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The map label for this gene is fabF1 [H]

Identifier: 17545773

GI number: 17545773

Start: 1106980

End: 1108212

Strand: Direct

Name: fabF1 [H]

Synonym: RSc1054

Alternate gene names: 17545773

Gene position: 1106980-1108212 (Clockwise)

Preceding gene: 17545772

Following gene: 17545774

Centisome position: 29.79

GC content: 64.8

Gene sequence:

>1233_bases
GTGAGCCGTCGTCGCGTAGTCGTTACCGGCCTGGGGCTGGTCTCTCCGGTAGGAAACTCGGTCGCCGAAGGGTGGGCCAA
TCTGGTCGCTGGCAAGTCCGGCATCGCCACCGTCACCAAATTCGATCCGTCTAACTTGGCCGTGCACTTCGCCGGCGAAG
TGAAGGGCTTCAACGTCGAGGAGTACCTCTCGGCCAAGGATGCTCGCCAGATGGATACCTTCATCCATTACGGCATTGCC
GCTGGGGTGCAGGCACTCAAGGACAGCGGCCTGGAGGTGAACGAGGCCAACGCCGAGCGTGCAGGCGTGCTGGTCGGCTC
CGGCATCGGTGGCCTGCCGATGATCGAAGACACCCATTCCACGTACGTCGAACGCGGTCCGCGCCGGATTTCGCCGTTCT
TCGTGCCGGGGTCGATCATCAACATGATCTCGGGGCACCTCAGCATCATGCATGGCCTGAAGGGGCCGAACCTGGCGGCG
GTCACGGCTTGCACGACCGGGCTGCACAGCATCGGGTTGGCGGCGCGCCTGATTCAGGCGGGCGATGCCGACGTGATGCT
GGCGGGTGGCGCCGAGTCGACGGTCTCGCCGCTCGGCATCGGCGGCTTCGCAGCAGCGCGCGCGCTGTCGACCCGCAACG
ACGATCCGGCCACCGCGTCCCGTCCGTGGGACAAGGATCGCGACGGCTTCGTGCTGGGCGAGGGTGCAGGCGTGATGGTG
CTGGAAGAGTACGAGTCCGCCAAGGCGCGCGGAGCCAGGATCTACGCGGAGCTCGTGGGCTTCGGCATGAGCGGTGACGC
TTATCACATGACTGCGCCCAACATGGATGGTCCGCGCCGCTGCATGCTCAATGCGCTGCGCGATGCCGGCATCAACACCG
ACCAGGTGCAGTACCTGAACGCGCACGGCACGTCCACCCCGCTGGGCGACAAGAATGAATCCGACGCCATCAAGGCGGCT
TTTGGCGAGCACGCCCGCAAGGTCGTCGTGAACTCCACCAAGTCCATGACCGGCCATCTGCTGGGCGGCGCGGGCGGCCT
GGAGTCGGTGTTCTCGGTGTTGGCGCTCCACCATCAGGTGTCGCCGCCGACCATCAATATTTTCAACCAGGATCCCGAGT
GCGATCTCGATTACTGCGCCAATACGGCGCGTGACATGAAGATCGACGTGGCCGTGAAGAACAACTTCGGCTTTGGCGGG
ACCAACGGCACGCTGGTGTTCCGACGCCTGTGA

Upstream 100 bases:

>100_bases
CTCTTGGCATCGCGGGCCACAGAAGTGGCGCTCTCCGGCTTGGCCGGGCAGCGCGCTTTCTGTGGCCTTTGTCGCTGATA
TAGAGTCGCAGGAAAGCATA

Downstream 100 bases:

>100_bases
TGGAACCTGAGGCGCGGCCTGGTGCCGCGCCGTCGCTTCCCGCTGCGGCGGCAGCCTGTTCCGTGCAGTGCTTCGTGTTT
TCACGGCAGTACCGGCGGAT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSRRRVVVTGLGLVSPVGNSVAEGWANLVAGKSGIATVTKFDPSNLAVHFAGEVKGFNVEEYLSAKDARQMDTFIHYGIA
AGVQALKDSGLEVNEANAERAGVLVGSGIGGLPMIEDTHSTYVERGPRRISPFFVPGSIINMISGHLSIMHGLKGPNLAA
VTACTTGLHSIGLAARLIQAGDADVMLAGGAESTVSPLGIGGFAAARALSTRNDDPATASRPWDKDRDGFVLGEGAGVMV
LEEYESAKARGARIYAELVGFGMSGDAYHMTAPNMDGPRRCMLNALRDAGINTDQVQYLNAHGTSTPLGDKNESDAIKAA
FGEHARKVVVNSTKSMTGHLLGGAGGLESVFSVLALHHQVSPPTINIFNQDPECDLDYCANTARDMKIDVAVKNNFGFGG
TNGTLVFRRL

Sequences:

>Translated_410_residues
MSRRRVVVTGLGLVSPVGNSVAEGWANLVAGKSGIATVTKFDPSNLAVHFAGEVKGFNVEEYLSAKDARQMDTFIHYGIA
AGVQALKDSGLEVNEANAERAGVLVGSGIGGLPMIEDTHSTYVERGPRRISPFFVPGSIINMISGHLSIMHGLKGPNLAA
VTACTTGLHSIGLAARLIQAGDADVMLAGGAESTVSPLGIGGFAAARALSTRNDDPATASRPWDKDRDGFVLGEGAGVMV
LEEYESAKARGARIYAELVGFGMSGDAYHMTAPNMDGPRRCMLNALRDAGINTDQVQYLNAHGTSTPLGDKNESDAIKAA
FGEHARKVVVNSTKSMTGHLLGGAGGLESVFSVLALHHQVSPPTINIFNQDPECDLDYCANTARDMKIDVAVKNNFGFGG
TNGTLVFRRL
>Mature_409_residues
SRRRVVVTGLGLVSPVGNSVAEGWANLVAGKSGIATVTKFDPSNLAVHFAGEVKGFNVEEYLSAKDARQMDTFIHYGIAA
GVQALKDSGLEVNEANAERAGVLVGSGIGGLPMIEDTHSTYVERGPRRISPFFVPGSIINMISGHLSIMHGLKGPNLAAV
TACTTGLHSIGLAARLIQAGDADVMLAGGAESTVSPLGIGGFAAARALSTRNDDPATASRPWDKDRDGFVLGEGAGVMVL
EEYESAKARGARIYAELVGFGMSGDAYHMTAPNMDGPRRCMLNALRDAGINTDQVQYLNAHGTSTPLGDKNESDAIKAAF
GEHARKVVVNSTKSMTGHLLGGAGGLESVFSVLALHHQVSPPTINIFNQDPECDLDYCANTARDMKIDVAVKNNFGFGGT
NGTLVFRRL

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=47.1153846153846, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI223972627, Length=167, Percent_Identity=45.5089820359281, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI41872631, Length=438, Percent_Identity=23.7442922374429, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=61.9854721549637, Blast_Score=502, Evalue=1e-143,
Organism=Escherichia coli, GI1788663, Length=412, Percent_Identity=39.3203883495146, Blast_Score=252, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI71983541, Length=413, Percent_Identity=35.5932203389831, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71983535, Length=256, Percent_Identity=39.453125, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI212642053, Length=363, Percent_Identity=24.5179063360882, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=376, Percent_Identity=27.1276595744681, Blast_Score=102, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=36.3028953229399, Blast_Score=261, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24644341, Length=415, Percent_Identity=46.0240963855422, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI221330659, Length=375, Percent_Identity=23.7333333333333, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI19920632, Length=375, Percent_Identity=23.7333333333333, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24581345, Length=429, Percent_Identity=22.3776223776224, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42997; Mature: 42866

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRRVVVTGLGLVSPVGNSVAEGWANLVAGKSGIATVTKFDPSNLAVHFAGEVKGFNVE
CCCCEEEEEECCHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCHH
EYLSAKDARQMDTFIHYGIAAGVQALKDSGLEVNEANAERAGVLVGSGIGGLPMIEDTHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEECCCCCCCCCCCCHH
TYVERGPRRISPFFVPGSIINMISGHLSIMHGLKGPNLAAVTACTTGLHSIGLAARLIQA
HHHHCCCCCCCCEECCHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHC
GDADVMLAGGAESTVSPLGIGGFAAARALSTRNDDPATASRPWDKDRDGFVLGEGAGVMV
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYESAKARGARIYAELVGFGMSGDAYHMTAPNMDGPRRCMLNALRDAGINTDQVQYLN
EECCHHHHHCCHHEEEHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEE
AHGTSTPLGDKNESDAIKAAFGEHARKVVVNSTKSMTGHLLGGAGGLESVFSVLALHHQV
CCCCCCCCCCCCCCHHHHHHHHHHHHEEEEECCCHHCCEEECCCCCHHHHHHHHHHHHCC
SPPTINIFNQDPECDLDYCANTARDMKIDVAVKNNFGFGGTNGTLVFRRL
CCCEEEEECCCCCCCHHHHCCCCCCEEEEEEEECCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
SRRRVVVTGLGLVSPVGNSVAEGWANLVAGKSGIATVTKFDPSNLAVHFAGEVKGFNVE
CCCEEEEEECCHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCHH
EYLSAKDARQMDTFIHYGIAAGVQALKDSGLEVNEANAERAGVLVGSGIGGLPMIEDTHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEECCCCCCCCCCCCHH
TYVERGPRRISPFFVPGSIINMISGHLSIMHGLKGPNLAAVTACTTGLHSIGLAARLIQA
HHHHCCCCCCCCEECCHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHC
GDADVMLAGGAESTVSPLGIGGFAAARALSTRNDDPATASRPWDKDRDGFVLGEGAGVMV
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYESAKARGARIYAELVGFGMSGDAYHMTAPNMDGPRRCMLNALRDAGINTDQVQYLN
EECCHHHHHCCHHEEEHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEE
AHGTSTPLGDKNESDAIKAAFGEHARKVVVNSTKSMTGHLLGGAGGLESVFSVLALHHQV
CCCCCCCCCCCCCCHHHHHHHHHHHHEEEEECCCHHCCEEECCCCCHHHHHHHHHHHHCC
SPPTINIFNQDPECDLDYCANTARDMKIDVAVKNNFGFGGTNGTLVFRRL
CCCEEEEECCCCCCCHHHHCCCCCCEEEEEEEECCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]