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The map label for this gene is gyaR [H]

Identifier: 17545753

GI number: 17545753

Start: 1086737

End: 1087741

Strand: Direct

Name: gyaR [H]

Synonym: RSc1034

Alternate gene names: 17545753

Gene position: 1086737-1087741 (Clockwise)

Preceding gene: 17545752

Following gene: 17545754

Centisome position: 29.24

GC content: 70.75

Gene sequence:

>1005_bases
ATGAAACCCGGAATCCTTGTCACCCGCGCGATCTTTCCCGAAGTGCTGGCGCGGCTGCGCGAGACCTTCGACGTGGCCGA
CAACCAGGCGGATGCCGTCCATCCGCCCGAGGCATTGGCCGAGCGCCTGCAGGGCCGCGTGGGCCTGCTCGCCAACGCCG
CCGATGCCATCAACGCCGACCTGATCGCCCGCGTGCCGACCCTGCGCGCGGTCGCCAACATGGCGGTCGGCTACAACAAC
CTGGACCTGCCGGCGATGACCCGCGCGGGCATTCTCGCCACCAACACGCCGGACATCCTGACCGAGACCACCGCCGATTT
CGGCTGGGCACTGCTGATGGCGGCCGCGCGGCGCGTGCCGGAATCGGAGCGCTGGCTGCGCGCGGGCCACTGGAAGCGCT
GGACGTACGACATGTTTCTCGGTGCCGAGGTCCATGGCAGCACGCTGGGCATCCTCGGCATGGGGCGCATCGGCCAGGCG
CTGGCGCGGCGCGCGAGCGGCTTTTCGATGCGCGTGATCTATCACAACCGCAGCCGGCTGTCGCCCGAGATCGAGCGGGA
CACCCGCGCCACCTACGTCGGCAAGGACGAACTGCTGGCCCAGGCCGACCACCTCGTGCTGGTGCTGCCGTATTCCAGTG
AGAGCCATCACGCCATCGGCGCGGCGGAACTGGCGCGCATGAAGCCGACCGCCACGCTGGTCAACCTCGCGCGCGGCGGC
ATCGTCGACGACGCGGCGCTGGCGCGGGCGCTGGCCGAAAAACGCCTCTTCGCGGCCGGGCTGGACGTGTACGAGGGGGA
GCCGGCGGTGCATCCGGCTCTGCTGGAGGCCGAGCCTGTCTCACTGACGCCGCATATCGCCAGCGCCACGCACGGCACGC
GGCTCGGCATGGCCAACCTGGCCGCCGACAACCTGATCGCCGCGCTGGGCTTCGGTCCGCGCGCCGGGCAGCCGCCCAAT
TTGTTGAACCCGGAGGCGCTGTCGGTACGGCGCGCCTCCGCCTGA

Upstream 100 bases:

>100_bases
AGCTTCTTCGGCTACATGCTGTGGTCAGGCGTCATCCTGGTCCCGATCTTCGTCCTGATGACCTTCGCTTTCTTCCGATA
ACCGCACGGTATTGCTGCGT

Downstream 100 bases:

>100_bases
TTGGAAACCTATGGACTGGATGGTATTACTGACGTTGCTGGGCGTGGCCGTGGTGGCCGTGCTGTGTGTGTTGATCTGGC
GCAGCGTATCGCGCCCGGCC

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKPGILVTRAIFPEVLARLRETFDVADNQADAVHPPEALAERLQGRVGLLANAADAINADLIARVPTLRAVANMAVGYNN
LDLPAMTRAGILATNTPDILTETTADFGWALLMAAARRVPESERWLRAGHWKRWTYDMFLGAEVHGSTLGILGMGRIGQA
LARRASGFSMRVIYHNRSRLSPEIERDTRATYVGKDELLAQADHLVLVLPYSSESHHAIGAAELARMKPTATLVNLARGG
IVDDAALARALAEKRLFAAGLDVYEGEPAVHPALLEAEPVSLTPHIASATHGTRLGMANLAADNLIAALGFGPRAGQPPN
LLNPEALSVRRASA

Sequences:

>Translated_334_residues
MKPGILVTRAIFPEVLARLRETFDVADNQADAVHPPEALAERLQGRVGLLANAADAINADLIARVPTLRAVANMAVGYNN
LDLPAMTRAGILATNTPDILTETTADFGWALLMAAARRVPESERWLRAGHWKRWTYDMFLGAEVHGSTLGILGMGRIGQA
LARRASGFSMRVIYHNRSRLSPEIERDTRATYVGKDELLAQADHLVLVLPYSSESHHAIGAAELARMKPTATLVNLARGG
IVDDAALARALAEKRLFAAGLDVYEGEPAVHPALLEAEPVSLTPHIASATHGTRLGMANLAADNLIAALGFGPRAGQPPN
LLNPEALSVRRASA
>Mature_334_residues
MKPGILVTRAIFPEVLARLRETFDVADNQADAVHPPEALAERLQGRVGLLANAADAINADLIARVPTLRAVANMAVGYNN
LDLPAMTRAGILATNTPDILTETTADFGWALLMAAARRVPESERWLRAGHWKRWTYDMFLGAEVHGSTLGILGMGRIGQA
LARRASGFSMRVIYHNRSRLSPEIERDTRATYVGKDELLAQADHLVLVLPYSSESHHAIGAAELARMKPTATLVNLARGG
IVDDAALARALAEKRLFAAGLDVYEGEPAVHPALLEAEPVSLTPHIASATHGTRLGMANLAADNLIAALGFGPRAGQPPN
LLNPEALSVRRASA

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=310, Percent_Identity=35.8064516129032, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI23308577, Length=255, Percent_Identity=34.1176470588235, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI145580578, Length=288, Percent_Identity=32.2916666666667, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI4557499, Length=288, Percent_Identity=32.2916666666667, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI61743967, Length=280, Percent_Identity=31.4285714285714, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI4557497, Length=280, Percent_Identity=31.4285714285714, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI145580575, Length=271, Percent_Identity=32.8413284132841, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI87082289, Length=329, Percent_Identity=41.6413373860182, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1789279, Length=240, Percent_Identity=32.0833333333333, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1787645, Length=204, Percent_Identity=27.9411764705882, Blast_Score=92, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17532191, Length=259, Percent_Identity=30.8880308880309, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25147481, Length=255, Percent_Identity=25.4901960784314, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=238, Percent_Identity=34.0336134453782, Blast_Score=139, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6320925, Length=269, Percent_Identity=26.7657992565056, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=269, Percent_Identity=25.6505576208178, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321253, Length=150, Percent_Identity=31.3333333333333, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28574286, Length=292, Percent_Identity=39.041095890411, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28574284, Length=324, Percent_Identity=36.1111111111111, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI45552429, Length=324, Percent_Identity=36.1111111111111, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24585514, Length=324, Percent_Identity=36.1111111111111, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI28574282, Length=324, Percent_Identity=36.1111111111111, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI45551003, Length=324, Percent_Identity=36.1111111111111, Blast_Score=184, Evalue=5e-47,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=35.3697749196142, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24585516, Length=248, Percent_Identity=31.8548387096774, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=28.9036544850498, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24646446, Length=302, Percent_Identity=31.4569536423841, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646448, Length=302, Percent_Identity=31.4569536423841, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646452, Length=302, Percent_Identity=31.4569536423841, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646450, Length=302, Percent_Identity=31.4569536423841, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI62472511, Length=302, Percent_Identity=31.4569536423841, Blast_Score=117, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35763; Mature: 35763

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPGILVTRAIFPEVLARLRETFDVADNQADAVHPPEALAERLQGRVGLLANAADAINAD
CCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHEHHCCHHHHCHH
LIARVPTLRAVANMAVGYNNLDLPAMTRAGILATNTPDILTETTADFGWALLMAAARRVP
HHHHHHHHHHHHHHHCCCCCCCCCCHHHCCEEECCCCCHHHHCHHHHHHHHHHHHHHHCC
ESERWLRAGHWKRWTYDMFLGAEVHGSTLGILGMGRIGQALARRASGFSMRVIYHNRSRL
CHHHHHHCCCCCEEEEEEEECCEECCCEEEEEECCHHHHHHHHHCCCCEEEEEEECCCCC
SPEIERDTRATYVGKDELLAQADHLVLVLPYSSESHHAIGAAELARMKPTATLVNLARGG
CCCHHCCCCEEECCHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHCCCHHHHHHHHCCC
IVDDAALARALAEKRLFAAGLDVYEGEPAVHPALLEAEPVSLTPHIASATHGTRLGMANL
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCCCCCHHCCCCCCCCCHHHH
AADNLIAALGFGPRAGQPPNLLNPEALSVRRASA
HHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MKPGILVTRAIFPEVLARLRETFDVADNQADAVHPPEALAERLQGRVGLLANAADAINAD
CCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHEHHCCHHHHCHH
LIARVPTLRAVANMAVGYNNLDLPAMTRAGILATNTPDILTETTADFGWALLMAAARRVP
HHHHHHHHHHHHHHHCCCCCCCCCCHHHCCEEECCCCCHHHHCHHHHHHHHHHHHHHHCC
ESERWLRAGHWKRWTYDMFLGAEVHGSTLGILGMGRIGQALARRASGFSMRVIYHNRSRL
CHHHHHHCCCCCEEEEEEEECCEECCCEEEEEECCHHHHHHHHHCCCCEEEEEEECCCCC
SPEIERDTRATYVGKDELLAQADHLVLVLPYSSESHHAIGAAELARMKPTATLVNLARGG
CCCHHCCCCEEECCHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHCCCHHHHHHHHCCC
IVDDAALARALAEKRLFAAGLDVYEGEPAVHPALLEAEPVSLTPHIASATHGTRLGMANL
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCCCCCHHCCCCCCCCCHHHH
AADNLIAALGFGPRAGQPPNLLNPEALSVRRASA
HHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA