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The map label for this gene is pyrH [H]

Identifier: 17228702

GI number: 17228702

Start: 1422293

End: 1423021

Strand: Direct

Name: pyrH [H]

Synonym: alr1207

Alternate gene names: 17228702

Gene position: 1422293-1423021 (Clockwise)

Preceding gene: 17228701

Following gene: 17228703

Centisome position: 22.18

GC content: 48.56

Gene sequence:

>729_bases
ATGGGAACGAATTACCGACGGGTTTTACTCAAACTGAGCGGTGAAGCCTTAATGGGCAACATGGGCTATGGGATTGATCC
AGAAGTGGTCAAGGAAATAGCTCAAGAAATAGCGGAGGTGATAGCCACTGGCGTTCAAATTGCCATCGTCGTTGGCGGTG
GGAATATTTTTCGTGGCGTGAAGGCAGCGTCGGCGGGGATGGACAGGGCAACCGCCGACTACATTGGGATGATTGCCACG
GTAATGAATGCCATGACTCTGCAAGATTCACTGGAACGCATAGGAGTACAAACGCGGGTACAAACTGCGATCGCTATGCA
GGAATTAGCCGAACCATATATTCGCCGTCGAGCCATCCGTCATCTAGAAAAGGGACGGGTGGTTATTTTTGGCGCTGGTT
CCGGTAATCCCTTTTTTACAACAGATACAACAGCAGCATTAAGAGCCGCAGAAATCGACGCAGAAGTAATTTTTAAAGCC
ACCAAGGTAGATGGGGTTTATGATGCAGACCCCGAAATCTATCCTAACGCCAAACGTTATAACAGTCTCACCTACGCCCA
TGTTCTCGCTCAGGACTTGCGGGTGATGGACAGTACGGCGATCGCCCTTTGTAAAGAAAATAATATCCCTATTCTTGTAT
TTGACCTAACAACGCGGGGTAATATTCGCCGCGCCGTTTTAGGAGAATCTATCGGTACCCTTGTGGGAGGTTCTTGTGAA
ATTAGCTGA

Upstream 100 bases:

>100_bases
GTAGGCACTTCATTGATCTGGCGTATATAGACATAGATAGTCATTGTACTGCTATCTTAAATTGGAGGCACTTGCAACTT
TTTTGATAAAGCGGAACTTC

Downstream 100 bases:

>100_bases
AGCTGAAAGTAAAATGCAACATACTGTTGAGGCGACTCAACGGGCATTTAATACAATTCGTACTGGCCGCGCCAATGCCA
GCTTGTTAGATAAGGTGTTA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MGTNYRRVLLKLSGEALMGNMGYGIDPEVVKEIAQEIAEVIATGVQIAIVVGGGNIFRGVKAASAGMDRATADYIGMIAT
VMNAMTLQDSLERIGVQTRVQTAIAMQELAEPYIRRRAIRHLEKGRVVIFGAGSGNPFFTTDTTAALRAAEIDAEVIFKA
TKVDGVYDADPEIYPNAKRYNSLTYAHVLAQDLRVMDSTAIALCKENNIPILVFDLTTRGNIRRAVLGESIGTLVGGSCE
IS

Sequences:

>Translated_242_residues
MGTNYRRVLLKLSGEALMGNMGYGIDPEVVKEIAQEIAEVIATGVQIAIVVGGGNIFRGVKAASAGMDRATADYIGMIAT
VMNAMTLQDSLERIGVQTRVQTAIAMQELAEPYIRRRAIRHLEKGRVVIFGAGSGNPFFTTDTTAALRAAEIDAEVIFKA
TKVDGVYDADPEIYPNAKRYNSLTYAHVLAQDLRVMDSTAIALCKENNIPILVFDLTTRGNIRRAVLGESIGTLVGGSCE
IS
>Mature_241_residues
GTNYRRVLLKLSGEALMGNMGYGIDPEVVKEIAQEIAEVIATGVQIAIVVGGGNIFRGVKAASAGMDRATADYIGMIATV
MNAMTLQDSLERIGVQTRVQTAIAMQELAEPYIRRRAIRHLEKGRVVIFGAGSGNPFFTTDTTAALRAAEIDAEVIFKAT
KVDGVYDADPEIYPNAKRYNSLTYAHVLAQDLRVMDSTAIALCKENNIPILVFDLTTRGNIRRAVLGESIGTLVGGSCEI
S

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=239, Percent_Identity=48.9539748953975, Blast_Score=243, Evalue=9e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 26042; Mature: 25911

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTNYRRVLLKLSGEALMGNMGYGIDPEVVKEIAQEIAEVIATGVQIAIVVGGGNIFRGV
CCCCHHEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHHH
KAASAGMDRATADYIGMIATVMNAMTLQDSLERIGVQTRVQTAIAMQELAEPYIRRRAIR
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
HLEKGRVVIFGAGSGNPFFTTDTTAALRAAEIDAEVIFKATKVDGVYDADPEIYPNAKRY
HHHCCCEEEEECCCCCCEEECCHHHHHHHHHCCHHHEEEEECCCCEECCCCCCCCCHHHH
NSLTYAHVLAQDLRVMDSTAIALCKENNIPILVFDLTTRGNIRRAVLGESIGTLVGGSCE
CCHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEE
IS
CC
>Mature Secondary Structure 
GTNYRRVLLKLSGEALMGNMGYGIDPEVVKEIAQEIAEVIATGVQIAIVVGGGNIFRGV
CCCHHEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHHH
KAASAGMDRATADYIGMIATVMNAMTLQDSLERIGVQTRVQTAIAMQELAEPYIRRRAIR
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
HLEKGRVVIFGAGSGNPFFTTDTTAALRAAEIDAEVIFKATKVDGVYDADPEIYPNAKRY
HHHCCCEEEEECCCCCCEEECCHHHHHHHHHCCHHHEEEEECCCCEECCCCCCCCCHHHH
NSLTYAHVLAQDLRVMDSTAIALCKENNIPILVFDLTTRGNIRRAVLGESIGTLVGGSCE
CCHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEE
IS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA