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The map label for this gene is vanR [H]

Identifier: 170757618

GI number: 170757618

Start: 339338

End: 340033

Strand: Direct

Name: vanR [H]

Synonym: CLD_0488

Alternate gene names: 170757618

Gene position: 339338-340033 (Clockwise)

Preceding gene: 170754505

Following gene: 170756558

Centisome position: 8.57

GC content: 28.74

Gene sequence:

>696_bases
ATGTTTAATGTACTTATTGTAGATGATGAAGCAGAAATAATTGAACTTATGGAAGTATATCTACTAAATGATGGTTATAA
AGTATTCAAAGCTACAAATGGATTAGATGCACTTAATATAATCAATGAGGAAAAGATTCATCTTGTGATTTTAGATATAA
TGATGCCGGGAATAGATGGGTTACAGGTTTGTATGAAAATTAGAAAAGAGTATAATATACCAATTATAATGGTTAGTGCA
AAAGGACAAGAAATGGATAAAATACAAGGTTTATCTACAGGTGCAGATGACTATATAGTAAAACCATTTAGCACAATGGA
ATTACTAGCTAGAGTAAAAGCTCAAATAAGAAGATATGTATATCTTAATGAAAATCATAAACAGCTTGATAATAAAGATG
TTATTGAAATAAAAGGTATTACTATAAACAAAAGAAATCATAAAGTTCATTTATTTGGTACAGAGTTAAAATTAACTCCA
ACAGAATATAAAATATTGTTATTATTAGCCAGCAATAGTGGGAAAGTATTTAGTGCTGAAGATATATATAAAGAGATTTG
GGCGGAAAAATATTTTGAAGGAAACAATACTGTTATGGCTCATATATGGAGGTTAAGGGAAAAATTAGAGGATAATCCTA
AGGAACCAAAGATAGTAGAAACGGTATGGGGAGTTGGATACAAAATTGAAGCATAG

Upstream 100 bases:

>100_bases
TTCAATCTTTTAGGATTCAAGATATAACATGATACACTAATTATTTTAAAGTATGATATAATTTCATTTAGATTAGTTAT
GTAATAGGAGTGTTAGCAGT

Downstream 100 bases:

>100_bases
TATTAAATATAATATTCTTATAAACTTTTTTATAGCAATGGTATTATCAATGATATCAACATTAATAATAGTTTTCTCAG
TAATTATGGAGTTGCATATT

Product: regulatory protein VanR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MFNVLIVDDEAEIIELMEVYLLNDGYKVFKATNGLDALNIINEEKIHLVILDIMMPGIDGLQVCMKIRKEYNIPIIMVSA
KGQEMDKIQGLSTGADDYIVKPFSTMELLARVKAQIRRYVYLNENHKQLDNKDVIEIKGITINKRNHKVHLFGTELKLTP
TEYKILLLLASNSGKVFSAEDIYKEIWAEKYFEGNNTVMAHIWRLREKLEDNPKEPKIVETVWGVGYKIEA

Sequences:

>Translated_231_residues
MFNVLIVDDEAEIIELMEVYLLNDGYKVFKATNGLDALNIINEEKIHLVILDIMMPGIDGLQVCMKIRKEYNIPIIMVSA
KGQEMDKIQGLSTGADDYIVKPFSTMELLARVKAQIRRYVYLNENHKQLDNKDVIEIKGITINKRNHKVHLFGTELKLTP
TEYKILLLLASNSGKVFSAEDIYKEIWAEKYFEGNNTVMAHIWRLREKLEDNPKEPKIVETVWGVGYKIEA
>Mature_231_residues
MFNVLIVDDEAEIIELMEVYLLNDGYKVFKATNGLDALNIINEEKIHLVILDIMMPGIDGLQVCMKIRKEYNIPIIMVSA
KGQEMDKIQGLSTGADDYIVKPFSTMELLARVKAQIRRYVYLNENHKQLDNKDVIEIKGITINKRNHKVHLFGTELKLTP
TEYKILLLLASNSGKVFSAEDIYKEIWAEKYFEGNNTVMAHIWRLREKLEDNPKEPKIVETVWGVGYKIEA

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=35.6521739130435, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=35.5263157894737, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=36.2445414847162, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI87082012, Length=228, Percent_Identity=35.5263157894737, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=33.0434782608696, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=31.8777292576419, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=31.7180616740088, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=32.4561403508772, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=32.7510917030568, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790860, Length=230, Percent_Identity=29.1304347826087, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=29.1304347826087, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.8701298701299, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI1787375, Length=231, Percent_Identity=29.4372294372294, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=27.9475982532751, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=32.0754716981132, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1788713, Length=130, Percent_Identity=29.2307692307692, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788905, Length=101, Percent_Identity=32.6732673267327, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790437, Length=184, Percent_Identity=25.5434782608696, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26631; Mature: 26631

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNVLIVDDEAEIIELMEVYLLNDGYKVFKATNGLDALNIINEEKIHLVILDIMMPGIDG
CEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCCCCEEEEEEEECCCCCHH
LQVCMKIRKEYNIPIIMVSAKGQEMDKIQGLSTGADDYIVKPFSTMELLARVKAQIRRYV
HHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHEEE
YLNENHKQLDNKDVIEIKGITINKRNHKVHLFGTELKLTPTEYKILLLLASNSGKVFSAE
EECCCHHHCCCCCEEEEEEEEEECCCCEEEEEEEEEEECCCCEEEEEEEECCCCCEEEHH
DIYKEIWAEKYFEGNNTVMAHIWRLREKLEDNPKEPKIVETVWGVGYKIEA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEECC
>Mature Secondary Structure
MFNVLIVDDEAEIIELMEVYLLNDGYKVFKATNGLDALNIINEEKIHLVILDIMMPGIDG
CEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCCCCEEEEEEEECCCCCHH
LQVCMKIRKEYNIPIIMVSAKGQEMDKIQGLSTGADDYIVKPFSTMELLARVKAQIRRYV
HHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHEEE
YLNENHKQLDNKDVIEIKGITINKRNHKVHLFGTELKLTPTEYKILLLLASNSGKVFSAE
EECCCHHHCCCCCEEEEEEEEEECCCCEEEEEEEEEEECCCCEEEEEEEECCCCCEEEHH
DIYKEIWAEKYFEGNNTVMAHIWRLREKLEDNPKEPKIVETVWGVGYKIEA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]