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The map label for this gene is pgi [H]

Identifier: 17228545

GI number: 17228545

Start: 1220346

End: 1221932

Strand: Direct

Name: pgi [H]

Synonym: alr1050

Alternate gene names: 17228545

Gene position: 1220346-1221932 (Clockwise)

Preceding gene: 17228544

Following gene: 17228547

Centisome position: 19.03

GC content: 45.94

Gene sequence:

>1587_bases
ATGGATGCGAAGGCACTTTGGCAACGATACCAAGAATGGTTATATTTCCACGAGGGATTAGGACTGTATCTAGATGTCAG
TCGGATGCGTTTTGATGATGCCTTCGTGAAGTCGTTGCTGCCGAAATTTGACAAAGCATTTGCGGATATGGCGGAATTAG
AAAAGGGTGCGATCGCCAATCCTGATGAGAACCGCATGGTGGGACACTATTGGCTGCGGAACCCAGACTTAGCGCCTACA
CCAGAAATTGCACAAGAAATTGTTCAAACCCTGGAACAAATTGAAGCTTTTGCGGAAAAAATCCAAACAGGTGCTATTCA
TCCTCCCAAAGCCAACCGCTTCACAGATATTATTTCCATTGGGATTGGTGGTTCGGCCCTGGGCCCCCAGTTTGTCGCTG
AAGCCCTCGCCCCTGAATTTCCCCCTCTGAAAATTCACTTTATCGACAATACCGACCCCGCCGGCATTGACAGGATTCTC
ACACACCTGCGGAATCATCTTGCCAGCACCTTGGTTTTGGTCATCTCCAAATCTGGAGGTACACCAGAACCTCGCAACGG
CATGATTGAAGTCAAAAAAGCCTACGCCGGACAAAATTTAGATTTTGCTCAGTATGCAGTAGCTATTACTAGTACTGGTA
GCAACCTAGACAAAGTAGCTCAATCTGAAGGCTGGCTAGCAACATTTCCCATGTATGATTGGGTGGGTGGACGTACCTCG
GAAATGTCCTCTGTAGGGCTAGTTCCTGCGGCATTACAGGGCATTGATGTCCGTGCCATGCTAGAAGGTGCAAAAGAAAT
GGATGACGCTACTCGCGTCCCAGAAGTGAAAAATAACCCTGCGGCTTTACTGGCTTTGTCTTGGTACTACTCTGGTAACG
GCAAGGGTGAAAAAGACATGGTTGTTTTACCCTATAAGGACAGCTTGCTGTTATTTAGCCGTTATTTGCAACAGCTAGTC
ATGGAATCTTTGGGTAAAGAAAAAGATTTAGACGGTAATACTGTTTATCAGGGTATCGCCGTTTATGGTAACAAAGGCTC
AACAGACCAACACGCTTACGTCCAGCAGTTACGCGAAGGCGTACCAAATTTCTTTGCTACCTTAATCGAAGTTTTGGAAG
ACCGTCATGGCGCATCTCCAGAAATAGACCCCGGTGTCACATCTGGTGATTATCTGTCTGGTTTTCTGCTAGGAACCCGC
CAAGCTTTGTATGAAAATCAGCGCGATTCCATTACAGTGACGATTCCCCAAGTTAACGCCCGTACTGTTGGGGCCTTAGT
TGCTTTGTATGAGCGTACTGTTGGTTTATATGCGAGTTTGGTCAACATTAACGCTTACCATCAACCAGGTGTAGAAGCTG
GTAAAAAAGCTGCTGCTGTCATTCTGGATCTACAAACAAAAGTAGTAGGATTACTCCAAAAGGAAAAAACCGCCCTTTCT
TTAGAGCAAATTGCTGAGAAAATAGGTGCAGCCGACCAAGTTGAAGCAATTTACAAGATTTTACGCCACCTTCAAGCAAA
TCAACGCGGTGTTGTATTCCAGGGAAATTTGGGACAACCAAGCAGCTTGAAAATTTCCCTTAGCTGA

Upstream 100 bases:

>100_bases
AAGAAATTTTCAACACTTAAAACTGTATAAGACTAAGCAGGGATGGCTCTAACCTTACATTACACTTGTTTTTGAAGGAC
ACTTTACTAGAGATTTCCCT

Downstream 100 bases:

>100_bases
TAATTCTTACTGAAATTCTCAACCCTTTCGGGTTGGGGATTTGGTACAGCTAATGCGCGCCTAAATTGCATAATTATTAA
TAAAGGCTGTTAACTGTTGA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MDAKALWQRYQEWLYFHEGLGLYLDVSRMRFDDAFVKSLLPKFDKAFADMAELEKGAIANPDENRMVGHYWLRNPDLAPT
PEIAQEIVQTLEQIEAFAEKIQTGAIHPPKANRFTDIISIGIGGSALGPQFVAEALAPEFPPLKIHFIDNTDPAGIDRIL
THLRNHLASTLVLVISKSGGTPEPRNGMIEVKKAYAGQNLDFAQYAVAITSTGSNLDKVAQSEGWLATFPMYDWVGGRTS
EMSSVGLVPAALQGIDVRAMLEGAKEMDDATRVPEVKNNPAALLALSWYYSGNGKGEKDMVVLPYKDSLLLFSRYLQQLV
MESLGKEKDLDGNTVYQGIAVYGNKGSTDQHAYVQQLREGVPNFFATLIEVLEDRHGASPEIDPGVTSGDYLSGFLLGTR
QALYENQRDSITVTIPQVNARTVGALVALYERTVGLYASLVNINAYHQPGVEAGKKAAAVILDLQTKVVGLLQKEKTALS
LEQIAEKIGAADQVEAIYKILRHLQANQRGVVFQGNLGQPSSLKISLS

Sequences:

>Translated_528_residues
MDAKALWQRYQEWLYFHEGLGLYLDVSRMRFDDAFVKSLLPKFDKAFADMAELEKGAIANPDENRMVGHYWLRNPDLAPT
PEIAQEIVQTLEQIEAFAEKIQTGAIHPPKANRFTDIISIGIGGSALGPQFVAEALAPEFPPLKIHFIDNTDPAGIDRIL
THLRNHLASTLVLVISKSGGTPEPRNGMIEVKKAYAGQNLDFAQYAVAITSTGSNLDKVAQSEGWLATFPMYDWVGGRTS
EMSSVGLVPAALQGIDVRAMLEGAKEMDDATRVPEVKNNPAALLALSWYYSGNGKGEKDMVVLPYKDSLLLFSRYLQQLV
MESLGKEKDLDGNTVYQGIAVYGNKGSTDQHAYVQQLREGVPNFFATLIEVLEDRHGASPEIDPGVTSGDYLSGFLLGTR
QALYENQRDSITVTIPQVNARTVGALVALYERTVGLYASLVNINAYHQPGVEAGKKAAAVILDLQTKVVGLLQKEKTALS
LEQIAEKIGAADQVEAIYKILRHLQANQRGVVFQGNLGQPSSLKISLS
>Mature_528_residues
MDAKALWQRYQEWLYFHEGLGLYLDVSRMRFDDAFVKSLLPKFDKAFADMAELEKGAIANPDENRMVGHYWLRNPDLAPT
PEIAQEIVQTLEQIEAFAEKIQTGAIHPPKANRFTDIISIGIGGSALGPQFVAEALAPEFPPLKIHFIDNTDPAGIDRIL
THLRNHLASTLVLVISKSGGTPEPRNGMIEVKKAYAGQNLDFAQYAVAITSTGSNLDKVAQSEGWLATFPMYDWVGGRTS
EMSSVGLVPAALQGIDVRAMLEGAKEMDDATRVPEVKNNPAALLALSWYYSGNGKGEKDMVVLPYKDSLLLFSRYLQQLV
MESLGKEKDLDGNTVYQGIAVYGNKGSTDQHAYVQQLREGVPNFFATLIEVLEDRHGASPEIDPGVTSGDYLSGFLLGTR
QALYENQRDSITVTIPQVNARTVGALVALYERTVGLYASLVNINAYHQPGVEAGKKAAAVILDLQTKVVGLLQKEKTALS
LEQIAEKIGAADQVEAIYKILRHLQANQRGVVFQGNLGQPSSLKISLS

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=477, Percent_Identity=28.0922431865828, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI296080693, Length=477, Percent_Identity=25.7861635220126, Blast_Score=111, Evalue=2e-24,
Organism=Escherichia coli, GI1790457, Length=486, Percent_Identity=30.6584362139918, Blast_Score=165, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI71996708, Length=442, Percent_Identity=28.5067873303167, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71996703, Length=442, Percent_Identity=28.5067873303167, Blast_Score=141, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6319673, Length=480, Percent_Identity=27.2916666666667, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24651916, Length=481, Percent_Identity=28.8981288981289, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24651914, Length=481, Percent_Identity=28.8981288981289, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI17737445, Length=481, Percent_Identity=28.8981288981289, Blast_Score=152, Evalue=7e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 57820; Mature: 57820

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAKALWQRYQEWLYFHEGLGLYLDVSRMRFDDAFVKSLLPKFDKAFADMAELEKGAIAN
CCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PDENRMVGHYWLRNPDLAPTPEIAQEIVQTLEQIEAFAEKIQTGAIHPPKANRFTDIISI
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEE
GIGGSALGPQFVAEALAPEFPPLKIHFIDNTDPAGIDRILTHLRNHLASTLVLVISKSGG
CCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHEEEEEECCCC
TPEPRNGMIEVKKAYAGQNLDFAQYAVAITSTGSNLDKVAQSEGWLATFPMYDWVGGRTS
CCCCCCCCEEEHHHHCCCCCCHHHEEEEEECCCCCHHHHHHCCCCEEECCCHHCCCCCCC
EMSSVGLVPAALQGIDVRAMLEGAKEMDDATRVPEVKNNPAALLALSWYYSGNGKGEKDM
CHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCE
VVLPYKDSLLLFSRYLQQLVMESLGKEKDLDGNTVYQGIAVYGNKGSTDQHAYVQQLREG
EEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHC
VPNFFATLIEVLEDRHGASPEIDPGVTSGDYLSGFLLGTRQALYENQRDSITVTIPQVNA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCH
RTVGALVALYERTVGLYASLVNINAYHQPGVEAGKKAAAVILDLQTKVVGLLQKEKTALS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHEEEEEEHHHHHHHHHHHHHHHHH
LEQIAEKIGAADQVEAIYKILRHLQANQRGVVFQGNLGQPSSLKISLS
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEEC
>Mature Secondary Structure
MDAKALWQRYQEWLYFHEGLGLYLDVSRMRFDDAFVKSLLPKFDKAFADMAELEKGAIAN
CCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PDENRMVGHYWLRNPDLAPTPEIAQEIVQTLEQIEAFAEKIQTGAIHPPKANRFTDIISI
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEE
GIGGSALGPQFVAEALAPEFPPLKIHFIDNTDPAGIDRILTHLRNHLASTLVLVISKSGG
CCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHEEEEEECCCC
TPEPRNGMIEVKKAYAGQNLDFAQYAVAITSTGSNLDKVAQSEGWLATFPMYDWVGGRTS
CCCCCCCCEEEHHHHCCCCCCHHHEEEEEECCCCCHHHHHHCCCCEEECCCHHCCCCCCC
EMSSVGLVPAALQGIDVRAMLEGAKEMDDATRVPEVKNNPAALLALSWYYSGNGKGEKDM
CHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCE
VVLPYKDSLLLFSRYLQQLVMESLGKEKDLDGNTVYQGIAVYGNKGSTDQHAYVQQLREG
EEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHC
VPNFFATLIEVLEDRHGASPEIDPGVTSGDYLSGFLLGTRQALYENQRDSITVTIPQVNA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCH
RTVGALVALYERTVGLYASLVNINAYHQPGVEAGKKAAAVILDLQTKVVGLLQKEKTALS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHEEEEEEHHHHHHHHHHHHHHHHH
LEQIAEKIGAADQVEAIYKILRHLQANQRGVVFQGNLGQPSSLKISLS
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA