Click here to switch to the map view.

The map label for this gene is bktB [H]

Identifier: 17546356

GI number: 17546356

Start: 1758926

End: 1760110

Strand: Direct

Name: bktB [H]

Synonym: RSc1637

Alternate gene names: 17546356

Gene position: 1758926-1760110 (Clockwise)

Preceding gene: 17546355

Following gene: 17546357

Centisome position: 47.33

GC content: 70.8

Gene sequence:

>1185_bases
ATGGCACGTGAAGTGGTGGTGGTCAGCGGTGTCCGCACCGCGGTCGGGACGTTCGGCGGCAGCCTGAAGGACGTGGCGCC
GTGCGAGCTGGGCGCCCTGGTGGTGCGCGAGGCGCTGGCGCGCGCGCAGGTCGGGGGCGAGGAGGTCGGCCACGTGGTGT
TCGGCCACGTCATCAATACCGAGCCGCGCGACATGTACCTGTCGCGCGTGGCCGCCCTGGAAGGCGGCGTGCCGGCCGAG
ACGCCCGCGTTCAACGTCAACCGCCTGTGCGGCTCCGGCCTGCAGGCCGTGGTGAGCGCCGCGCAGACCATCCTGCTGGG
CGATGTCGACGTCGCCATCGGCGGCGGCGCCGAGAGCATGAGCCGCGCGCCGTACCTGGCGCCGGCGGCGCGCTGGGGTT
CGCGCATGGGCGACGCCGGGCTGGTCGACATGATGCTGGGCGCGCTGCACGACCCGTTCCAGGCGATCCACATGGGCGTG
ACGGCGGAGAACGTCGCCCGCGAATACGGCATCGGTCGCGAACTGCAGGACCAGACCGCGGTGGAGTCGCATCGGCGTGC
GTCGCGCGCCATCCAGGCCGGCTATTTCAAGGGCCAGATCGTCCCGGTGACGATCAAGTCGCGCAAGGGCGATGTGCAGT
TCGATACCGACGAACATGTCCGCCATGATGCGACCCTCGAGGACATGGCCAAGCTCAGGCCGGTCTTCGCGAAGGAAAAC
GGCACCGTGACGGCGGGCAACGCCTCGGGCCTGAACGATGCGGCCGCGGCCCTGGTGCTGATGGAGCGCTCGCTGGCCGA
GCGGCGCGGCCTGAAGCCGCTGGCGCGGCTGGTGTCATACGGCCACGCGGGCGTGGACCCGAAGGTGATGGGCATCGGCC
CGGTGCCGGCGACGCGCAAGGCGCTGGAGCGGGCCGGGCTGACGGTCAAGGACCTGGACGTGGTGGAGGCCAACGAGGCC
TTCGCGGCCCAGGCCTGCGCGGTGACGCAGCAGCTGGGCCTGGACCCGGCCAGAGTCAACCCGAACGGCTCGGGCATTTC
GCTCGGCCATCCGATCGGCGCGACCGGCGCCCTGATCACGGTGAAGGCGCTGCACGAGCTGCAGCGCATCGGCGGCCGCT
ACGCGTTGGTGACCATGTGCATTGGTGGAGGACAAGGCATTGCCGCGGTGTTCGAACGCATCTGA

Upstream 100 bases:

>100_bases
TCTGATCCGTCGAGGCGGGCCTCCAGCAGGCCAGGCCATTTTCGAACGATCGTTTGCTTATACTGGTTGCCATTGACGAT
CAATTGCCTTGGAGACAGCA

Downstream 100 bases:

>100_bases
ACGCATGTTTCCGGCGGGGCGCTTCGCCTGGGCGGCCGGCGCGCTGGTCGCGCTGCTGCTGGCCGGGGCGCCGGCGGTCG
CGCAGACGCCGGCCACGGCT

Product: beta-ketothiolase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MAREVVVVSGVRTAVGTFGGSLKDVAPCELGALVVREALARAQVGGEEVGHVVFGHVINTEPRDMYLSRVAALEGGVPAE
TPAFNVNRLCGSGLQAVVSAAQTILLGDVDVAIGGGAESMSRAPYLAPAARWGSRMGDAGLVDMMLGALHDPFQAIHMGV
TAENVAREYGIGRELQDQTAVESHRRASRAIQAGYFKGQIVPVTIKSRKGDVQFDTDEHVRHDATLEDMAKLRPVFAKEN
GTVTAGNASGLNDAAAALVLMERSLAERRGLKPLARLVSYGHAGVDPKVMGIGPVPATRKALERAGLTVKDLDVVEANEA
FAAQACAVTQQLGLDPARVNPNGSGISLGHPIGATGALITVKALHELQRIGGRYALVTMCIGGGQGIAAVFERI

Sequences:

>Translated_394_residues
MAREVVVVSGVRTAVGTFGGSLKDVAPCELGALVVREALARAQVGGEEVGHVVFGHVINTEPRDMYLSRVAALEGGVPAE
TPAFNVNRLCGSGLQAVVSAAQTILLGDVDVAIGGGAESMSRAPYLAPAARWGSRMGDAGLVDMMLGALHDPFQAIHMGV
TAENVAREYGIGRELQDQTAVESHRRASRAIQAGYFKGQIVPVTIKSRKGDVQFDTDEHVRHDATLEDMAKLRPVFAKEN
GTVTAGNASGLNDAAAALVLMERSLAERRGLKPLARLVSYGHAGVDPKVMGIGPVPATRKALERAGLTVKDLDVVEANEA
FAAQACAVTQQLGLDPARVNPNGSGISLGHPIGATGALITVKALHELQRIGGRYALVTMCIGGGQGIAAVFERI
>Mature_393_residues
AREVVVVSGVRTAVGTFGGSLKDVAPCELGALVVREALARAQVGGEEVGHVVFGHVINTEPRDMYLSRVAALEGGVPAET
PAFNVNRLCGSGLQAVVSAAQTILLGDVDVAIGGGAESMSRAPYLAPAARWGSRMGDAGLVDMMLGALHDPFQAIHMGVT
AENVAREYGIGRELQDQTAVESHRRASRAIQAGYFKGQIVPVTIKSRKGDVQFDTDEHVRHDATLEDMAKLRPVFAKENG
TVTAGNASGLNDAAAALVLMERSLAERRGLKPLARLVSYGHAGVDPKVMGIGPVPATRKALERAGLTVKDLDVVEANEAF
AAQACAVTQQLGLDPARVNPNGSGISLGHPIGATGALITVKALHELQRIGGRYALVTMCIGGGQGIAAVFERI

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=46.5473145780051, Blast_Score=358, Evalue=6e-99,
Organism=Homo sapiens, GI167614485, Length=393, Percent_Identity=44.529262086514, Blast_Score=345, Evalue=3e-95,
Organism=Homo sapiens, GI4501853, Length=399, Percent_Identity=42.8571428571429, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI4557237, Length=398, Percent_Identity=38.9447236180905, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=35.0588235294118, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI194353979, Length=395, Percent_Identity=31.8987341772152, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=49.4974874371859, Blast_Score=349, Evalue=1e-97,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=46.1734693877551, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1787663, Length=403, Percent_Identity=45.6575682382134, Blast_Score=320, Evalue=9e-89,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=41.4572864321608, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI1788683, Length=412, Percent_Identity=35.4368932038835, Blast_Score=216, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=46.0358056265985, Blast_Score=349, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI25147385, Length=393, Percent_Identity=35.6234096692112, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17535921, Length=399, Percent_Identity=33.5839598997494, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=30.8962264150943, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=405, Percent_Identity=27.9012345679012, Blast_Score=147, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=38.75, Blast_Score=266, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6322031, Length=403, Percent_Identity=37.2208436724566, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=46.6836734693878, Blast_Score=352, Evalue=3e-97,
Organism=Drosophila melanogaster, GI17648125, Length=394, Percent_Identity=42.3857868020305, Blast_Score=316, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24640423, Length=397, Percent_Identity=37.5314861460957, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=32.5526932084309, Blast_Score=181, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41072; Mature: 40940

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAREVVVVSGVRTAVGTFGGSLKDVAPCELGALVVREALARAQVGGEEVGHVVFGHVINT
CCCCEEEECCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEECC
EPRDMYLSRVAALEGGVPAETPAFNVNRLCGSGLQAVVSAAQTILLGDVDVAIGGGAESM
CHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHEEECEEEEECCCHHHH
SRAPYLAPAARWGSRMGDAGLVDMMLGALHDPFQAIHMGVTAENVAREYGIGRELQDQTA
CCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHCCCCCHHHHHH
VESHRRASRAIQAGYFKGQIVPVTIKSRKGDVQFDTDEHVRHDATLEDMAKLRPVFAKEN
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCHHHHHCCCCHHHHHHHCCCEECCC
GTVTAGNASGLNDAAAALVLMERSLAERRGLKPLARLVSYGHAGVDPKVMGIGPVPATRK
CEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEECCCCCHHHH
ALERAGLTVKDLDVVEANEAFAAQACAVTQQLGLDPARVNPNGSGISLGHPIGATGALIT
HHHHCCCEEEECCEEECCHHHHHHHHHHHHHHCCCCCEECCCCCCEECCCCCCCCCHHHH
VKALHELQRIGGRYALVTMCIGGGQGIAAVFERI
HHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHCC
>Mature Secondary Structure 
AREVVVVSGVRTAVGTFGGSLKDVAPCELGALVVREALARAQVGGEEVGHVVFGHVINT
CCCEEEECCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEECC
EPRDMYLSRVAALEGGVPAETPAFNVNRLCGSGLQAVVSAAQTILLGDVDVAIGGGAESM
CHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHEEECEEEEECCCHHHH
SRAPYLAPAARWGSRMGDAGLVDMMLGALHDPFQAIHMGVTAENVAREYGIGRELQDQTA
CCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHCCCCCHHHHHH
VESHRRASRAIQAGYFKGQIVPVTIKSRKGDVQFDTDEHVRHDATLEDMAKLRPVFAKEN
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCHHHHHCCCCHHHHHHHCCCEECCC
GTVTAGNASGLNDAAAALVLMERSLAERRGLKPLARLVSYGHAGVDPKVMGIGPVPATRK
CEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEECCCCCHHHH
ALERAGLTVKDLDVVEANEAFAAQACAVTQQLGLDPARVNPNGSGISLGHPIGATGALIT
HHHHCCCEEEECCEEECCHHHHHHHHHHHHHHCCCCCEECCCCCCEECCCCCCCCCHHHH
VKALHELQRIGGRYALVTMCIGGGQGIAAVFERI
HHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]