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The map label for this gene is nprM [H]

Identifier: 170754660

GI number: 170754660

Start: 1608054

End: 1609793

Strand: Reverse

Name: nprM [H]

Synonym: CLD_3104

Alternate gene names: 170754660

Gene position: 1609793-1608054 (Counterclockwise)

Preceding gene: 170757583

Following gene: 170755979

Centisome position: 40.67

GC content: 30.75

Gene sequence:

>1740_bases
ATGAAAAGTAAAAAATTATTAGCTACAGTGTTAAGTGCTGTAATCACTTTTTCCACTGTTTCAGCAGTTTATGCTGCACC
TGTAGGAAAAGAGAATAAAAGTGAGCCAAAAACCACAACAATATTTTGGGGAAACAACACACAAAATACCAGAAAAGCTA
CTACTGGCATAACTCAAGAGAAATTTAACAATTCTCAGGATATAACTAATTTCTTTGAAAAGAACATCTCTAAATTTGGT
GTAAAGAAAGGTTCTCTTAAAAATACTAAAGTTGTAAAAGCTGACAAAGGTAAAACTAACTATCATATGATCTATCAAGT
AGATGATATCCCTGTATATTATGGAAGAATTGTTTTTACAACTAAAAAAGACTCATCTATAGACTCTATAACTGGTAGAA
TTGATGCTACTTTTGAAAATGACAGTTGGAAAGACAAAGTAAAACTATCAAAGGATAATGCTATAGAAAAAGCTAAAGAT
AGCATAAAATGCGATAGCTTATCTAAAAGCAATGCAGATTTATATTTATACAATTTTGAAGGAAAACCTTATGTAGCTTA
TTTAGTTAATTTGGTTGCAGATAATGGAGATTGGAATGTTTTTGTTAATGCTGAAGATGGTTCTATAGTAAATCAATTTA
ACAACACCCCTACCCTAATTGATAATAAAGATGAAGATTTACCTAATGCTGAAGAAATTAAAAAAGCTTCCAAAGAACCT
GCCAATATAAATAGTGTAATAAATGTTAATGGTGAAACTGTTAAAGGACAAGGTAAAACTACTTTAGACGGAATAGTTGA
TATTGATTTAACTTATAAAGACGGTAAATATTATTTGAAAGATAGTAATAAAAATGTTTATCTATATGACGTAAATCATA
GTCTTACTCCTATGTATTCTCGCTTTAAAGATCGTATATTAAGACACTCAACTCTTGTAGAAAATAACAGCAATAAATTT
ACAAGTGATGAACATGTTACTGCAGTAGATGGTTACGTTAATTTATCAAAAACTTATGATTACTATAAAAATAAGTTTAA
TAGAAATAGTATAGATAATAACGGTATGAATGTTGAAGGATTTATCCATACTGGTGTAAAATACAATAATGCCTTTTGGA
GAGATGATCTTGGTTCTATGTTCTTCGGTGATGGAGATGGAGTAAGATTCTCTTCCTTTGCAAGTGCTTTAGATGTTGTA
GGTCATGAAGTGAGCCATGGTATAACTAGTAAGGAATCCAAGCTTAAATATGAAAAAGAGTCTGGTGCTTTAAATGAATC
CTTCTCTGATATTATGGGCGTAGCTATAGAAGGAAAAAATTTCCAAATAGGTGAAGACTGCTACACACCAAATATTCCTG
GAGATGCATTGAGAGATATGGAAGACCCATCTAAAGGAAATCAACCAGCTCATATGAAAGACTTTAAAAATCTTCCTAAT
GATAAAGACAATGATTGGGGTGGAGTTCATACAAATTCAGGTATAATAAATCATGCTGCTTATTTAATTGCAGTTGGAAT
GGAAAAATCCGGTGAGTCAAATGGTAAAGATATTATGGCAAATTTATTTTATAAAGCAAATTGCCATTACTGGGATGAAA
CAACAGACTTTGCTAAATGCAGAAATGATGTAGTTCAAGTTGCTAAAGATATTTATGGGGAAAATAGTAAATATGTTAAA
ATTGTAGAAAATGCTTTCGACCAAGTTGGAATAACTGCCACACCTCAATTACCATTATAA

Upstream 100 bases:

>100_bases
TAATTGGTTAATATGTGAAATTGTTATTCATTTTCAATATTGATATAATTAATATTGAAAATTCCAATTAATCATAAATT
TGCTAGGGGGTTATTTATTT

Downstream 100 bases:

>100_bases
TTAAAAATATTTTAATTATATAAATATTCTTATATAAAATTATAAACCTATTAATATTTTACTATATAAATATTAATAGG
TTTATAAGTAAAAATATGCT

Product: bacillolysin

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 579; Mature: 579

Protein sequence:

>579_residues
MKSKKLLATVLSAVITFSTVSAVYAAPVGKENKSEPKTTTIFWGNNTQNTRKATTGITQEKFNNSQDITNFFEKNISKFG
VKKGSLKNTKVVKADKGKTNYHMIYQVDDIPVYYGRIVFTTKKDSSIDSITGRIDATFENDSWKDKVKLSKDNAIEKAKD
SIKCDSLSKSNADLYLYNFEGKPYVAYLVNLVADNGDWNVFVNAEDGSIVNQFNNTPTLIDNKDEDLPNAEEIKKASKEP
ANINSVINVNGETVKGQGKTTLDGIVDIDLTYKDGKYYLKDSNKNVYLYDVNHSLTPMYSRFKDRILRHSTLVENNSNKF
TSDEHVTAVDGYVNLSKTYDYYKNKFNRNSIDNNGMNVEGFIHTGVKYNNAFWRDDLGSMFFGDGDGVRFSSFASALDVV
GHEVSHGITSKESKLKYEKESGALNESFSDIMGVAIEGKNFQIGEDCYTPNIPGDALRDMEDPSKGNQPAHMKDFKNLPN
DKDNDWGGVHTNSGIINHAAYLIAVGMEKSGESNGKDIMANLFYKANCHYWDETTDFAKCRNDVVQVAKDIYGENSKYVK
IVENAFDQVGITATPQLPL

Sequences:

>Translated_579_residues
MKSKKLLATVLSAVITFSTVSAVYAAPVGKENKSEPKTTTIFWGNNTQNTRKATTGITQEKFNNSQDITNFFEKNISKFG
VKKGSLKNTKVVKADKGKTNYHMIYQVDDIPVYYGRIVFTTKKDSSIDSITGRIDATFENDSWKDKVKLSKDNAIEKAKD
SIKCDSLSKSNADLYLYNFEGKPYVAYLVNLVADNGDWNVFVNAEDGSIVNQFNNTPTLIDNKDEDLPNAEEIKKASKEP
ANINSVINVNGETVKGQGKTTLDGIVDIDLTYKDGKYYLKDSNKNVYLYDVNHSLTPMYSRFKDRILRHSTLVENNSNKF
TSDEHVTAVDGYVNLSKTYDYYKNKFNRNSIDNNGMNVEGFIHTGVKYNNAFWRDDLGSMFFGDGDGVRFSSFASALDVV
GHEVSHGITSKESKLKYEKESGALNESFSDIMGVAIEGKNFQIGEDCYTPNIPGDALRDMEDPSKGNQPAHMKDFKNLPN
DKDNDWGGVHTNSGIINHAAYLIAVGMEKSGESNGKDIMANLFYKANCHYWDETTDFAKCRNDVVQVAKDIYGENSKYVK
IVENAFDQVGITATPQLPL
>Mature_579_residues
MKSKKLLATVLSAVITFSTVSAVYAAPVGKENKSEPKTTTIFWGNNTQNTRKATTGITQEKFNNSQDITNFFEKNISKFG
VKKGSLKNTKVVKADKGKTNYHMIYQVDDIPVYYGRIVFTTKKDSSIDSITGRIDATFENDSWKDKVKLSKDNAIEKAKD
SIKCDSLSKSNADLYLYNFEGKPYVAYLVNLVADNGDWNVFVNAEDGSIVNQFNNTPTLIDNKDEDLPNAEEIKKASKEP
ANINSVINVNGETVKGQGKTTLDGIVDIDLTYKDGKYYLKDSNKNVYLYDVNHSLTPMYSRFKDRILRHSTLVENNSNKF
TSDEHVTAVDGYVNLSKTYDYYKNKFNRNSIDNNGMNVEGFIHTGVKYNNAFWRDDLGSMFFGDGDGVRFSSFASALDVV
GHEVSHGITSKESKLKYEKESGALNESFSDIMGVAIEGKNFQIGEDCYTPNIPGDALRDMEDPSKGNQPAHMKDFKNLPN
DKDNDWGGVHTNSGIINHAAYLIAVGMEKSGESNGKDIMANLFYKANCHYWDETTDFAKCRNDVVQVAKDIYGENSKYVK
IVENAFDQVGITATPQLPL

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 64681; Mature: 64681

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKKLLATVLSAVITFSTVSAVYAAPVGKENKSEPKTTTIFWGNNTQNTRKATTGITQE
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHCCCCHH
KFNNSQDITNFFEKNISKFGVKKGSLKNTKVVKADKGKTNYHMIYQVDDIPVYYGRIVFT
HCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEEEECCCEEEEEEEEEE
TKKDSSIDSITGRIDATFENDSWKDKVKLSKDNAIEKAKDSIKCDSLSKSNADLYLYNFE
ECCCCCCHHHCCEEEEEECCCCCCCCEEECCCHHHHHHHHCCCCCCCCCCCCCEEEEEEC
GKPYVAYLVNLVADNGDWNVFVNAEDGSIVNQFNNTPTLIDNKDEDLPNAEEIKKASKEP
CCCHHHEEEEHHCCCCCEEEEEECCCCCHHHHCCCCCCEECCCCCCCCCHHHHHHHCCCC
ANINSVINVNGETVKGQGKTTLDGIVDIDLTYKDGKYYLKDSNKNVYLYDVNHSLTPMYS
CCCCEEEECCCCEEECCCCEEECCEEEEEEEEECCEEEEEECCCEEEEEECCCCCCHHHH
RFKDRILRHSTLVENNSNKFTSDEHVTAVDGYVNLSKTYDYYKNKFNRNSIDNNGMNVEG
HHHHHHHHHHHHEECCCCCCCCCCCEEEECCEEECHHHHHHHHCCCCCCCCCCCCCEEEE
FIHTGVKYNNAFWRDDLGSMFFGDGDGVRFSSFASALDVVGHEVSHGITSKESKLKYEKE
EEECCEEECCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCEECHH
SGALNESFSDIMGVAIEGKNFQIGEDCYTPNIPGDALRDMEDPSKGNQPAHMKDFKNLPN
CCCCCCCHHHHEEEEEECCCEEECCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHCCCC
DKDNDWGGVHTNSGIINHAAYLIAVGMEKSGESNGKDIMANLFYKANCHYWDETTDFAKC
CCCCCCCCEECCCCHHHHEEEEEEEECCCCCCCCCHHHEEEEEEEECCEECCCCCHHHHH
RNDVVQVAKDIYGENSKYVKIVENAFDQVGITATPQLPL
HHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKSKKLLATVLSAVITFSTVSAVYAAPVGKENKSEPKTTTIFWGNNTQNTRKATTGITQE
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHCCCCHH
KFNNSQDITNFFEKNISKFGVKKGSLKNTKVVKADKGKTNYHMIYQVDDIPVYYGRIVFT
HCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEEEECCCEEEEEEEEEE
TKKDSSIDSITGRIDATFENDSWKDKVKLSKDNAIEKAKDSIKCDSLSKSNADLYLYNFE
ECCCCCCHHHCCEEEEEECCCCCCCCEEECCCHHHHHHHHCCCCCCCCCCCCCEEEEEEC
GKPYVAYLVNLVADNGDWNVFVNAEDGSIVNQFNNTPTLIDNKDEDLPNAEEIKKASKEP
CCCHHHEEEEHHCCCCCEEEEEECCCCCHHHHCCCCCCEECCCCCCCCCHHHHHHHCCCC
ANINSVINVNGETVKGQGKTTLDGIVDIDLTYKDGKYYLKDSNKNVYLYDVNHSLTPMYS
CCCCEEEECCCCEEECCCCEEECCEEEEEEEEECCEEEEEECCCEEEEEECCCCCCHHHH
RFKDRILRHSTLVENNSNKFTSDEHVTAVDGYVNLSKTYDYYKNKFNRNSIDNNGMNVEG
HHHHHHHHHHHHEECCCCCCCCCCCEEEECCEEECHHHHHHHHCCCCCCCCCCCCCEEEE
FIHTGVKYNNAFWRDDLGSMFFGDGDGVRFSSFASALDVVGHEVSHGITSKESKLKYEKE
EEECCEEECCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCEECHH
SGALNESFSDIMGVAIEGKNFQIGEDCYTPNIPGDALRDMEDPSKGNQPAHMKDFKNLPN
CCCCCCCHHHHEEEEEECCCEEECCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHCCCC
DKDNDWGGVHTNSGIINHAAYLIAVGMEKSGESNGKDIMANLFYKANCHYWDETTDFAKC
CCCCCCCCEECCCCHHHHEEEEEEEECCCCCCCCCHHHEEEEEEEECCEECCCCCHHHHH
RNDVVQVAKDIYGENSKYVKIVENAFDQVGITATPQLPL
HHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7764969 [H]