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The map label for this gene is fadE [H]

Identifier: 172087736

GI number: 172087736

Start: 2160834

End: 2163281

Strand: Direct

Name: fadE [H]

Synonym: VF_1932

Alternate gene names: 172087736

Gene position: 2160834-2163281 (Clockwise)

Preceding gene: 59712536

Following gene: 59712543

Centisome position: 74.57

GC content: 41.09

Gene sequence:

>2448_bases
ATGGCCCTGACACTATTAGCAACAGTAATTGCACTTGCTGCATTAAGCTATCATCGACAATCTTTGAAAACCTCAACCTT
GGTTATTGCAGGTATTCTTGCCATTAGCTCTGGGTTAGGTTACGCTGGTTTTATTTCTTGGACTGTCTTTCTACTGGTCT
CAGTTCCACTAAATATTCCTTCAATTCGACAATCTCTATTCAGTAATAAAGCACTTTCTCTATTCAAAGGCGTTATGCCG
GAGATGTCACAAACCGAAAAAGATGCGATTGAAGCCGGTACAGTTTGGTGGGAAGCCGAATTATTTAAAGGTAACCCTGA
TTGGAAATTTCTTCATGGTATTCCTAAAAATACGCTATCAGATGAAGAACAAGCTTTTATGGATGGTCCAGTAACAGAAG
TGTGTCGCATGGTTAATGACTATGAAGTCACCCATGAGCTTGCCGATCTTCCACCAGAAGTATGGCAATACCTAAAAGAT
CATAAGTTCTTCGCTATGATCATTAAAAAGAAATACGGCGGCTTAGAATTTTCTGCTTACGCTCAGTCTTGCGTACTTCA
AAAATTAACTAGCGTATCTGGCGTACTCTCTATCACTGTCGGTGTTCCTAATTCATTAGGTCCTGGTGAGTTATTACAGC
ATTACGGTACAGAGGAACAAAAAAACTATTATTTACCTCGCTTAGCTGAAGGTAAAGAGATCCCATGTTTTGCACTAACA
AGTCCAGAAGCTGGTTCTGATGCAGGCTCGATTCCTGACTATGGTGTTGTGACTAAAGGCATGTGGGAAGGTGAAGAAGT
CGTAGGTATGCGTATTACTTGGAACAAACGCTATATCACACTCGCCCCTGTCGCTACCGTTTTAGGTTTAGCTTTCAAAC
TTCAAGATCCAGATGGTTTACTTGGTGATAAAAAAGATCTTGGTATTACTTGTGCTCTTATCCCGACGGATTTAGATGGT
GTTAAAATTGGCCGTCGTCATTTCCCATTAAACGTACCATTCCAAAATGGTCCAACTCAAGGTAACGATCTATTTGTTCC
GCTGGATTACATTATTGGTGGAGAAAAAATGGCAGGACATGGCTGGCGTATGCTGGTGGAATGCTTGTCGGTTGGTCGTG
GTATTACACTGCCATCTAATGCCACTGGTGGAGCGAAAACAGCAGCACTTGCAACAGGAGCTTACGCTCGCATTCGTCGT
CAATTTAAGCTTCCTATTGGTAAAATGGAAGGTATTGAAGAACCATTAGCACGTATGGCAGGTAATGCTTATATGATGGA
CGCTGCGAGTAACTTGACCGTTGCAGGTATTGTTCAAGGCGAAAAACCATCGGTTATCTCTGCAATTGTGAAATACCACT
GTACACATCGAGCTCAGCGTGTCGCTATTGACGGAATGGATATTTCAGGTGGTAAAGGGATCTGTTTAGGTAATTCCAAC
TTCTTAGCTCGAGGCTATCAAGGTTCACCGATCGCTGTCACGGTTGAGGGGGCAAACATTCTCACTCGTTCAATGATCAT
TTATGGCCAAGGAGCTATTCGTTGTCACCCTTATGTACTTGCTGAAATGGATGCCGCTTATCTTGATGATAAAAAAGCAT
CATTAGAACAATTCGATTCCGCAGTCTTTGGACATATTGGTTTTGGTATCAGTAATTTTGTTCGCAGTTTCTGGCTTGGC
TTAACGGATGGTTATGGCTCGAAAACACCATTTAATGATGAAACCAAACGTTATTACCAACAAGTAAACCGATACAGTAC
AAACCTTGCTTTATTGTCTGATATTTCAATGGCTGTATTAGGAGGAAGTTTAAAACGTCGTGAACGTATGTCTGCACGTC
TTGGGGATGTATTAAGTCAACTTTATTTAACAACATCAACATTAAAACGTTTTGATGATGATGGTCGTCAAAAAGAAGAT
TTAGCTCTGGTTCATTGGAGTGTTCAAGATTCTCTGCATCAAGCAGAACAAGCGATTGATGGATTACTGTCTAACTTTCC
AAATCGATTTGTTGCTGGTGCGATGCGCTTTATTCTATTACCAACCGGGCTTCGTCGTCAGAAACCAAGCGACAAACTTG
ACCATAAATTAGCGCGTATTCTTCAAGAACCGTCAGGCGTTCGTAGTCGAATTGGTCGAGGGTTATTCTTAGAAGCAAGT
CGCTTTAACCCTGTAGGAAAAATGGAAGAAGCATTAATTGATATTTTAACTGCTGAACCAATTTATGACCGCGTATGCAA
AGAGTCTAAGCAACGTTTACCATTTATGCAGCTTGATCGCGTGGCGAAAGTTGGATTAGAACTCAATATAATTTCTGATA
AAGAAGCGCTGTTATTACGTAAAGCAGAGAAAAGTCGATTAGCAACCATCAACGTTGATGACTTTGACCCAAGCGAACTT
ATCGTAAAACCACAAAACCACAGTGTTGAGCACAGTAAAATTGCATAA

