTGGATCTCATCGATCGACGTGGAGAACGTGGCCGCCG
CGCACCCGGCCGTGCACATGGCGGCGTGCATCGCCTGCCGGCATCCGAAGTGGGACGAGCGCCCGCTGCTGGTGGTGATG
AAGAAACCGGGCGCGGAGCTGACGCGCGACGAAATGCTGCGCTACTTCGAGGGCAAGGTCGCCAAGTGGTGGATTCCGGA
CGACGTGGTGTTCGTCACCGAGATCCCGCTCACGGCCACCGGCAAGATGCAGAAGCTCAAGCTGCGCGAGCAGTTCCGCG
ACTACCAGTTGCCGCTCGCGCAGGCTTAG

Upstream 100 bases:

>100_bases
GCGCACAACGGAATCCCGTTGACGCGCTCCTGGATCGCGGGAACAATCGGCCGAAAAATAGAACGGTTGTTCAGTTTTTC
GAGGAGACACCATGGCCCTG

Downstream 100 bases:

>100_bases
CGCGCAGGACAGAAACCGCCGCCCGCGCACCGGCACCACCCGGGCACGAGGACGGCGGACGGAAGACGGAAGACAACCGG
ATCAGGGCCGGCCGCCGCGC

Product: long-chain-fatty-acid--CoA ligase

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MGHMMSAPLLISTIIEHAARNYGSTEVVSRRVEGDGGELHRTTYAAVRDRAKQLANALAALGVQPGERIGTLAWNGYRHL
EIYYGVSGSGAVCHTINPRLFPDQVAYIVNHADDQYVFFDLTFVPLVEGLAPHCPNVKGWVAMTDRAHMPASSVPMLCYE
DLLAAQRAEYTWPLFDENTASSLCYTSGTTGNPKGALYSHRSTVLHSYGSALPDALGCSAQDVILPVVPMFHVNAWGLPY
SVPLVGAKLVFPGPKLDGASLYELFEQEQVSFSAGVPTVWLGLLQHVQGKGLKFSSFRRTVIGGSACPPAMIRTLNALGV
EVIHAWGMTEMSPLGTTCKLMSKHNGLPDETRQQVLERQGRAIYGVEMKIVDGNGHELPWDGKAFGDLHVRGPWTIASYY
RNGQSPLVDGWFPTGDVANIDPDGYMQITDRSKDVIKSGGEWISSIDVENVAAAHPAVHMAACIACRHPKWDERPLLVVM
KKPGAELTRDEMLRYFEGKVAKWWIPDDVVFVTEIPLTATGKMQKLKLREQFRDYQLPLAQA

Sequences:

>Translated_542_residues
MGHMMSAPLLISTIIEHAARNYGSTEVVSRRVEGDGGELHRTTYAAVRDRAKQLANALAALGVQPGERIGTLAWNGYRHL
EIYYGVSGSGAVCHTINPRLFPDQVAYIVNHADDQYVFFDLTFVPLVEGLAPHCPNVKGWVAMTDRAHMPASSVPMLCYE
DLLAAQRAEYTWPLFDENTASSLCYTSGTTGNPKGALYSHRSTVLHSYGSALPDALGCSAQDVILPVVPMFHVNAWGLPY
SVPLVGAKLVFPGPKLDGASLYELFEQEQVSFSAGVPTVWLGLLQHVQGKGLKFSSFRRTVIGGSACPPAMIRTLNALGV
EVIHAWGMTEMSPLGTTCKLMSKHNGLPDETRQQVLERQGRAIYGVEMKIVDGNGHELPWDGKAFGDLHVRGPWTIASYY
RNGQSPLVDGWFPTGDVANIDPDGYMQITDRSKDVIKSGGEWISSIDVENVAAAHPAVHMAACIACRHPKWDERPLLVVM
KKPGAELTRDEMLRYFEGKVAKWWIPDDVVFVTEIPLTATGKMQKLKLREQFRDYQLPLAQA
>Mature_541_residues
GHMMSAPLLISTIIEHAARNYGSTEVVSRRVEGDGGELHRTTYAAVRDRAKQLANALAALGVQPGERIGTLAWNGYRHLE
IYYGVSGSGAVCHTINPRLFPDQVAYIVNHADDQYVFFDLTFVPLVEGLAPHCPNVKGWVAMTDRAHMPASSVPMLCYED
LLAAQRAEYTWPLFDENTASSLCYTSGTTGNPKGALYSHRSTVLHSYGSALPDALGCSAQDVILPVVPMFHVNAWGLPYS
VPLVGAKLVFPGPKLDGASLYELFEQEQVSFSAGVPTVWLGLLQHVQGKGLKFSSFRRTVIGGSACPPAMIRTLNALGVE
VIHAWGMTEMSPLGTTCKLMSKHNGLPDETRQQVLERQGRAIYGVEMKIVDGNGHELPWDGKAFGDLHVRGPWTIASYYR
NGQSPLVDGWFPTGDVANIDPDGYMQITDRSKDVIKSGGEWISSIDVENVAAAHPAVHMAACIACRHPKWDERPLLVVMK
KPGAELTRDEMLRYFEGKVAKWWIPDDVVFVTEIPLTATGKMQKLKLREQFRDYQLPLAQA

Specific function: Unknown

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=526, Percent_Identity=26.2357414448669, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI187761345, Length=385, Percent_Identity=29.3506493506493, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI187761343, Length=385, Percent_Identity=29.3506493506493, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI38505220, Length=516, Percent_Identity=24.2248062015504, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI157311624, Length=519, Percent_Identity=24.2774566473988, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI157311622, Length=519, Percent_Identity=24.2774566473988, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI42544132, Length=518, Percent_Identity=22.5868725868726, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI58082049, Length=523, Percent_Identity=24.0917782026769, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI122937307, Length=522, Percent_Identity=24.1379310344828, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI28416953, Length=580, Percent_Identity=22.4137931034483, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI115511026, Length=519, Percent_Identity=21.3872832369942, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI13375727, Length=535, Percent_Identity=21.6822429906542, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI145693145, Length=502, Percent_Identity=27.6892430278884, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI221142682, Length=506, Percent_Identity=23.5177865612648, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1788107, Length=529, Percent_Identity=22.8733459357278, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1786810, Length=358, Percent_Identity=28.7709497206704, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1789201, Length=480, Percent_Identity=23.125, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788595, Length=455, Percent_Identity=23.956043956044, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994694, Length=574, Percent_Identity=24.2160278745645, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI71994703, Length=574, Percent_Identity=24.2160278745645, Blast_Score=145, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI71994690, Length=574, Percent_Identity=24.2160278745645, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17558820, Length=510, Percent_Identity=25.6862745098039, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17560308, Length=528, Percent_Identity=25.3787878787879, Blast_Score=131, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17531443, Length=505, Percent_Identity=23.960396039604, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI32563687, Length=525, Percent_Identity=24.7619047619048, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17557194, Length=514, Percent_Identity=24.3190661478599, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17559526, Length=524, Percent_Identity=25, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17538037, Length=514, Percent_Identity=23.1517509727626, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71985884, Length=370, Percent_Identity=25.9459459459459, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560140, Length=505, Percent_Identity=21.7821782178218, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71996755, Length=498, Percent_Identity=21.8875502008032, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319699, Length=360, Percent_Identity=27.7777777777778, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24581924, Length=578, Percent_Identity=27.1626297577855, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI18859661, Length=522, Percent_Identity=26.0536398467433, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI21355181, Length=497, Percent_Identity=23.1388329979879, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24648260, Length=509, Percent_Identity=24.950884086444, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI19922652, Length=502, Percent_Identity=23.1075697211155, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24656500, Length=516, Percent_Identity=23.8372093023256, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281365686, Length=247, Percent_Identity=25.9109311740891, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21356441, Length=506, Percent_Identity=22.1343873517787, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356947, Length=533, Percent_Identity=21.5759849906191, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24648257, Length=373, Percent_Identity=23.8605898123324, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24653035, Length=500, Percent_Identity=19, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 59572; Mature: 59441

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHMMSAPLLISTIIEHAARNYGSTEVVSRRVEGDGGELHRTTYAAVRDRAKQLANALAA
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LGVQPGERIGTLAWNGYRHLEIYYGVSGSGAVCHTINPRLFPDQVAYIVNHADDQYVFFD
HCCCCCCCEEEEEECCEEEEEEEEEECCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEE
LTFVPLVEGLAPHCPNVKGWVAMTDRAHMPASSVPMLCYEDLLAAQRAEYTWPLFDENTA
EEHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
SSLCYTSGTTGNPKGALYSHRSTVLHSYGSALPDALGCSAQDVILPVVPMFHVNAWGLPY
CCEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCHHHCCCCCCHHHCCCHHHEEECCCCCE
SVPLVGAKLVFPGPKLDGASLYELFEQEQVSFSAGVPTVWLGLLQHVQGKGLKFSSFRRT
ECCEECEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHH
VIGGSACPPAMIRTLNALGVEVIHAWGMTEMSPLGTTCKLMSKHNGLPDETRQQVLERQG
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCC
RAIYGVEMKIVDGNGHELPWDGKAFGDLHVRGPWTIASYYRNGQSPLVDGWFPTGDVANI
CEEEEEEEEEECCCCCCCCCCCCCCCEEEECCCEEHHHHHHCCCCCCCCCCCCCCCCCCC
DPDGYMQITDRSKDVIKSGGEWISSIDVENVAAAHPAVHMAACIACRHPKWDERPLLVVM
CCCCCEEECCCCHHHHHCCCHHHHHCCHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEEEE
KKPGAELTRDEMLRYFEGKVAKWWIPDDVVFVTEIPLTATGKMQKLKLREQFRDYQLPLA
CCCCCCCCHHHHHHHHCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCC
QA
CC
>Mature Secondary Structure 
GHMMSAPLLISTIIEHAARNYGSTEVVSRRVEGDGGELHRTTYAAVRDRAKQLANALAA
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LGVQPGERIGTLAWNGYRHLEIYYGVSGSGAVCHTINPRLFPDQVAYIVNHADDQYVFFD
HCCCCCCCEEEEEECCEEEEEEEEEECCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEE
LTFVPLVEGLAPHCPNVKGWVAMTDRAHMPASSVPMLCYEDLLAAQRAEYTWPLFDENTA
EEHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
SSLCYTSGTTGNPKGALYSHRSTVLHSYGSALPDALGCSAQDVILPVVPMFHVNAWGLPY
CCEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCHHHCCCCCCHHHCCCHHHEEECCCCCE
SVPLVGAKLVFPGPKLDGASLYELFEQEQVSFSAGVPTVWLGLLQHVQGKGLKFSSFRRT
ECCEECEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHH
VIGGSACPPAMIRTLNALGVEVIHAWGMTEMSPLGTTCKLMSKHNGLPDETRQQVLERQG
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCC
RAIYGVEMKIVDGNGHELPWDGKAFGDLHVRGPWTIASYYRNGQSPLVDGWFPTGDVANI
CEEEEEEEEEECCCCCCCCCCCCCCCEEEECCCEEHHHHHHCCCCCCCCCCCCCCCCCCC
DPDGYMQITDRSKDVIKSGGEWISSIDVENVAAAHPAVHMAACIACRHPKWDERPLLVVM
CCCCCEEECCCCHHHHHCCCHHHHHCCHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEEEE
KKPGAELTRDEMLRYFEGKVAKWWIPDDVVFVTEIPLTATGKMQKLKLREQFRDYQLPLA
CCCCCCCCHHHHHHHHCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCC
QA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]