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The map label for this gene is fdh [H]

Identifier: 17228390

GI number: 17228390

Start: 1033466

End: 1034635

Strand: Direct

Name: fdh [H]

Synonym: alr0895

Alternate gene names: 17228390

Gene position: 1033466-1034635 (Clockwise)

Preceding gene: 17228389

Following gene: 17228391

Centisome position: 16.11

GC content: 44.96

Gene sequence:

>1170_bases
ATGAAAGCAGTCTGCTGGTATGGTGCTAACGAGGTACGGGTAGAGACTGTACCAGACCCGAAAATCCTCAATCCGCGTGA
TGCGATTATTAAAATTACTTCCACCGCAATTTGTGGTTCTGATTTACATATTTATGGCGGCTATATCCCGACAGTGCAGC
AGGGTGACATTATTGGTCACGAGTTTATGGGGGAAGTCGTTGAGGTGGGGAGCAGAGTTGATAATTTAAAAATAGGCGAT
CGCGTTGTTGTTCCTTCTACAATTGGTTGTGGTAGATGCCACTATTGTGAGCATGATATGTGGTCGCTGTGCGATAACTC
TAATCCCAATGGTTGGTTAGAAGAAAAACTCTACGGTAATATCACCTCAGCCATTTACGGTTATTCTCATCTCTTGGGTG
GTTACGCCGGCGCACAAGCTGAATATATCCGCGTCCCCTTCGCCGATGTCGGTGTGGTAAAAGTCCCGCCAGATTTACCA
GACGAAATGCTGTTATTTATCTCTGATGCTATCCCCACAGGTTATATGGGTGCAGAGATGTGTGACATTCAACCAGGTGA
TACTGTCGCTGTTTGGGGTTGCGGTGCTGTTGGTCAATTTGCCATGATTAGCGCCTATATGATGGGTGCAGAAAAAGTCA
TCGCTATAGATCGCTTTCCCGAACGTCTAGAGATGGCGAAAAAATATGCTAAAGCCGAAGTCATCAATTACGAAGAAGTC
AATGCAGGTGAGGCTTTAAAAGAAATGACCGGCGGACGAGGCCCTGATGCTTGTATTGATGCGGTCGGGTTAGAAGCGCA
TGGCGTTGGTTTAGAAGACTTTTACGACCAAACAAAGCAAAAGCTGAAGCTAGAAAGCGATCGCCCCCATGTATTGCGGG
AAATGATGGTTGCTTGTCGTAAAGGCGGGACTCTCTCAATCATGGGTGTCTACGGTGGGTTTGTAGACAAAATACCTTTT
GGTGCTGCTTTTAATAAGGGTCTAACCTTCAGGATGGGACAAATGCACGGACAGAAATATATGAATTTGTTATTACAACT
CATCCTAGATGGCAAACTCGACCCGTCTTTTGTAGTTAGTCATCAATTACCTCTAGAACAAGCCCCTCTCGGTTATCACA
TTTTCCAGCAAAAAAAAGATAACTGCATCAAAGTTGTACTCAAACCGTAA

Upstream 100 bases:

>100_bases
GACAACCATCGGGAAGAAAATAGGGAGTGGAAGGATAACAACAACTGTTGACTGACGACTTTTAACAGTCAACTGACAAC
AGACAACTAACTAAATAACT

Downstream 100 bases:

>100_bases
AAGTGGGGATAAGAAGAATGATTAATTATGACTTACGGATGAAAAGAAAAAATCAAGGGTTTGGACAACTTTGAAAATTC
TTACACCCTTACACCCAGTC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKAVCWYGANEVRVETVPDPKILNPRDAIIKITSTAICGSDLHIYGGYIPTVQQGDIIGHEFMGEVVEVGSRVDNLKIGD
RVVVPSTIGCGRCHYCEHDMWSLCDNSNPNGWLEEKLYGNITSAIYGYSHLLGGYAGAQAEYIRVPFADVGVVKVPPDLP
DEMLLFISDAIPTGYMGAEMCDIQPGDTVAVWGCGAVGQFAMISAYMMGAEKVIAIDRFPERLEMAKKYAKAEVINYEEV
NAGEALKEMTGGRGPDACIDAVGLEAHGVGLEDFYDQTKQKLKLESDRPHVLREMMVACRKGGTLSIMGVYGGFVDKIPF
GAAFNKGLTFRMGQMHGQKYMNLLLQLILDGKLDPSFVVSHQLPLEQAPLGYHIFQQKKDNCIKVVLKP

Sequences:

>Translated_389_residues
MKAVCWYGANEVRVETVPDPKILNPRDAIIKITSTAICGSDLHIYGGYIPTVQQGDIIGHEFMGEVVEVGSRVDNLKIGD
RVVVPSTIGCGRCHYCEHDMWSLCDNSNPNGWLEEKLYGNITSAIYGYSHLLGGYAGAQAEYIRVPFADVGVVKVPPDLP
DEMLLFISDAIPTGYMGAEMCDIQPGDTVAVWGCGAVGQFAMISAYMMGAEKVIAIDRFPERLEMAKKYAKAEVINYEEV
NAGEALKEMTGGRGPDACIDAVGLEAHGVGLEDFYDQTKQKLKLESDRPHVLREMMVACRKGGTLSIMGVYGGFVDKIPF
GAAFNKGLTFRMGQMHGQKYMNLLLQLILDGKLDPSFVVSHQLPLEQAPLGYHIFQQKKDNCIKVVLKP
>Mature_389_residues
MKAVCWYGANEVRVETVPDPKILNPRDAIIKITSTAICGSDLHIYGGYIPTVQQGDIIGHEFMGEVVEVGSRVDNLKIGD
RVVVPSTIGCGRCHYCEHDMWSLCDNSNPNGWLEEKLYGNITSAIYGYSHLLGGYAGAQAEYIRVPFADVGVVKVPPDLP
DEMLLFISDAIPTGYMGAEMCDIQPGDTVAVWGCGAVGQFAMISAYMMGAEKVIAIDRFPERLEMAKKYAKAEVINYEEV
NAGEALKEMTGGRGPDACIDAVGLEAHGVGLEDFYDQTKQKLKLESDRPHVLREMMVACRKGGTLSIMGVYGGFVDKIPF
GAAFNKGLTFRMGQMHGQKYMNLLLQLILDGKLDPSFVVSHQLPLEQAPLGYHIFQQKKDNCIKVVLKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=397, Percent_Identity=26.9521410579345, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI34577061, Length=397, Percent_Identity=26.9521410579345, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI71565154, Length=399, Percent_Identity=26.3157894736842, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI4501933, Length=269, Percent_Identity=30.8550185873606, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI156523966, Length=384, Percent_Identity=24.4791666666667, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI4501939, Length=364, Percent_Identity=24.7252747252747, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI71565152, Length=393, Percent_Identity=23.4096692111959, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI71743840, Length=255, Percent_Identity=28.6274509803922, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI262073058, Length=255, Percent_Identity=28.6274509803922, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=45.9183673469388, Blast_Score=347, Evalue=9e-97,
Organism=Escherichia coli, GI1790045, Length=396, Percent_Identity=27.5252525252525, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787863, Length=392, Percent_Identity=25, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87082125, Length=403, Percent_Identity=28.5359801488834, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788073, Length=376, Percent_Identity=23.936170212766, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI226510992, Length=343, Percent_Identity=23.9067055393586, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788407, Length=246, Percent_Identity=30.4878048780488, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786552, Length=372, Percent_Identity=25, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87081918, Length=253, Percent_Identity=31.6205533596838, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788075, Length=243, Percent_Identity=28.3950617283951, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790718, Length=219, Percent_Identity=24.6575342465753, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=388, Percent_Identity=27.0618556701031, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71997431, Length=388, Percent_Identity=26.8041237113402, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=389, Percent_Identity=24.9357326478149, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17565904, Length=221, Percent_Identity=31.2217194570136, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=271, Percent_Identity=27.3062730627306, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=215, Percent_Identity=29.7674418604651, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320033, Length=410, Percent_Identity=28.2926829268293, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=286, Percent_Identity=28.3216783216783, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=250, Percent_Identity=26.4, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=311, Percent_Identity=25.4019292604502, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=92, Percent_Identity=40.2173913043478, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17737895, Length=401, Percent_Identity=26.4339152119701, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137530, Length=274, Percent_Identity=25.5474452554745, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17737897, Length=271, Percent_Identity=25.830258302583, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42653; Mature: 42653

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVCWYGANEVRVETVPDPKILNPRDAIIKITSTAICGSDLHIYGGYIPTVQQGDIIGH
CCEEEEECCCEEEEEECCCCCCCCCCCCEEEEEEHEEECCCEEEECCCCCCCCCCCCCCH
EFMGEVVEVGSRVDNLKIGDRVVVPSTIGCGRCHYCEHDMWSLCDNSNPNGWLEEKLYGN
HHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHCC
ITSAIYGYSHLLGGYAGAQAEYIRVPFADVGVVKVPPDLPDEMLLFISDAIPTGYMGAEM
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCEE
CDIQPGDTVAVWGCGAVGQFAMISAYMMGAEKVIAIDRFPERLEMAKKYAKAEVINYEEV
ECCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHC
NAGEALKEMTGGRGPDACIDAVGLEAHGVGLEDFYDQTKQKLKLESDRPHVLREMMVACR
CHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHC
KGGTLSIMGVYGGFVDKIPFGAAFNKGLTFRMGQMHGQKYMNLLLQLILDGKLDPSFVVS
CCCCEEEEEECCCHHHHCCCCCHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
HQLPLEQAPLGYHIFQQKKDNCIKVVLKP
ECCCCCCCCCCHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MKAVCWYGANEVRVETVPDPKILNPRDAIIKITSTAICGSDLHIYGGYIPTVQQGDIIGH
CCEEEEECCCEEEEEECCCCCCCCCCCCEEEEEEHEEECCCEEEECCCCCCCCCCCCCCH
EFMGEVVEVGSRVDNLKIGDRVVVPSTIGCGRCHYCEHDMWSLCDNSNPNGWLEEKLYGN
HHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHCC
ITSAIYGYSHLLGGYAGAQAEYIRVPFADVGVVKVPPDLPDEMLLFISDAIPTGYMGAEM
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCEE
CDIQPGDTVAVWGCGAVGQFAMISAYMMGAEKVIAIDRFPERLEMAKKYAKAEVINYEEV
ECCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHC
NAGEALKEMTGGRGPDACIDAVGLEAHGVGLEDFYDQTKQKLKLESDRPHVLREMMVACR
CHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHC
KGGTLSIMGVYGGFVDKIPFGAAFNKGLTFRMGQMHGQKYMNLLLQLILDGKLDPSFVVS
CCCCEEEEEECCCHHHHCCCCCHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
HQLPLEQAPLGYHIFQQKKDNCIKVVLKP
ECCCCCCCCCCHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]