Upstream 100 bases:

>100_bases
TTTAACTGGTTAGACCTCTTACCTAAATAATAAATTTACGACATGTAATCGTAATACCTCTGTTCCTACAAACAGAGCAG
CGCCGGAAAAGGAGAATCAC

Downstream 100 bases:

>100_bases
CCCTTAAAATCAAAAAAGGCCAGAGTAACTAACATTACTCTGGCCTTTTTCATAATGTCTCTATCTTATTAAGGTAAAGA
CATTACTAATTTTAAATAAA

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 815; Mature: 814

Protein sequence:

>815_residues
MALTLLATVIALAALSYHRQSLKTSTLVIAGILAISSGLGYAGFISWTVFLLVSVPLNIPSIRQSLFSNKALSLFKGVMP
EMSQTEKDAIEAGTVWWEAELFKGNPDWKFLHGIPKNTLSDEEQAFMDGPVTEVCRMVNDYEVTHELADLPPEVWQYLKD
HKFFAMIIKKKYGGLEFSAYAQSCVLQKLTSVSGVLSITVGVPNSLGPGELLQHYGTEEQKNYYLPRLAEGKEIPCFALT
SPEAGSDAGSIPDYGVVTKGMWEGEEVVGMRITWNKRYITLAPVATVLGLAFKLQDPDGLLGDKKDLGITCALIPTDLDG
VKIGRRHFPLNVPFQNGPTQGNDLFVPLDYIIGGEKMAGHGWRMLVECLSVGRGITLPSNATGGAKTAALATGAYARIRR
QFKLPIGKMEGIEEPLARMAGNAYMMDAASNLTVAGIVQGEKPSVISAIVKYHCTHRAQRVAIDGMDISGGKGICLGNSN
FLARGYQGSPIAVTVEGANILTRSMIIYGQGAIRCHPYVLAEMDAAYLDDKKASLEQFDSAVFGHIGFGISNFVRSFWLG
LTDGYGSKTPFNDETKRYYQQVNRYSTNLALLSDISMAVLGGSLKRRERMSARLGDVLSQLYLTTSTLKRFDDDGRQKED
LALVHWSVQDSLHQAEQAIDGLLSNFPNRFVAGAMRFILLPTGLRRQKPSDKLDHKLARILQEPSGVRSRIGRGLFLEAS
RFNPVGKMEEALIDILTAEPIYDRVCKESKQRLPFMQLDRVAKVGLELNIISDKEALLLRKAEKSRLATINVDDFDPSEL
IVKPQNHSVEHSKIA

Sequences:

