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The map label for this gene is coxA [H]

Identifier: 17230224

GI number: 17230224

Start: 3329430

End: 3331097

Strand: Direct

Name: coxA [H]

Synonym: alr2732

Alternate gene names: 17230224

Gene position: 3329430-3331097 (Clockwise)

Preceding gene: 17230223

Following gene: 17230226

Centisome position: 51.91

GC content: 48.38

Gene sequence:

>1668_bases
ATGACCAACATCCCCATAGAAGGCGTTCAACTCCCTGAGGGGAAGCCTCACCACCCATCTCCCGGAGGCTGGAAGGAATA
TTTCAGCTTTAGCCATGACCACAAGGTTATTGGTATCCAATACCTTGTAACCTCCTTTATCTTCTTTCTCGTTGGCGGTA
TCTTCGCCATGATACTGCGGGGAGAACTCATCACCCCCGAATCAGACCTCATCGACCGCACCGTTTATAACGGAATGTTC
ACCATGCACGGCACGGTGATGCTGTTCTTGTGGACATTCCCCTCACTCGTTGGACTAGCTAACTACCTAGTACCCTTGAT
GATTGGGGCGCGGGATATGGCCTTCCCTCGCCTCAACGCCGCCGCCTTCTGGATGGTTCCCGTAGTCGGGATTCTCTTGA
TGACTAGCTTCTTTGTCCCTGGTGGCCCAGCCCAATCCGGTTGGTGGGCTTATCCTCCGGTAAGTACCCAGAATCCCACA
GGTAACTTAATTAATGGTCAAGTAATTTGGCTATTAGCAGTTGCTATTTCCGGTGTCTCCTCAATTATGGGGGCTGTGAA
CTTTGTAACCACTATCGTCAAGATGCGTGCGCCAGGGATGGGCTTCTTTCGGATGCCCTTATTTGTCTGGGCAGTATTTA
GCGCTCAAATTATCCAATTGTTTGGCTTACCAGCCCTGACAGCAGGCGCAGTCATGCTGTTGTTGGACATTACCGTGGGG
ACTAGCTTTTTTGACCCTAGCAAGGGCGGAAATCCAGTCATGTTCCAACATTATTTCTGGTTCTATTCCCACCCGGCTGT
TTACGTGATTATTCTGCCCATCTTCGGTATCTTCTCAGAAATCTTTCCCGTCTACTCTCGTAAACCATTGTTTGGTTACA
AGGTAGTGGCAATTTCTTCCATGTTAATTGCCGTAGTTAGCGCCATTGTTTGGGTACACCACTTATACGTCAGTGGTACA
CCTGCTTGGATGCGGATGTTTTTCATGCTGACGACGATGTTAGTATCCGTTCCCACAGGTATTAAGGTATTTGCTTGGGT
TGCAACTATCTGGGGCGGAAAAATTCGACTCAACACCCCCATGCTGTTCGCTTTGGGTGGACTAATTTTATTCGTCTTCG
CCGGTATTGTCGGCATCATGCTTTCTTCTGTACCTGTTGATGTCCACGTCAACAATACCTACTTTGTCGTCGGACACTTC
CACTACGTCCTGTTCGGAACCGTGACGATGGGTATGTATGCTGCTATCTATCACTGGTTCCCCAAAATGACCGGCAGAAT
GTACTACGAAGGCTGGGGTAAACTACACTTCTGGTTGACATTCATCGGTACTAACCTCAACTTCTTCCCCATGCACCCCT
TAGGTTTACAAGGGATGTTACGGCGAGTTTCTTCCTACGCACCAGAATATGAAGGCTGGAATATCGTTGCTAGTCTTGGT
GCATTCTTGTTAGGTATGTCTACTTTGCCCTTCATCTTCAATATGGTGGTTTCTTGGATGCACGGTGAGAAAGCACCAGA
TAATCCTTGGCGCGCTATTGGTTTGGAGTGGTTGGTAGCTTCTCCTCCACCTGTAGAAAACTTTGAAGAAATCCCCGTTG
TGATTTCTGAACCCTACGGTTATGGCAAATCAGAACCATTGACGGCGGAAAGGGGTATGGGGGTATAG

Upstream 100 bases:

>100_bases
GCAAGTCAAAACTGGTTGGAAAACCGTAGCACCAGCCGCCGCACCTTTGGTTAATTACCCTGGTTAAAAGCTCAACCCCT
ACACCACTACTATTTCACCA

Downstream 100 bases:

>100_bases
GGGTATAGGGGTATAGGGGTATAGGGGAAAGACTAAAAGTAAATTCTTCCCTCACCCCCCCCTACACCCCTATTTCTCTA
ATGAGCGAATCAGAAATAAT

Product: cytochrome c oxidase subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I; Oxidase aa(3) subunit 1 [H]

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MTNIPIEGVQLPEGKPHHPSPGGWKEYFSFSHDHKVIGIQYLVTSFIFFLVGGIFAMILRGELITPESDLIDRTVYNGMF
TMHGTVMLFLWTFPSLVGLANYLVPLMIGARDMAFPRLNAAAFWMVPVVGILLMTSFFVPGGPAQSGWWAYPPVSTQNPT
GNLINGQVIWLLAVAISGVSSIMGAVNFVTTIVKMRAPGMGFFRMPLFVWAVFSAQIIQLFGLPALTAGAVMLLLDITVG
TSFFDPSKGGNPVMFQHYFWFYSHPAVYVIILPIFGIFSEIFPVYSRKPLFGYKVVAISSMLIAVVSAIVWVHHLYVSGT
PAWMRMFFMLTTMLVSVPTGIKVFAWVATIWGGKIRLNTPMLFALGGLILFVFAGIVGIMLSSVPVDVHVNNTYFVVGHF
HYVLFGTVTMGMYAAIYHWFPKMTGRMYYEGWGKLHFWLTFIGTNLNFFPMHPLGLQGMLRRVSSYAPEYEGWNIVASLG
AFLLGMSTLPFIFNMVVSWMHGEKAPDNPWRAIGLEWLVASPPPVENFEEIPVVISEPYGYGKSEPLTAERGMGV

Sequences:

>Translated_555_residues
MTNIPIEGVQLPEGKPHHPSPGGWKEYFSFSHDHKVIGIQYLVTSFIFFLVGGIFAMILRGELITPESDLIDRTVYNGMF
TMHGTVMLFLWTFPSLVGLANYLVPLMIGARDMAFPRLNAAAFWMVPVVGILLMTSFFVPGGPAQSGWWAYPPVSTQNPT
GNLINGQVIWLLAVAISGVSSIMGAVNFVTTIVKMRAPGMGFFRMPLFVWAVFSAQIIQLFGLPALTAGAVMLLLDITVG
TSFFDPSKGGNPVMFQHYFWFYSHPAVYVIILPIFGIFSEIFPVYSRKPLFGYKVVAISSMLIAVVSAIVWVHHLYVSGT
PAWMRMFFMLTTMLVSVPTGIKVFAWVATIWGGKIRLNTPMLFALGGLILFVFAGIVGIMLSSVPVDVHVNNTYFVVGHF
HYVLFGTVTMGMYAAIYHWFPKMTGRMYYEGWGKLHFWLTFIGTNLNFFPMHPLGLQGMLRRVSSYAPEYEGWNIVASLG
AFLLGMSTLPFIFNMVVSWMHGEKAPDNPWRAIGLEWLVASPPPVENFEEIPVVISEPYGYGKSEPLTAERGMGV
>Mature_554_residues
TNIPIEGVQLPEGKPHHPSPGGWKEYFSFSHDHKVIGIQYLVTSFIFFLVGGIFAMILRGELITPESDLIDRTVYNGMFT
MHGTVMLFLWTFPSLVGLANYLVPLMIGARDMAFPRLNAAAFWMVPVVGILLMTSFFVPGGPAQSGWWAYPPVSTQNPTG
NLINGQVIWLLAVAISGVSSIMGAVNFVTTIVKMRAPGMGFFRMPLFVWAVFSAQIIQLFGLPALTAGAVMLLLDITVGT
SFFDPSKGGNPVMFQHYFWFYSHPAVYVIILPIFGIFSEIFPVYSRKPLFGYKVVAISSMLIAVVSAIVWVHHLYVSGTP
AWMRMFFMLTTMLVSVPTGIKVFAWVATIWGGKIRLNTPMLFALGGLILFVFAGIVGIMLSSVPVDVHVNNTYFVVGHFH
YVLFGTVTMGMYAAIYHWFPKMTGRMYYEGWGKLHFWLTFIGTNLNFFPMHPLGLQGMLRRVSSYAPEYEGWNIVASLGA
FLLGMSTLPFIFNMVVSWMHGEKAPDNPWRAIGLEWLVASPPPVENFEEIPVVISEPYGYGKSEPLTAERGMGV

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=504, Percent_Identity=40.4761904761905, Blast_Score=351, Evalue=8e-97,
Organism=Escherichia coli, GI1786634, Length=535, Percent_Identity=37.3831775700935, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6226519, Length=526, Percent_Identity=39.7338403041825, Blast_Score=383, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6226524, Length=322, Percent_Identity=39.4409937888199, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6226523, Length=250, Percent_Identity=37.6, Blast_Score=157, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 61754; Mature: 61623

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIPIEGVQLPEGKPHHPSPGGWKEYFSFSHDHKVIGIQYLVTSFIFFLVGGIFAMILR
CCCCCCCCEECCCCCCCCCCCCCHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHC
GELITPESDLIDRTVYNGMFTMHGTVMLFLWTFPSLVGLANYLVPLMIGARDMAFPRLNA
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCH
AAFWMVPVVGILLMTSFFVPGGPAQSGWWAYPPVSTQNPTGNLINGQVIWLLAVAISGVS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
SIMGAVNFVTTIVKMRAPGMGFFRMPLFVWAVFSAQIIQLFGLPALTAGAVMLLLDITVG
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
TSFFDPSKGGNPVMFQHYFWFYSHPAVYVIILPIFGIFSEIFPVYSRKPLFGYKVVAISS
CCCCCCCCCCCCEEEEEEEEHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
MLIAVVSAIVWVHHLYVSGTPAWMRMFFMLTTMLVSVPTGIKVFAWVATIWGGKIRLNTP
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCC
MLFALGGLILFVFAGIVGIMLSSVPVDVHVNNTYFVVGHFHYVLFGTVTMGMYAAIYHWF
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHH
PKMTGRMYYEGWGKLHFWLTFIGTNLNFFPMHPLGLQGMLRRVSSYAPEYEGWNIVASLG
HHHCCCEEECCCCCEEEEEEEEECCCCEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHH
AFLLGMSTLPFIFNMVVSWMHGEKAPDNPWRAIGLEWLVASPPPVENFEEIPVVISEPYG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECEEEEECCCCCCCCCCCCCEEEECCCC
YGKSEPLTAERGMGV
CCCCCCCCCCCCCCC
>Mature Secondary Structure 
TNIPIEGVQLPEGKPHHPSPGGWKEYFSFSHDHKVIGIQYLVTSFIFFLVGGIFAMILR
CCCCCCCEECCCCCCCCCCCCCHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHC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CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8399373 [H]