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The map label for this gene is nadC

Identifier: 170757583

GI number: 170757583

Start: 1610398

End: 1611234

Strand: Reverse

Name: nadC

Synonym: CLD_3103

Alternate gene names: 170757583

Gene position: 1611234-1610398 (Counterclockwise)

Preceding gene: 170756082

Following gene: 170754660

Centisome position: 40.71

GC content: 29.39

Gene sequence:

>837_bases
ATGAATTGGTTAGTTGTTGATGAAATACTTAAATCTGCACTTAAAGAAGATATATCCTTTGAGGACATAACTACAGAATC
TATATTTAAAGAAAATAAAAGAGCAAAAATAGATTTAATTGCAAAAGAAGACGGTATAATTGCTGGCTTAGAAGTTTTTA
GACGAGTATTTTTACTAATTGGTGATGCAGATGCTCAGTTCTATATAAAAGATGGTGAGAAAGTACATAAAGGCGAAAAA
ATAGGCACAGTTTTTGGAAATGTAAAAACTCTCTTAACCGGTGAAAGAGTTGCCTTAAACTTTCTCCAAAGGATGAGTGG
AATAGCTACTTTAACTAAACAATTTGTAGAGGAATTGAAAAGCACAAAAACTAAATTACTAGATACTAGAAAAACTACTC
CAAATCTTAGAATTTTTGAAAAATATGCTGTAAGGATTGGTGGCGGTTTTAATCACAGATTTGGATTAAATGATGGGATC
CTTATAAAGGATAATCATATAGATGCAGCTGGTGGAATAAAAAATGCTATAACTTTAGCAAAAAACAATGCCCCTTTTGT
AAGAAAGATAGAAGTTGAAGTTGAAAATTTAAAACAATTAGAAGAAGCTCTAGATTATAAAGCAGATATAATTATGCTTG
ATAATATGTCTTTAGATATGATGAAAAAAGCCATATACATAATAGATGGGAGAGCTGTAACTGAAGCTTCTGGAAATGTA
ACCATAGAAAAAATAAAATATATAGCAAACTGCGGTGTAGACTATATTTCTACTGGATCACTTACTCATTCTTTTAAAGT
TTTAGATTTAAGCATGAAAAATTTAACATATTTATAA

Upstream 100 bases:

>100_bases
ACAAAGATTTATACATTGAAACATAATGTAGAATATTATAGTTTATTAAATAAAAAAATAATTACAAAATCTCTACTTAA
ACTAAGGAGTGATTTACAAA

Downstream 100 bases:

>100_bases
TTACAAAATTTCATTTCTCATTTTTCTATAGTTATCTTACAATAAAAATTTAAAATAATTTGTGAAAATTCTATTTTTAT
AAAAATTACTATTACTTTCT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MNWLVVDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLIGDADAQFYIKDGEKVHKGEK
IGTVFGNVKTLLTGERVALNFLQRMSGIATLTKQFVEELKSTKTKLLDTRKTTPNLRIFEKYAVRIGGGFNHRFGLNDGI
LIKDNHIDAAGGIKNAITLAKNNAPFVRKIEVEVENLKQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRAVTEASGNV
TIEKIKYIANCGVDYISTGSLTHSFKVLDLSMKNLTYL

Sequences:

>Translated_278_residues
MNWLVVDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLIGDADAQFYIKDGEKVHKGEK
IGTVFGNVKTLLTGERVALNFLQRMSGIATLTKQFVEELKSTKTKLLDTRKTTPNLRIFEKYAVRIGGGFNHRFGLNDGI
LIKDNHIDAAGGIKNAITLAKNNAPFVRKIEVEVENLKQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRAVTEASGNV
TIEKIKYIANCGVDYISTGSLTHSFKVLDLSMKNLTYL
>Mature_278_residues
MNWLVVDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLIGDADAQFYIKDGEKVHKGEK
IGTVFGNVKTLLTGERVALNFLQRMSGIATLTKQFVEELKSTKTKLLDTRKTTPNLRIFEKYAVRIGGGFNHRFGLNDGI
LIKDNHIDAAGGIKNAITLAKNNAPFVRKIEVEVENLKQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRAVTEASGNV
TIEKIKYIANCGVDYISTGSLTHSFKVLDLSMKNLTYL

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=270, Percent_Identity=31.8518518518519, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI1786299, Length=271, Percent_Identity=42.8044280442804, Blast_Score=192, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321162, Length=274, Percent_Identity=32.1167883211679, Blast_Score=131, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31156; Mature: 31156

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWLVVDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLI
CCEEEHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHEE
GDADAQFYIKDGEKVHKGEKIGTVFGNVKTLLTGERVALNFLQRMSGIATLTKQFVEELK
ECCCCEEEEECCCCHHCCCHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
STKTKLLDTRKTTPNLRIFEKYAVRIGGGFNHRFGLNDGILIKDNHIDAAGGIKNAITLA
HHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEE
KNNAPFVRKIEVEVENLKQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRAVTEASGNV
CCCCCEEEEEEEEHHHHHHHHHHHCCCCCEEEEECCCHHHHHCEEEEECCCEEEECCCCE
TIEKIKYIANCGVDYISTGSLTHSFKVLDLSMKNLTYL
EHHHHHHHHHCCCCEEECCCCCEEEEEEEEEHHCCCCC
>Mature Secondary Structure
MNWLVVDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLI
CCEEEHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHEE
GDADAQFYIKDGEKVHKGEKIGTVFGNVKTLLTGERVALNFLQRMSGIATLTKQFVEELK
ECCCCEEEEECCCCHHCCCHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
STKTKLLDTRKTTPNLRIFEKYAVRIGGGFNHRFGLNDGILIKDNHIDAAGGIKNAITLA
HHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEE
KNNAPFVRKIEVEVENLKQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRAVTEASGNV
CCCCCEEEEEEEEHHHHHHHHHHHCCCCCEEEEECCCHHHHHCEEEEECCCEEEECCCCE
TIEKIKYIANCGVDYISTGSLTHSFKVLDLSMKNLTYL
EHHHHHHHHHCCCCEEECCCCCEEEEEEEEEHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]