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The map label for this gene is nhaA [H]

Identifier: 17545763

GI number: 17545763

Start: 1098911

End: 1100047

Strand: Direct

Name: nhaA [H]

Synonym: RSc1044

Alternate gene names: 17545763

Gene position: 1098911-1100047 (Clockwise)

Preceding gene: 17545762

Following gene: 17545766

Centisome position: 29.57

GC content: 67.99

Gene sequence:

>1137_bases
ATGACCGATCCGACCCCGCCGAAATCGCCGGAAGAAGGCGCCGGCAAGCCCGATGAACTGGAATTCACGCACCAGGCGGA
CCATCCGCTGGAGGCCGAGCTGCGAGATGCCGCTGCCGGCAAGCCGGCGTCCAGGCCCGGTCTGTTCGGCCGCTTCCGAC
ATGGCGAGAGCGGCGCGCCGCGCGCATCGGGCGCCCCCGCCGGCTGGGAGCGCGACGTACTCGAGCGCGTCCTCCTGGCG
GCGATCCGCGAGCAGCGCGCCGCCCGCCGCTGGCGCATCTTTTTCCGCTTCGTGACGCTGGGCATCATCGGCGGGCTGCT
GTATCTGTTCGCCAGCTTCGAGGGCGAGACCGTCAGCTCCGGCCGCCACACCGCGCTGGTGACGCTCGATGGCGAGATCG
CCGCCAACACCAACGCCAGCGCCGACAACATCAACGCCTCGCTGGAAGCCGCGTTCGCCGACGACAACACCGCCGGGGTG
ATCCTCAAGATCAACTCGCCGGGCGGCTCGCCGGTGCAGGCCGGCATGATCAACGACGACATCCGCCGCCTGCGCGCCAA
GTACAAGAACATCCCGCTGTATGTGGTGGTCGAGGAGATGTGCGCCTCGGGCGGCTACTACGTGGCCGCCGCCGCCGACA
AGATCTATGTCGACAAGGCCAGCATCGTCGGCTCGATCGGCGTGCTGATGGACGGCTTCGGCTTCACCGGCCTGATGGAC
AAGCTGGGTGTGGAGCGGCGTCTGCTGACGGCCGGTACCAACAAGGGCATGCTCGACCCGTTCTCGCCGGTGGCCCCGCA
GCAGCGGCAATTCGCCCAGGCGATGCTCGACGAGGTGCACCAGCAGTTCATCGATGTGGTCAAGCAGGGGCGCGGCAGCC
GCCTGAAGGACGATCCGCAGCTGTTCTCCGGCCTGTTCTGGACCGGTGCCAAGGCGGTCGATCTGGGCTTGGCGGACGGC
ATCGGCGGCACCGATTTCGTCGCCCGCAACATCATCAAGGCGCCGGACTTGGTCGACTACACGGTCAAGGAGAACTTCGC
CGAGCGCGTGGCACGCAAGTTCGGCACGGCCATGGGCGCAGGGGCCATCAAGGCGCTGGCCGCGACCGGCCAGCTCAAGC
TCCTGATGAGGCAGTAG

Upstream 100 bases:

>100_bases
GCGGCCCGACGCGCTGTGCCGCCTGCCCGCCGCGCCCGACCCCGCCCCGGTACCGCCGGCGGCCTGACAACGACTCTCTT
CGATTGCATTGTCTTAGTCC

Downstream 100 bases:

>100_bases
GCGCGGCGCCTCAGCGCGCCAGCAGCGAGAAGATGGCCGGCCGCTTGTGCAGGGCCAGCCGATCCGGGCGCCAATCGCCC
ACCGGCAGGGTCACCACCTG

Product: protease transmembrane protein

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MTDPTPPKSPEEGAGKPDELEFTHQADHPLEAELRDAAAGKPASRPGLFGRFRHGESGAPRASGAPAGWERDVLERVLLA
AIREQRAARRWRIFFRFVTLGIIGGLLYLFASFEGETVSSGRHTALVTLDGEIAANTNASADNINASLEAAFADDNTAGV
ILKINSPGGSPVQAGMINDDIRRLRAKYKNIPLYVVVEEMCASGGYYVAAAADKIYVDKASIVGSIGVLMDGFGFTGLMD
KLGVERRLLTAGTNKGMLDPFSPVAPQQRQFAQAMLDEVHQQFIDVVKQGRGSRLKDDPQLFSGLFWTGAKAVDLGLADG
IGGTDFVARNIIKAPDLVDYTVKENFAERVARKFGTAMGAGAIKALAATGQLKLLMRQ

Sequences:

>Translated_378_residues
MTDPTPPKSPEEGAGKPDELEFTHQADHPLEAELRDAAAGKPASRPGLFGRFRHGESGAPRASGAPAGWERDVLERVLLA
AIREQRAARRWRIFFRFVTLGIIGGLLYLFASFEGETVSSGRHTALVTLDGEIAANTNASADNINASLEAAFADDNTAGV
ILKINSPGGSPVQAGMINDDIRRLRAKYKNIPLYVVVEEMCASGGYYVAAAADKIYVDKASIVGSIGVLMDGFGFTGLMD
KLGVERRLLTAGTNKGMLDPFSPVAPQQRQFAQAMLDEVHQQFIDVVKQGRGSRLKDDPQLFSGLFWTGAKAVDLGLADG
IGGTDFVARNIIKAPDLVDYTVKENFAERVARKFGTAMGAGAIKALAATGQLKLLMRQ
>Mature_377_residues
TDPTPPKSPEEGAGKPDELEFTHQADHPLEAELRDAAAGKPASRPGLFGRFRHGESGAPRASGAPAGWERDVLERVLLAA
IREQRAARRWRIFFRFVTLGIIGGLLYLFASFEGETVSSGRHTALVTLDGEIAANTNASADNINASLEAAFADDNTAGVI
LKINSPGGSPVQAGMINDDIRRLRAKYKNIPLYVVVEEMCASGGYYVAAAADKIYVDKASIVGSIGVLMDGFGFTGLMDK
LGVERRLLTAGTNKGMLDPFSPVAPQQRQFAQAMLDEVHQQFIDVVKQGRGSRLKDDPQLFSGLFWTGAKAVDLGLADGI
GGTDFVARNIIKAPDLVDYTVKENFAERVARKFGTAMGAGAIKALAATGQLKLLMRQ

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=218, Percent_Identity=34.8623853211009, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788064, Length=200, Percent_Identity=28.5, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 40522; Mature: 40390

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPTPPKSPEEGAGKPDELEFTHQADHPLEAELRDAAAGKPASRPGLFGRFRHGESGAP
CCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCCCCC
RASGAPAGWERDVLERVLLAAIREQRAARRWRIFFRFVTLGIIGGLLYLFASFEGETVSS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECC
GRHTALVTLDGEIAANTNASADNINASLEAAFADDNTAGVILKINSPGGSPVQAGMINDD
CCEEEEEEECCCEECCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCEECCCCHHH
IRRLRAKYKNIPLYVVVEEMCASGGYYVAAAADKIYVDKASIVGSIGVLMDGFGFTGLMD
HHHHHHHHCCCCEEEEEHHHHHCCCEEEEEECCEEEEEHHHHHHHHHHHHCCCCHHHHHH
KLGVERRLLTAGTNKGMLDPFSPVAPQQRQFAQAMLDEVHQQFIDVVKQGRGSRLKDDPQ
HHCHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
LFSGLFWTGAKAVDLGLADGIGGTDFVARNIIKAPDLVDYTVKENFAERVARKFGTAMGA
HHHHHHHCCCHHEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCH
GAIKALAATGQLKLLMRQ
HHHHHHHHCCCEEEEECC
>Mature Secondary Structure 
TDPTPPKSPEEGAGKPDELEFTHQADHPLEAELRDAAAGKPASRPGLFGRFRHGESGAP
CCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCCCCC
RASGAPAGWERDVLERVLLAAIREQRAARRWRIFFRFVTLGIIGGLLYLFASFEGETVSS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECC
GRHTALVTLDGEIAANTNASADNINASLEAAFADDNTAGVILKINSPGGSPVQAGMINDD
CCEEEEEEECCCEECCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCEECCCCHHH
IRRLRAKYKNIPLYVVVEEMCASGGYYVAAAADKIYVDKASIVGSIGVLMDGFGFTGLMD
HHHHHHHHCCCCEEEEEHHHHHCCCEEEEEECCEEEEEHHHHHHHHHHHHCCCCHHHHHH
KLGVERRLLTAGTNKGMLDPFSPVAPQQRQFAQAMLDEVHQQFIDVVKQGRGSRLKDDPQ
HHCHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
LFSGLFWTGAKAVDLGLADGIGGTDFVARNIIKAPDLVDYTVKENFAERVARKFGTAMGA
HHHHHHHCCCHHEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCH
GAIKALAATGQLKLLMRQ
HHHHHHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA