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The map label for this gene is serS

Identifier: 170762301

GI number: 170762301

Start: 135162

End: 136418

Strand: Direct

Name: serS

Synonym: UPA3_0109

Alternate gene names: 170762301

Gene position: 135162-136418 (Clockwise)

Preceding gene: 170761853

Following gene: 170761953

Centisome position: 17.98

GC content: 27.68

Gene sequence:

>1257_bases
ATGTTTGATATTAATTTAATACGAAAAGATATTGCAACTACTAAAGAAAAGATGTTAAATAAAAAGGTGCCAAGCAATTT
GTTTGATCAAATTTTTGATTTAGATGTTTTAGTACGAAGTTTAATGCAACAAGAACAAAATCTTAATGCTAAGAAAAATC
AATTATCAAAAGAAATTGGTATTTTAGCTAAAAACAAAGATCCTAAATTACAACAAACATTAGATTTAGTTAATAATATT
AAAAACGAATTGCAAGATATTTCATTAACATTATCAAACAAACAAGATGAATTAAATAAATTATTATTAGTAATTCCTAA
TATGCCAGATGATTCAGTGCCCATTGGCAATGATGAAAATGACAACGTCGAAATTAAAAAAGTTTTTAAACCAAAAAAAT
TTGATTTTTTACCCCTTGCGCATTGAGATTTAGCAGTAAAAAACAAGTTAATTGATTTTGATAAATCAACAAAAATTACT
GGTAGTCGTTTTATTATTTATACTAATTTTGGTGCACGTTTATATCGTGCTTTACAACAATTTTGTTTAGATATGAATGT
AAAAGCAGGTTTTAGTGAAATTTGAGCACCTGTTATTGTTAATCAAGAATCTTTAATTGGTTCTGGAAACTTACCTAAAT
TTGCAGATGATTTATTCAAATTAGAAAATTCAAATTATTATTTATCACCAACTGCTGAAGTGCAATTAACAAATTTACAT
CGTAATGAAATTTTAAAAGCTAGTGATTTACCTTTATACTATACAGCTCTAACACCTTGTTTTCGTAGTGAAGCAGGATC
TGCAGGACGCGATGTTAGAGGTGTAATTCGTCAACACCAATTCCATAAAGTAGAATTAGTAAAATTATGTAAACCAGAAG
ATAGTTTTAAAGAATTAGAATCAATGACAAGACAGGCTGAAAGTATTTTAGAAGCTTTAGAATTACCTTATAGAAGAATC
GTTTTATGCACAGGCGATTTAGGTTTTAGTTCAGCTAAAACATATGATTTAGAAGTTTGATTACCATCATATAACGCTTA
TAAAGAAATTTCAAGTTGTTCAAATTGCACTAATTTCCAAGCGCGTCGTGCAAAAATTCGTTATAAAGAAACAATTGATG
CAACAACCGAATTAGTTCATACATTAAACGGATCATCATTAGCAATTGATCGATTATGGGCTGCAATTGTTGAAAATTAT
CAACAAGAAGATGGTAGTATCAACATTCCTAAAGTATTAAAAAAATACATCTATTAA

Upstream 100 bases:

>100_bases
AAAATGCTTGCTAACCTTTTTGTTTGGTTAAATAGCATTTTATTTTATTAAAATATATGTTTATATAGGTTGTTAAGCAA
ACTTAAAGAGGAAGAGTTAT

Downstream 100 bases:

>100_bases
TAAATAAAATAAGAAGTTAACTTTAGTCATAAAGCTAGCTTCTTATTTTTAATAAATACTGCTTGAAATTTTATACCTTT
ATTGATTGATATATCATTAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MFDINLIRKDIATTKEKMLNKKVPSNLFDQIFDLDVLVRSLMQQEQNLNAKKNQLSKEIGILAKNKDPKLQQTLDLVNNI
KNELQDISLTLSNKQDELNKLLLVIPNMPDDSVPIGNDENDNVEIKKVFKPKKFDFLPLAHWDLAVKNKLIDFDKSTKIT
GSRFIIYTNFGARLYRALQQFCLDMNVKAGFSEIWAPVIVNQESLIGSGNLPKFADDLFKLENSNYYLSPTAEVQLTNLH
RNEILKASDLPLYYTALTPCFRSEAGSAGRDVRGVIRQHQFHKVELVKLCKPEDSFKELESMTRQAESILEALELPYRRI
VLCTGDLGFSSAKTYDLEVWLPSYNAYKEISSCSNCTNFQARRAKIRYKETIDATTELVHTLNGSSLAIDRLWAAIVENY
QQEDGSINIPKVLKKYIY

Sequences:

