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The map label for this gene is pncB [H]

Identifier: 170757648

GI number: 170757648

Start: 1576799

End: 1578280

Strand: Reverse

Name: pncB [H]

Synonym: CLD_3127

Alternate gene names: 170757648

Gene position: 1578280-1576799 (Counterclockwise)

Preceding gene: 170756583

Following gene: 170755054

Centisome position: 39.87

GC content: 32.79

Gene sequence:

>1482_bases
ATGGAATACAGTAAAAACTTCGATGTGAGAAATAATAGAAATCTTACTATGTTAGTAGATTTTTATGAACTTACTATGGG
AAATGGATATTTAAAAAGTGGTATGGGAGATAAAATGGCCTACTATGATATGTTCTTTAGAAGAGTTCCTGATGGCGGGG
GCTATTGTATTATGGCAGGAGTTCAACAACTTATTGAATATTTATCCGGTTTAAAATTTACAGAAGATGATATAGAATAT
TTAAGATCTAAAAAGGAATTTTCCGAAGAATTTTTAGACTATCTAAAAAACTTTAAATTTTCTTGTGATGTTTGGGCAGT
ACCAGAAGGATATCCTGTTTTTCCAAATGAGCCTTTAGTTACAGTCCGCGGTCCAGCCATTCAAGCTCAATTTGTAGAAA
CTATGATACTTCTTACTATAAATCACCAAACTCTAATTGCTACCAAAGCTAATAGAATCTGTAGAGCCGCTGAAAATCGT
TCTGTTATGGAATTTGGATCTAGACGTGCTCAAGGTTATGATGGTGCTATATATGGTGCAAGAGCAGCTGTAATTGGTGG
ATGTAATGCAACTGCTTGTACTATAGCTGAAGAAATGTTTGGAATACCTGCTGCAGGTACTATGGCACATAGTTGGATAC
AACTATTTCCTACAGAGTATGAAGCTTTTAAAGCCTGGGCAGAGGTAAATCCAGAAAATTGTGTGCTTTTAGTAGATACC
TATAATGTACTAAAATCTGGTATTCCTAATGCTATAAAAGTGTTTAATGAAGTATTAAGACCTAAAGGTATTAGACCTAA
AGGCATTAGAATAGATAGCGGTGACATAACTTACCTTACTAAAACCTGTAGAAAAATGTTAGACGACGCAGGCTATAAAG
ATGTAGGCATTGTGGTTTCAAATTCTCTAGATGAATTTATAATAAGAGATGTTCTAAATCAAGGAGCTAAGATTGATAGC
TTTGGTGTAGGCGAAAGACTTATAACTGCAAGATCAGAACCTGTTTTTGGTGGCGTGTATAAATTAGTTGCAGTAGAAGC
TTGTGATGGAATAATAACACCTAAAATTAAAATAAGTGAAAATGAAGAGAAAATAACTAATCCAGGCTTCAAAAAACTTT
ATAGAATATATGACAAAAATTCACATCAAGCTATTGCGGATCTTATTACTATGCATGATGAAAAAATAGACGAAAGTAAG
CCCTTAGAAATATTTAATCCTTTATTTACATGGAAAAAGAAAAAAATTAAGGATTACTATGTAGAAGAATTGCTAGTTAA
AATATTTAATAAGGGAAAACAAGTTTATGAAAGCCCTGATGTTATGGATATAAAAGCCTTTGCCAAAAAACAAACTGAAA
GATTTTGGCCTGAAGTTTTAAGGTTTGAAAACCCTCATAAGTATTACGTAGACCTTTCCCCAAAGCTTTGGAGAGTTAAA
CAAGAACTTTTACATAAGTTTTCAGATACTTATGAAGAATAA

Upstream 100 bases:

>100_bases
AGTTAATATTTTAATTTTAACCACTAAGTATTGTAATAGCTCTTGTAAAGTATTACAATGTTGTTATATATTTTTACTAT
TACATAGAGGAGAATTAATA

Downstream 100 bases:

>100_bases
GATATATTTATAGCTCTAAAATAGGCTTCTAAAAATTTTGAATTTATTTTTACCTTTTAACTTATAATAAGCAATAAAAG
CTATGAATTGAAATATAATA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MEYSKNFDVRNNRNLTMLVDFYELTMGNGYLKSGMGDKMAYYDMFFRRVPDGGGYCIMAGVQQLIEYLSGLKFTEDDIEY
LRSKKEFSEEFLDYLKNFKFSCDVWAVPEGYPVFPNEPLVTVRGPAIQAQFVETMILLTINHQTLIATKANRICRAAENR
SVMEFGSRRAQGYDGAIYGARAAVIGGCNATACTIAEEMFGIPAAGTMAHSWIQLFPTEYEAFKAWAEVNPENCVLLVDT
YNVLKSGIPNAIKVFNEVLRPKGIRPKGIRIDSGDITYLTKTCRKMLDDAGYKDVGIVVSNSLDEFIIRDVLNQGAKIDS
FGVGERLITARSEPVFGGVYKLVAVEACDGIITPKIKISENEEKITNPGFKKLYRIYDKNSHQAIADLITMHDEKIDESK
PLEIFNPLFTWKKKKIKDYYVEELLVKIFNKGKQVYESPDVMDIKAFAKKQTERFWPEVLRFENPHKYYVDLSPKLWRVK
QELLHKFSDTYEE

Sequences:

>Translated_493_residues
MEYSKNFDVRNNRNLTMLVDFYELTMGNGYLKSGMGDKMAYYDMFFRRVPDGGGYCIMAGVQQLIEYLSGLKFTEDDIEY
LRSKKEFSEEFLDYLKNFKFSCDVWAVPEGYPVFPNEPLVTVRGPAIQAQFVETMILLTINHQTLIATKANRICRAAENR
SVMEFGSRRAQGYDGAIYGARAAVIGGCNATACTIAEEMFGIPAAGTMAHSWIQLFPTEYEAFKAWAEVNPENCVLLVDT
YNVLKSGIPNAIKVFNEVLRPKGIRPKGIRIDSGDITYLTKTCRKMLDDAGYKDVGIVVSNSLDEFIIRDVLNQGAKIDS
FGVGERLITARSEPVFGGVYKLVAVEACDGIITPKIKISENEEKITNPGFKKLYRIYDKNSHQAIADLITMHDEKIDESK
PLEIFNPLFTWKKKKIKDYYVEELLVKIFNKGKQVYESPDVMDIKAFAKKQTERFWPEVLRFENPHKYYVDLSPKLWRVK
QELLHKFSDTYEE
>Mature_493_residues
MEYSKNFDVRNNRNLTMLVDFYELTMGNGYLKSGMGDKMAYYDMFFRRVPDGGGYCIMAGVQQLIEYLSGLKFTEDDIEY
LRSKKEFSEEFLDYLKNFKFSCDVWAVPEGYPVFPNEPLVTVRGPAIQAQFVETMILLTINHQTLIATKANRICRAAENR
SVMEFGSRRAQGYDGAIYGARAAVIGGCNATACTIAEEMFGIPAAGTMAHSWIQLFPTEYEAFKAWAEVNPENCVLLVDT
YNVLKSGIPNAIKVFNEVLRPKGIRPKGIRIDSGDITYLTKTCRKMLDDAGYKDVGIVVSNSLDEFIIRDVLNQGAKIDS
FGVGERLITARSEPVFGGVYKLVAVEACDGIITPKIKISENEEKITNPGFKKLYRIYDKNSHQAIADLITMHDEKIDESK
PLEIFNPLFTWKKKKIKDYYVEELLVKIFNKGKQVYESPDVMDIKAFAKKQTERFWPEVLRFENPHKYYVDLSPKLWRVK
QELLHKFSDTYEE

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=518, Percent_Identity=29.1505791505791, Blast_Score=243, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI71997952, Length=531, Percent_Identity=31.638418079096, Blast_Score=252, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI71997947, Length=531, Percent_Identity=31.638418079096, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI71997955, Length=213, Percent_Identity=37.5586854460094, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24581587, Length=528, Percent_Identity=29.9242424242424, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI161076680, Length=206, Percent_Identity=35.4368932038835, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24581595, Length=206, Percent_Identity=35.4368932038835, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI28574709, Length=206, Percent_Identity=35.4368932038835, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24581593, Length=206, Percent_Identity=35.4368932038835, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24581591, Length=206, Percent_Identity=35.4368932038835, Blast_Score=136, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 56351; Mature: 56351

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYSKNFDVRNNRNLTMLVDFYELTMGNGYLKSGMGDKMAYYDMFFRRVPDGGGYCIMAG
CCCCCCCCCCCCCCEEEEEEEEHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCCCEEHHHH
VQQLIEYLSGLKFTEDDIEYLRSKKEFSEEFLDYLKNFKFSCDVWAVPEGYPVFPNEPLV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEE
TVRGPAIQAQFVETMILLTINHQTLIATKANRICRAAENRSVMEFGSRRAQGYDGAIYGA
EEECCCHHHHHHHEEEEEEECCCEEEEEHHHHHHHHHCCCCHHHHHHHHCCCCCCCEECC
RAAVIGGCNATACTIAEEMFGIPAAGTMAHSWIQLFPTEYEAFKAWAEVNPENCVLLVDT
CEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEC
YNVLKSGIPNAIKVFNEVLRPKGIRPKGIRIDSGDITYLTKTCRKMLDDAGYKDVGIVVS
HHHHHHCCCHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEE
NSLDEFIIRDVLNQGAKIDSFGVGERLITARSEPVFGGVYKLVAVEACDGIITPKIKISE
CCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEECC
NEEKITNPGFKKLYRIYDKNSHQAIADLITMHDEKIDESKPLEIFNPLFTWKKKKIKDYY
CCHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
VEELLVKIFNKGKQVYESPDVMDIKAFAKKQTERFWPEVLRFENPHKYYVDLSPKLWRVK
HHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHH
QELLHKFSDTYEE
HHHHHHHHHHCCC
>Mature Secondary Structure
MEYSKNFDVRNNRNLTMLVDFYELTMGNGYLKSGMGDKMAYYDMFFRRVPDGGGYCIMAG
CCCCCCCCCCCCCCEEEEEEEEHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCCCEEHHHH
VQQLIEYLSGLKFTEDDIEYLRSKKEFSEEFLDYLKNFKFSCDVWAVPEGYPVFPNEPLV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEE
TVRGPAIQAQFVETMILLTINHQTLIATKANRICRAAENRSVMEFGSRRAQGYDGAIYGA
EEECCCHHHHHHHEEEEEEECCCEEEEEHHHHHHHHHCCCCHHHHHHHHCCCCCCCEECC
RAAVIGGCNATACTIAEEMFGIPAAGTMAHSWIQLFPTEYEAFKAWAEVNPENCVLLVDT
CEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEC
YNVLKSGIPNAIKVFNEVLRPKGIRPKGIRIDSGDITYLTKTCRKMLDDAGYKDVGIVVS
HHHHHHCCCHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEE
NSLDEFIIRDVLNQGAKIDSFGVGERLITARSEPVFGGVYKLVAVEACDGIITPKIKISE
CCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEECC
NEEKITNPGFKKLYRIYDKNSHQAIADLITMHDEKIDESKPLEIFNPLFTWKKKKIKDYY
CCHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
VEELLVKIFNKGKQVYESPDVMDIKAFAKKQTERFWPEVLRFENPHKYYVDLSPKLWRVK
HHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHH
QELLHKFSDTYEE
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]