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The map label for this gene is apr [H]

Identifier: 17228491

GI number: 17228491

Start: 1166972

End: 1168438

Strand: Direct

Name: apr [H]

Synonym: alr0996

Alternate gene names: 17228491

Gene position: 1166972-1168438 (Clockwise)

Preceding gene: 17228487

Following gene: 17228493

Centisome position: 18.19

GC content: 41.92

Gene sequence:

>1467_bases
ATGCCCACAAATCAGACTGATCAAAATCCCCTTTCAATTGACAGGCAAAATTCCGCTTATATCTCCTCATCAGATATTTT
TAATACAGACAATAATTATACTTCTCAGCTAGGTTTTCGTAGTAGCTACACTTCAGATATAAATAATCATGCTACTGCTA
CCAGCACTTACAACTCAACTAATGGTTATGGTTTAGTCAATGCAGGCGCAGCCGTACCTCAAGCTGCTGGACAAAATCCT
TATAGTGATGTTGCTAACCTTGGCGGGAATAATTGGGGCTTAGATATGATTAATGCTCCAGAAGTATGGGCAAATGGACA
TACAGGCCAAGGCATAATTGTGGCGGTGATAGATACGGGCGTAGACACTAACCATGAGGATTTACGTAATAATATCTGGA
CTAATAGCAAAGAAATTGCTGGTAATGGCATAGATGACGATGGTAATGGCTATGTCGATGATGTCCACGGCTGGAATTTT
AACGACAACAATAACAACACCCTTGATAATAATGGTCATGGAACCCATGTTTCCGGGATTATTGCTGGGGGGAATAATGG
CTTTGGTGTGACTGGTGTTGCTTACAATTCCCAGATTATGGCTGTGAAGGTGCTGGATGAATCTGGTTCTGGTTCTTATA
GTGCGATCGCCAACGGAATTTACTATGCTGTAGATAATGGGGCAAAAGTCATCAACCTCAGTCTGGGTGGTGATTCGTCC
AGTCGTACACTCAAGTCTGCAATTGAATATGCTAGCAGTAAAGGGGCGATCGTGGTCATGGCCGCAGGTAATGATGGTGA
ATCTGCGCCAGACTACCCCGCTCGTTACGCCAATCAAACAGGAATCGCTGTTGGTGCGGTAGATGCTAATAAAAATTTAA
CTGATTTCTCCAACCGTTCTGGCAATACGACTATGGCTTATGTCACCGCCCCAGGACAAAGCGTTTATTCTTCAGTACCA
AATAATCAGTATGCCAATTATAGTGGTACATCAATGGCAACTCCTTACGTTGCTGGTGTAGTCGCCCTCATGCTCAGTGC
TAACCCCAATTTAACTGAAGCCCAGGTGCGAGATATTATTACCAGCACCGCAGGAAACACCAGCAACGACACTACACCCA
AAACAGACTCTGATTTTAACTTTGACTTTGGTTCTGTTGTAGATGACTTATTTGGTGGTTTAAGTCTAAATACCACATCA
ATTAGTGCTTCTAGTCTCAACTCCCAATCTTTGCAAAAGAGCAATATTTTCACCACAAGTTCAAATACTGCATCTGTATT
ATCTAATAATCAAACATCCACCGCTTACCAAATGGAGTTTACCCACAAATATTATCAAGACTCTCTACCCAACAGCCTAG
CCAACAGCCCAACAGATATTGACACTGGTAATAATATTGATTTTACAGAGTTCATGAATATCATCGTTACACGACTGAGA
GAGTACCAAAAATTGTTGGGTGCATAA

Upstream 100 bases:

>100_bases
AAAGTGTATTGCATACAAACAAGAAGCGTAAATATTGCTTGGAAGGGTTTAAGAATTAAAACCGCAAAAAACACTTAAGT
TAGTTGAGGAGCAAATACCT

Downstream 100 bases:

>100_bases
GAGAATGTAATATTGCAAAGTCATTAGTCTACAGCCCAAATCCCAATTTATACAACCAGTTAACGAGCTAATGACTAATG
ACTTATATGCAGACGTTGTA

Product: protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MPTNQTDQNPLSIDRQNSAYISSSDIFNTDNNYTSQLGFRSSYTSDINNHATATSTYNSTNGYGLVNAGAAVPQAAGQNP
YSDVANLGGNNWGLDMINAPEVWANGHTGQGIIVAVIDTGVDTNHEDLRNNIWTNSKEIAGNGIDDDGNGYVDDVHGWNF
NDNNNNTLDNNGHGTHVSGIIAGGNNGFGVTGVAYNSQIMAVKVLDESGSGSYSAIANGIYYAVDNGAKVINLSLGGDSS
SRTLKSAIEYASSKGAIVVMAAGNDGESAPDYPARYANQTGIAVGAVDANKNLTDFSNRSGNTTMAYVTAPGQSVYSSVP
NNQYANYSGTSMATPYVAGVVALMLSANPNLTEAQVRDIITSTAGNTSNDTTPKTDSDFNFDFGSVVDDLFGGLSLNTTS
ISASSLNSQSLQKSNIFTTSSNTASVLSNNQTSTAYQMEFTHKYYQDSLPNSLANSPTDIDTGNNIDFTEFMNIIVTRLR
EYQKLLGA

Sequences:

>Translated_488_residues
MPTNQTDQNPLSIDRQNSAYISSSDIFNTDNNYTSQLGFRSSYTSDINNHATATSTYNSTNGYGLVNAGAAVPQAAGQNP
YSDVANLGGNNWGLDMINAPEVWANGHTGQGIIVAVIDTGVDTNHEDLRNNIWTNSKEIAGNGIDDDGNGYVDDVHGWNF
NDNNNNTLDNNGHGTHVSGIIAGGNNGFGVTGVAYNSQIMAVKVLDESGSGSYSAIANGIYYAVDNGAKVINLSLGGDSS
SRTLKSAIEYASSKGAIVVMAAGNDGESAPDYPARYANQTGIAVGAVDANKNLTDFSNRSGNTTMAYVTAPGQSVYSSVP
NNQYANYSGTSMATPYVAGVVALMLSANPNLTEAQVRDIITSTAGNTSNDTTPKTDSDFNFDFGSVVDDLFGGLSLNTTS
ISASSLNSQSLQKSNIFTTSSNTASVLSNNQTSTAYQMEFTHKYYQDSLPNSLANSPTDIDTGNNIDFTEFMNIIVTRLR
EYQKLLGA
>Mature_487_residues
PTNQTDQNPLSIDRQNSAYISSSDIFNTDNNYTSQLGFRSSYTSDINNHATATSTYNSTNGYGLVNAGAAVPQAAGQNPY
SDVANLGGNNWGLDMINAPEVWANGHTGQGIIVAVIDTGVDTNHEDLRNNIWTNSKEIAGNGIDDDGNGYVDDVHGWNFN
DNNNNTLDNNGHGTHVSGIIAGGNNGFGVTGVAYNSQIMAVKVLDESGSGSYSAIANGIYYAVDNGAKVINLSLGGDSSS
RTLKSAIEYASSKGAIVVMAAGNDGESAPDYPARYANQTGIAVGAVDANKNLTDFSNRSGNTTMAYVTAPGQSVYSSVPN
NQYANYSGTSMATPYVAGVVALMLSANPNLTEAQVRDIITSTAGNTSNDTTPKTDSDFNFDFGSVVDDLFGGLSLNTTSI
SASSLNSQSLQKSNIFTTSSNTASVLSNNQTSTAYQMEFTHKYYQDSLPNSLANSPTDIDTGNNIDFTEFMNIIVTRLRE
YQKLLGA

Specific function: Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI299523015, Length=301, Percent_Identity=27.2425249169435, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI295424143, Length=307, Percent_Identity=27.3615635179153, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI20336242, Length=307, Percent_Identity=27.3615635179153, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI20336180, Length=290, Percent_Identity=27.9310344827586, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4505577, Length=290, Percent_Identity=27.9310344827586, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI20336190, Length=290, Percent_Identity=27.9310344827586, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI27894285, Length=290, Percent_Identity=27.9310344827586, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI20336188, Length=290, Percent_Identity=27.9310344827586, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI20336186, Length=290, Percent_Identity=27.9310344827586, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI20336184, Length=290, Percent_Identity=27.9310344827586, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI20336182, Length=290, Percent_Identity=27.9310344827586, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI4505579, Length=289, Percent_Identity=26.643598615917, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI20336248, Length=219, Percent_Identity=30.1369863013699, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI31317307, Length=293, Percent_Identity=26.962457337884, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI20336246, Length=369, Percent_Identity=24.9322493224932, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4506775, Length=281, Percent_Identity=28.1138790035587, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI76443679, Length=293, Percent_Identity=27.3037542662116, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71983555, Length=291, Percent_Identity=29.2096219931272, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI25141268, Length=291, Percent_Identity=29.2096219931272, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71988308, Length=327, Percent_Identity=26.9113149847095, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71988301, Length=327, Percent_Identity=26.9113149847095, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988315, Length=327, Percent_Identity=26.9113149847095, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988312, Length=327, Percent_Identity=26.9113149847095, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988321, Length=327, Percent_Identity=26.9113149847095, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988297, Length=327, Percent_Identity=26.9113149847095, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71987206, Length=292, Percent_Identity=26.7123287671233, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324091, Length=296, Percent_Identity=33.7837837837838, Blast_Score=106, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6320775, Length=282, Percent_Identity=31.9148936170213, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324576, Length=283, Percent_Identity=33.2155477031802, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319893, Length=270, Percent_Identity=29.6296296296296, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24650058, Length=297, Percent_Identity=26.9360269360269, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24650060, Length=297, Percent_Identity=26.9360269360269, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45553513, Length=297, Percent_Identity=26.9360269360269, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24650056, Length=297, Percent_Identity=26.9360269360269, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45553515, Length=297, Percent_Identity=26.9360269360269, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17864552, Length=297, Percent_Identity=26.9360269360269, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45550681, Length=267, Percent_Identity=27.7153558052434, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24642488, Length=364, Percent_Identity=26.9230769230769, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24642484, Length=364, Percent_Identity=26.9230769230769, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24642486, Length=364, Percent_Identity=26.9230769230769, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281360987, Length=313, Percent_Identity=28.7539936102236, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24642494, Length=313, Percent_Identity=28.7539936102236, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24642490, Length=313, Percent_Identity=28.7539936102236, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45555723, Length=313, Percent_Identity=28.7539936102236, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24642492, Length=313, Percent_Identity=28.7539936102236, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: =3.4.21.62 [H]

Molecular weight: Translated: 51461; Mature: 51330

Theoretical pI: Translated: 4.09; Mature: 4.09

Prosite motif: PS00018 EF_HAND_1 ; PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTNQTDQNPLSIDRQNSAYISSSDIFNTDNNYTSQLGFRSSYTSDINNHATATSTYNST
CCCCCCCCCCCEEECCCCEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEECCCCC
NGYGLVNAGAAVPQAAGQNPYSDVANLGGNNWGLDMINAPEVWANGHTGQGIIVAVIDTG
CCCEEEECCCCCCHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECC
VDTNHEDLRNNIWTNSKEIAGNGIDDDGNGYVDDVHGWNFNDNNNNTLDNNGHGTHVSGI
CCCCHHHHHHHHCCCCHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEE
IAGGNNGFGVTGVAYNSQIMAVKVLDESGSGSYSAIANGIYYAVDNGAKVINLSLGGDSS
EECCCCCCEEEEEEECCEEEEEEEEECCCCCCHHHHHCCEEEEEECCCEEEEEEECCCCC
SRTLKSAIEYASSKGAIVVMAAGNDGESAPDYPARYANQTGIAVGAVDANKNLTDFSNRS
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCCCCCC
GNTTMAYVTAPGQSVYSSVPNNQYANYSGTSMATPYVAGVVALMLSANPNLTEAQVRDII
CCEEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHH
TSTAGNTSNDTTPKTDSDFNFDFGSVVDDLFGGLSLNTTSISASSLNSQSLQKSNIFTTS
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCHHHHHHCCCEEEC
SNTASVLSNNQTSTAYQMEFTHKYYQDSLPNSLANSPTDIDTGNNIDFTEFMNIIVTRLR
CCCHHHHCCCCCCEEEEEEHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
EYQKLLGA
HHHHHHCC
>Mature Secondary Structure 
PTNQTDQNPLSIDRQNSAYISSSDIFNTDNNYTSQLGFRSSYTSDINNHATATSTYNST
CCCCCCCCCCEEECCCCEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEECCCCC
NGYGLVNAGAAVPQAAGQNPYSDVANLGGNNWGLDMINAPEVWANGHTGQGIIVAVIDTG
CCCEEEECCCCCCHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECC
VDTNHEDLRNNIWTNSKEIAGNGIDDDGNGYVDDVHGWNFNDNNNNTLDNNGHGTHVSGI
CCCCHHHHHHHHCCCCHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEE
IAGGNNGFGVTGVAYNSQIMAVKVLDESGSGSYSAIANGIYYAVDNGAKVINLSLGGDSS
EECCCCCCEEEEEEECCEEEEEEEEECCCCCCHHHHHCCEEEEEECCCEEEEEEECCCCC
SRTLKSAIEYASSKGAIVVMAAGNDGESAPDYPARYANQTGIAVGAVDANKNLTDFSNRS
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCCCCCC
GNTTMAYVTAPGQSVYSSVPNNQYANYSGTSMATPYVAGVVALMLSANPNLTEAQVRDII
CCEEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHH
TSTAGNTSNDTTPKTDSDFNFDFGSVVDDLFGGLSLNTTSISASSLNSQSLQKSNIFTTS
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCHHHHHHCCCEEEC
SNTASVLSNNQTSTAYQMEFTHKYYQDSLPNSLANSPTDIDTGNNIDFTEFMNIIVTRLR
CCCHHHHCCCCCCEEEEEEHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
EYQKLLGA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6420308; 9826175 [H]