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The map label for this gene is metC [H]

Identifier: 17546358

GI number: 17546358

Start: 1760865

End: 1762079

Strand: Direct

Name: metC [H]

Synonym: RSc1639

Alternate gene names: 17546358

Gene position: 1760865-1762079 (Clockwise)

Preceding gene: 17546357

Following gene: 17546362

Centisome position: 47.38

GC content: 69.71

Gene sequence:

>1215_bases
GTGACCGACGAAACCAAGCTCCCGCCCCCATTCCCCGCCACGCAGGCCGTCCATCCGGACCTGCACATCCCGCCCGGATT
CGCGGCGTTCTCGCATGCCACGCACCGTGCTTCCACGGTGGTCTTCAAGAACCTGGCCGACATGCGTGCCTTCGGGCACG
GCAGCGTGGTGCACTGGCGCTACGGCCTGCATGCCACGCCGACATCCGACACGCTGTGCCAGGCGCTGGCCCAGATCGAA
GGCGGCAGGCACGCGCTGCTGCTGCCGTCGGGGCTGGGGGCGATTTCGCTGGTGTATTTCGCGCTGGTCAAGTCGGGCGA
CGACGTGCTGATCCCGGACAACGCCTACGGCCCGACCCGTGACCACGGCGAATGGATGGCGCGCCAGTTCGGCATCACGG
TGCGCTATTACGATCCGATGATCGGTGCCGGCATCGCCGGCCTGATCCGCCATAACACGCGGCTGGTGTGGCTGGAAGCG
CCCGGCTCGGTGACGATGGAGGTGCCGGACTGCACCGCCATCGCCGAGGCGGCGCGCGCGGCCGGGGCCATCACCGCGAT
CGACAACACCTGGAGCGGCGGCCTGTACTACCAGCCGTTCGCGCACGGCATCGACATCTCGGTCCAGGCGCTGACCAAGT
ACCAGTCGGGCGGCAGCGACGTGCTGATGGGGGCCACCATCACCAACGACGAAGCGCTGTACCACACGCTGCTGTCCACG
CGCATGCGCATGGGCTGGGGTGTGTCGGCGGACGACTGCTTCCTGGTGCTGCGCGGGCTGCCCAGCCTGCCGGCCCGGCT
GGCGGCGCACGACGCCCACGCGCGCGAAGTGGCGGAATGGCTGGCCGAGCGGCCCGAGGTGGTGCGTGTGCTGCATCCGG
CGCTGCCCGACTGTCCGGGGCACGCGTACTGGAAGCGCGATTTCACCGGCGCGAGCGGGTTGTTTTCGATCGTGCTGCAC
ACGCGCTATGCGCCGGCGCAGATCGACGCCTTTGTCGAGGCGCTGCGCTATTTCGCGATCGGCTTTTCGTGGGGCGGGGC
GAACAGCCTGGCGCTGCCGTACAGCGTCCCGTCGATGCGCACCGCGACGGTCTGGCCGCCGGCGGGCTGGGAGAGCGCGG
GCGGCCTGGTCCGCCTGTACATCGGCCTGGAAGACCCGCGCGACCTGATCGCCGACCTGAAGAAGGCGATGGAAGCGCAC
CTGCGGGCGGCCTGA

Upstream 100 bases:

>100_bases
GTCGCCGGCCCCGGTGCTGCCGCCCGTCAATCCCGCGCGCTCCGGCGCGCGCTGGTAAGCTGCGGGGCAGTTGCCCCGCG
CCACTTCCCAGGACGCCTCC

Downstream 100 bases:

>100_bases
GCGGCCCGCAGGGCGTTGCCGTGGCGCTTACGGCTGCGGGAAAAGATTGAGCAGGCCGTCCAGGCCGACGACGTTGAACG
CCACGTCGGCCTGTGCCTGC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MTDETKLPPPFPATQAVHPDLHIPPGFAAFSHATHRASTVVFKNLADMRAFGHGSVVHWRYGLHATPTSDTLCQALAQIE
GGRHALLLPSGLGAISLVYFALVKSGDDVLIPDNAYGPTRDHGEWMARQFGITVRYYDPMIGAGIAGLIRHNTRLVWLEA
PGSVTMEVPDCTAIAEAARAAGAITAIDNTWSGGLYYQPFAHGIDISVQALTKYQSGGSDVLMGATITNDEALYHTLLST
RMRMGWGVSADDCFLVLRGLPSLPARLAAHDAHAREVAEWLAERPEVVRVLHPALPDCPGHAYWKRDFTGASGLFSIVLH
TRYAPAQIDAFVEALRYFAIGFSWGGANSLALPYSVPSMRTATVWPPAGWESAGGLVRLYIGLEDPRDLIADLKKAMEAH
LRAA

Sequences:

>Translated_404_residues
MTDETKLPPPFPATQAVHPDLHIPPGFAAFSHATHRASTVVFKNLADMRAFGHGSVVHWRYGLHATPTSDTLCQALAQIE
GGRHALLLPSGLGAISLVYFALVKSGDDVLIPDNAYGPTRDHGEWMARQFGITVRYYDPMIGAGIAGLIRHNTRLVWLEA
PGSVTMEVPDCTAIAEAARAAGAITAIDNTWSGGLYYQPFAHGIDISVQALTKYQSGGSDVLMGATITNDEALYHTLLST
RMRMGWGVSADDCFLVLRGLPSLPARLAAHDAHAREVAEWLAERPEVVRVLHPALPDCPGHAYWKRDFTGASGLFSIVLH
TRYAPAQIDAFVEALRYFAIGFSWGGANSLALPYSVPSMRTATVWPPAGWESAGGLVRLYIGLEDPRDLIADLKKAMEAH
LRAA
>Mature_403_residues
TDETKLPPPFPATQAVHPDLHIPPGFAAFSHATHRASTVVFKNLADMRAFGHGSVVHWRYGLHATPTSDTLCQALAQIEG
GRHALLLPSGLGAISLVYFALVKSGDDVLIPDNAYGPTRDHGEWMARQFGITVRYYDPMIGAGIAGLIRHNTRLVWLEAP
GSVTMEVPDCTAIAEAARAAGAITAIDNTWSGGLYYQPFAHGIDISVQALTKYQSGGSDVLMGATITNDEALYHTLLSTR
MRMGWGVSADDCFLVLRGLPSLPARLAAHDAHAREVAEWLAERPEVVRVLHPALPDCPGHAYWKRDFTGASGLFSIVLHT
RYAPAQIDAFVEALRYFAIGFSWGGANSLALPYSVPSMRTATVWPPAGWESAGGLVRLYIGLEDPRDLIADLKKAMEAHL
RAA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=294, Percent_Identity=32.9931972789116, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI299473759, Length=240, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI25453487, Length=293, Percent_Identity=29.3515358361775, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1789383, Length=383, Percent_Identity=39.4255874673629, Blast_Score=272, Evalue=4e-74,
Organism=Escherichia coli, GI1790375, Length=390, Percent_Identity=29.4871794871795, Blast_Score=152, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17560056, Length=332, Percent_Identity=33.7349397590361, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17538055, Length=330, Percent_Identity=33.030303030303, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71980708, Length=371, Percent_Identity=30.7277628032345, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321170, Length=312, Percent_Identity=43.9102564102564, Blast_Score=255, Evalue=9e-69,
Organism=Saccharomyces cerevisiae, GI6319307, Length=348, Percent_Identity=29.8850574712644, Blast_Score=142, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6321904, Length=350, Percent_Identity=26.8571428571429, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323333, Length=437, Percent_Identity=23.5697940503432, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922554, Length=350, Percent_Identity=34.2857142857143, Blast_Score=197, Evalue=8e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43695; Mature: 43564

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDETKLPPPFPATQAVHPDLHIPPGFAAFSHATHRASTVVFKNLADMRAFGHGSVVHWR
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
YGLHATPTSDTLCQALAQIEGGRHALLLPSGLGAISLVYFALVKSGDDVLIPDNAYGPTR
ECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEECCCCCCCCC
DHGEWMARQFGITVRYYDPMIGAGIAGLIRHNTRLVWLEAPGSVTMEVPDCTAIAEAARA
CHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCEEEEEECCCCEEEECCCHHHHHHHHHH
AGAITAIDNTWSGGLYYQPFAHGIDISVQALTKYQSGGSDVLMGATITNDEALYHTLLST
CCCEEEECCCCCCCEEECCCCCCCCEEEHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHH
RMRMGWGVSADDCFLVLRGLPSLPARLAAHDAHAREVAEWLAERPEVVRVLHPALPDCPG
HHHHCCCCCCHHHHHHECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
HAYWKRDFTGASGLFSIVLHTRYAPAQIDAFVEALRYFAIGFSWGGANSLALPYSVPSMR
CCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEECCCCCCEECCCCCCCCC
TATVWPPAGWESAGGLVRLYIGLEDPRDLIADLKKAMEAHLRAA
EEEECCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDETKLPPPFPATQAVHPDLHIPPGFAAFSHATHRASTVVFKNLADMRAFGHGSVVHWR
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
YGLHATPTSDTLCQALAQIEGGRHALLLPSGLGAISLVYFALVKSGDDVLIPDNAYGPTR
ECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEECCCCCCCCC
DHGEWMARQFGITVRYYDPMIGAGIAGLIRHNTRLVWLEAPGSVTMEVPDCTAIAEAARA
CHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCEEEEEECCCCEEEECCCHHHHHHHHHH
AGAITAIDNTWSGGLYYQPFAHGIDISVQALTKYQSGGSDVLMGATITNDEALYHTLLST
CCCEEEECCCCCCCEEECCCCCCCCEEEHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHH
RMRMGWGVSADDCFLVLRGLPSLPARLAAHDAHAREVAEWLAERPEVVRVLHPALPDCPG
HHHHCCCCCCHHHHHHECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
HAYWKRDFTGASGLFSIVLHTRYAPAQIDAFVEALRYFAIGFSWGGANSLALPYSVPSMR
CCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEECCCCCCEECCCCCCCCC
TATVWPPAGWESAGGLVRLYIGLEDPRDLIADLKKAMEAHLRAA
EEEECCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]