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The map label for this gene is tmk

Identifier: 170762140

GI number: 170762140

Start: 20494

End: 21186

Strand: Reverse

Name: tmk

Synonym: UPA3_0020

Alternate gene names: 170762140

Gene position: 21186-20494 (Counterclockwise)

Preceding gene: 170762067

Following gene: 170762264

Centisome position: 2.82

GC content: 24.1

Gene sequence:

>693_bases
ATGATATTAACGAAAAATAGTAATGAAAAAAAACCGCTTAAAAAAGGATTATTTATTGTTTTTGAAGGAATTGATGGTGC
AGGGAAAACTTCAATCTTAAAACAACTTTTAGAGGTTTTAAAAGAACCTAAACTAGTTAATAAAATTTTTTTAACGCGTG
AACCTGGTGGAAAAAACAATAATGCAGCAGAGATGATACGTGAGTTTTTTTTAAAAAATTTAGAAGTTTTTGATCCGTTA
ACACTAGCTTATTTATATGCAAGCAGTCGTGCTGAACACGTAAAAAAAACAATCAATCCTCATTTAGAAAAAGATCATAT
TGTAATTTCAGATCGTTTTGTTCATTCTTCATATATTTATCAAGGTATTGTTCAAAATCAAAGTTTAGATGTTATTTACC
AAATTAATCAACAAGCAATTGGTGAATTAGAAATAGATTATGTTTTTTATTTTGATGTTAATGTTAATAATGCATTAAAT
CGAATGAAAAATCGTTTTGACAATACAAATGCATTCGATTCACAAAATAAACAATTTTATGAAAAGTTATTAAAACAATA
CCCTAGTGTTTTTAAAGTTTATAATCAACCTAAAAAAATTATTTTTATTGATGCCAATAAAAATGAAAATGAAGTATTAT
GTGAGGTTAAAGAACAATTATTAAAAATTTTTAAAGAACATAAATATATATAA

Upstream 100 bases:

>100_bases
TCTGGTCATATTCCTTTTATTGAAGAACCAAAATTATTTACTAATATATTACTAAGTTTTTTAGAGGATAGATTTGTAGA
ACAAGAGGAAAATGATAACA

Downstream 100 bases:

>100_bases
ATGAAATACAGTTTTGCTAATTTATTAATTCAATCACCTAAAACCTCACTAGAATCAGGTATTGAAGAAATTATGTTAGC
TTTTATTTATGAGAAAAATC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MILTKNSNEKKPLKKGLFIVFEGIDGAGKTSILKQLLEVLKEPKLVNKIFLTREPGGKNNNAAEMIREFFLKNLEVFDPL
TLAYLYASSRAEHVKKTINPHLEKDHIVISDRFVHSSYIYQGIVQNQSLDVIYQINQQAIGELEIDYVFYFDVNVNNALN
RMKNRFDNTNAFDSQNKQFYEKLLKQYPSVFKVYNQPKKIIFIDANKNENEVLCEVKEQLLKIFKEHKYI

Sequences:

>Translated_230_residues
MILTKNSNEKKPLKKGLFIVFEGIDGAGKTSILKQLLEVLKEPKLVNKIFLTREPGGKNNNAAEMIREFFLKNLEVFDPL
TLAYLYASSRAEHVKKTINPHLEKDHIVISDRFVHSSYIYQGIVQNQSLDVIYQINQQAIGELEIDYVFYFDVNVNNALN
RMKNRFDNTNAFDSQNKQFYEKLLKQYPSVFKVYNQPKKIIFIDANKNENEVLCEVKEQLLKIFKEHKYI
>Mature_230_residues
MILTKNSNEKKPLKKGLFIVFEGIDGAGKTSILKQLLEVLKEPKLVNKIFLTREPGGKNNNAAEMIREFFLKNLEVFDPL
TLAYLYASSRAEHVKKTINPHLEKDHIVISDRFVHSSYIYQGIVQNQSLDVIYQINQQAIGELEIDYVFYFDVNVNNALN
RMKNRFDNTNAFDSQNKQFYEKLLKQYPSVFKVYNQPKKIIFIDANKNENEVLCEVKEQLLKIFKEHKYI

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=213, Percent_Identity=26.2910798122066, Blast_Score=75, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_UREP2 (B1AI06)

Other databases:

- EMBL:   CP000942
- RefSeq:   YP_001752100.1
- ProteinModelPortal:   B1AI06
- GeneID:   6155253
- GenomeReviews:   CP000942_GR
- KEGG:   upa:UPA3_0020
- HOGENOM:   HBG626009
- OMA:   KGHIVIS
- ProtClustDB:   CLSK2298742
- BioCyc:   UPAR505682:UPA3_0020-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 26900; Mature: 26900

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILTKNSNEKKPLKKGLFIVFEGIDGAGKTSILKQLLEVLKEPKLVNKIFLTREPGGKNN
CEECCCCCCCCHHHCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHEEEEECCCCCCC
NAAEMIREFFLKNLEVFDPLTLAYLYASSRAEHVKKTINPHLEKDHIVISDRFVHSSYIY
CHHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHH
QGIVQNQSLDVIYQINQQAIGELEIDYVFYFDVNVNNALNRMKNRFDNTNAFDSQNKQFY
HHHHCCCCCEEEEEECHHHCCCEEEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHH
EKLLKQYPSVFKVYNQPKKIIFIDANKNENEVLCEVKEQLLKIFKEHKYI
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MILTKNSNEKKPLKKGLFIVFEGIDGAGKTSILKQLLEVLKEPKLVNKIFLTREPGGKNN
CEECCCCCCCCHHHCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHEEEEECCCCCCC
NAAEMIREFFLKNLEVFDPLTLAYLYASSRAEHVKKTINPHLEKDHIVISDRFVHSSYIY
CHHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHH
QGIVQNQSLDVIYQINQQAIGELEIDYVFYFDVNVNNALNRMKNRFDNTNAFDSQNKQFY
HHHHCCCCCEEEEEECHHHCCCEEEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHH
EKLLKQYPSVFKVYNQPKKIIFIDANKNENEVLCEVKEQLLKIFKEHKYI
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA