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The map label for this gene is lpsI [H]

Identifier: 17546289

GI number: 17546289

Start: 1686234

End: 1686932

Strand: Direct

Name: lpsI [H]

Synonym: RSc1570

Alternate gene names: 17546289

Gene position: 1686234-1686932 (Clockwise)

Preceding gene: 17546287

Following gene: 17546290

Centisome position: 45.37

GC content: 66.24

Gene sequence:

>699_bases
ATGAACAAAATCTACGCCAGCGCCGCCGAGGCGCTCGCGGGTATCGTCAAGGACGGCCAGACCATCGCCGTGGGCGGCTT
CGGCCTGTGCGGCATCCCGGAGGCGCTGATCGGCGCGCTGCGCGATTCCGGTGCCAAGGGGCTCACCTGCATTTCCAACA
ACGCCGGCGTCGACGGCTTCGGCCTGGGGCGGCTGCTGGAAACCCGCCAGATCAAGAAGATGATCTCGTCCTACGTGGGC
GAGAACAAGGAGTTCGAGCGCCAGTACCTGTCCGGCGAGCTCGAGCTGGAATTCACCCCGCAGGGCACGCTGGCCGAGAA
GCTGCGCGCCGGCGGCGCCGGCATCCCGGCATTCTTCACCCGCACCGGCGTCGGCACCGTGGTGGCCGACGGCAAGGAGG
TGCGCGAATTCGACGGCGAGCAGTACGTCATGGAGCGCTCCCTGATCGCCGACGTGGCCCTGGTCAAGGCGTGGAAGGCC
GACAAGTCCGGCAACCTGAAGTACCACCGCACCGCGCGCAACTTCAACCCGATGTGTGCCATGGCCGGCCGCATCACCAT
CGTTGAAGTCGAAGAGATCGTCGAGACCGGCACGTTCGACCCGGACGAGGTCCACACCCCGGGCGTGTTCGTGCAGCGCA
TCGTGCTGAACGCCCATCCGGAAAAACGCATCGAGCAGCGCACCGTGCGCGCCAAATAA

Upstream 100 bases:

>100_bases
TTGTACCGTTACAATTTTCCGGCACCGCGCCGCGCAAGCCCGTCTGTGCGCCCGGTCAAAACCCCGCCGGATTCGTTGGA
TCACCAAGGAAGGAGCACGC

Downstream 100 bases:

>100_bases
CCAGGACGATCAGGAGACCGAACATGGCATGGACGCGTGATGAAATGGCTGCGCGCGCAGCCAGGGAGCTGCAGGACGGC
TTCTATGTGAACCTGGGCAT

Product: fesuccinyl-CoA:3-ketoacid-coenzyme A transferase subunit A protein

Products: NA

Alternate protein names: Succinyl CoA:3-oxoacid CoA-transferase; OXCT A [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MNKIYASAAEALAGIVKDGQTIAVGGFGLCGIPEALIGALRDSGAKGLTCISNNAGVDGFGLGRLLETRQIKKMISSYVG
ENKEFERQYLSGELELEFTPQGTLAEKLRAGGAGIPAFFTRTGVGTVVADGKEVREFDGEQYVMERSLIADVALVKAWKA
DKSGNLKYHRTARNFNPMCAMAGRITIVEVEEIVETGTFDPDEVHTPGVFVQRIVLNAHPEKRIEQRTVRAK

Sequences:

>Translated_232_residues
MNKIYASAAEALAGIVKDGQTIAVGGFGLCGIPEALIGALRDSGAKGLTCISNNAGVDGFGLGRLLETRQIKKMISSYVG
ENKEFERQYLSGELELEFTPQGTLAEKLRAGGAGIPAFFTRTGVGTVVADGKEVREFDGEQYVMERSLIADVALVKAWKA
DKSGNLKYHRTARNFNPMCAMAGRITIVEVEEIVETGTFDPDEVHTPGVFVQRIVLNAHPEKRIEQRTVRAK
>Mature_232_residues
MNKIYASAAEALAGIVKDGQTIAVGGFGLCGIPEALIGALRDSGAKGLTCISNNAGVDGFGLGRLLETRQIKKMISSYVG
ENKEFERQYLSGELELEFTPQGTLAEKLRAGGAGIPAFFTRTGVGTVVADGKEVREFDGEQYVMERSLIADVALVKAWKA
DKSGNLKYHRTARNFNPMCAMAGRITIVEVEEIVETGTFDPDEVHTPGVFVQRIVLNAHPEKRIEQRTVRAK

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG1788

COG function: function code I; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-oxoacid CoA-transferase subunit A family [H]

Homologues:

Organism=Homo sapiens, GI4557817, Length=247, Percent_Identity=55.8704453441296, Blast_Score=281, Evalue=5e-76,
Organism=Homo sapiens, GI11545841, Length=246, Percent_Identity=52.0325203252033, Blast_Score=238, Evalue=3e-63,
Organism=Escherichia coli, GI1788551, Length=205, Percent_Identity=45.3658536585366, Blast_Score=194, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17531517, Length=245, Percent_Identity=56.3265306122449, Blast_Score=269, Evalue=8e-73,
Organism=Drosophila melanogaster, GI24655794, Length=243, Percent_Identity=53.4979423868313, Blast_Score=252, Evalue=2e-67,
Organism=Drosophila melanogaster, GI21358325, Length=243, Percent_Identity=53.4979423868313, Blast_Score=252, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012792
- InterPro:   IPR004165
- InterPro:   IPR004163 [H]

Pfam domain/function: PF01144 CoA_trans [H]

EC number: =2.8.3.5 [H]

Molecular weight: Translated: 25106; Mature: 25106

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS01273 COA_TRANSF_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIYASAAEALAGIVKDGQTIAVGGFGLCGIPEALIGALRDSGAKGLTCISNNAGVDGF
CCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCH
GLGRLLETRQIKKMISSYVGENKEFERQYLSGELELEFTPQGTLAEKLRAGGAGIPAFFT
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCCCHHHH
RTGVGTVVADGKEVREFDGEQYVMERSLIADVALVKAWKADKSGNLKYHRTARNFNPMCA
HCCCCEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHH
MAGRITIVEVEEIVETGTFDPDEVHTPGVFVQRIVLNAHPEKRIEQRTVRAK
HCCCEEEEEHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MNKIYASAAEALAGIVKDGQTIAVGGFGLCGIPEALIGALRDSGAKGLTCISNNAGVDGF
CCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCH
GLGRLLETRQIKKMISSYVGENKEFERQYLSGELELEFTPQGTLAEKLRAGGAGIPAFFT
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCCCHHHH
RTGVGTVVADGKEVREFDGEQYVMERSLIADVALVKAWKADKSGNLKYHRTARNFNPMCA
HCCCCEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHH
MAGRITIVEVEEIVETGTFDPDEVHTPGVFVQRIVLNAHPEKRIEQRTVRAK
HCCCEEEEEHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9385134; 11589581 [H]