>Translated_815_residues
MALTLLATVIALAALSYHRQSLKTSTLVIAGILAISSGLGYAGFISWTVFLLVSVPLNIPSIRQSLFSNKALSLFKGVMP
EMSQTEKDAIEAGTVWWEAELFKGNPDWKFLHGIPKNTLSDEEQAFMDGPVTEVCRMVNDYEVTHELADLPPEVWQYLKD
HKFFAMIIKKKYGGLEFSAYAQSCVLQKLTSVSGVLSITVGVPNSLGPGELLQHYGTEEQKNYYLPRLAEGKEIPCFALT
SPEAGSDAGSIPDYGVVTKGMWEGEEVVGMRITWNKRYITLAPVATVLGLAFKLQDPDGLLGDKKDLGITCALIPTDLDG
VKIGRRHFPLNVPFQNGPTQGNDLFVPLDYIIGGEKMAGHGWRMLVECLSVGRGITLPSNATGGAKTAALATGAYARIRR
QFKLPIGKMEGIEEPLARMAGNAYMMDAASNLTVAGIVQGEKPSVISAIVKYHCTHRAQRVAIDGMDISGGKGICLGNSN
FLARGYQGSPIAVTVEGANILTRSMIIYGQGAIRCHPYVLAEMDAAYLDDKKASLEQFDSAVFGHIGFGISNFVRSFWLG
LTDGYGSKTPFNDETKRYYQQVNRYSTNLALLSDISMAVLGGSLKRRERMSARLGDVLSQLYLTTSTLKRFDDDGRQKED
LALVHWSVQDSLHQAEQAIDGLLSNFPNRFVAGAMRFILLPTGLRRQKPSDKLDHKLARILQEPSGVRSRIGRGLFLEAS
RFNPVGKMEEALIDILTAEPIYDRVCKESKQRLPFMQLDRVAKVGLELNIISDKEALLLRKAEKSRLATINVDDFDPSEL
IVKPQNHSVEHSKIA
>Mature_814_residues
ALTLLATVIALAALSYHRQSLKTSTLVIAGILAISSGLGYAGFISWTVFLLVSVPLNIPSIRQSLFSNKALSLFKGVMPE
MSQTEKDAIEAGTVWWEAELFKGNPDWKFLHGIPKNTLSDEEQAFMDGPVTEVCRMVNDYEVTHELADLPPEVWQYLKDH
KFFAMIIKKKYGGLEFSAYAQSCVLQKLTSVSGVLSITVGVPNSLGPGELLQHYGTEEQKNYYLPRLAEGKEIPCFALTS
PEAGSDAGSIPDYGVVTKGMWEGEEVVGMRITWNKRYITLAPVATVLGLAFKLQDPDGLLGDKKDLGITCALIPTDLDGV
KIGRRHFPLNVPFQNGPTQGNDLFVPLDYIIGGEKMAGHGWRMLVECLSVGRGITLPSNATGGAKTAALATGAYARIRRQ
FKLPIGKMEGIEEPLARMAGNAYMMDAASNLTVAGIVQGEKPSVISAIVKYHCTHRAQRVAIDGMDISGGKGICLGNSNF
LARGYQGSPIAVTVEGANILTRSMIIYGQGAIRCHPYVLAEMDAAYLDDKKASLEQFDSAVFGHIGFGISNFVRSFWLGL
TDGYGSKTPFNDETKRYYQQVNRYSTNLALLSDISMAVLGGSLKRRERMSARLGDVLSQLYLTTSTLKRFDDDGRQKEDL
ALVHWSVQDSLHQAEQAIDGLLSNFPNRFVAGAMRFILLPTGLRRQKPSDKLDHKLARILQEPSGVRSRIGRGLFLEASR
FNPVGKMEEALIDILTAEPIYDRVCKESKQRLPFMQLDRVAKVGLELNIISDKEALLLRKAEKSRLATINVDDFDPSELI
VKPQNHSVEHSKIA

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=546, Percent_Identity=26.1904761904762, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI4557233, Length=422, Percent_Identity=27.4881516587678, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI4557235, Length=409, Percent_Identity=26.4058679706601, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI76496475, Length=388, Percent_Identity=26.5463917525773, Blast_Score=82, Evalue=3e-15,
Organism=Homo sapiens, GI4501859, Length=371, Percent_Identity=25.8760107816712, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI87081702, Length=809, Percent_Identity=67.9851668726823, Blast_Score=1145, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985184, Length=415, Percent_Identity=24.8192771084337, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17506239, Length=335, Percent_Identity=25.6716417910448, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71985192, Length=358, Percent_Identity=24.0223463687151, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508101, Length=252, Percent_Identity=29.3650793650794, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32563615, Length=236, Percent_Identity=28.3898305084746, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=332, Percent_Identity=24.3975903614458, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281363737, Length=348, Percent_Identity=27.0114942528736, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646207, Length=299, Percent_Identity=27.4247491638796, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24666513, Length=370, Percent_Identity=25.9459459459459, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21356377, Length=387, Percent_Identity=24.5478036175711, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355753, Length=350, Percent_Identity=23.4285714285714, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 89547; Mature: 89416

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTLLATVIALAALSYHRQSLKTSTLVIAGILAISSGLGYAGFISWTVFLLVSVPLNIP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCH
SIRQSLFSNKALSLFKGVMPEMSQTEKDAIEAGTVWWEAELFKGNPDWKFLHGIPKNTLS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEEEECCCCCCEEECCCCCCCCC
DEEQAFMDGPVTEVCRMVNDYEVTHELADLPPEVWQYLKDHKFFAMIIKKKYGGLEFSAY
CHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHEEHHHHHCCCCCHHHH
AQSCVLQKLTSVSGVLSITVGVPNSLGPGELLQHYGTEEQKNYYLPRLAEGKEIPCFALT
HHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEC
SPEAGSDAGSIPDYGVVTKGMWEGEEVVGMRITWNKRYITLAPVATVLGLAFKLQDPDGL
CCCCCCCCCCCCCCCCEECCCCCCCEEEEEEEEECCCEEEHHHHHHHHHHHEEECCCCCC
LGDKKDLGITCALIPTDLDGVKIGRRHFPLNVPFQNGPTQGNDLFVPLDYIIGGEKMAGH
CCCCCCCCEEEEEECCCCCCCEECCEECCEECCCCCCCCCCCEEEEEHHHEECCCCCCCC
GWRMLVECLSVGRGITLPSNATGGAKTAALATGAYARIRRQFKLPIGKMEGIEEPLARMA
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHC
GNAYMMDAASNLTVAGIVQGEKPSVISAIVKYHCTHRAQRVAIDGMDISGGKGICLGNSN
CCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHEEEEECEEECCCCEEEECCCC
FLARGYQGSPIAVTVEGANILTRSMIIYGQGAIRCHPYVLAEMDAAYLDDKKASLEQFDS
EEEECCCCCCEEEEECCCHHHHHEEEEEECCCEEECCEEEECCCHHHHCCHHHHHHHHHH
AVFGHIGFGISNFVRSFWLGLTDGYGSKTPFNDETKRYYQQVNRYSTNLALLSDISMAVL
HHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GGSLKRRERMSARLGDVLSQLYLTTSTLKRFDDDGRQKEDLALVHWSVQDSLHQAEQAID
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
GLLSNFPNRFVAGAMRFILLPTGLRRQKPSDKLDHKLARILQEPSGVRSRIGRGLFLEAS
HHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCEEEEEC
RFNPVGKMEEALIDILTAEPIYDRVCKESKQRLPFMQLDRVAKVGLELNIISDKEALLLR
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEECCCHHHHHH
KAEKSRLATINVDDFDPSELIVKPQNHSVEHSKIA
HHCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure 
ALTLLATVIALAALSYHRQSLKTSTLVIAGILAISSGLGYAGFISWTVFLLVSVPLNIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCH
SIRQSLFSNKALSLFKGVMPEMSQTEKDAIEAGTVWWEAELFKGNPDWKFLHGIPKNTLS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEEEECCCCCCEEECCCCCCCCC
DEEQAFMDGPVTEVCRMVNDYEVTHELADLPPEVWQYLKDHKFFAMIIKKKYGGLEFSAY
CHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHEEHHHHHCCCCCHHHH
AQSCVLQKLTSVSGVLSITVGVPNSLGPGELLQHYGTEEQKNYYLPRLAEGKEIPCFALT
HHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEC
SPEAGSDAGSIPDYGVVTKGMWEGEEVVGMRITWNKRYITLAPVATVLGLAFKLQDPDGL
CCCCCCCCCCCCCCCCEECCCCCCCEEEEEEEEECCCEEEHHHHHHHHHHHEEECCCCCC
LGDKKDLGITCALIPTDLDGVKIGRRHFPLNVPFQNGPTQGNDLFVPLDYIIGGEKMAGH
CCCCCCCCEEEEEECCCCCCCEECCEECCEECCCCCCCCCCCEEEEEHHHEECCCCCCCC
GWRMLVECLSVGRGITLPSNATGGAKTAALATGAYARIRRQFKLPIGKMEGIEEPLARMA
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHC
GNAYMMDAASNLTVAGIVQGEKPSVISAIVKYHCTHRAQRVAIDGMDISGGKGICLGNSN
CCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHEEEEECEEECCCCEEEECCCC
FLARGYQGSPIAVTVEGANILTRSMIIYGQGAIRCHPYVLAEMDAAYLDDKKASLEQFDS
EEEECCCCCCEEEEECCCHHHHHEEEEEECCCEEECCEEEECCCHHHHCCHHHHHHHHHH
AVFGHIGFGISNFVRSFWLGLTDGYGSKTPFNDETKRYYQQVNRYSTNLALLSDISMAVL
HHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GGSLKRRERMSARLGDVLSQLYLTTSTLKRFDDDGRQKEDLALVHWSVQDSLHQAEQAID
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
GLLSNFPNRFVAGAMRFILLPTGLRRQKPSDKLDHKLARILQEPSGVRSRIGRGLFLEAS
HHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCEEEEEC
RFNPVGKMEEALIDILTAEPIYDRVCKESKQRLPFMQLDRVAKVGLELNIISDKEALLLR
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEECCCHHHHHH
KAEKSRLATINVDDFDPSELIVKPQNHSVEHSKIA
HHCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]