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The map label for this gene is fkpA [H]

Identifier: 17546284

GI number: 17546284

Start: 1681174

End: 1681599

Strand: Direct

Name: fkpA [H]

Synonym: RSc1565

Alternate gene names: 17546284

Gene position: 1681174-1681599 (Clockwise)

Preceding gene: 17546283

Following gene: 17546285

Centisome position: 45.24

GC content: 68.54

Gene sequence:

>426_bases
ATGAAACGCCTTTCCCTGCTGCTGTGCGCCACGTCGCTCGCCCTCGCTGCATACAACGTTCAGGCGGCATCCGCCGTGTC
GGCCGCGCCGGCCGAGTCGCTGCCGTCGGGCGTGACCATCCAGCATGTGGCCAAGGGTAGCGGGCCGTCGCCCAAGGCGA
CCGATACGGTCAAGGTGCACTATCGCGGCACGCTGGCCGACGGCACCGAGTTCGACAGCTCCTACAAGCGCGGCCAGCCG
ATCTCCTTCCCGCTGAATCGCGTGATCCCGTGCTGGACCGAGGGCGTGCAGAAGATGCAGGTGGGGGGCAAGGCCAAGCT
GACGTGTCCGCCGGCGACCGCCTACGGTGCGCGCGGTGTGCCCGGCACGATTCCGCCCAACGCCACGCTGAACTTCGAGG
TCGAGCTGCTCGGCATCGGCGGCTGA

Upstream 100 bases:

>100_bases
TAGCCGCGGCGCAATTGGATACACTGCCGGCTGGCAACGCGGCGGGTCAAGCGGCCCGCCACCTGAAACCCTGATTCCCA
ACCCCGTTCGTCATACGCCT

Downstream 100 bases:

>100_bases
TCCGTCAGCCTTACAATAGCGGTTTCCCGATGTTTCGCGCCACGCACCGCCGTGGCGCCTTTCCGAGCACGATCATGTCT
GGCAATACCCTGGGCCTGCT

Product: FKBP-type peptidyl-prolyl cis-trans isomerase signal peptide protein

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MKRLSLLLCATSLALAAYNVQAASAVSAAPAESLPSGVTIQHVAKGSGPSPKATDTVKVHYRGTLADGTEFDSSYKRGQP
ISFPLNRVIPCWTEGVQKMQVGGKAKLTCPPATAYGARGVPGTIPPNATLNFEVELLGIGG

Sequences:

>Translated_141_residues
MKRLSLLLCATSLALAAYNVQAASAVSAAPAESLPSGVTIQHVAKGSGPSPKATDTVKVHYRGTLADGTEFDSSYKRGQP
ISFPLNRVIPCWTEGVQKMQVGGKAKLTCPPATAYGARGVPGTIPPNATLNFEVELLGIGG
>Mature_141_residues
MKRLSLLLCATSLALAAYNVQAASAVSAAPAESLPSGVTIQHVAKGSGPSPKATDTVKVHYRGTLADGTEFDSSYKRGQP
ISFPLNRVIPCWTEGVQKMQVGGKAKLTCPPATAYGARGVPGTIPPNATLNFEVELLGIGG

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=50.9433962264151, Blast_Score=99, Evalue=8e-22,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=50.9433962264151, Blast_Score=99, Evalue=8e-22,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=49.0566037735849, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI4503729, Length=100, Percent_Identity=48, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI224809329, Length=134, Percent_Identity=39.5522388059701, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI224809327, Length=134, Percent_Identity=39.5522388059701, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4758384, Length=134, Percent_Identity=39.5522388059701, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI224809331, Length=134, Percent_Identity=39.5522388059701, Blast_Score=84, Evalue=3e-17,
Organism=Homo sapiens, GI206725530, Length=141, Percent_Identity=41.1347517730496, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI17149844, Length=141, Percent_Identity=41.1347517730496, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI17149842, Length=141, Percent_Identity=41.1347517730496, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI4503727, Length=99, Percent_Identity=44.4444444444444, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI192448443, Length=116, Percent_Identity=37.0689655172414, Blast_Score=70, Evalue=4e-13,
Organism=Homo sapiens, GI8923659, Length=93, Percent_Identity=45.1612903225806, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI33469985, Length=118, Percent_Identity=34.7457627118644, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789745, Length=104, Percent_Identity=57.6923076923077, Blast_Score=117, Evalue=4e-28,
Organism=Escherichia coli, GI87082390, Length=107, Percent_Identity=52.3364485981308, Blast_Score=111, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=48.1132075471698, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17540882, Length=135, Percent_Identity=38.5185185185185, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17561782, Length=89, Percent_Identity=50.561797752809, Blast_Score=75, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=57.9545454545455, Blast_Score=98, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324194, Length=112, Percent_Identity=46.4285714285714, Blast_Score=98, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323566, Length=108, Percent_Identity=37.962962962963, Blast_Score=68, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323482, Length=108, Percent_Identity=37.962962962963, Blast_Score=68, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=51.8867924528302, Blast_Score=106, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24583150, Length=108, Percent_Identity=47.2222222222222, Blast_Score=96, Evalue=8e-21,
Organism=Drosophila melanogaster, GI281363946, Length=93, Percent_Identity=50.5376344086022, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17352457, Length=93, Percent_Identity=50.5376344086022, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21356629, Length=125, Percent_Identity=40.8, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24647110, Length=109, Percent_Identity=43.1192660550459, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 14537; Mature: 14537

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLSLLLCATSLALAAYNVQAASAVSAAPAESLPSGVTIQHVAKGSGPSPKATDTVKVH
CCHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHCCCCCEEEEEECCCCCCCCCCCEEEEE
YRGTLADGTEFDSSYKRGQPISFPLNRVIPCWTEGVQKMQVGGKAKLTCPPATAYGARGV
EEEEECCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
PGTIPPNATLNFEVELLGIGG
CCCCCCCCEEEEEEEEEEECC
>Mature Secondary Structure
MKRLSLLLCATSLALAAYNVQAASAVSAAPAESLPSGVTIQHVAKGSGPSPKATDTVKVH
CCHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHCCCCCEEEEEECCCCCCCCCCCEEEEE
YRGTLADGTEFDSSYKRGQPISFPLNRVIPCWTEGVQKMQVGGKAKLTCPPATAYGARGV
EEEEECCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
PGTIPPNATLNFEVELLGIGG
CCCCCCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]