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The map label for this gene is dinP [H]

Identifier: 17546306

GI number: 17546306

Start: 1702478

End: 1703566

Strand: Direct

Name: dinP [H]

Synonym: RSc1587

Alternate gene names: 17546306

Gene position: 1702478-1703566 (Clockwise)

Preceding gene: 17546305

Following gene: 17546307

Centisome position: 45.81

GC content: 69.61

Gene sequence:

>1089_bases
ATGCGGCGGCCTGCCGTGCGAAAGATCATCCATTGCGACTGTGACTGCTTCTACGCGGCCATCGAGATGCGCGACGATCC
GCGACTCGTGGGGAGGCCGCTGGCCGTGGGCGGGCGCCCCGAGCGGCGCGGCGTGGTCGCCACCTGTAATTACGAGGCGC
GCAAGTTCGGCATCCACTCGGCGATGCCGATGGCGCAGGCGGTCAAGCGCTGTCCCGACCTGCTGATCGTGCCGCCCGCG
ATGGACAAGTACCGCCAGGTCGCCCGGCAGATCTTCGCCATCTACCAGGGCTACACGCCGCTGGTGGAGCCGCTGTCGCT
CGACGAGGCCTACCTGGACGTGACCGACAGCCCGATGCTGGCCGGCAGCGGCACGCGCATCGCCGAGGACATCCGCCGTC
GCGTGCGCGAGGAGATCGGCATCACGGTGTCGGCGGGCGTGGCGCCCAACAAGTTCATCGCCAAGATCGCCAGCGACTGG
AACAAGCCCGACGGCCTGTTCGTGGTCCGGCCGGAGCAGGTGGATGCCTTCGTGGCGGCCCTGCCGGTCGAGCGCCTGTT
CGGCGTGGGCAAGGTGACGGCCGCCAAGCTGCGGCGCCTGGGCGCGCAGACCTGCGGCGACCTGCGCGGCTGGGGCGCCG
ACCGGCTGCAGCAGCATTTCGGCAGCTTCGGCTTCCGGCTGCATGACCTGTGCCGGGGGATCGATCACCGGCAGGTGCAG
CCGTCGCAGATCCGCAAGTCGGTGAGCGTGGAGGAAACCTATGCGACGGACCTGCGCACGCTGGACGACTGCCAGCGCGA
ACTGACCATCCTGGTCGATCAGCTCGCCGCGCGCGTGGAGCGGGCCCGTGCCGGCGACATGATCCACAAGACCTTCGTCA
AGCTGCGCTTTGCGGATTTCCGCGGTACCACGGTGGAGTGCGTTTATCCGCAGGTGGCGCTGCCGGTCTTCAACCGGCTG
CTGGCACAGGGTTTCGAGCGGCGGCGCATGCCGGTGCGGTTGCTCGGCGTGGGCGTGCGCCTGCATGAGACGGATGCCCA
TGCGCGCCAGCAGGCGCTGTTTGCCGAGGGCCCGCCGCCCGGCGCCTGA

Upstream 100 bases:

>100_bases
GATCGAAACGTCCTGTTGCGGCGCCGCCCGGCCCGGCGCCGTGCACGGCCTGCGGAAGCTGGTACGCTTGCGTTCCTCCT
GAACGACGCCTGCCTGCTCG

Downstream 100 bases:

>100_bases
CCCGGTTCCGGGGGCCTGTCTTGCCGATCGCGCCAGTCGGTGCGATTTATCCTATGTTTTCGTCTGCATTGAGCGATAGA
AGGGCGGCAGTCGCCAACGG

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MRRPAVRKIIHCDCDCFYAAIEMRDDPRLVGRPLAVGGRPERRGVVATCNYEARKFGIHSAMPMAQAVKRCPDLLIVPPA
MDKYRQVARQIFAIYQGYTPLVEPLSLDEAYLDVTDSPMLAGSGTRIAEDIRRRVREEIGITVSAGVAPNKFIAKIASDW
NKPDGLFVVRPEQVDAFVAALPVERLFGVGKVTAAKLRRLGAQTCGDLRGWGADRLQQHFGSFGFRLHDLCRGIDHRQVQ
PSQIRKSVSVEETYATDLRTLDDCQRELTILVDQLAARVERARAGDMIHKTFVKLRFADFRGTTVECVYPQVALPVFNRL
LAQGFERRRMPVRLLGVGVRLHETDAHARQQALFAEGPPPGA

Sequences:

>Translated_362_residues
MRRPAVRKIIHCDCDCFYAAIEMRDDPRLVGRPLAVGGRPERRGVVATCNYEARKFGIHSAMPMAQAVKRCPDLLIVPPA
MDKYRQVARQIFAIYQGYTPLVEPLSLDEAYLDVTDSPMLAGSGTRIAEDIRRRVREEIGITVSAGVAPNKFIAKIASDW
NKPDGLFVVRPEQVDAFVAALPVERLFGVGKVTAAKLRRLGAQTCGDLRGWGADRLQQHFGSFGFRLHDLCRGIDHRQVQ
PSQIRKSVSVEETYATDLRTLDDCQRELTILVDQLAARVERARAGDMIHKTFVKLRFADFRGTTVECVYPQVALPVFNRL
LAQGFERRRMPVRLLGVGVRLHETDAHARQQALFAEGPPPGA
>Mature_362_residues
MRRPAVRKIIHCDCDCFYAAIEMRDDPRLVGRPLAVGGRPERRGVVATCNYEARKFGIHSAMPMAQAVKRCPDLLIVPPA
MDKYRQVARQIFAIYQGYTPLVEPLSLDEAYLDVTDSPMLAGSGTRIAEDIRRRVREEIGITVSAGVAPNKFIAKIASDW
NKPDGLFVVRPEQVDAFVAALPVERLFGVGKVTAAKLRRLGAQTCGDLRGWGADRLQQHFGSFGFRLHDLCRGIDHRQVQ
PSQIRKSVSVEETYATDLRTLDDCQRELTILVDQLAARVERARAGDMIHKTFVKLRFADFRGTTVECVYPQVALPVFNRL
LAQGFERRRMPVRLLGVGVRLHETDAHARQQALFAEGPPPGA

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI84043967, Length=327, Percent_Identity=29.9694189602446, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI7706681, Length=328, Percent_Identity=29.8780487804878, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI154350220, Length=287, Percent_Identity=29.616724738676, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI7705344, Length=113, Percent_Identity=46.9026548672566, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI5729982, Length=350, Percent_Identity=26.5714285714286, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786425, Length=338, Percent_Identity=46.7455621301775, Blast_Score=297, Evalue=6e-82,
Organism=Escherichia coli, GI1787432, Length=219, Percent_Identity=27.3972602739726, Blast_Score=78, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17537959, Length=258, Percent_Identity=28.6821705426357, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193205700, Length=114, Percent_Identity=42.1052631578947, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI115534089, Length=122, Percent_Identity=36.0655737704918, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193205702, Length=240, Percent_Identity=27.5, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324921, Length=289, Percent_Identity=23.8754325259516, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19923006, Length=327, Percent_Identity=28.7461773700306, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21355641, Length=284, Percent_Identity=32.0422535211268, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24644984, Length=284, Percent_Identity=32.0422535211268, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24668444, Length=125, Percent_Identity=33.6, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 40484; Mature: 40484

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRPAVRKIIHCDCDCFYAAIEMRDDPRLVGRPLAVGGRPERRGVVATCNYEARKFGIHS
CCCHHHHHHHHCCCHHHHHHEECCCCCHHHCCCCCCCCCCCCCCEEEEECCHHHHHCCHH
AMPMAQAVKRCPDLLIVPPAMDKYRQVARQIFAIYQGYTPLVEPLSLDEAYLDVTDSPML
CCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHCCCCCCCC
AGSGTRIAEDIRRRVREEIGITVSAGVAPNKFIAKIASDWNKPDGLFVVRPEQVDAFVAA
CCCCCHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHH
LPVERLFGVGKVTAAKLRRLGAQTCGDLRGWGADRLQQHFGSFGFRLHDLCRGIDHRQVQ
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCC
PSQIRKSVSVEETYATDLRTLDDCQRELTILVDQLAARVERARAGDMIHKTFVKLRFADF
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
RGTTVECVYPQVALPVFNRLLAQGFERRRMPVRLLGVGVRLHETDAHARQQALFAEGPPP
CCCEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEECEEEECCHHHHHHHHHHCCCCCC
GA
CC
>Mature Secondary Structure
MRRPAVRKIIHCDCDCFYAAIEMRDDPRLVGRPLAVGGRPERRGVVATCNYEARKFGIHS
CCCHHHHHHHHCCCHHHHHHEECCCCCHHHCCCCCCCCCCCCCCEEEEECCHHHHHCCHH
AMPMAQAVKRCPDLLIVPPAMDKYRQVARQIFAIYQGYTPLVEPLSLDEAYLDVTDSPML
CCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHCCCCCCCC
AGSGTRIAEDIRRRVREEIGITVSAGVAPNKFIAKIASDWNKPDGLFVVRPEQVDAFVAA
CCCCCHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHH
LPVERLFGVGKVTAAKLRRLGAQTCGDLRGWGADRLQQHFGSFGFRLHDLCRGIDHRQVQ
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCC
PSQIRKSVSVEETYATDLRTLDDCQRELTILVDQLAARVERARAGDMIHKTFVKLRFADF
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
RGTTVECVYPQVALPVFNRLLAQGFERRRMPVRLLGVGVRLHETDAHARQQALFAEGPPP
CCCEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEECEEEECCHHHHHHHHHHCCCCCC
GA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]