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The map label for this gene is cya [H]

Identifier: 17228898

GI number: 17228898

Start: 1667912

End: 1669582

Strand: Direct

Name: cya [H]

Synonym: alr1403

Alternate gene names: 17228898

Gene position: 1667912-1669582 (Clockwise)

Preceding gene: 17228896

Following gene: 17228899

Centisome position: 26.01

GC content: 44.82

Gene sequence:

>1671_bases
ATGGGAGGAGATGACATCCTAACTGGTGGAAGTCAAAATGACACGATTGAAGGTGGCGAAGGTAAAGATACCATCAATGG
TGGCGCTGGTTTTGATATCCTCAAAGGCGGTGATGGTGATGACACCTTGATTGATACTGAGGGTAATATCGATGGCGGTG
CAGGTACTGATACTCTCCGGGCAGACTACAGCAAGTATGACAATGGTGCTGGTGTTCATGTCGGTTATTTAGGACAAGCT
CAGATTTTCAGTCGCCAAACTGGTACTGGCATACTTGGTTACAGCAATATTGAAAAGTTTGAGATTACCGGGACAAAATA
CGCAGATATTCTTCAAGGCGGCGTTGGCAATGACGTTCTCAAAGGTGGAGCCGGCAATGATGAACTGAGTGGTGGTGCTG
GTAATGACACCCTTGATGGTGGCACTGGTTTTGATATCCTCAAAGGTGGTGATGGTGATGATACCTTGATTGATACTGAG
GGTAATATCGATGGCGGTGCAGGTACTGATACTCTCCGGGCAGACTACAGCAGGTATGACAATGGTGCTGGTGTTCACGT
CGGTTATTTAGGACAAGCTCAAATTTTCAGTCGCTTGACTGGTACTGGCATACTTGGTTACAGCAATATTGAAAAGTTTG
AGATTACTGGGACAAATTACGCAGATATCCTCCAAGGCGGTAGTGGCAATGACATCCTCAAAGGTGGAGCCGGCAATGAT
GAACTGAGTGGTAAAGGTGGTAACGATACTCTTGATGGTGGCTTTGGCTATGACACCGTTGTTTATGACGGTAATTATGC
AGATTATGGTATCTCTTTCCTGAGCAATGGTGATTTGCAAGTCATTGACAAGAACCTCACCAATGGAAATGACGGTACTG
ACACCATCAGGGGTGTAGAAGTCATCAACTTTAGACAAGGCGGAAGTTATGGAGTGGTCACAGGTACTACAGGTAATGAT
GTATTGACCGCATCAAATATGTGGTCATTCGTCTTCGGTGGTGGCGGTAACGACATTATTACTGGTGGGACTGGCAACGA
TACCTTGGATGGTAGTACTGGCAATGATACGTTGATTGGTGGCGCTGGCAATGATACGTTGATTGGTGGTGCTGGTGTTG
ATACTGCCGTTTATGCGGGAAATTATGCAGATTATGGTATCTCTTTCCTGAGCAATGGTGATTTGCAAGTCATTGACAAG
AACCTCACCAATGGAAATGACGGTACTGACATCCTCAAGGGTGTAGAAGTCATCAACTTTACACAAGGCGGAAGTTATGG
AGTGGTCACAGGTACTACTGGTAATAATGTATTGACCGCATCAAATATGTGGTCATTTGTCTTCGGTGGTAATGGTAACG
ACACTATTACTGGCGGCACTGGCAATGATACTTTAGTCGGAGGGCTTGGTGCTGATACCCTCACAGGTGGACTTGGGGCT
GATAAATTTGTCTTTAACTCTCTTTCTGAAGGAATTGATGTGATCAAAGACTTTTCTTGGCAACAAGGAGATAAGATTCA
AATTCTCGGCTCTAGTTTTGGTGCAACTTCCACTAGTCAGTTCAGCTTTGACCAGAATACAGGTGGTTTATTCTTTAACG
CCCAGCAATTTGCCACTCTTGAGAACAAACCTGCTGGTTTCTTGACAAATGCTGACATCCAAATTGTTTAG

Upstream 100 bases:

>100_bases
CAAAATTACAGGAGAAATAACAATGCCTACATATACTGGTGATAATAACAAAAATATTTTCACAGCACCTAATGACGGTC
TAGCCTGGACAATCTCCGGC

Downstream 100 bases:

>100_bases
AACTTTTTACCCGACTTGAGATCCCCTCTTTAGATCCCCGACTTCTTTGAGAATTCGGGGATCTATAAACAAAATGAAGA
ATTTGGTTTTTTAAGTGCCA

Product: hypothetical protein

Products: NA

Alternate protein names: AC-HLY; ACT; Cyclolysin; ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MGGDDILTGGSQNDTIEGGEGKDTINGGAGFDILKGGDGDDTLIDTEGNIDGGAGTDTLRADYSKYDNGAGVHVGYLGQA
QIFSRQTGTGILGYSNIEKFEITGTKYADILQGGVGNDVLKGGAGNDELSGGAGNDTLDGGTGFDILKGGDGDDTLIDTE
GNIDGGAGTDTLRADYSRYDNGAGVHVGYLGQAQIFSRLTGTGILGYSNIEKFEITGTNYADILQGGSGNDILKGGAGND
ELSGKGGNDTLDGGFGYDTVVYDGNYADYGISFLSNGDLQVIDKNLTNGNDGTDTIRGVEVINFRQGGSYGVVTGTTGND
VLTASNMWSFVFGGGGNDIITGGTGNDTLDGSTGNDTLIGGAGNDTLIGGAGVDTAVYAGNYADYGISFLSNGDLQVIDK
NLTNGNDGTDILKGVEVINFTQGGSYGVVTGTTGNNVLTASNMWSFVFGGNGNDTITGGTGNDTLVGGLGADTLTGGLGA
DKFVFNSLSEGIDVIKDFSWQQGDKIQILGSSFGATSTSQFSFDQNTGGLFFNAQQFATLENKPAGFLTNADIQIV

Sequences:

>Translated_556_residues
MGGDDILTGGSQNDTIEGGEGKDTINGGAGFDILKGGDGDDTLIDTEGNIDGGAGTDTLRADYSKYDNGAGVHVGYLGQA
QIFSRQTGTGILGYSNIEKFEITGTKYADILQGGVGNDVLKGGAGNDELSGGAGNDTLDGGTGFDILKGGDGDDTLIDTE
GNIDGGAGTDTLRADYSRYDNGAGVHVGYLGQAQIFSRLTGTGILGYSNIEKFEITGTNYADILQGGSGNDILKGGAGND
ELSGKGGNDTLDGGFGYDTVVYDGNYADYGISFLSNGDLQVIDKNLTNGNDGTDTIRGVEVINFRQGGSYGVVTGTTGND
VLTASNMWSFVFGGGGNDIITGGTGNDTLDGSTGNDTLIGGAGNDTLIGGAGVDTAVYAGNYADYGISFLSNGDLQVIDK
NLTNGNDGTDILKGVEVINFTQGGSYGVVTGTTGNNVLTASNMWSFVFGGNGNDTITGGTGNDTLVGGLGADTLTGGLGA
DKFVFNSLSEGIDVIKDFSWQQGDKIQILGSSFGATSTSQFSFDQNTGGLFFNAQQFATLENKPAGFLTNADIQIV
>Mature_555_residues
GGDDILTGGSQNDTIEGGEGKDTINGGAGFDILKGGDGDDTLIDTEGNIDGGAGTDTLRADYSKYDNGAGVHVGYLGQAQ
IFSRQTGTGILGYSNIEKFEITGTKYADILQGGVGNDVLKGGAGNDELSGGAGNDTLDGGTGFDILKGGDGDDTLIDTEG
NIDGGAGTDTLRADYSRYDNGAGVHVGYLGQAQIFSRLTGTGILGYSNIEKFEITGTNYADILQGGSGNDILKGGAGNDE
LSGKGGNDTLDGGFGYDTVVYDGNYADYGISFLSNGDLQVIDKNLTNGNDGTDTIRGVEVINFRQGGSYGVVTGTTGNDV
LTASNMWSFVFGGGGNDIITGGTGNDTLDGSTGNDTLIGGAGNDTLIGGAGVDTAVYAGNYADYGISFLSNGDLQVIDKN
LTNGNDGTDILKGVEVINFTQGGSYGVVTGTTGNNVLTASNMWSFVFGGNGNDTITGGTGNDTLVGGLGADTLTGGLGAD
KFVFNSLSEGIDVIKDFSWQQGDKIQILGSSFGATSTSQFSFDQNTGGLFFNAQQFATLENKPAGFLTNADIQIV

Specific function: This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 17 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005165
- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF03497 Anthrax_toxA; PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 56512; Mature: 56381

Theoretical pI: Translated: 3.68; Mature: 3.68

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGDDILTGGSQNDTIEGGEGKDTINGGAGFDILKGGDGDDTLIDTEGNIDGGAGTDTLR
CCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCHHH
ADYSKYDNGAGVHVGYLGQAQIFSRQTGTGILGYSNIEKFEITGTKYADILQGGVGNDVL
HHHHHCCCCCCEEEEECCCHHEEECCCCCEEEECCCCEEEEECCCHHHHHHCCCCCCHHH
KGGAGNDELSGGAGNDTLDGGTGFDILKGGDGDDTLIDTEGNIDGGAGTDTLRADYSRYD
CCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCHHHHHHHHCC
NGAGVHVGYLGQAQIFSRLTGTGILGYSNIEKFEITGTNYADILQGGSGNDILKGGAGND
CCCCEEEEECCHHHHHHHHCCCEEEECCCCEEEEECCCCHHHHHCCCCCCCEEECCCCCC
ELSGKGGNDTLDGGFGYDTVVYDGNYADYGISFLSNGDLQVIDKNLTNGNDGTDTIRGVE
CCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCEEEEEECCCCCCCCCCEEEEEE
VINFRQGGSYGVVTGTTGNDVLTASNMWSFVFGGGGNDIITGGTGNDTLDGSTGNDTLIG
EEEEECCCCEEEEECCCCCCEEEECCCEEEEEECCCCEEEECCCCCCCCCCCCCCCEEEE
GAGNDTLIGGAGVDTAVYAGNYADYGISFLSNGDLQVIDKNLTNGNDGTDILKGVEVINF
CCCCCCEEECCCCCCEEEECCCHHCCEEEECCCCEEEEECCCCCCCCCHHHHCCCEEEEE
TQGGSYGVVTGTTGNNVLTASNMWSFVFGGNGNDTITGGTGNDTLVGGLGADTLTGGLGA
ECCCCEEEEECCCCCCEEEECCCEEEEECCCCCCEEECCCCCCEEEECCCCHHHCCCCCC
DKFVFNSLSEGIDVIKDFSWQQGDKIQILGSSFGATSTSQFSFDQNTGGLFFNAQQFATL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCEEEEHHHHEEE
ENKPAGFLTNADIQIV
CCCCCCEEECCCEEEC
>Mature Secondary Structure 
GGDDILTGGSQNDTIEGGEGKDTINGGAGFDILKGGDGDDTLIDTEGNIDGGAGTDTLR
CCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCHHH
ADYSKYDNGAGVHVGYLGQAQIFSRQTGTGILGYSNIEKFEITGTKYADILQGGVGNDVL
HHHHHCCCCCCEEEEECCCHHEEECCCCCEEEECCCCEEEEECCCHHHHHHCCCCCCHHH
KGGAGNDELSGGAGNDTLDGGTGFDILKGGDGDDTLIDTEGNIDGGAGTDTLRADYSRYD
CCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCHHHHHHHHCC
NGAGVHVGYLGQAQIFSRLTGTGILGYSNIEKFEITGTNYADILQGGSGNDILKGGAGND
CCCCEEEEECCHHHHHHHHCCCEEEECCCCEEEEECCCCHHHHHCCCCCCCEEECCCCCC
ELSGKGGNDTLDGGFGYDTVVYDGNYADYGISFLSNGDLQVIDKNLTNGNDGTDTIRGVE
CCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCEEEEEECCCCCCCCCCEEEEEE
VINFRQGGSYGVVTGTTGNDVLTASNMWSFVFGGGGNDIITGGTGNDTLDGSTGNDTLIG
EEEEECCCCEEEEECCCCCCEEEECCCEEEEEECCCCEEEECCCCCCCCCCCCCCCEEEE
GAGNDTLIGGAGVDTAVYAGNYADYGISFLSNGDLQVIDKNLTNGNDGTDILKGVEVINF
CCCCCCEEECCCCCCEEEECCCHHCCEEEECCCCEEEEECCCCCCCCCHHHHCCCEEEEE
TQGGSYGVVTGTTGNNVLTASNMWSFVFGGNGNDTITGGTGNDTLVGGLGADTLTGGLGA
ECCCCEEEEECCCCCCEEEECCCEEEEECCCCCCEEECCCCCCEEEECCCCHHHCCCCCC
DKFVFNSLSEGIDVIKDFSWQQGDKIQILGSSFGATSTSQFSFDQNTGGLFFNAQQFATL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCEEEEHHHHEEE
ENKPAGFLTNADIQIV
CCCCCCEEECCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7557410; 12910271 [H]