>Translated_418_residues
MFDINLIRKDIATTKEKMLNKKVPSNLFDQIFDLDVLVRSLMQQEQNLNAKKNQLSKEIGILAKNKDPKLQQTLDLVNNI
KNELQDISLTLSNKQDELNKLLLVIPNMPDDSVPIGNDENDNVEIKKVFKPKKFDFLPLAH*DLAVKNKLIDFDKSTKIT
GSRFIIYTNFGARLYRALQQFCLDMNVKAGFSEI*APVIVNQESLIGSGNLPKFADDLFKLENSNYYLSPTAEVQLTNLH
RNEILKASDLPLYYTALTPCFRSEAGSAGRDVRGVIRQHQFHKVELVKLCKPEDSFKELESMTRQAESILEALELPYRRI
VLCTGDLGFSSAKTYDLEV*LPSYNAYKEISSCSNCTNFQARRAKIRYKETIDATTELVHTLNGSSLAIDRLWAAIVENY
QQEDGSINIPKVLKKYIY
>Mature_418_residues
MFDINLIRKDIATTKEKMLNKKVPSNLFDQIFDLDVLVRSLMQQEQNLNAKKNQLSKEIGILAKNKDPKLQQTLDLVNNI
KNELQDISLTLSNKQDELNKLLLVIPNMPDDSVPIGNDENDNVEIKKVFKPKKFDFLPLAH*DLAVKNKLIDFDKSTKIT
GSRFIIYTNFGARLYRALQQFCLDMNVKAGFSEI*APVIVNQESLIGSGNLPKFADDLFKLENSNYYLSPTAEVQLTNLH
RNEILKASDLPLYYTALTPCFRSEAGSAGRDVRGVIRQHQFHKVELVKLCKPEDSFKELESMTRQAESILEALELPYRRI
VLCTGDLGFSSAKTYDLEV*LPSYNAYKEISSCSNCTNFQARRAKIRYKETIDATTELVHTLNGSSLAIDRLWAAIVENY
QQEDGSINIPKVLKKYIY

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=467, Percent_Identity=31.9057815845824, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI8923421, Length=393, Percent_Identity=26.972010178117, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI225579074, Length=395, Percent_Identity=26.0759493670886, Blast_Score=139, Evalue=4e-33,
Organism=Escherichia coli, GI1787120, Length=425, Percent_Identity=47.5294117647059, Blast_Score=382, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17539260, Length=443, Percent_Identity=32.0541760722348, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17542084, Length=329, Percent_Identity=30.3951367781155, Blast_Score=144, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=441, Percent_Identity=33.1065759637188, Blast_Score=209, Evalue=7e-55,
Organism=Saccharomyces cerevisiae, GI6321799, Length=337, Percent_Identity=33.2344213649852, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24581334, Length=466, Percent_Identity=30.0429184549356, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI17737985, Length=276, Percent_Identity=35.1449275362319, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47202; Mature: 47202

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDINLIRKDIATTKEKMLNKKVPSNLFDQIFDLDVLVRSLMQQEQNLNAKKNQLSKEIG
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
ILAKNKDPKLQQTLDLVNNIKNELQDISLTLSNKQDELNKLLLVIPNMPDDSVPIGNDEN
EEECCCCCHHHHHHHHHHHHHHHHHHEEEEECCCHHHCCEEEEEECCCCCCCCCCCCCCC
DNVEIKKVFKPKKFDFLPLAHDLAVKNKLIDFDKSTKITGSRFIIYTNFGARLYRALQQF
CCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCEEEEEECCHHHHHHHHHHH
CLDMNVKAGFSEIAPVIVNQESLIGSGNLPKFADDLFKLENSNYYLSPTAEVQLTNLHRN
HHCCCCCCCHHHHCHHEECCHHHCCCCCCCHHHHHHHHHCCCCEEECCCCEEEEECCCHH
EILKASDLPLYYTALTPCFRSEAGSAGRDVRGVIRQHQFHKVELVKLCKPEDSFKELESM
HCCCCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
TRQAESILEALELPYRRIVLCTGDLGFSSAKTYDLEVLPSYNAYKEISSCSNCTNFQARR
HHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHH
AKIRYKETIDATTELVHTLNGSSLAIDRLWAAIVENYQQEDGSINIPKVLKKYIY
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MFDINLIRKDIATTKEKMLNKKVPSNLFDQIFDLDVLVRSLMQQEQNLNAKKNQLSKEIG
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
ILAKNKDPKLQQTLDLVNNIKNELQDISLTLSNKQDELNKLLLVIPNMPDDSVPIGNDEN
EEECCCCCHHHHHHHHHHHHHHHHHHEEEEECCCHHHCCEEEEEECCCCCCCCCCCCCCC
DNVEIKKVFKPKKFDFLPLAHDLAVKNKLIDFDKSTKITGSRFIIYTNFGARLYRALQQF
CCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCEEEEEECCHHHHHHHHHHH
CLDMNVKAGFSEIAPVIVNQESLIGSGNLPKFADDLFKLENSNYYLSPTAEVQLTNLHRN
HHCCCCCCCHHHHCHHEECCHHHCCCCCCCHHHHHHHHHCCCCEEECCCCEEEEECCCHH
EILKASDLPLYYTALTPCFRSEAGSAGRDVRGVIRQHQFHKVELVKLCKPEDSFKELESM
HCCCCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
TRQAESILEALELPYRRIVLCTGDLGFSSAKTYDLEVLPSYNAYKEISSCSNCTNFQARR
HHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHH
AKIRYKETIDATTELVHTLNGSSLAIDRLWAAIVENYQQEDGSINIPKVLKKYIY
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA