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The map label for this gene is fabF [H]

Identifier: 17545146

GI number: 17545146

Start: 453907

End: 455124

Strand: Reverse

Name: fabF [H]

Synonym: RSc0427

Alternate gene names: 17545146

Gene position: 455124-453907 (Counterclockwise)

Preceding gene: 17545147

Following gene: 17545145

Centisome position: 12.25

GC content: 71.92

Gene sequence:

>1218_bases
TTGAAACCTCTCCTGCTCACGCACTTCACCGCCACGAGCTGCCTCGGACGCGGCCTCGACGCCACGCTCGATGCCCTGCG
CGGGCAGCGCGGCGGCCTCGCGCCCTGCCGCTTCGAGCGCGCTGACCTCGACACCTGGACCGGCGCGGTCGAGGACGTCG
ACGCCCAGCCCGTGCGCGCCGACCTGAGCGACTTCGAGTGCCGCAACAACCGGCTCGCGCAGATCGGCCTGACGCAGGAC
GGCTTCGCCGAACAGGTCGAGGCAGCACGGGCGCGCCATGGCGCCGGGCGCATCGGCGTCTTCGTGGGCACCAGCACCGC
CGGCATCCTGGAGACCGAACTCGCCTACCGGCACCGCGATCCGCAGACCGGCGCCCTGCCCGCCGATTTCCGCTACGCGC
ACACGCACAGCCCCTATTCGTCCGCCGCCTTCGTGCGCGCCTATTTCGGGCTGCACGGCCCGGCCATGTCGGTCTCGTCG
GCCTGCTCGTCCGGCGCCAAGGTCTTCGGCTCGGCGCGGCGCATGCTCGAAGCCGGCCTGATCGACGCGGCGGTCGTGGG
CGGCGTGGATTCGCTGTGCCTGACCACGCTGTACGGCTTCAACTCGCTCGAACTGCTGTCGCGGCAACCATGCAAGCCGT
TCGACGTGGCGCGTGACGGCATCTCGATCGGCGAGGCTGCAGCCTTCGTCCTGCTCGAGCGCGCCGACGGCCGGTCCGGG
CACGACGAGGCCATCCTGCTGCTCGGCGTCGGCGAATCGAGCGACGCGCACCACATGTCGACGCCGCATCCGGAGGGACT
GGGCGCGCGCCTGGCGATGGAGCAGGCGCTGGCCTCGGCCGGCATCGCGGCCGAGGCGATCGACTACATCAACCTGCACG
GCACGGCCACCGCCAGCAACGACGCCGCCGAAAGCCACGCGGTCAACGCACTGTTCAGCGGCACGCCGTGCAGTTCGACC
AAGGGCGCGACCGGCCACACGCTGGGCGCGGCGGGGGCGCTGGAAGCGGTGATCGCGGCGCTCGCGCTGCGCCATCAACT
GCTGCCCGCCGGCATCAACACGACCCGGCCCGATCCGGTGCTCGCGCTCGACTACGTGCTGACGAGCCGACCGGCCCGCC
TGCGCGCCGCCCTCAGCAATGCGTTCGGCTTCGGCGGCACCAACTGCAGCCTGGTGCTCGGCCGCACGGACAGCCTCGCC
ACCTCCATCGCCCCATGA

Upstream 100 bases:

>100_bases
CCGCCCCGGCCGCTTGATAAAATTTGAAAAGACCGGCACCCAGACCGTCCCATCGACCACCCCATCGCGGCCCCGCAAGG
CCGCCACCGGACCCGTCCCG

Downstream 100 bases:

>100_bases
CCCGACTGAGCGCATTCATCGAAGGCGTCGGGCTGCTCGGGCCCGGCCTGAACCAGTGGCCGCACGCGGCCGCCCTGCTG
ACCGGCCAGGCGCCCTACGC

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MKPLLLTHFTATSCLGRGLDATLDALRGQRGGLAPCRFERADLDTWTGAVEDVDAQPVRADLSDFECRNNRLAQIGLTQD
GFAEQVEAARARHGAGRIGVFVGTSTAGILETELAYRHRDPQTGALPADFRYAHTHSPYSSAAFVRAYFGLHGPAMSVSS
ACSSGAKVFGSARRMLEAGLIDAAVVGGVDSLCLTTLYGFNSLELLSRQPCKPFDVARDGISIGEAAAFVLLERADGRSG
HDEAILLLGVGESSDAHHMSTPHPEGLGARLAMEQALASAGIAAEAIDYINLHGTATASNDAAESHAVNALFSGTPCSST
KGATGHTLGAAGALEAVIAALALRHQLLPAGINTTRPDPVLALDYVLTSRPARLRAALSNAFGFGGTNCSLVLGRTDSLA
TSIAP

Sequences:

>Translated_405_residues
MKPLLLTHFTATSCLGRGLDATLDALRGQRGGLAPCRFERADLDTWTGAVEDVDAQPVRADLSDFECRNNRLAQIGLTQD
GFAEQVEAARARHGAGRIGVFVGTSTAGILETELAYRHRDPQTGALPADFRYAHTHSPYSSAAFVRAYFGLHGPAMSVSS
ACSSGAKVFGSARRMLEAGLIDAAVVGGVDSLCLTTLYGFNSLELLSRQPCKPFDVARDGISIGEAAAFVLLERADGRSG
HDEAILLLGVGESSDAHHMSTPHPEGLGARLAMEQALASAGIAAEAIDYINLHGTATASNDAAESHAVNALFSGTPCSST
KGATGHTLGAAGALEAVIAALALRHQLLPAGINTTRPDPVLALDYVLTSRPARLRAALSNAFGFGGTNCSLVLGRTDSLA
TSIAP
>Mature_405_residues
MKPLLLTHFTATSCLGRGLDATLDALRGQRGGLAPCRFERADLDTWTGAVEDVDAQPVRADLSDFECRNNRLAQIGLTQD
GFAEQVEAARARHGAGRIGVFVGTSTAGILETELAYRHRDPQTGALPADFRYAHTHSPYSSAAFVRAYFGLHGPAMSVSS
ACSSGAKVFGSARRMLEAGLIDAAVVGGVDSLCLTTLYGFNSLELLSRQPCKPFDVARDGISIGEAAAFVLLERADGRSG
HDEAILLLGVGESSDAHHMSTPHPEGLGARLAMEQALASAGIAAEAIDYINLHGTATASNDAAESHAVNALFSGTPCSST
KGATGHTLGAAGALEAVIAALALRHQLLPAGINTTRPDPVLALDYVLTSRPARLRAALSNAFGFGGTNCSLVLGRTDSLA
TSIAP

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=270, Percent_Identity=40.7407407407407, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI223972627, Length=147, Percent_Identity=45.578231292517, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI41872631, Length=261, Percent_Identity=28.735632183908, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1787337, Length=262, Percent_Identity=40.0763358778626, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1788663, Length=258, Percent_Identity=34.4961240310078, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71983541, Length=267, Percent_Identity=34.0823970037453, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71983535, Length=258, Percent_Identity=34.4961240310078, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI212642053, Length=334, Percent_Identity=26.6467065868263, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=309, Percent_Identity=24.9190938511327, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320904, Length=278, Percent_Identity=34.1726618705036, Blast_Score=130, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24644341, Length=314, Percent_Identity=37.8980891719745, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24581345, Length=320, Percent_Identity=26.25, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI221330659, Length=314, Percent_Identity=25.1592356687898, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19920632, Length=314, Percent_Identity=25.1592356687898, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42046; Mature: 42046

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLLLTHFTATSCLGRGLDATLDALRGQRGGLAPCRFERADLDTWTGAVEDVDAQPVRA
CCCEEEEHHHHHHHHHCCHHHHHHHHCCCCCCCCCCEECCCCCHHHCCCHHCCCCCCCCC
DLSDFECRNNRLAQIGLTQDGFAEQVEAARARHGAGRIGVFVGTSTAGILETELAYRHRD
CCHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCC
PQTGALPADFRYAHTHSPYSSAAFVRAYFGLHGPAMSVSSACSSGAKVFGSARRMLEAGL
CCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IDAAVVGGVDSLCLTTLYGFNSLELLSRQPCKPFDVARDGISIGEAAAFVLLERADGRSG
HHHHHHCCHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHCCCCHHHHHEEEEEECCCCCCC
HDEAILLLGVGESSDAHHMSTPHPEGLGARLAMEQALASAGIAAEAIDYINLHGTATASN
CCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHEEEECCCCCCCC
DAAESHAVNALFSGTPCSSTKGATGHTLGAAGALEAVIAALALRHQLLPAGINTTRPDPV
CHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
LALDYVLTSRPARLRAALSNAFGFGGTNCSLVLGRTDSLATSIAP
EEEHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEECCHHHHHCCCC
>Mature Secondary Structure
MKPLLLTHFTATSCLGRGLDATLDALRGQRGGLAPCRFERADLDTWTGAVEDVDAQPVRA
CCCEEEEHHHHHHHHHCCHHHHHHHHCCCCCCCCCCEECCCCCHHHCCCHHCCCCCCCCC
DLSDFECRNNRLAQIGLTQDGFAEQVEAARARHGAGRIGVFVGTSTAGILETELAYRHRD
CCHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCC
PQTGALPADFRYAHTHSPYSSAAFVRAYFGLHGPAMSVSSACSSGAKVFGSARRMLEAGL
CCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IDAAVVGGVDSLCLTTLYGFNSLELLSRQPCKPFDVARDGISIGEAAAFVLLERADGRSG
HHHHHHCCHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHCCCCHHHHHEEEEEECCCCCCC
HDEAILLLGVGESSDAHHMSTPHPEGLGARLAMEQALASAGIAAEAIDYINLHGTATASN
CCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHEEEECCCCCCCC
DAAESHAVNALFSGTPCSSTKGATGHTLGAAGALEAVIAALALRHQLLPAGINTTRPDPV
CHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
LALDYVLTSRPARLRAALSNAFGFGGTNCSLVLGRTDSLATSIAP
EEEHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEECCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]