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The map label for this gene is dctB [H]

Identifier: 17230231

GI number: 17230231

Start: 3336138

End: 3337913

Strand: Direct

Name: dctB [H]

Synonym: alr2739

Alternate gene names: 17230231

Gene position: 3336138-3337913 (Clockwise)

Preceding gene: 17230230

Following gene: 17230233

Centisome position: 52.02

GC content: 36.26

Gene sequence:

>1776_bases
ATGAAAATCTCCACCAAGTTTCTCACAGGTTCTACTATATCTGTCGGACTCATAGTGGCTATTCTTATCGGCAATACTGT
AGTTGTGCAGCAAATTAGGCAGAATGTCCGCGAAAAAAGTTATCAAACTACTCAAACTATAAAGGCCGTTTTAGAAACAA
ATAATACTTTAAAGTCGGAAATAATTGCCCTCAAAGATATTGTTTTATTCAAAACTAAAAGCACACGTACAGAAATACTG
CACGCCGAGTTCCTTGATTCCTTAAATCAAGTAGAACAGTTAATGCCAAATTCACCCGAAATTGCTTTAATTCGTCGGCG
GCATCAATTGCTTGACAATATGGCAGTACAATTAACTCAACGTAGTTCTAGTCCAACATATCTAGAAGATTCTCAGCAGT
ATTTTAGAGCAATTAATTCTTTTAATCAAGATATTCAGTTATTTCTAGAACAGATAATTCAACGTGCTTATCAAGAGCGA
ATTTTATTAGAGCAAGACTTAGAAAACCTCTACCAAGTACAGAGAATCATCTCTATAGTGGTTGTAGCCGTAATTTTAAT
GCTATTGATTGGGAAATTTATACTCATTTGGCAACCAACAATCAAATCTATACAAAATTTACAGTTAGGTACGGCAGAAA
TTGCAGCAGGTAATTTTGATTATCGCTTAAACATCCACACAGGTGATGAAATTGAAGACTTAGCTCAAGCATTCAATGAT
ATGGCAGTTAAGTTATCCCAATCGCGGGAAACCTTGATGAAAAATACTGAGTTAACTAACATGAATCAGCGTTTGGAATT
AGAAATTGCCGAACGCAAACAAGCTGAATTAGAATTGCAAAAAGCTTTACAGGAACTACAGCAAACTCAAGCCCAACTGA
TTCAAACTGAGAAAATGTCTAGCTTAGGTCAGCTAGTAGCTGGAGTAGCTCATGAAATTAATAATCCAGTTAGTTTTATC
TATGGCAATATTACTCATGCCAAGGAATATACAGAAAAACTTTTAGAATTAATCCATCTCTATCAACAAGAGTTAACCGA
GCCGAGTGCAGTAATTCAAGAAAAAATTGCAGAAATAGACCTAGAATTTTTACAAGAAGACCTTCCCAAAATCCTCAGTT
CAATGAAAATGGGGTCTCAGCGAATTCAACAGATTGTTTTATCTTTACGCAATTTTTCTCGCCTGGATGAAGCAGAGATG
AAAGAGGTAGATATTCATGAAGGCATTGAAAGTACTCTGCTGATTCTACAAAATCGATTTAAGGCTAAATCGCAATCTTA
TAATATTGAAATTATTAAGGAATATGGACAATTACCTTTAGTAGAGTGCCATGCAGGACAGTTAAATCAGGTATTTATGA
ATATTATTAATAATGCCGTTGATGCTTTAGAAGGGTCAGTGGTCAGTGGTCAGTGGTCAATTGTAAATGGCAAAACAACT
AATAATGAACGACTGACAAATAACAGCCCCCAAATTTCAATTCGTACTGAAATAAATAATAATAACCGGGTGGTAATTAG
AATCGCTGATAACGGCCCAGGTATTAATCAACTGGTGATGCAAAAGCTGTTTGACCCGTTTTTCACAACCAAGCCTGTTG
GTCAAGGTACGGGGTTGGGTTTATCCATTAGTTACCAAATTGTGGTTGACAAACATTCTGGAGTGCTACGATGTGAGTCT
GAAATAGGCAAAGGAACAGAGTTTTGGATTGAAATTCCTTTACGTCAGGTGCAACCGGAGAAACCAGAACACGGTTTCAG
TACAATGGAAGTTTAA

Upstream 100 bases:

>100_bases
TAGGAGCTGAATCAGCCGGCTATACTCTTGTCGGCCCAGACCACTACGCTCCTATTCAACAACTCCGTCAAGAACTCAAC
TTAACATCCATCCCGAAAAA

Downstream 100 bases:

>100_bases
AATTTTCTCTCCAAGGATAATTGATTCATAATTATTGAGTGCGGTTAATACTACAGTCTTTAGATTTTAAAAACTGCTCT
CGGATGAAGAAATTCCTAGA

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MKISTKFLTGSTISVGLIVAILIGNTVVVQQIRQNVREKSYQTTQTIKAVLETNNTLKSEIIALKDIVLFKTKSTRTEIL
HAEFLDSLNQVEQLMPNSPEIALIRRRHQLLDNMAVQLTQRSSSPTYLEDSQQYFRAINSFNQDIQLFLEQIIQRAYQER
ILLEQDLENLYQVQRIISIVVVAVILMLLIGKFILIWQPTIKSIQNLQLGTAEIAAGNFDYRLNIHTGDEIEDLAQAFND
MAVKLSQSRETLMKNTELTNMNQRLELEIAERKQAELELQKALQELQQTQAQLIQTEKMSSLGQLVAGVAHEINNPVSFI
YGNITHAKEYTEKLLELIHLYQQELTEPSAVIQEKIAEIDLEFLQEDLPKILSSMKMGSQRIQQIVLSLRNFSRLDEAEM
KEVDIHEGIESTLLILQNRFKAKSQSYNIEIIKEYGQLPLVECHAGQLNQVFMNIINNAVDALEGSVVSGQWSIVNGKTT
NNERLTNNSPQISIRTEINNNNRVVIRIADNGPGINQLVMQKLFDPFFTTKPVGQGTGLGLSISYQIVVDKHSGVLRCES
EIGKGTEFWIEIPLRQVQPEKPEHGFSTMEV

Sequences:

>Translated_591_residues
MKISTKFLTGSTISVGLIVAILIGNTVVVQQIRQNVREKSYQTTQTIKAVLETNNTLKSEIIALKDIVLFKTKSTRTEIL
HAEFLDSLNQVEQLMPNSPEIALIRRRHQLLDNMAVQLTQRSSSPTYLEDSQQYFRAINSFNQDIQLFLEQIIQRAYQER
ILLEQDLENLYQVQRIISIVVVAVILMLLIGKFILIWQPTIKSIQNLQLGTAEIAAGNFDYRLNIHTGDEIEDLAQAFND
MAVKLSQSRETLMKNTELTNMNQRLELEIAERKQAELELQKALQELQQTQAQLIQTEKMSSLGQLVAGVAHEINNPVSFI
YGNITHAKEYTEKLLELIHLYQQELTEPSAVIQEKIAEIDLEFLQEDLPKILSSMKMGSQRIQQIVLSLRNFSRLDEAEM
KEVDIHEGIESTLLILQNRFKAKSQSYNIEIIKEYGQLPLVECHAGQLNQVFMNIINNAVDALEGSVVSGQWSIVNGKTT
NNERLTNNSPQISIRTEINNNNRVVIRIADNGPGINQLVMQKLFDPFFTTKPVGQGTGLGLSISYQIVVDKHSGVLRCES
EIGKGTEFWIEIPLRQVQPEKPEHGFSTMEV
>Mature_591_residues
MKISTKFLTGSTISVGLIVAILIGNTVVVQQIRQNVREKSYQTTQTIKAVLETNNTLKSEIIALKDIVLFKTKSTRTEIL
HAEFLDSLNQVEQLMPNSPEIALIRRRHQLLDNMAVQLTQRSSSPTYLEDSQQYFRAINSFNQDIQLFLEQIIQRAYQER
ILLEQDLENLYQVQRIISIVVVAVILMLLIGKFILIWQPTIKSIQNLQLGTAEIAAGNFDYRLNIHTGDEIEDLAQAFND
MAVKLSQSRETLMKNTELTNMNQRLELEIAERKQAELELQKALQELQQTQAQLIQTEKMSSLGQLVAGVAHEINNPVSFI
YGNITHAKEYTEKLLELIHLYQQELTEPSAVIQEKIAEIDLEFLQEDLPKILSSMKMGSQRIQQIVLSLRNFSRLDEAEM
KEVDIHEGIESTLLILQNRFKAKSQSYNIEIIKEYGQLPLVECHAGQLNQVFMNIINNAVDALEGSVVSGQWSIVNGKTT
NNERLTNNSPQISIRTEINNNNRVVIRIADNGPGINQLVMQKLFDPFFTTKPVGQGTGLGLSISYQIVVDKHSGVLRCES
EIGKGTEFWIEIPLRQVQPEKPEHGFSTMEV

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=289, Percent_Identity=29.757785467128, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1790436, Length=304, Percent_Identity=25.9868421052632, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790300, Length=360, Percent_Identity=25.5555555555556, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 67108; Mature: 67108

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISTKFLTGSTISVGLIVAILIGNTVVVQQIRQNVREKSYQTTQTIKAVLETNNTLKSE
CCCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
IIALKDIVLFKTKSTRTEILHAEFLDSLNQVEQLMPNSPEIALIRRRHQLLDNMAVQLTQ
HHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
RSSSPTYLEDSQQYFRAINSFNQDIQLFLEQIIQRAYQERILLEQDLENLYQVQRIISIV
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVAVILMLLIGKFILIWQPTIKSIQNLQLGTAEIAAGNFDYRLNIHTGDEIEDLAQAFND
HHHHHHHHHHHHHHEEECHHHHHHHHCCCCCHHEECCCEEEEEEECCCCCHHHHHHHHHH
MAVKLSQSRETLMKNTELTNMNQRLELEIAERKQAELELQKALQELQQTQAQLIQTEKMS
HHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGQLVAGVAHEINNPVSFIYGNITHAKEYTEKLLELIHLYQQELTEPSAVIQEKIAEID
HHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LEFLQEDLPKILSSMKMGSQRIQQIVLSLRNFSRLDEAEMKEVDIHEGIESTLLILQNRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHH
KAKSQSYNIEIIKEYGQLPLVECHAGQLNQVFMNIINNAVDALEGSVVSGQWSIVNGKTT
HCCCCCCCHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCEECCEEEEECCCCC
NNERLTNNSPQISIRTEINNNNRVVIRIADNGPGINQLVMQKLFDPFFTTKPVGQGTGLG
CCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCHHHCCCCCCCCCCCC
LSISYQIVVDKHSGVLRCESEIGKGTEFWIEIPLRQVQPEKPEHGFSTMEV
EEEEEEEEEECCCCCEEEHHHCCCCCEEEEECCHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKISTKFLTGSTISVGLIVAILIGNTVVVQQIRQNVREKSYQTTQTIKAVLETNNTLKSE
CCCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
IIALKDIVLFKTKSTRTEILHAEFLDSLNQVEQLMPNSPEIALIRRRHQLLDNMAVQLTQ
HHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
RSSSPTYLEDSQQYFRAINSFNQDIQLFLEQIIQRAYQERILLEQDLENLYQVQRIISIV
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVAVILMLLIGKFILIWQPTIKSIQNLQLGTAEIAAGNFDYRLNIHTGDEIEDLAQAFND
HHHHHHHHHHHHHHEEECHHHHHHHHCCCCCHHEECCCEEEEEEECCCCCHHHHHHHHHH
MAVKLSQSRETLMKNTELTNMNQRLELEIAERKQAELELQKALQELQQTQAQLIQTEKMS
HHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGQLVAGVAHEINNPVSFIYGNITHAKEYTEKLLELIHLYQQELTEPSAVIQEKIAEID
HHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LEFLQEDLPKILSSMKMGSQRIQQIVLSLRNFSRLDEAEMKEVDIHEGIESTLLILQNRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHH
KAKSQSYNIEIIKEYGQLPLVECHAGQLNQVFMNIINNAVDALEGSVVSGQWSIVNGKTT
HCCCCCCCHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCEECCEEEEECCCCC
NNERLTNNSPQISIRTEINNNNRVVIRIADNGPGINQLVMQKLFDPFFTTKPVGQGTGLG
CCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCHHHCCCCCCCCCCCC
LSISYQIVVDKHSGVLRCESEIGKGTEFWIEIPLRQVQPEKPEHGFSTMEV
EEEEEEEEEECCCCCEEEHHHCCCCCEEEEECCHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3671068 [H]